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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 934 Documents
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Efek Pemberian Madu terhadap Kadar Leukosit Urin pada Wanita Usia Subur Medi Apriansyah; Adang Muhammad Gugun
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 1 (s) (2009)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v9i1 (s).1619

Abstract

There are predisposition factors to develop into urinary tract infection in women with sex active. The leukosuria or piuria is one of the major sign for suspecting infection in the urinary tract. Honey is a sweet liquid which distribute by bees and produce from nectar. Honey contains antibacteria substance which can cure superficial injury and infection diseases. One of the function of honey is perservatif and high osmolality so bacteria has difficulty to life. This study aims to determine the effect of honey for decreasing urine leukocyte in fertile age women. The design of this study is experimental clinical test with pretest-posttest group control. Subject of research is fertile age women with leukosuria. Material form of the morning urine with urine stick special leukocyte test and honey. Measurements conducted in place intake of urine. Research was the subject of 28people. The provision of honey made in the test group of 3 tablespoon perday. Both group (test and control) were given equal treatment with white water to drink as much as 6 glasses a day. There are 15 person (100%) who get honey therapy which has decreasing value of leukosuria. For people who get control, there are 9 person (70%) who has decreasing of leukosuria value, 2 person (15%) with a fixed rate leukosuria same as before, and 2 person (15%) has increasing of leukosuria. The results of this research is found that honey is effective of to decrease leukosuria in fertile age women.Pada wanita dengan seksualitas yang aktif terdapat faktor predisposisi untuk berkembang menjadi Infeksi Saluran Kemih (ISK). Adanya leukosuria atau piuria merupakan salah satu petunjuk penting terhadap dugaan adanya ISK. Zat anti bakteri yang terkandung dalam madu baik untuk mengobati luka luar dan penyakit infeksi. Salah satu sifat madu adalah bersifat mengawetkan dan memiliki osmolalitas tinggi sehingga bakteri sulit untuk hidup. Penelitian ini bertujuan untuk mengetahui efek pemberian madu terhadap penurunan kadar leukosit urin pada wanita usia subur. Penelitian ini menggunakan desain eksperimental uji klinik dengan rancangan pretes posttes kontrol grup. Subyek penelitian adalah wanita usia subur dengan peningkatan kadar leukosit urin. Bahan berupa urin pagi yang dilakukan uji stik urin khusus leukosit dan madu. Pengukuran dilakukan di tempat pengambilan urin. Subyek penelitian berjumlah 28 orang. Pemberian madu dilakukan pada kelompok uji sebanyak 3 sendok makan perhari. Kedua kelompok (uji dan kontrol) diberi perlakuan sama dengan minum air putih sebanyak 6 gelas sehari. Kelompok uji madu yang mengalami penurunan kadar lekosit urin sebanyak 100% (15 orang), sedangkan kelompok kontrol didapatkan penurunan kadar leukosit urin sebanyak 70% (9 orang), kadar leukosit urin tetap sama seperti sebelumnya sebanyak 15% (2 orang), dan terjadi peningkatan kadar leukosit urin sebanyak 15% (2 orang). Disimpulkan bahwa pemberian madu memiliki efektifitas terhadap penurunan kadar leukosit urin wanita usia subur.
Sensitivity of Staphylococcus aureus Isolated from Nasal and Throat of Pre-Clerkship Students to Antibiotics Rahayu, Suci; Widiyanti, Dian; Arsyad, Muhammad
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2 (2020): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200251

Abstract

Background: Cases of nosocomial infection are many caused by the bacteria of  S.aureus. Bacteria infection caused by S.aureus may result in various skin and soft tissue infections. The infection may become difficult to treat if the strain of  S.aureus responsible is the methicillin resistant strain or methicillin-resistant Staphylococcus aureus (MRSA). Currently there are two known types of MRSA: Hospital Acquired MRSA/HA-MRSA and Community Acquired MRSA/CA-MRSA. Transmission of the bacteria from one patient to another may be caused by unsterile medical equipment or from the hospital staff, especially pre-clinical students who will work in a hospital. The purpose of this study was to obtained the difference of bacteria colonisations S.aureus from nasal and throat swabs, and the sensitivity patterns of S.aureus when exposed to antibiotics (methicillin, vancomycin, imipenem, penicillin, ofloxacin, ciprofloxacin) and the prevalence of MRSA carriers and also to obtain an understanding of the characteristics of medical drug use through Islamic views. Metodes: This study used descriptive analysis method with samples taken from nasal and throat swabs applied to healthy pre-clinic student from Universitas YARSI. Statistical analysis using Mann-Whitney test in the program SPSS for windows. Results: The results bacteria colonisations S.aureus from nasal swabs was positive (23,3%), while from the throat sample was positive (10%). The results of statistical analysis (Sig. = 0.051 0.05) shows that there is no significant difference between the bacterial colonies of S.aureus originating from the nasal swabs and throat swabs of the pre-clinical students. From 60 samples a positive prevalence of (1.7%) was obtained for MRSA carriers. The result of the sensitivity test shows that the isolated sample of the bacteria S.aureus shows the highest sensitivity to the antibiotic imipenem and almost all the isolated samples show resistance to the antibiotic penicillin. Conclusion: There are more S.aureus bacteria colonies on nasal swabs compared to throat swabs. There was no significant difference between S.aureus bacteria colonization of nose and throat swabs in pre-clinical-students. The positive prevalence of MRSA carrier among pre-clinical-students of Yarsi University was (1.7%). In nasal swabs all isolates were still sensitive to the antibiotics methicillin, imipenem, ofloxacin and ciprofloxacin. But on the nasal swab there were three VISA isolates. In the throat swab, there was one MRSA isolate and one isolate that was resistant to ofloxacin. The inhibition zone of the highest sensitivity was obtained for imipenem antibiotics. Almost all isolates showed resistance to penicillin antibiotics. In Islamic medicine, drugs or antibiotics must not contain unclean and haram objects for human consumption.
Pengaruh Konsumsi Teh Hitam terhadap Kadar Fe dan Hemoglobin dalam Plasma Salmah Orbayinah
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 1 (s) (2007)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v7i1 (s).1682

Abstract

Tea is one of the most popular drinks in the world. According to its production process, traditionally, tea divided into 3 kinds: green tea, oolong tea and black tea. Either green tea or black tea contains katekin. Both have potential to reduce non-hem iron absorption. The aim of this study is to reveal the effect of black tea consumption on non-heme iron absorption and hemoglobin concentration in plasma. This study is an experimental laboratory study. The subjects are 10 male mice (Mus muculus), ± 2 month years old, and weight of ± 25 grams which divided randomly into 2 groups. Each group consist of 5 mice, first group role as a control group which receive an aquades consumption and second group role as a black tea group which receive black tea water with 0,04gr/10ml dose for 14 days, one hour before meal. Non-heme iron and hemoglobin measurement was done before the study start and on 15th day of the study which use blood sample collect from lateral part of mice ’s eyes. The data collected then were analyzed with t- test paired samples method using SPSS program version 10 W. Results showed that non-heme iron concentration in black tea group (96,6800 ± 0,8273) higher significantly (p0,05) and in control group (87,6760 ± 1,5340) less significantly (p0,05). Hemoglobin concentration in black tea group (11, 2180 ± 0, 3355) and control group (10, 0100 ± 0, 2709) higher significantly (p0,05). This results indicates that black tea consumption with 0,04gr/10ml dose for 14 days, one hour before meal not enough to reduce non-heme iron absorption and not decreasing the hemoglobin concentration of mice ’s plasma.Teh merupakan salah satu minuman yang sangat populer di dunia. Berdasarkan proses pengolahannya, secara tradisional produk teh dibagi menjadi 3 jenis, yaitu teh hijau, teh oolong, dan teh hitam. Baik teh hijau maupun teh hitam mengandung katekin. Keduanya berpotensi untuk menghambat penyerapan besi nonheme. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsumsi teh hitam terhadap absorpsi besi nonheme dan kadar hemoglobin dalam plasma . Penelitian ini adalah penelitian eksperimental laboratorium. Subyek penelitian adalah 10 ekor mencit (Mus musculus) jantan, umur ± 2 bulan, berat badan ± 25 gram dibagi menjadi 2 kelompok secara acak. Tiap kelompok berjumlah 5 ekor mencit, kelompok kontrol yang diberi konsumsi akuades sedangkan kelompok perlakuan diberi konsumsi seduhan teh hitam dengan dosis 0,04gr/10ml selama 14 hari satu jam sebelum makan. Pengukuran fe non-heme dan hemoglobin dilakukan sebelum perlakuan dan pada hari ke-15 dengan menggunakan sampel darah yang diambil dari bagian lateral mata mencit. Data yang diperoleh dianalisis dengan metode t-test paired samples. Hasil penelitian menunjukkan, terjadi peningkatan kadar Fe nonheme pada kelompok teh hitam (96,6800 ± ± 0,8273) yang signifikan (p 0,05) dan penurunan kadar Fe nonheme pada kelompok kontrol (87,6760 ± 1,5340) yang signifikan (p0,05). Terjadi peningkatan kadar hemoglobin pada kelompok teh hitam (11,2180 ± 0,3355) dan kelompok kontrol (10,0100 ± 0,2709) yang signifikan (p0,05). Dapat disimpulkan bahwa konsumsi teh hitam dengan dosis 0,04gr/10ml selama 14 hari satujam sebelum makan tidak cukup menghambat penyerapan Fe non heme dan tidak menurunkan kadar hemoglobin plasma mencit.
Potensi ADP dan Katalase dalam Ekstrak Air Lidah Buaya (Aloe vera) sebagai Antiinflamasi pada Model Tikus Luka Terkontaminasi Agung Biworo; Windy Yuliana Budianto; Rismia Agustina; Eko Suhartono
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2013)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v13i1.1054

Abstract

Lidah buaya (Aloe vera) mengandung enzim antioksidan yang dapat menghambat kerja dari mediator inflamasi dan penghilang rasa sakit. Pada penelitian ini akan diukur aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase ekstrak air Aloe vera serta potensinya sebagai antiinflamasi pada tikus yang mengalami luka terkontaminasi. Penelitian ini menggunakan rancangan post test only control group dengan simple random sampling pada 36 ekor tikus yang terbagi atas 2 kelompok, yaitu kelompok kontrol (P0)  dan perlakuan (P1) merupakan kelompok tikus dengan luka terkontaminasi yang diberikan balutan dengan menggunakan ekstrak air lidah buaya 0,2 mg/g BB. Hasil penelitian menunjukkan bahwa aktivitas enzim antioksidan askorbat dependent peroksidase dan katalase masing-masing 37,8 menit-1 dan 3,145 menit-1 dan rata-rata penurunan intensitas warna kemerahan dari eritema pada kelompok yang diberi ekstrak air lidah buaya (Aloe vera) lebih cepat daripada kelompok kontrol. Diismpulkan bahwa ekstrak air lidah buaya berpotensi sebagai antiinflamasi pada model tikus luka terkontaminasi. Aloe vera contained an antioxidant enzyme that can inhibit the work of the mediators of inflammation and pain. With this research, however, will be measured the antioxidant enzyme activity of ascorbic dependent peroxidase and catalase on water extract Aloe vera and its potential as an anti-inflammatory on rat model wound contaminated. This research uses the post test only control group with simple random sampling techniques, with 36 rats were divided into two groups, namely the control and treatment groups. The control group (P0) is a control group and treatment group (P1)  is a group of mice with wounds contaminated given the wrap by using water extracts of Aloe vera 0.2 mg/g BB. In this study it was concluded that the antioxidant enzyme activity of activity of ascorbic dependent and catalase each 37.8 seconds-1 minute-1 and 3,145. In addition, the decrease in intensity of redness of erythema on the group that was given a water extract of Aloe Vera (Aloe vera) is faster than the control group. It can be concluded that the water extract of Aloe vera as anti-inflammatory potential in a mouse model of contaminated wounds.
Pengaruh Pemberian Jus Belimbing Wuluh (Averrhoa bilimbi L) terhadap Kadar HDL dan LDL-Kolesterol pada Tikus Putih Hiperkolesterolemia Anggoro, Dedy Sukmo; Astuti, Yoni
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 2 (2015): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v15i2.3754

Abstract

Hiperkolesterolemia terjadi jika kadar kolesterol melebihi batas normal. Belimbing wuluh mempunyai banyak kandungan senyawa yang dibutuhkan manusia diantaranya pektin. Pektin mempunyai peranan dalam menurunkan kadar kolesterol. Penelitian ini bertujuan untuk membuktikan  pengaruh  jus belimbing wuluh terhadap kadar HDL dan LDL-kolesterol pada tikus putih yang mengalami Hiperkolesterolemia. Penelitian ini merupakan penelitian eksperimental dengan rancangan penelitian pre and post test design. Penelitian ini menggunakan tikus putih (Strain Wistar) jantan berusia 2 bulan dengan berat badan rata-rata antara 180 - 260  gram. Jumlah subyek penelitian 16 ekor, dibagi menjadi 4 kelompok masing-masing terdiri dari 4 ekor tikus, yaitu kelompok I adalah kontrol, kelompok II perlakuan dengan dosis 2 ml/200grBB/ hari,Kelompok III dengan perlakuan 3 ml/200grBB/hari dan   kelompok IV dengan perlakuan 4ml/200grBB/ hari). Sebelum diberi perlakuan semua kelompok diberi kuning telur untuk proses hiperkolestrolemia selama 15 hari.Data di uji dengan paired t-test dan one-way anova. Hasil menunjukkan bahwa dosis jus Wuluh yang paling baik dan signifikan (p 0,05) untuk menurunkan LDL-kolesterol dan menaikkan HDL-kolesterol serum darah tikus putih jantan yang mengalami hiperkolesterolemi adalah 4 ml/200grBB/hari. Dapat disimpulkan bahwa jus belimbing wuluh terbukti dapat menurunkan kadar LDL kolesterol dan menaikkan kadar HDL kolesterol pada tikus hiperkolesterolemia.Hypercholesterolemia occurs when cholesterol level exceeds from the normal value. Wuluh star fruit has some beneficial substances for human such as   pectin. Pectin was able to decrease cholesterol levels. This research aims to prove the influence of wuluh starfruit juice on serum HDL and LDL-cholesterol on hipercholesterolemia rats. This research is an experimental research, with the pre- pro test research design. This study used (Wistar strain) 2-month-old male rats which were an average weight between 180 to 260 grams. The Rats, were divided into 4 groups, each was 4 male rats. The group 1  as  placebo and group II used dose 2 ml/200gr weight/day, Group III used  dose 3 ml/200gr weight/day and  group IV used 4ml/ 200gr weight/day. Before treatment, all groups were given egg yolk for 15 days to make hipercholestrolemia. The data analyzed by one-way anova. The results showed that the best dose of wuluh star  Juice and most significant (p 0.05) to lower LDL-cholesterol and raise HDL-cholesterol blood serum  were 4 ml/200gr weight/day).The conclution of the research was Wuluh star fruit juice was  proved decrease LDL Cholesterol and increase HDL cholesterol on Hipercholesterolemia rats.
Pengaruh Bekam (Al Hijamah) terhadap Kadar Kolesterol LDL pada Pria Dewasa Normal Alfian Fahmy; Adang Muhammad Gugun
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (s) (2008): Oktober
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i2 (s).1635

Abstract

Cupping is an Arabian traditional method of treatment in which a jar is attached to the skin surface to cause local congestion through the negative pressure created. Cupping is a therapeutic process of removing unclean blood from the body. Blood letting has been a recommended method to reduce serum lipoprotein concentrations. There are many testimony which cupping can affects a large group of blood related disorders. The aim of this research is to investigate the effect of cupping on LDL cholesterol. Reduction in LDL cholesterol, is a preventive approach against atherosclerosis. In a quasi experimental with pre test and post test, 30 men, 20-24 year old, without chronic disease, no history of hyperlipidemia and also not anti-hyperlipidemic drug consumption, were admitted. All of subjects were treated with cupping in one time. To know the serum concentrations of lipids we collect the blood from cubiti at the time of cupping and an hour after that. The data were analyzed using pair t- test.and pearson correlation. A significant LDL cholesterol increase (P 0.0000) was found in almost subjects. There was strong positive correlation between LDL cholesterol pre and an hour post cupping (r= 0.987). Cupping will increase the number of LDL cholesterol an hour after treatment.Bekam adalah metode pengobatan tradisional Arab dengan melekatkan tabung pada permukaan kulit yang menyebabkan kongesti lokal melalui tekanan negatif. Bekam adalah proses terapeutik dari tubuh untuk mengeluarkan darah kotor. Membiarkan darah keluar telah menjadi metode yang dianjurkan untuk mengurangi konsentrasi lipoprotein serum. Ada banyak testimoni bahwa bekam dapat menyembuhkan sebagian besar penyakit yang berhubungan dengan darah. Tujuan penelitian ini adalah untuk menentukan efek bekam terhadap kolesterol LDL. Penurunan kolesterol LDL dapat mencegah aterosklerosis. Penelitian ini bersifat eksperimental kuasi dengan model pre dan post test. Subyek sebanyak 30 orang berumur 20-24 tahun tanpa penyakit kronis, tidak ada sejarah hiperlipidemia atau mengkonsumsi obat anti-hiperlipidemia, dan telah menyetujui. Semua subyek diperlakukan sama pada satu waktu. Untuk mengetahui konsentrasi lipid serum, darah diambil dari vena cubiti pada awal bekam dan satu jam setelahnya. Data dianalisis menggunakan korelasi pearson pasangan dan t-test.  Terdapat peningkatan kolesterol LDL yang signifikan (p=0,000) pada hampir semua subyek. Ada korelasi positif yang kuat antara LDL sebelum dan satu jam setelah bekam (R=0.987). Disimpulkan bahwa bekam meningkatkan jumlah kolesterol LDL satu jam setelah perawatan.
The Correlation between Position and Duration Use of Laptops with Musculoskeletal Disorders (MSDs) Tanzila, Raden Ayu; Prameswarie, Thia; Hartanti, Miranti Dwi; Denaneer, Talitha
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 2 (2021): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i2.11375

Abstract

The pandemic period forces all learning processes to be carried out online by utilizing internet facilities with a laptop. The position of using a laptop that is not ergonomic can cause musculoskeletal disorder. This study aims to determine the correlation between position and duration of student use of laptops during online learning with Musculoskeletal Disorders (MSDs). This research is analytic observational with a cross-sectional approach. The research was conducted on active students of the Medical Study Program, Muhammadiyah Palembang University, with 416 respondents. Primary data collection was taken using a questionnaire with a Nordic Body Map score. The analysis technique used the Chi-Square test. The results showed that the respondents had a high duration of laptop use (48.8%), with a not good position (42.3%).Most musculoskeletal disorders were felt in the neck (75.5%). There was a correlation between the position of using a laptop and musculoskeletal disorders (p 0.652). However, there was no correlation between the duration of laptop use and musculoskeletal disorders (p 0.002). It can be concluded that the position of using a laptop that is not ergonomic caused musculoskeletal disorders.
Perbedaan Kadar Endotelin-1 pada Penderita Hipertensi Stadium 1, 2 dan Bukan Penderita Hipertensi Widyatmoko, Agus
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 2 (2010)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v10i2.1570

Abstract

Hypertension is a risk factor of cardiovascular disease. Endothelin-1 is a strong vasoconstrictor andrelatedwith angiotensin IIin the arteriapressure regulation. This regulation influence in pathologic condition such as hypertension, congestive heart failure and cronic renal failure. The aim of this study is to compare the levels of endothelin-1 between the patient of hypertension stage 1; stage 2 and no hypertension person. The design of this study is cross sectional. Subjects were resident in the territory of District Health Center 2 Mlati, Sleman, DIY, men and women, aged 18-75 years. Hypertension Stage 1, Stage 2 and no hypertension groups were determined according to Joint National Committee (JNC) 7 criteria. Research subjects used randomly with stratification, fasting at least 8 hours before blood samples were taken for examination to measure the level of endothelin-1. There are 43 patients with hypertension stage 1, 54 patients with hypertension stage 2 and 54 non hypertension person. The difference of endothelin-1 level among groups were analyzed by Anova. This research shows that the increasing levels of endothelin-1 is in a row with increasing of blood pressure in hypertension stage 1 and 2; and the increasing more clear and meaningful in the 50-75 year age of group.Hipertensi merupakan faktor risiko penyakit jantung. Endotelin-1 adalah vasokonstriktor kuat dan berkaitan dengan angiotensin II dalam pengaturan tekanan arteria. Pengaturan ini berpengaruh terhadap kondisi patologis seperti hipertensi, gagal jantung kongesti dan gagal ginjal kronis. Tujuan penelitian ini adalah ingin membandingkan kadar endotelin-1 antara penderita hipertensi stadium 1; stadium 2, dan bukan penderita hipertensi. Rancangan penelitian ini adalah cross sectional. Subjek adalah penduduk di wilayah Kabupaten Puskesmas 2 Mlati, Sleman, DIY, pria dan wanita, usia 18-75 tahun. Hipertensi stadium 1, stadium 2 dan bukan penderita hipertensi ditentukan menurut kriteria JNC 7. Subyek penelitian diambil secara acak dengan stratifikasi, puasa minimal 8 jam sebelum sampel darah diambil untuk pemeriksaan kadar endotelin-1. Ada 43 pasien dengan hipertensi stadium 1, 54 pasien dengan hipertensi stadium 2 dan 54 orang non hipertensi. Perbedaan kadar endotelin-1 antar kelompok dianalisis dengan Anova. Hasil penelitian ini menunjukkan bahwa semakin tinggi kadar endotelin-1 maka semakin meningkat tekanan darah pada hipertensi tahap 1 dan 2; dan peningkatan usia lebih jelas dan berarti pada kelompok usia 50-75 tahun.
Efektifitas Gel Ekstrak Pithecellobium lobatum Benth. pada Proses Kesembuhan Luka Pascapencabutan Gigi: Studi pada Cavia cobaya dengan Pengamatan Histologis Afiyah, Lisa Lamusul; Medawati, Ana
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 17, No 2 (2017): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.170205

Abstract

Sel yang berperan penting dalam penyembuhan luka adalah kepadatan serabut kolagen. Kulit buah jengkol (P. lobatum Benth.) mengandung senyawa aktif saponin, tanin dan flavonoid yang berperan pada penyembuhan luka. Penelitian ini bertujuan untuk mengetahui efek pemberian gel ekstrak kulit buah P. lobatum Benth. terhadap kepadatan kolagen pada proses penyembuhan luka pascapencabutan gigi Cavia cobaya jantan. Jenis penelitian eksperimental murni in vivo,  rancangan posttest only control group. Subjek penelitian 45 ekor C. cobaya, dibagi lima kelompok perlakuan yaitu kelompok I (povidone iodin) sebagai kontrol positif, kelompok II (tanpa perlakuan) sebagai kontrol negatif, kelompok III, IV dan V adalah kelompok perlakuan yang diberi  gel ekstrak dengan konsetrasi 1%, 5% dan 10%. C. cobaya didekapitulasi rahang pada hari pertama, ketiga dan ketujuh. Analisis data menggunakan uji normalitas Shapiro Wilk, dilanjutkan uji One Way Anova dan uji Tukey HSD (Honestly Significant Difference). Hasil uji normalitas Shapiro Wilk menunjukkan distribusi data yang normal (p0,05). Uji One Way Anova menunjukkan terdapat perbedaan kepadatan kolagen di antara kelima kelompok. Hasil penelitian menunjukkan kepadatan kolagen signifikan pada kelompok V (gel ekstrak kulit buah P. lobatum Benth. konsentrasi 10%) dengan nilai signifikansi 0,000 (p 0,05). Kesimpulan menunjukkan  pemberian gel ekstrak kulit buah P. lobatum Benth. konsentrasi 10% efektif terhadap peningkatan kepadatan kolagen pada proses penyembuhan luka pascapencabutan gigi.
Pengaruh Ekstrak Metanol Akar Pasak Bumi (Eurycoma Longifolia, Jack.) terhadap Jumlah Splenosit Mencit Diinfeksi Listeria monocytogenes Darmawati, Idiani; HNES, Marsetyawan; Herwiyanti, Sri
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 2 (2011)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v11i2.935

Abstract

Percobaan ini dirancang untuk mempelajari pengaruh ekstrak metanol akar E. longifolia, Jack (MEEL) pada respon imun spesifik dengan penekanan khusus pada jumlah splenoctyes. Desain penelitian adalah posttest only control group design. Empat puluh delapan tikus betina Balb / c yang digunakan di seluruh. Empat puluh delapan tikus yang digunakan berpikir studi, dan dibagi menjadi 4 kelompok. Kelompok pertama sebagai kontrol hanya menerima aquadest. Kelompok II, III, dan IV diberikan 100, 200 , dan 400 mg / kgBB per hari, masing-masing yang MEEL diberikan bersama 14 hari. Kemudian, pada hari-15, diinfeksi Listeria monocytogenes. Observasi dilakukan pada hari 0, 3, dan 10 setelah infeksi. Jumlah splenocytes layak diukur dengan MTT Assay. Data dianalisis menggunakan Anova satu jalan. Hasil penelitian menunjukkan bahwa ekstrak metanol E. longifolia, Jack pada 200 mg / kg BB per hari sejauh 14 hari dapat meningkatkan persentase splenocytes, dan puncaknya terdeteksi pada hari-0 infeksi, pada Kii 11.363% yaitu, pada hari-3 setelah infeksi di KIII, yaitu 10.433% dan pada hari-10 di KIII yaitu 8.907%. Uji Anova menunjukkan perbedaan bermakna dengan pengecualian kelompok I dengan IV, dan II dengan III dan III dengan IV. Disimpulan ekstrak metanol E. longifolia, Jack. root mampu meningkatkan persentase splenocytes di Balb / c tikus yang terinfeksi dengan L. monocytogenes.

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