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INDONESIA
Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 425 Documents
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In Silico Analysis of Bioactive Compounds in The Faloak (Sterculia quadrifida R. Br) Stem Bark to Identify Antidiabetic Activity Utami, Fajar Dwi; Achmad Daud, Rizqi Akbar Fandi; Nurmayati, Adi; Ratumakin, Monika Buka Kopon; Siung, Chris Nicholas; Stephanie, Adiva; Fadillah, Almufti; Mulatsari, Esti; Mumpuni, Esti; Prasetyo, Andri
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.177-184

Abstract

Sterculia quadrifida R. Br or known as the faloak plant is a typical plant originating from the East Nusa Tenggara region, Indonesia. This plant has long been used by local people in the treatment of diabetes. In vivo, bioactive compounds from the extract of stem bark Sterculia quadrifida R. Br have been reported to have antidiabetic activity. The present study aims to analyse the potential of bioactive compounds in the faloak stem bark as inhibitors of the enzymes ?-glucosidase, PPAR-?, SGLT2, and DPP-IV. The preparation of bioactive compounds and their comparison was conducted utilising ChemDraw 2D & 3D, while proteins were obtained from the Protein Data Bank (PDB). The docking process used Molegro Virtual Docker, and visualisation was performed using BIOVIA Discovery Studio. Pharmacokinetic prediction (ADMET) was also carried out using the pkCSM website. The results of molecular docking with DPP-IV receptors showed that three bioactive compounds of faloak have better affinity than the comparative compounds, namely beta sisterol (-98.8838) to Alogliptin, Linagliptin, and Sitagliptin. While epicatechin (-83.9022) and cathecin (-83.4336) have better affinity than the comparative compounds Vidagliptin, Saxagliptin.
Taxonomic Study and Bioprospecting Indonesian Termitomyces eurrhizus Ayu, Siti Maulyda; Mahardhika, Wahyu Aji; Putra, Ivan Permana; Nurhayat, Oktan Dwi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.289-297

Abstract

Termitomyces are known as wild edible mushrooms that are commonly consumed in Africa and Asia. T. eurrhizus can be easily found in many areas in Indonesia. However, the recent collection and proper documentation of this species has not been done in Indonesia. In addition, the potential utilization of this species needs to be revealed. This research aims to identify, investigate the proximate value, and test the antibacterial activity of T. eurrhizus. The exploration was carried out at the IPB University campus forest using an opportunistic sampling method. Fresh basidiomata were used for morphological identification. Proximate analysis was done following AOAC method. Mushroom extract was subjected to antibacterial test against Enteropathogenic Escherichia coli. Our specimen was identified as T. eurrhizus based on pileus characters (macroscopically) and spore features under an electron microscope (microscopically). The proximate result showed that the moisture content was 13,70 %, the ash 13,66 %, total fat content 2,05 %, total protein content 27,73 % and fiber content 8,49 %. The investigated antibacterial was evaluated based on size of antibacterial zone for concentration 200 mg/ml extract (3,5 mm), 100 mg/ml (6,5 mm), 50 mg/ml (3,83 mm), 25 mg/ml (2,5 mm), and 12.5 mg/ml 6,33 mm. Our result showed the potential utilization of T. eurrhizus as nutraceutical food and antibacterial. Further research is expected to collaborate with various cultivation or product development fields.
Potential Medicinal Plant Antioxidant Compounds Based on Local Ethnobotany of Dadap Ayam (Erythrina variegata L.) from East OKU District Permata, Ending; Hanum, Laila; Salni, Salni
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.395-400

Abstract

Indonesia is one of the countries rich in natural resources, especially plant diversity. This plant diversity includes various plants that have the potential of being traditional medicine. Types of plants that can be used in traditional medicine are useful for curing various diseases in the community and can be used as raw materials for medicine. In Ogan Komering Ulu Timur (OKU Timur) district there are 20 sub-districts but only 2 sub-districts are used as plant exploration areas that are used as observation objects, namely Bunga Mayang and Martapura. The plant surveyed is the dadap ayam plant (Erythrina variegata L.), used in traditional medicine by the Javanese people in Buay Madang Timur, OKU Timur. To determine the chemical content and antioxidant activity of the dadap ayam plant leaves. The dadap ayam plant is used in traditional medicine by the Javanese people in Buay Madang Timur, OKU Timur and is known as a herbal plant based on previous research journals. The study of the antioxidant activity of dadap ayam leaves was conducted from October to March 2025. Sampling was conducted in Bunga Mayang District, Peracak Village and Martapura District, East Ogan Komering Ulu Regency, South Sumatra. Dadap ayam leaf samples were identified at the Botany Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, University of Lampung (UNILA). Sample processing such as extraction, fractionation and compound purification were performed at the Genetics and Biotechnology Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Sriwijaya University (Indralaya). Metabolite profile analysis of dadap ayam leaf extract using GC-MS was conducted at the Integrated Research and Testing Laboratory, Universitas Gadjah Mada Yogyakarta. The results of this study obtained strong antioxidant activity in the thick extract of dadap ayam leaves (Erythrina variegata L.) obtained in the N-Hexane fraction, which was 5.4306 ppm and the ethyl acetate fraction, which was 17.819 ppm. The methanol-water fraction was not active in antioxidant activity. The groups of pure compounds that have antioxidant activity obtained in dadap ayam leaf samples are the terpenoid group (N1), phenol group (N2 and E1), steroid group (N3) and flavonoid group (N4, and E4). Pure compounds obtained from dadap ayam leaf samples have very strong, strong and moderate antioxidant activity. Pure compounds with the terpenoid group (N1) obtained an IC50 value of 58.49 ppm. The phenol compound group (N2 and E1) obtained an IC50 value of (17.12 ppm and 100.15 ppm). Meanwhile, the steroid compound group (N3) obtained an IC50 value of (65.59 ppm) and the flavonoid compound group (N4 and E4) obtained an IC50 value of (10.29 ppm and 25.09 ppm).
Phytochemicals Composition and Anti-bacterial Activity of Methanol Leaves Extract of Vernonia amygdalina Galadima, Abdulganiyu Mohammed; Chidimma, Amaechi Jessica; Abubakar, Ibrahim; Ibrahim, Shehu; Said, Said Sani
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.519-527

Abstract

Bacterial infections have been a major health challenge associated with high morbidity and mortality rates. Plants and their metabolite constituents are important in local therapies and drug synthesis. This study aimed to evaluate the phytochemical composition and anti-bacterial activity of the methanol leaves extract of Vernonia amygdalina. Phytochemicals in the extract were estimated using standard analytical methods. The antibacterial activity test of the plant extract was carried out using the agar diffusion method. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined using the tube dilution method and sub-culturing technique, respectively. The extract contains significant amount of alkaloids (47.44 %), flavonoids (16.60 %), tannins (4.35 %), saponins (12.28 %), steroids (0.86%), and glycosides (0.18%). The extract exhibited significant (p < 0.005) inhibitory effect against Staphylococcus aureus, Streptococcus agalactiae, and Lactobacillus rhamnosus isolates with MIC and MBC values of 12.45 and 25.51 mg/mL, 22.03 and 44.84 mg/mL, and 31.64 and 63.95 mg/mL, respectively. The methanol leaves extract of Vernonia amygdalina demonstrated an inhibitory effect against Staphylococcus aureus, Streptococcus agalactiae, and Lactobacillus rhamnosus isolates with low minimum inhibitory concentration values.
Phytochemical Screening and Antioxidant Activities of Rytigynia nigerica (S. Moore) Robyns Roots Extracts Odeja, Oluwakayode Olubunmi; Ibok, Michael Gabriel; Okpala, Ejike O.; Afolabi-Owolabi, Oluwafunke Toyin; Oluwafemi, Kola Augustus; Adja, Emmanuel; Nosiru, Idris Abayomi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.481-487

Abstract

Rytigynia nigerica (Rubiaceae), a medicinal herb native to West Africa, is known for its antimalarial and anticancer properties and is traditionally used to treat various ailments. However, the biological activities of R. nigerica have not yet been fully studied. However, this study was designed to extract, analyse, and evaluate the antioxidant potential and phytochemical screening in the root extracts of R. nigerica. The roots were obtained from the Forestry Research Institute of Nigeria (FRIN), Ibadan and authenticated. The air-dried and pulverised root samples were extracted with methanol using the Maceration method and then partitioned into n-hexane and ethyl acetate using the liquid-liquid extraction method. The phytochemical screening was evaluated using the standard method, while antioxidant activity was investigated viz 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) assays. The phytochemical screening analysis revealed the presence of saponins, cardiac glycosides, tannins, phenols, reducing sugars, alkaloids and resins in the root extract. The antioxidant activity of the extracts was significant when compared to reference standards. The percentage inhibition of the antioxidant extracts and reference standard are as follows: n-hexane extract (58.50 -45.08%), ethyl acetate extract (90.62-67.82%), Methanol extract (70.81-52.97%), Vitamin C (95.66-91.63%) and butyl hydroxyanisole (94.76-90.96%). The antioxidant inhibition of the free radical was concentration-dependent. The results obtained in this study indicate that R. nigerica root extracts exhibit antioxidant properties, suggesting potential pharmaceutical applications.
Assessment of Escherichia coli Contamination in Drinking Water from Refill Depots Savitri, Lisa; Kholis, Muhammad Akbar Nur; Prasetyawan, Fendy; Saristiana, Yuneka; Amanda, Cornelia; Mebung, Konradus Klala
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.443-446

Abstract

Refill Drinking Water Depots (DAMIU) have become a popular source of drinking water in Indonesia due to their affordability and accessibility. However, concerns about hygiene and microbial contamination persist, particularly in areas with limited health oversight. This study aimed to evaluate the microbiological quality of refilled drinking water in Kediri City by detecting the presence of Escherichia coli as an indicator of fecal contamination. A descriptive, cross-sectional design involving 22 depots selected based on hygiene criteria was employed. Microbiological analysis used the Most Probable Number (MPN) method, with confirmatory tests including IMViC and Eosin Methylene Blue (EMB) media. The results showed that 20 of 22 depots met the microbiological safety standard of 0 CFU/100 mL for E. coli as set by the Indonesian Ministry of Health and national standards (SNI 3554:2015). Two samples (5 and 7) tested positive for E. coli, likely due to environmental contamination, inadequate sanitation, and poor water handling practices. The positive samples demonstrated typical E. coli characteristics in IMViC (++-+) and gas formation in BGLB media. This study underscores the importance of routine surveillance, public health regulation enforcement, and improved hygiene practices in refilled water depots. Ensuring the microbiological safety of refilled drinking water is essential to prevent waterborne diseases such as diarrhea. The findings call for enhanced collaboration between local health offices and depot operators to maintain clean and safe drinking water standards across communities.
Demographic Characteristics of Fruit Sellers and Chemical Preservation Practices in Birnin Kebbi, Nigeria Yahaya, Tajudeen; Faruk, Mohammed Umar; Abdulazzez, Abdulmalik
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.401-407

Abstract

Fruits in Birnin Kebbi, Nigeria, are often preserved using chemicals to extend their shelf life, maintain freshness, and enhance quality and taste. However, global concerns persist about the safety of these preservatives, particularly when applied indiscriminately. This study aimed to determine the demographic characteristics of fruit sellers in Birnin Kebbi and the preservatives they commonly use. Structured questionnaires were administered to 200 participants who provided informed consent. The results showed that 116 (58%) of the respondents were male, while 84 (42%) were female. Most participants (38%) were aged 18–25 years (76 individuals), followed by those aged 26–35 years (60 individuals, 30%). A significant proportion of participants (82; 41%) had no formal education, while 48 (24%) had primary education. The majority of participants (120; 60%) belonged to the Hausa ethnic group, and 156 individuals (78%) identified as Muslims. Marital status was evenly distributed, with 84 participants (42%) being single and 80 (40%) married. Regarding fruit preservation practices, watermelon was the most frequently preserved fruit, cited by 50 participants (25%), followed by oranges (42; 21%) and bananas (22; 11%). Among chemical preservatives, sulfite was the most commonly used, reported by 84 (42%) participants, followed by citric acid (36; 18%), sodium benzoate (28; 14%), calcium chloride (24; 12%), benzoic acid (18; 9%), and ethanol (10; 5%). Alarmingly, 95% of participants demonstrated inadequate knowledge of proper preservative application methods, raising concerns about potential health risks for consumers. These findings suggest that fruit preservation practices in Birnin Kebbi may expose consumers to health hazards. It is imperative to educate fruit sellers and consumers on the safe use of chemical preservatives, including appropriate concentrations and application techniques, to mitigate these risks and promote safer fruit consumption.
Evaluation of Antidiabetic Activity of Croton zambesicus Root Extract: In Vivo Inhibitory Effect on Alpha Amylase and Alpha Glucosidase of Rats Okokon, Jude Efiom; Edem, Utibe Anietie; OSIGWE, Chinyelu Clementina; Uwaeme, Ugonma Florence
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.529-533

Abstract

Diabetes mellitus is a global health challenge, necessitating the need for alternative treatments. Croton zambesicus Muell Arg. (Euphorbiaceace) a medicinal plant used traditionally in the treatment of some ailments was investigated for its inhibitory potential on alpha-amylase and alpha-glucosidase enzymes in rats. The root extract of C. zambesicus (27 - 81 mg/kg) was investigated in vivo for the inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose, and maltose as substrates. Acarbose was used as a reference drug. Blood glucose levels (BGL) of rats, post administration of the substrate and extract concurrently, were monitored over 3 hours as a parameter to measure the inhibitory potential of the extract. The root extract dose-dependently caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the root extract of Croton zambesicus has the potentials to inhibit alpha amylase and alpha glucosidase in rats.
Diversity of Anatomical Morphological Characters of Leaves of Mangrove Plant Types In Panimbang Banten Nabilah, Amanda; Suyamto, Suyamto; Mu’jijah, Mu’jijah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.489-498

Abstract

Mangroves are plants that produce seeds (spermatophyta), mangroves also have many benefits, namely as an economic or ecological function. Mangrove plants have different types of leaf shapes. Leaves have the task of absorbing nutrients and gases, as well as processing food through the process of photosynthesis. This study aims to determine the differences in leaf shape based on morphological and anatomical characters. The method used is exploration and preparation of preserved preparations. The samples used were some mangrove leaves found in Panimbang District. The stages of the research are starting with taking the third leaf sample, observing the morphological characters of the leaves, taking samples. Parameters used to observe morphological characters were leaf shape, base shape, leaf tip, leaf length, width and length of petiole. Anatomical character of shape and number of stomata, shape and length of palidase.
Immunomodulatory Activity of Chinese Betel (Peperomia pellucida L.) Extract on the Spleen Histopathology in a Murine Model of Gastroenteritis Savitri, Lisa; Prasetyawan, Fendy; Saristiana, Yuneka; Meri, Meri; Mebung, Konradus Klala; Amanda, Cornelia
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.447-452

Abstract

Gastroenteritis, a prevalent digestive disorder caused by various pathogens including Escherichia coli, remains a global health challenge with significant morbidity and mortality, particularly in low-income countries. The spleen, as a critical immune organ, is often compromised during systemic infections. Peperomia pellucida (L.) , a traditional medicinal herb, is known for its antimicrobial, anti-inflammatory, and antioxidant properties. This study investigates the histopathological effects of P. pellucida leaf ethanol extract on spleen tissue in mice induced with E. coli to model bacterial gastroenteritis. Thirty male Swiss mice were divided into six groups (n=5): normal control, negative control (aquades), positive control (Yakult), and three treatment groups receiving P. pellucida extract at 100, 300, and 500 mg/kg BW. After seven days of pretreatment, mice were orally infected with E. coli (1×10⁶ CFU/mL) for another seven days. Spleen tissues were harvested, fixed, and stained with hematoxylin-eosin for histopathological evaluation focusing on degeneration, necrosis, and PMN infiltration. Statistical analysis was performed using ANOVA followed by LSD tests. The highest dose of P. pellucida extract (500 mg/kg BW) significantly reduced spleen tissue damage, showing decreased degeneration (9.08%), necrosis (6.05%), and PMN infiltration (18.45%) compared to lower doses. The effect was comparable to the positive control. The ethanol extract of P. pellucida demonstrates a dose-dependent protective effect on spleen histopathology in E. coli-induced gastroenteritis in mice, supporting its potential as a natural antiseptic agent.

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