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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 15 Documents
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Search results for , issue "Vol 12 (2025): Vol. 12 Suppl. 2 (2025)" : 15 Documents clear
Hypoglycaemic Properties of The Combination of Roselle Calyx (Hibiscus sabdariffa Linn.) and Stevia Leaves (Stevia rebaudiana B.) in Alloxan-Induced White Rats Febriyanti, Raden Maya; Putri, Refitha Nurul; Diantini, Ajeng; Levita, Jutti
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59646

Abstract

Roselle (Hibiscus sabdariffa L.) and stevia (Stevia rebaudiana Bertoni) are known to contain phenolic compounds and flavonoids that act as antioxidants and are beneficial in lowering blood sugar levels. This study aimed to determine the phytochemical content and evaluate the hypoglycemic effects of a combined aqueous extract of H. sabdariffa and S. rebaudiana in a 3:1 ratio on diabetic rats. Aqueous extracts were prepared and analyzed for total phenolic and flavonoid contents using the Folin-Ciocalteu and aluminum chloride methods. Diabetes was induced in male Wistar rats by intraperitoneal injection of alloxan (235 mg/kgBW). Rats in the test groups received 500 or 1000 mg/kgBW of the combination, with blood glucose levels measured on the 0th, 7th, and 14th days post-treatment using a glucometer. H. sabdariffa, S. rebaudiana, and their combination contained total phenolic contents of 102.75, 188.053, and 118.856 mgGAE/g, respectively, and flavonoid contents of 3.099, 6.987, and 4.791 mgQE/g, subsequently. Administration of the combination extract at 1000 mg/kgBW showed the highest hypoglycemic effect, reducing blood glucose levels by 35.98% on the 14th day compared to the negative control (p<0.05). The combination of H. sabdariffa and S. rebaudiana extracts demonstrates significant hypoglycemic activity, attributed to their phenolic and flavonoid content.
In-Silico Study of N-Hydroxysuccinimide Folate and GAPDH as Targeting Agents for Tuberculosis Treatment Marhaendra, Laurentius Ivan Ageng; Muchtaridi, Muchtaridi; Rosandi, Yudi; Gazzali, Amirah Mohd
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59597

Abstract

Tuberculosis remains a major public health concern due to emerging cases of drug resistance. To overcome this issue, the effectiveness of antitubercular medications must be reinforced. One of the methods that can be used is using active targeting, which involves small molecules that bind to a specific receptor. In this research, we study the potential of N-hydroxysuccinimide (NHS) folate to be used as the targeting agent against the GAPDH (glyceraldehyde-3-phosphate dehydrogenase) cell-surface receptor, a common virulence factor found on many pathogenic bacteria, including Mycobacterium tuberculosis. We conducted this research using computational methods, specifically molecular docking and molecular dynamics simulation. Based on the evaluation of molecular docking and molecular dynamics simulation results, NHS-folate is predicted to have a huge potential to be an active targeting agent against the GAPDH receptor of Mycobacterium tuberculosis.
Aktivitas Ekstrak Etanol Daun Kate Mas (Euphorbia heterophylla Desf.) pada Tikus Putih Jantan Galur Wistar yang Resistensi Insulin Susilawati, Elis; Syihabbudin, Nazar; Kaniawati, Marita
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.59555

Abstract

Euphorbia heterophylla. Desf (kate mas) menunjukkan aktivitas penurunan glukosa darah, serta memiliki sifat antioksidan dan antiinflamasi. Penelitian ini bertujuan untuk mengeksplorasi potensi ekstrak etanol daun Euphorbia heterophylla Desf (EEH) sebagai anti resistensi insulin dalam pengelolaan diabetes mellitus tipe 2 (DMT2). Tujuan penelitian ini untuk mengetahui efek dan dosis efektif Ekstrak Etanol Daun Kate Mas (Euphorbia heterophylla Desf), disingkat EEH, terhadap tikus yang diinduksi makanan tinggi karbohidrat, lemak, dan fruktosa 30%. Metode penelitian dilakukan secara in vivo menggunakan 24 tikus jantan putih galur wistar yang dibagi menjadi 6 kelompok, yaitu kelompok kontrol normal, kontrol negatif, kontrol positif, EEH 50 mg/KgBB, 100 mg/KgBB, dan 200 mg/Kg BB dengan melakukan tes  kadar glukosa darah (KGD), pengukuran konstanta tes toleransi insulin (KTTI) dan histopatologi sel pankreas. Hasil penelitian menunjukkan bahwa EEH pada semua kelompok dapat menurunkan KGD (92,25 mg/dL±7,04 untuk 50 mg/KgBB; 99,75 mg/dL±13,57 untuk 100 mg/Kg BB; 117,00 mg/dL ±0,85 untuk 200 mg/Kg BB; dan 89,00 mg/dL ±5,34 untuk metformin) dibandingkan dengan kelompok kontrol negatif (132,00 mg/dL ±7,16). EEH 50 mg/Kg BB secara signifikan dapat meningkatkan sensitivitas insulin (3,95±0,53) dibandingkan dengan kelompok negatif (1,24±0,98). Hasil histologi pankreas menunjukan EEH pada semua kelompok uji dapat menurunkan jumlah nekrosis sel pankreas dibandingkan dengan kelompok kontrol negatif.  Kesimpulannya, EEH memiliki potensi untuk dieksplorasi lebih lanjut untuk aktivitas dalam meningkatkan sensitivitas insulin.
Lawsonia inermis: Review of Its Anti-inflammatory Properties and Therapeutic Potential Hidayat, Nafisa Nurfatia; Musfiroh, Ida
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.58785

Abstract

Lawsonia inermis often referred to as henna has been utilized for millennia in many parts of the world in traditional medicine including antibacterial, antifungal, antioxidant, anticancer and immunomodulatory effects and also to treat various inflammatory conditions. This review aims to comprehensively evaluate the anti-inflammatory effects of L. inermis and its potential therapeutic applications. Primary methods included literature searches in scientific databases like PubMed, Scopus, Springer that analyzed the bioactive compounds and their effects on inflammation. L. inermis contains active compounds like lawsone, alkaloids, flavonoids, and tannins, which have been shown to reduce inflammation in various experimental settings by inhibiting the production of pro-inflammatory such as cytokines and enzymes. Studies conducted in vivo and in vitro have shown that effectivity of Lawsonia inermis is effective in lowering edema, healing wounds, and both acute and chronic inflammation which involve regulatory mechanism and mediators of inflammation signalling pathways. Promising outcomes in the treatment of contact dermatitis, wound healing, reduce symptoms and pain management have also been seen in clinical studies. L. inermis shows promise as a natural anti-inflammatory agent. However, further research is needed to fully understand its mechanisms of action and optimize its therapeutic applications, including investigating its potential interactions with other medications and identifying the optimal dosage and administration routes.
Exploration of Anti-FABP3 Aptamer Conformation Using Coarse-Grained Molecular Dynamics Simulation Aathirah, A Sayyidatina; Hardianto, Ari; Gaffar, Shabarni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12s2.58912

Abstract

Aptamers have been extensively utilized in the development of diagnostic and therapeutic methodologies for a variety of diseases. Aptamer N13, obtained through the SELEX process in previous research, has been identified as an anti-FABP3 ssDNA aptamer to enhance diagnostic techniques for myocardial infarction. This study provides an in-depth examination of the conformation and structural dynamics of aptamer N13 using in-silico methods. These include secondary structure prediction via DNA-fold, 3D structures modeling through RNA-Composer, and coarse-grained molecular dynamics (MD) simulations with SIRAH AMBER. The 83 μs MD simulation results reveal that the predicted conformation generally struggles to maintain stability, as indicated by the RMSD values and their fluctuations. However, residues 1-50 demonstrate relatively stable conformations, particularly beyond the 40 μs point in the simulation. In contrast, residues 51-90, constituting the free end, exhibit persistent conformational instability. This instability is likely attributable to their single-stranded and free nature compared to the other regions characterized by loops that confer greater stability. Our findings suggest that the predicted conformation from existing tools does not yet provide the most stable reference structure, necessitating further exploration through extended molecular dynamics simulations. While current simulations offer a relatively stable conformational reference, additional simulations are warranted to determine the most stable configuration of the free-end region, thereby elucidating its role in the aptamer’s affinity and specificity
Therapeutic Synergy of Combination of Kaempferia galanga and Zingiber officinale Extracts on Hyperuricemia-Induced Arterial Stiffness Hasimun, Patonah; Muzaki, Yoga Adi Restu; Sodik, Jajang Japar; Sukmawati, Ika Kurnia; Kusriani, Herni
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.59175

Abstract

Hyperuricemia, characterized by high uric acid levels, is associated with an elevated risk of cardiovascular diseases. Xanthine oxidoreductase (XOR), an enzyme central to uric acid generation, is implicated in oxidative stress and diminished vascular function. It has become a focal point for potential therapeutic interventions. This investigation aimed to assess the influence of combined ethanol extracts of Kaempferia galanga L. and Zingiber officinale (KGZE) on xanthine oxidase activity and arterial rigidity in hyperuricemic rat models. Furthermore, the research sought to explore these extracts' potential in managing hyperuricemia and its associated vascular disorders. Hyperuricemia was established in Wistar rats by administering potassium oxonate at 4.5 mg/kg via injection. A total of 25 rats were divided into five groups: a normal control group receiving 0.5% CMC, a positive control group with hyperuricemia, a reference group treated with allopurinol (1.8 mg/kgBW), and two experimental groups receiving KGZE at doses of 50 mg/kgBW and 100 mg/kgBW. All rats consumed 25% fructose in their drinking water for 28 days. This study measured uric acid levels and arterial stiffness, revealing that KGZE significantly reduced uric acid levels and improved arterial stiffness, indicating its potential as an XOR inhibitor.
Formulasi dan Evaluasi Sediaan Parfum dari Bahan Pewangi Alami dengan Minyak Nilam Khairan, Khairan; Husna, Nurul; Maisyarah, Hilda; Diah, Muhammad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60116

Abstract

Bau badan adalah aroma tidak sedap yang timbul karena keringat yang bercampur dengan bakteri kulit. Parfum adalah salah satu produk kosmetik yang dapat digunakan untuk mengurangi bau badan. Tujuan dari penelitian ini adalah untuk formulasi dan evaluasi sediaan parfum dengan menggunakan bahan pewangi alami sebagai aroma dan minyak nilam fraksi berat sebagai agen pengikat. Ada dua fase metode yang digunakan dalam pembuatan parfum, yaitu formulasi dan evaluasi sediaan. Formulasi dibuat dalam empat sediaan formula dengan perentase minyak nilam fraksi berat sebagai (MNFB) yang berbeda beda yaitu F0 (0%); F1 (0,25%); F2 (0,5%); dan F3 (0,75%). Evaluasi sediaan parfum yang dilakukan yaitu berupa uji homogenitas, berat jenis, pH, spot, uji SPL (sillage, projection, dan longevity), uji siklus dipercepat dan uji hedonik. Hasil uji homogenitas, berat jenis, pH, dan uji spot memperlihatkan bahwa semua sediaan sesuai dengan standar. Uji SPL memperlihatkan bahwa sediaan F3 mempunyai ketahanan aroma yang paling lama yaitu 96 jam, diikuti oleh F2 (87 jam), F1 (80 jam), dan F0 (68 jam). Uji hedonik memperlihatkan bahwa sediaan F3 mempunyai longevity yang paling baik dibandingkan dengan sediaan lainnya, serta lebih disukai karena memiliki warna, aroma dan kejernihan yang paling baik dibandingkan dengan sediaan lainnya.
Kajian In Silico Senyawa Turunan Flavonoid Terhadap ER-α Sebagai Antikanker Payudara Dinata, Deden Indra; Muttaqin, Fauzan Z.; Sodik, Jajang J.; Irfani, Abdul M.
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.60035

Abstract

Di Indonesia, terdapat 65.858 kasus kanker payudara dengan angka kematian 22.430 jiwa. Pengobatan lini pertama kanker payudara melibatkan penggunaan Selective Estrogen Receptor Modulators (SERM), salah satunya adalah Tamoxifen. Turunan flavonoid telah terbukti secara farmakologi efektif dalam pengobatan kanker dan dapat menginduksi apoptosis sel. Penelitian dilakukan terhadap 103 turunan flavonoid menggunakan metode simulasi molecular docking dan dinamika molekul dengan Autodock versi 4.2.3, dengan parameter observasi Ki dan ∆G, sedangkan simulasi dinamika molekul menggunakan aplikasi AMBER 18 dengan parameter RMSD, RMSF, dan MMGBSA serta ikatan hidrogen. Berdasarkan hasil penambatan molekuler, senyawa scutellarein, maritimin, baicalein, maesopsin, formononetin, calycosin, pratensein, biochanin A, sulfuretin, dan eriodyctiol menunjukkan potensi sebagai antagonis ERα dengan nilai Ki yang lebih baik dibandingkan ligan alami. Berdasarkan parameter simulasi dinamika molekul, stabilitas pengikatan dan aktivitas antagonis dari turunan flavonoid ini terhadap ERα sebanding namun sedikit lebih rendah dibandingkan tamoxifen. Analisis simulasi dinamika molekul mengungkapkan bahwa meskipun senyawa flavonoid ini menunjukkan nilai Ki yang menjanjikan, stabilitas interaksi keseluruhan senyawa-senyawa ini dengan ERα kurang menguntungkan dibandingkan tamoxifen, seperti yang ditunjukkan oleh parameter dinamika molekul gabungan.
Selective Determination of Tetracycline in Broiler Chicken Meat by Molecularly Imprinted Polymer Suryana, Shendi; Najihudin, Aji; Elivania, Salma; Suherman, Meillia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.58889

Abstract

Tetracycline (TC) residues in poultry meat products can create antibiotic resistance in humans who consume them. Hence, sensitive analytical procedures to evaluate the quantities of tetracycline residues are required to assess the safety of these products for consumption. The study aimed to develop a sorbent using molecular imprinting technology to analyze tetracycline in chicken broiler meat products. The study used several tests and computational techniques to increase the effectiveness of screening for the best MIP systems. According to the bond energybased computational analysis, methacrylate acid (MAA) was the best functional monomer at a TC-to-MAA molar ratio of 1:6. The mixture of methanol and chloroform yielded the greatest Ka. The Job plot showed that a TC-to-MAA-molar ratio of 1:6 was best for synthesizing imprinted polymer in the mixture of methanol and chloroform. We generated MIPs using two alternative production methods: bulk (MIP1) and precipitation (MIP2). Adsorption capacity results revealed that MIP1 matches well with the Langmuir model, whereas MIP2 fits better with the Freundlich. MIP1 application produced recovery rates of 82,74±4.1% and MIP2 results of 92.14±3.2% for TC in spike-chicken meat. The outcomes of the selectivity test also demonstrated that MIP2 is superior to MIP1 and can recover TC from spiked chicken meat while coexisting with another antibiotic drug. The study’s findings indicate that MIP2 helps determine TC in spike chicken meat.
Antioxidant Activity of Extract Combination from Moringa oleifera Leaves and Garcinia mangostana L. Pericarp Hartanti, Yesiska Kristina; Lukas, Diksa T.; Hardy, Junius
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.59284

Abstract

Radical-related diseases can be mitigated through natural antioxidant therapies that help regulate the formation and accumulation of free radicals. The pericarp of Garcinia mangostana L. and the leaves of Moringa oleifera are well-known for their antioxidant properties due to their high level of bioactive compounds, such as flavonoids, phenolics, and xanthones. This study aimed to explore the antioxidant capabilities of these two herbal extract combinations. Using the maceration method with 96% ethanol, the extraction yields were 11.4% w/w for M. oleifera and 24.11% w/w for G. mangostana. Qualitative phytochemical screening revealed differences in secondary metabolites, particularly steroids and triterpenes, between the two extracts. The antioxidant activity was categorized based on EC50 values, with crude G. mangostana showing very strong activity (<50 µg/mL) and M. oleifera classified as strong (50–100 µg/mL). Combinations of the extracts (2–10 ppm) produced very strong antioxidant activity but showed reduced efficacy compared to G. mangostana alone, suggesting antagonistic interactions based on combination index (IC) calculation. This study emphasizes the need for multiple antioxidant assays to evaluate diverse mechanisms and recommends further research to optimize synergistic effects in herbal extract combinations.

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