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Medicina
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Articles 234 Documents
DIAGNOSIS DAN TATA LAKSANA ENSEFALITIS HERPES SIMPLEKS Yuliantini, Tri; Suwarba, IGN Made; Kari, Komang; Mahalini, Dewi Sutriani
Medicina Vol 44 No 3 (2013): September 2013
Publisher : Medicina

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Abstract

Infeksi Herpes simpleks pada susunan saraf pusat (SSP) merupakan infeksi SSP yang paling beratdan sering berakibat fatal. Angka kejadiannya diperkirakan 1 kasus per 250 000 sampai 500 000orang per tahun, sepertiganya terjadi pada anak-anak. Gejala dan tanda klinis pada fase awal sangattidak khas. Pemberian terapi yang terlambat membawa dampak terjadinya kecacatan permanen.Deteksi virus Herpes simpleks (VHS) di dalam cairan serebrospinal dengan polymerase chain reactionmerupakan modalitas pilihan untuk diagnosis ensefalitis herpes simpleks (EHS). Asiklovir intravenamerupakan obat pilihan pertama. Pengobatan segera diberikan kepada pasien yang dicurigai menderitaEHS, kemudian pengobatan dapat dilanjutkan atau dihentikan sesuai konfirmasi laboratorium atauhasil biopsi otak. Pasien yang tidak diberikan antivirus atau pengobatannya terlambat angkakematiannya cukup tinggi.
PERANAN FARMASI KLINIK Ernawati, Desak Ketut
Medicina Vol 38 No 3 (2007): September 2007
Publisher : Medicina

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TIDAK TERDAPAT PERBEDAAN YANG BERMAKNA ANTARA NILAI ABSOLUT CLUSTER DIFFERENTIATION4 DAN PERSENTASE CLUSTER DIFFERENTIATION4 IBU HAMIL 162 TERINFEKSI HUMAN IMMUNODEFICIENCY VIRUS PADA TRIMESTER II DAN III Pangkahila, Evert Solomon; Suwiyoga, Ketut; Mahayasa, Putu Doster
Medicina Vol 46 No 3 (2015): September 2015
Publisher : Medicina

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Nilai absolut cluster differentiation 4 (CD4) diduga dipengaruhi oleh tingkat hemodilusi yang berbeda pada tiap trimester, sedangkan nilai persentase CD4 diduga tidak dipengaruhi oleh tingkat hemodilusi. Oleh karena itu penelitian mengenai perbandingan antara nilai aboslut CD4 dan persentase CD4 pada trimester yang berbeda pada kehamilan dengan HIV penting untuk dilakukan untuk melihat variasi nilai hitung CD4 (absolut dan persentase).Untuk membuktikan pengaruh kehamilan terhadap variasi nilai hitungabsolut CD4 dan persentase CD4 pada kehamilan dengan HIVtrimester II dan III,penelitian observasional dengan menggunakan rancangan studi kohort dilakukan untuk melihat bagaimana variasi nilai absolut CD4 dibandingkan persentase CD4 pada wanita hamil dengan HIV trimester II dan III. Penelitian dilaksanakan selama dua tahun dimulai dari Oktober 2011 sampai Oktober 2013. Dua puluh sampel penelitian dianalisis secara statistik. Hasil uji t menunjukkan nilai P>0.05 pada nilai absolut CD4 maupun persentase CD4. Hasil penelitian menunjukkan bahwa nilai absolut CD4 dan persentase CD4 tidak mengalami fluktuasi yang bermakna selama trimester II dan III pada kehamilan dengan HIV. Nilai absolut CD4 merupakan metode yang dapat dipercaya dalam menilai status imun ibu hamil dengan HIV, tanpa perlu melakukan pemeriksaan persentase CD4. Nilai persentase CD4 dapat dipertimbangkan dalam menilai status imun ibu hamil dengan HIV apabila terdapat faktor lain selain kehamilan yang dapat memengaruhi nilai absolut CD4. [MEDICINA 2015;46:162-5].Absolute cluster differentiation 4 (CD4) count is suspected to be influenced by the degree of hemodilution which is different in each trimester of pregnancy, while percentage of CD4 is thought not to be under significant influence of hemodilution. Thus, a study about the comparison between absolut CD4 and percentage of CD4 at different trimester (2nd and 3rd trimester) of pregnancy with HIV infection, are important to evaluate the variation of CD4 (absolute and percentage). To prove the influence of pregnancy to the variation of absolute CD4 count and percentage of CD4 in pregnancy with HIV infection at 2 nd and 3 trimester, an observational study using cohort design was conducted to evaluate the variation of absolute CD4 and percentage of CD4 in pregnant woman with HIV infection at 2 nd and 3 rd rd trimester. This study was held from October 2011 until October 2013.Twenty sample were statistically analyzed. T-paired test showed that the P value >0.05 in both CD4 count. It means that there was no significant difference in mean of CD4, either absolute or percentage in 2 trimester. The result showed that the absolute and percentage of CD4 did not fluctuate significantly during the 2 nd and 3 trimester of pregnancy. Absolute CD4 count is a valid method to asses the immune status of pregnant woman with HIV, and its not necesarry to count the percentage of CD4. Percentage of CD4 probably should be considered if there are any other factors beside the pregnancy itself that can interfere with the absolute CD4 count. [MEDICINA 2015;46:162-5].
GUSHER PERILIMFE PADA OPERASI IMPLAN KOKLEA PENDERITA DISPLASIA MONDINI Suryana, W; Andi, DS; Sudana, W
Medicina Vol 44 No 2 (2013): Mei 2013
Publisher : Medicina

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Abstract

Displasia Mondini merupakan salah satu kelainan koklea yang sering kali dijumpai. Evaluasi dan penanganan gangguan pendengaran penderita malformasi telinga dalam ini memberi tantangan yang besar bahkan bagi dokter yang telah berpengalaman sekalipun. Salah satu risiko yang paling sering dilaporkan selama operasi implan koklea penderita displasia Mondini adalah terjadinya kebocoran perilimfe saat kokleostomi atau disebut dengan gusher perilimfe. Kami tertarik melaporkan satu kasus gusher perilimfe pada operasi implan koklea anak penderita displasia Mondini di RSUP Sanglah Denpasar. Kebocoran cairan perilimfe tersebut ditangani dengan menyumbat lubang kokleostomi dan obliterasi kavum timpani menggunakan fasia dan otot.[MEDICINA 2013;44:109-112].
BAHAYA RADIASI DAN CARA PROTEKSINYA P, Badunggawa; IN, Sandi; IW, Merta
Medicina Vol 40 No 1 (2009): Januari 2009
Publisher : Medicina

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Radiasi yang kita terima setiap saat, termasuk radiasi untuk tujuan kedokteran, mempunyai dampak positif dan negatif terhadap keselamatan manusia dan lingkungan. Dampak positif dari radiasi terhadap keselamatan manusia diantaranya adalah digunakan sebagai pengobatan dan dampak negatifnya adalah tergantung dari besar dosis yang diterima diantaranya adalah mulai dari mual, muntah, pusing-pusing, rambut rontok, menyebabkan kanker, diturunkan secara genetik, dan yang lebih berbahaya lagi adalah menyebabkan kematian. Oleh karena itu kita harus berhati-hati terhadap bahaya yang ditimbulkannya, baik terhadap pekerja radiasi maupun masyarakat umum termasuk pasien. Perlindungan terhadap bahaya yang ditimbulkan radiasi ini dikenal dengan istilah proteksi radiasi. Sehingga dosis yang diterima pertahun oleh pekerja atau masyarakat umum tidak melebihi batas dosis yang ditetapkan oleh Bapeten. Berbagai upaya telah dilakukan untuk meminimalkan bahaya tersebut sehingga pekerja dan pasien merasa aman melakukan dan dikenai tindakan medik.[medicina 2009;40:47-51].  
EVANS SYNDROME IN A 10 YEAR OLD GIRL Ariputra, A.
Medicina Vol 46 No 1 (2015): Januari 2015
Publisher : Medicina

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Evans syndrome is a coexistence of simultaneous or sequential positive direct Coombs test in conjunctionwith  immune-mediated  thrombocytopenia with no known underlying etiology. The  clinical  course  ischronic and relapsing, and the therapy is generally progressive. Recurrences of thrombocytopenia, anemiaand neutropenia are common, as well as episodes of hemorrhage and serious infections. Noncrossreactingautoantibodies are directed against red cells, platelets, and neutrophils antigens. Evans syndrome isa rare condition, no predilection is known and its exact prevalent is unknown. We report a case of Evanssyndrome in 10 years old girl with severe anemia and thrombocytopenia. Patient came with clinicalsymptoms of severe anemia. The laboratory evaluation showed severe anemia, increased reticulocytecount, anisopoikilocytosis erythrocyte, increased unconjugated bilirubin, positive direct Coombs testand thrombocytopenia. Patient was then managed with high doses of corticosteroids and showed goodresponse from both clinical and laboratory evaluations. [MEDICINA 2015;46:61-66].Sindrom Evans adalah suatu penyakit yang ditandai dengan adanya hasil positif pada direct Coombstest dan trombositopenia yang diperantarai  imun secara simultan atau sekuensial tanpa penyebabyang  jelas. Perjalanan klinis umumnya bersifat kronis, sering mengalami relaps dan memerlukanterapi yang progresif. Kejadian trombositopenia, anemia, neutropenia, perdarahan dan episode infeksiberat berulang umum terjadi. Pada sindrom ini, terjadi reaksi autoantibodi spesifik terhadap antigensel darah merah, trombosit dan juga neutrofil. Sindrom Evans merupakan kasus yang jarang ditemukandan dengan predileksi serta prevalensi yang belum banyak diketahui. Kami melaporkan satu kasusSindrom Evans pada anak perempuan usia 10 tahun.  Pasien dengan gejala klinis anemia berat dan padapemeriksaan laboratorium menunjukkan suatu anemia berat, peningkatan hitung retikulosit, gambaraneritrosit anisopoikilositosis, peningkatan kadar bilirubin yang tidak terkonjugasi, direct Coombs test yangpositif  dan  trombositopenia.  Pasien  kemudian  diterapi  dengan  kortikosteroid  dosis  tinggi  dandidapatkan respon yang baik pada evaluasi klinis dan laboratorium. [MEDICINA 2015;46:61-66].
HUMAN PAPILLOMA VIRUS VACCINE Bayu Mahendra, Nyoman
Medicina Vol 43 No 2 (2012): Mei 2012
Publisher : Medicina

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Abstract

Cervical cancer is the most common gynecologic cancer in womer, and it has the highest cancer-related deaths in developing country. The incidences kept increasing every year, associated with  delay on diagnosis, limited human resources, knowledge, education, facilities, and influence of socioeconomicculture. Currently, infection of oncogenic group high risk human papillomavirus (HPV), especially HPV-16 and HPV-18 has been widely accepted as the cause of cervical cancer. The finding of  HPV vaccine brings new hope to all of us. With primary prevention, the incidence can be brought down. Later on, every women can be freed from in cervical cancer
Seroprevalens serta faktor-faktor risiko toksoplasmosis pada penduduk di Desa Kubu Kabupaten Karangasem Bali Laksmi, Dewa Ayu; Sudarmaja, I Made; Swastika, I Kadek; Damayanti, Putu Ayu Asri; Diarthini, Ni Luh Putu Eka
Medicina Vol 47 No 1 (2016): Januari 2016
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Toksoplasmosis menjadi salah satu masalah kesehatan masyarakat di seluruh dunia karena dapat menyebabkan kelainan kongenital pada neonatus. Tujuan dari penelitian ini adalah untuk menentukan prevalens dan mengidentifikasi faktor-faktor risiko toksoplasmosis pada penduduk di Desa Kubu Karangasem. Sampel serum dikumpulkan dari penduduk di beberapa banjar secara consecutive. Kuesioner diberikan untuk memperoleh data tentang demografi dan faktor risiko toksoplasmosis. Faktor risiko yang diteliti adalah kontak dengan tanah, kebiasaan pola makan termasuk konsumsi daging mentah atau setengah matang, sayuran yang tidak dicuci, dan sumber air minum. Besar sampel dalam penelitian ini adalah 106 orang dengan usia rerata 45,20 (SB 17,03) tahun. Prevalens IgG anti-Toksoplasma gondii di Kabupaten Kubu adalah 13,2%. Seroprevalens tertinggi toksoplasmosis dalam penelitian ini adalah 20%, ditemukan pada usia 50-59 tahun. Prevalens kelompok usia reproduksi (20-49 tahun) pada populasi penelitian adalah 15%. Faktor risiko yang signifikan terkait dengan toksoplasmosis adalah sumber air minum. Disimpulkan bahwa seroprevalens toksoplasmosis pada penduduk di Desa Kubu Kabupaten Karangasem Bali sebesar 13,3%, dan sumber air minum merupakan faktor risiko yang terkait. Toxoplasmosis has become one of public health problem worldwide because it can cause congenital malformation in newborn. The objective of this study was to determine the seroprevalence and to identify risk factors of toxoplasmosis in population of Kubu district Karangasem. We collected serum samples consecutively from resident of several banjar in Kubu. A questionnaire was administered to elicit data on demographics and practices considered to be risk factors for toxoplasmosis. Risk factor that had been evaluated in this study were contact with soil, food pattern habits including consumption of rare/ improperly cooked meat and unwashed vegetables, drinking water sources. The total sample in this study were 106 people with an average age of 45.20 (SD 17,03) years. Seroprevalence of IgG anti- Toksoplasma gondii in Kubu district was 13.2%. The highest seroprevalence of toxoplasmosis in this study was 20%, found in the age 50-59 years. The prevalence of reproductive age group (20-49 years ) in the study population was 15%. Risk factors significant associated with toxoplasmosis was source of drinking water. We conclude that seroprevalence of toxoplasmosis in population of Kubu district Karangasem was 13.2%, and source of drinking water was a significant risk factor.
HENOCH SCHONLEIN PURPURA ASSOCIATED WITH ACUTE POSTSTREPTOCOCCAL GLOMERULONEPHRITIS: A CASE REPORT Melati, Deborah; Kumara Wati, Ketut Dewi; Putu Nilawati, Gusti Ayu
Medicina Vol 45 No 2 (2014): Mei 2014
Publisher : Medicina

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Acute post-streptococcal glomerulonephritis (APSGN) is one of the most common renal disease resulting from a prior infection with group A â-hemolytic streptococcus (GAS). Henoch Schonlein Purpura (HSP) is a systemic disease with frequent renal involvement, its etiology is still unknown but several infections have been described as trigger includingGAS infection. A 4 year 10 month old Balinese boy presented with full blown acute nephritic syndrome, an elevation in serum creatinine and four fold increase of anti streptolysin-O, also low serum levels of complement C3 with normal C4 confirmed the diagnosis of APSGN. During hospitalization he developed palpable purpura, gastrointestinal symptoms as well as leucytoclastic vasculitis in skin biopsy conclude HSP diagnosis.He was treated with anti-hypertensions and metylprednisolone intravenous. The prognosis of the patient was excellent, he showed normal physical examination with normal complete blood count and urinalysis after 3 months follow up. We conclude that both APSGN and HSP could appear concurrently after GAS infection. [MEDICINA 2014;45:102-7]  
PREVALENCE AND RISK FACTORS OF OBESITY IN PRIMARY SCHOOL IN URBAN AND RURAL AREAS Ratna Dewi, Made; Sidiartha, I Gusti Lanang
Medicina Vol 44 No 1 (2013): Januari 2013
Publisher : Medicina

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Abstract

Obesity has become a continous increasing global health problem. Obesity can happen in adult population and also on children as well as teenagers. There are several factors that influence the occurrence of obesity. The aim of this study is to determine the prevalence and risk factors for obesity in primary school children in urban and rural areas. A cross sectional study was conducted with a total sample of 241 pupils in several elementary schools. Anthropometric status determine using body mass index for age and obesity stated if measurement exceed ?95th percentile based on CDC 2000. Analysis data perform with the Pearson Chi-square, Fisher's Exact Test, and logistic regression. A P value of <0.05 was considered significant. This study showed the prevalence of obesity was 15%. The prevalence of obesity in urban areas was 21% and rural areas was 5%. The result showed risk of obesity multiplied by 3.8 times in urban children as they had a habit of "snacking" had risk of suffering obesity by 3.4 times (95% CI 1.2 to 9.0). Children who had habit of having fast food more than 2 times per week had the more risk of obesity by 5 times (95% CI 1.9 to 13.5). Mothers education in urban areas as a protective factor. Conclusion of this study show that the prevalence of obesity in urban areas is 21% and 5% in rural areas. “Snacking” habit and eating fast food more than 2 times per week increase the risk of obesity in urban areas, while in rural areas no risk factors consider significant for obesity.