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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 452 Documents
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The Comparison of Long-term Effect Between Intermittent Fasting and Calorie Restriction on Neurological Parameters of Mice Ni'ma, Neli Syahida; Anggadiredja, Kusnandar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.199-204

Abstract

Intermittent fasting (IF) and calorie restriction (CR) were purported to have health benefits. This research aimed to determine the long-term effect of IF and CR on selected neurological parameters in mice. Swiss Webster male mice were divided into 3 groups: ad libitum feeding (AL), IF, and CR. Mice in each group received the treatment for 16 weeks. They were then tested for anhedonia, depression, aggressiveness, and social approach. They were also subjected to contextual fear conditioning tests to model PTSD. Compared to AL, sucrose intake in the IF group was lower, while the CR group showed higher intake (p<0.01). This anhedonia characteristic shown in the IF group was confirmed not related to depression, as shown by significantly lower immobility time in the forced swimming test compared to AL (p<0.05). In the resident-intruder test, attack numbers in the IF group were fewer than in the AL group (p<0.05). As demonstrated by the results of the three-chamber test, the reduced aggressiveness in IF mice was unrelated to a deficit in sociability. In the fear extinction test (PTSD model), mice in the IF group showed lower freezing compared to those in AL (p<0.001). Although both IF and CR caused a reduction in total food intake, in the mice model tested, IF was shown to have favorable impacts on neurological parameters.
Potential Effects of Myrmecodia Pendants (Ant Nests) on Healing Bone Injuries Najah, Adilla Syahsiyatun; Kilo, Akram La; Kadir, Ahmad
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.311-319

Abstract

Myrmecodia pendens is a medical plant that can have a healing effect on bone injuries. Bone injuries can occur due to many things, including injuries due to infection, non-infection, degeneration and neoplasms. Bones are the most important part of the body for the human body because the decreased bone function will affect human activities. Therefore better bone healing is needed. This review article aims to study and analyze the role of Myrmecodia pendens in the bone wound healing process. Several studies show that Myrmecodia pendens contain flavonoids, vitamins, terpenoid saponins, quones, and glycosides, as well as anti-inflammatory substances. These ingredients are markers in the healing process. Myrmecodia pendens has been proven to speed up the healing process. The conclusion shows that Myrmecodia pendens is a medicinal plant that can speed up the healing process of bone injuries.
In Vitro Anti-inflammatory Activity of Bamboo Tali Leaf (Gigantochloa apus) Ethanol Extract Hidayah, Nurul; Hafshah, Mutista
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.601-606

Abstract

Inflammation is a physiological process that serves as a defense mechanism for the body against foreign substances, bacteria, or irritants. Inflammation can be cured with anti-inflammatory drugs. One of the plants that has the potential to be an anti-inflammatory agent is the bamboo leaf. This research aims to analyze the content of secondary metabolites, determine the inhibition value and IC50 value of the anti-inflammatory activity of the ethanol extract of bamboo tali leaves. Bamboo tali leaves were macerated using 96% ethanol and subjected to phytochemical screening. The extract was then tested for anti-inflammatory activity in vitro with the Bovine Serum Albumin (BSA) protein denaturation inhibition method. Bamboo tali leaf ethanol extract contains flavonoids, alkaloids, saponins, and phenols. The anti-inflammatory activity of the ethanol extract of bamboo tali leaves with concentrations of 28, 42, 56, 70, and 84 ppm had an inhibition percentage value of 23.14 ± 0.008%; 34.30 0.026%; 54.51 0.060%; 69.07 ± 0.006%; and 87.02 ± 0.021% with an IC50 value of 52.991 ppm. These results indicate that the ethanol extract of bamboo tali leaves has the potential to be an anti-inflammatory with a strong IC50 value below 100 ppm.
The Neuroprotective and Therapeutic Effects of Medicinal Plants and Natural Products against Aluminium Chloride-Induced Alzheimer's Disease: Recent Update Ojetunde, Ayodeji Oluwatobi
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.7-33

Abstract

Alzheimer's disease currently affects more than 35 million individuals worldwide. Aluminium has been implicated in the pathogenesis of various cognitive disorders. Meanwhile, aluminium chloride (AlCl3) has a significant impact on the progression of neurodegenerative diseases including Alzheimer's disease. The majority of Alzheimer's disease medications now on the market are cholinesterase inhibitors. However, the effectiveness of these drugs is limited because they can't totally arrest the progression of the disease. The utilization of medicinal plants and natural products may present excellent prospective options for Alzheimer's disease prevention and therapy. This study summarized medicinal plants and natural products for the prevention and treatment of AlCl3-induced Alzheimer's disease as an alternative therapy using published data in the literature from the years 2021-2023. The medicinal plants and natural products help to reduce Alzheimer's disease pathogenesis by controlling different pathways and could be used as a therapeutic agent against the symptoms. The majority of the medicinal plants and natural products discussed in this review have been shown to have neuroprotective, antioxidant, anti-amyloid, anti-inflammatory, anticholinesterase, anti-apoptotic, and therapeutic actions. Therefore, medicinal plants and natural products may offer neuroprotective and therapeutic effects in the treatment of Alzheimer's disease.
The Diversity of Understory (Shrubs and Herbs) in the Kalikuning Area Supriyati, Hikmah; Ariyanti, Nur Aeni
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.159-163

Abstract

Kalikuning is one of the areas that has a diversity of flora. Kalikuning's fertile land helps a variety of plants flourish there. Since there are no people living here, a wide variety of unidentified and underexplored plants can be known. Therefore, more research on the plant diversity is required. The research aims to invent, document, and find out the diversity of the understory (shrubs and herbs) in Kalikuning. This research used survey and exploration methods. The researchers documented shrub and herb species. Based on the results, 28 families consist of 65 species of shrubs and herbs. Those species are flora that have specific characteristics.
Testing Antibacterial Activity of Daun Kentut (Paederia foetida L.) Leaf Extract against Escherichia coli in Vitro Savitri, Lisa; Tiyas, Eka Wahyuning; Krissanjaya, Rochmad
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.277-283

Abstract

Escherichia coli is a pathogenic bacterium that causes infectious diseases in the digestive tract and can produce Lipopolysaccharide (LPS), including lipid A. Exposure to endotoxins in lipid A, can cause systemic effects, such as sepsis, which can lead to clinical manifestations and even death. Daun Kentut (Paederia foetida L.) is one of the herbal plants containing bioactive compounds that can inhibit the growth of E. coli bacteria. The aim of this research is to determine the effective concentration of daun kentut leaf extract to inhibit E. coli growth. This study is an experimental research using maceration extraction method and antibacterial disc diffusion method with 3 repetitions at concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, negative control (aquadest), and positive control (ciprofloxacin) conducted from March to April 2023 in the Microbiology Laboratory of Kadiri University. The observation results of inhibition zones in each treatment varied. The presence of these inhibition zones is due to the presence of secondary metabolite compounds in daun kentut leaf extract that have antibacterial activity, such as inhibiting protein synthesis mechanisms, causing damage to cell wall permeability, and ultimately leading to bacterial cell lysis and death. The statistical analysis using the One Way Anova test with a P-value of 0.05 shows that each variable has significant differences and effects. Thus, it can be concluded that the effective extract variation is the 100% concentration because, in this study, the 100% concentration has an inhibition zone of 26.72 mm and is classified as very strong in inhibiting E. coli bacteria.
Antimicrobial Activities of Oyster Mushroom (Plerotous ostreatus), Garlic (Allium sativum), and Ginger Extracts (Zingiber officinale) Against Some Clinical Isolates Adenuga, Victoria Oluwapelumi; Fakoya, Soji; Sanni, Joseph Adaviruku; Adenuga, Akinola; Adenuga, Ore-ofe Oluwatoyin; Ajayi, Oluwaferanmi Timileyhin
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.389-395

Abstract

The prevalence of multiple drug resistance among human pathogenic bacteria necessitates a continual search for new antimicrobial medicines, particularly among plants that are frequently farmed or naturally found in our surroundings. The study aims to investigate the inhibitory effect of garlic, ginger, and mushroom extracts at different concentrations against some clinical isolates. Anti-bacterial components from mushrooms, garlic, and ginger were extracted with hot water, cold water, ethanol, and acetone, and their anti-bacterial activity was determined using the agar well diffusion method. Zones of inhibition were observed primarily on hot water extracts of mushrooms (Pleurotus ostreatus) on culture plates inoculated with Staphylococcus aureus, Escherichia coli, and Klebsiella pneumonia at 370C for 24 hours. The cold water extracts of the mushroom (Pleurotus ostreatus) gave the highest zone of inhibition of 14.0±1.0mm when used against S. aureus. For spices, the cold water extracts yielded the highest zones of inhibition of 22.0±1.0mm followed by 16.0±1.0mm as observed with ginger. The results obtained have shown clearly that the mushrooms (Pleurotus ostreatus), garlic (Allium sativum), and ginger (Zingiber officinale) extracts contain phytochemicals with some antimicrobial activities. The water extracts of the mushrooms and spices showed broad-spectrum antimicrobial activity much more than ethanol and acetone extracts. The antimicrobial activities of mushroom and garlic extracts were highly effective against the bacterial pathogens studied. However, the antimicrobial activity of the ginger extract was poor. To address the multi-drug resistance to antibiotics, I recommend: that bioactive compounds found in mushrooms, ginger, and garlic be patented and used as alternative antimicrobials.
Bioactivity of Vernonia arborea Leaves from Bentian Tribe as Natural Antioxidant and Antibacterial Based on Local Knowledge Sari, Nur Maulida; Aziza, Humairo; Aryani, Farida; Murdianto, Murdianto
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.675-680

Abstract

The utilization of natural organic materials as raw materials for standardized medicine, including the use of organic materials in medicine manufacture are currently being encouraged by the Government. Based on the information from Bentian Tribe people, Vernonia arborea leaf or Kutu Bu’ut leaf has the potential to be developed as natural medicine derived from plants. This study explored the potential of V.arborea leaf for its phytochemicals screening by Harborne, Kokate and Senthilmurugan method, antioxidant analysis was evaluated by DPPH radical scavenging assay. Antibacterial analysis was examined using agar well diffusion method against Escherichia coli and Propionibacterium acnes. The results showed that the V.arborea leaf contained alkaloid on n-hexan extract and coumarin on ethyl acetate extract. Ethanol extract from V.arborea leaf contained alkaloid, flavonoid, saponin, tannin, and carbohydrate. Antioxidant activity showed that the highest inhibition by 83% at 50 ppm consentration of ethanol solvent. Antibacterial activity of E. coli and P.acnes showed that the highest inhibition zone by 12 mm and 11 mm at 400 µg/well of ethanol extract. Based on the results, the V.arborea leaf contains natural bioactivity and has potential to be further developed as a natural traditional medicine.
Formulation and Antibacterial Activity Testing of Eco-Soap Based on Sodium Lauryl Sulfate Surfactant Widiani, Nurhaida; Novitasari, Aulia; Winandari, Ovi Prasetya; Saputri, Dwijowati Asih
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.121-125

Abstract

Pineapple is a fruit that is often used only for its flesh, while the skin remains waste. As a form of dealing with pineapple waste, one way is to use it as an eco-enzyme. Making soap with added eco-enzyme can be used as an alternative for washing dishes. Therefore, this research aims to determine the formulation and test the antibacterial activity of eco-soap based on the surfactant Sodium Lauryl Sulphate. This research is experimental research, which was carried out in July-October 2023. The research results showed that the pH of eco-Soap was 3.46; foam height 1.5 cm; viscosity testing 14.9 mPas; fatty acids 1.44%; and 6 mm antibacterial activity testing. Based on the research results, it was concluded that the surfactant-based eco-soap formulation had good stability in the eco-soap foam height test. The diameter of the zone of inhibition of eco-soap's antibacterial activity showed that bacterial inhibition was moderate.
Commercial Incense: Compound Analysis and Its Molecular Docking Studies as Anxiolytic Agents Apsari, Cintya Nurul; Ujiantari, Navista Sri Octa; Rohmah, Zuliyati; Utami, Setyowati Triastuti; Suma, Artania Adnin Tri; Gusnaniar, Niar
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.239-250

Abstract

In the context of Indonesian culture, incense has been traditionally utilized in various rituals. Incense possesses a calming impact and has the potential to reduce anxiety. This physiological response stems from the interplay of chemical components within incense and receptors associated with relaxation, specifically GABAA. This research aims to explore the interaction between substances found in commercially incenses with the GABAA receptors. The compounds of incense were identified through Gas Chromatography-Mass Spectrometry (GCMS) analysis. And there were 54 compounds identified from the 5 incense samples. Next, the ligands employed for docking studies were compounds predicted to traverse the blood-brain barrier (BBB). There were 31 compounds potential of crossing the blood-brain barrier (BBB). Docking results indicated that the majority of tested compounds exhibited notably lower S-scores during receptor interaction, suggesting their potential as anxiety-relieving agents. Furthermore, molecular docking outcomes highlighted that 9-Octadecenoic acid (Z)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester showed the lowest S-score (-6.573). These findings imply that odorant and other volatile organic compounds (VOCs) present in incenses possess the ability to function as anxiety-reducing (anxiolytic) agents, potentially assisting in anxiety treatment.

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