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Berkala Kedokteran
Published by Universitas Lambung Mangkurat
ISSN : 14120550     EISSN : 25485660     DOI : http://dx.doi.org/10.20527
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Berkala Kedokteran is a journal contains scientific articles from original research and literature review in medical and health scope. It is published twice in a year, on February and September.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 478 Documents
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Profil Penderita Kanker Paru Primer Di RSUD Ulin Banjarmasin Tahun 2006-2011 Nur Aisah, Shinta Kartika; Haryati, Haryati; Bakhriansyah, Mohammad
Jurnal Berkala Kedokteran Vol 9, No 2 (2013): September 2013
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i2.947

Abstract

ABSTRACT: Lung cancer is one of the most common malignancies causing very high morbidity and mortality. Many factors can contribute to the incidence of lung cancer instead of the mayor factor, smoking. It was the ten of pulmonary diseases at RSUD Ulin Banjarmasin. The aim of this research was to describe the profile of patients with primary lung cancer at RSUD Ulin Banjarmasin in 2006-2011. It was a descriptive study using medical records data. There were 134 data with confirmed case of lung cancer. Most of patients with lung cancer were male (76.12%), and male and female ratio was 3: 1. The mean age of patients was 57 years old, particularly at the fifth decade (29.85%). The most common clinical symptom was shortness of breath (53.73%). The most common histological type of lung cancer was adenocarcinoma (61.96%). Most patiens were diagnosed in the final stages of the disease, i.e IVA and IVB (56.72% and 17.91%). There were 33.59% patients with of primary lung cancer living in the city of Banjarmasin.  Keywords:      primary lung cancer, risk factors of primary lung cancer, histological  type, clinical stage, RSUD Ulin Banjarmasin ABSTRAK: Kanker paru merupakan salah satu keganasan yang mempunyai tingkat morbiditas dan mortalitas yang tinggi. Banyak faktor yang dapat memicu terjadinya kanker paru, selain faktor utamanya yaitu merokok. Di RSUD Ulin Banjarmasin, kanker paru masuk dalam urutan sepuluh besar penyakit paru. Tujuan penelitian ini untuk mengetahui profil penderita kanker paru primer di RSUD Ulin Banjarmasin tahun 2006-2011. Penelitian ini merupakan penelitian deskriptif dengan menggunakan data sekunder. Penelitian ini melibatkan 134 data pasien yang didiagnosis kanker paru primer. Sebagian besar penderita kanker paru primer adalah laki-laki (76,12%) dengan perbandingan antara laki-laki dan perempuan 3:1. Umur rata-rata adalah 57 tahun dengan umur terbanyak pada dekade kelima (29,85%). Gejala klinis yang paling sering dikeluhkan adalah sesak nafas (53,73%). Jenis histologi kanker paru primer yang terbanyak adalah adenokarsinoma (61,96%). Sebagian besar pasien berada pada stadium akhir yaitu stadium IVA dan IVB (56,72% dan 17,91%). Sebanyak 33,59% penderita kanker paru primer bertempat tinggal di kota Banjarmasin. Kata kunci:  kanker paru primer, faktor risiko kanker paru primer, jenis histologi sel,  stadium klinis, RSUD Ulin Banjarmasin
HUBUNGAN USIA DAN PARITAS DENGAN KEJADIAN PERSALINAN SUNGSANG DI RSUD ULIN BANJARMASIN TAHUN 2013 Riskiviawinanda, Firdausi; Aditya, Renny; Mutmainnah, Noor
Berkala Kedokteran Vol 11, No 2 (2015): September 2015
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i2.173

Abstract

Breech delivery is a labor complication which could come to death of fetus. Some risk factors of breech delivery are age and parity. This research had a purpose to know the relation of age and parity with breech delivery at RSUD Ulin Banjarmasin in 2013. This research had used analitic observational metode with cross-sectional approachment. Data analytic which had been used was chi-square test. Result of this research had shown that from 284 research subjects who gave birth at RSUD Ulin Banjarmasin, 89 (31,34%) research subjects had breech delivery and 195 (64,86%) research subjects  had normal labor without complications. There were 72 (29,15%) breech deliveries from all research subjects who had no risk ages. There were 17 (45,95%) breech deliveries from all resarch subjects who had risk ages. There were 38 (25,68%) breech deliveries from all research subjects with primiparity. There were 51 (37,50%) breech deliveries from all research subjects with multiparity. The result of chi- square test for the relationship between age and breech delivery was P=0,040 with POR=2,06) and the relationship between parity and breech delivery was P=0,032 with POR=1,73. So, there was a relitionship of ages and parity in breech delivery at RSUD Ulin Banjarmasin 2013. Keywords: breech delivery, age, parity
Tingkat Pengetahuan Tentang HIV/AIDS ppada Siswa SMA Negeri di Banjarmasin Tahun 2013 Ningtyas, Novita; Noor, Robiana M.; Triawanti, Triawanti
Jurnal Berkala Kedokteran Vol 10, No 1 (2014): Februari 2014
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.936

Abstract

ABSTRACT: HIV/AIDS has become one of serious problem for adolescents around the world including Indonesia. A Half of all new HIV infections occur in adolescent between the ages of 15-24. Knowledge of HIV/AIDS is considered as one of the method to reduction HIV/AIDS prevalence. The aim of this study is to know the knowledge level of HIV/AIDS among the public high school students in Banjarmasin. This study was  a descriptive survey with cross sectional approach. A number of 380 public high school students were choosed as samples by using cluster random sampling technique. This study was conducted in SMA N 1, SMA N 3, SMA N 5, SMA N 6, dan SMA N 9 Banjarmasin. HIV knowledge questionnaire(HIV-KQ) 45 version by Carey was used to determine the knowledge level among the students. The result showed that 312 students (82,10%) have lack knowledge about HIV/AIDS, 65students (17,11%) have enough knowledge, and only 3 students (0,79%) have good knowledge about HIV/AIDS. The main sources of information about HIV/AIDS are internet and television, respectively 154 students (40,53%) and 109 students (28,68%). Education and sosialiszation about HIV/AIDS are needed to increase the knowledge level of students. Keywords: HIV/AIDS, knowledge, adolescent, public high-school student ABSTRAK: HIV/AIDS telah menjadi salah satu masalah serius bagi remaja di seluruh dunia termasuk Indonesia. Setengah dari seluruh infeksi baru HIV dialami oleh remaja berusia 15-24 tahun. Meningkatkan pengetahuan tentang HIV/AIDS dianggap sebagai salah satu metode yang dapat digunakan untuk mereduksi prevalensi penyakit ini. Tujuan dari penelitian ini adalah untuk mengetahui tingkat pengetahuan tentang HIV/AIDS pada siswa SMA Negeri di Banjarmasin. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional. Sebanyak 380 orang siswa dipilih sebagai sampel dengan menggunakan teknik cluster random sampling. Penelitian dilakukan di SMA N 1, SMA N 3, SMA N 5, SMA N 6, dan SMA N 9 Banjarmasin. Instrumen yang digunakan untuk menentukan tingkat pengetahuan siswa adalah HIV knowledge questionnaire (HIV-KQ) versi 45 yang dibuat oleh Carey. Hasil dari penelitian ini menunjukkan bahwa sebagian besar siswa SMA Negeri di Banjarmasin memiliki tingkat pengetahuan yang kurang tentang HIV/AIDS, yaitu sebanyak 312 orang (82,10%). Siswa yang memiliki tingkat pengetahuan yang cukup berjumlah 65 orang (17,11%) dan hanya 3 orang (0,79%) yang memiliki tingkat pengetahuan yang baik tentang HIV/AIDS. Sumber informasi utama tentang HIV/AIDS adalah internet dan TV, masing-masing sebanyak 154 orang (40,53%) dan 109 orang (28,68%). Pendidikan dan sosialisasi tentang HIV/AIDS dibutuhkan untuk meningkatkan pengetahauan siswa tentang HIV/AIDS. Kata-kata kunci: HIV/AIDS, pengetahuan, remaja, siswa SMA
POTENSI ANTIINFLAMASI JUS BUAH MANGGIS (Garcinia mangostana) TERHADAP DENATURASI PROTEIN IN VITRO Aditya, Muhammad Rizky Tri; Marisa, Donna; Suhartono, Eko
Berkala Kedokteran Vol 11, No 2 (2015): September 2015
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i2.138

Abstract

Protein denaturation is a cause of inflammation. Autoantigens produced in diseases linked with inflammation are thought to be caused by protein denaturation. Mangosteen fruit (Garcinia mangostana) is used widely in Southeast Asia as an alternativemedicine because of its strong antioxidant property, thus it potentially has an antiinflammatory effect. The aim of this study is to test the anti inflammatory potency of mangosteen juice. This is a quasi experimental study with non randomized posttest-only with control group design method, using reaction model of inflammation consisted of two groups: mangosteen juice as the test group and natrium diclofenac as the standard group, divided into 10%, 20%, and 30% concentration. IC50 value is used to determine the anti-inflammatory potency of mangosteen juice as protein denaturation inhibitor. The result of this study indicate that the mangosteen fruit juice has the IC50 value of 16,91% (r = 0,965), whereas for diclofenac sodium by 11,87% (r = 0,866). A positive value of r indicates a positive relation between concentration and anti inflammatory potency. The result shows that mangosteen juice has a potential as a protein denaturation inhibitor.Keywords: protein denaturation, antiinflammation, mangosteen.
Perbedaan Kadar LDH Serum Total Sebelum dan Sesudah Kemoterapi pada Berbagai Kelompok Stadium Kanker LNH Hamidah, Hamidah; Prenggono, Muh.Darwin; Heriyani, Farida
Berkala Kedokteran Vol 12, No 1 (2016): Februari 2016
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i1.356

Abstract

Abstract: Lactate dehydrogenase (LDH) is tumor prognostic for Non Hodgkin Lymphoma (NHL) and it levels would be elevated. The several papers has reported there are an association of total serum LDH levels and staging group of NHL. The study aimed to determine the differences of total serum LDH levels before and after the combination chemotherapy CHOP (Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone) for NHL’s patients at RSUD Ulin Banjarmasin during 3 years. It was an observational analyticstudy design and cross-sectional approach, data collected with design method of totally sampling. Of the 51 patient medical records who included, 54,9% were staging group I-II and 45,1% were staging group III-IV. The first statistic analytic used dependent T test with p=0,303 (p>0,05)showed no differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging group I-II. The second statistic analytic used alternative wilcoxon test with p=0,013 (p<0,05) showed differencesof total serum LDH levels before and after the combination chemotherapy CHOP in NHL’s patients with staging groupIII-IV. The third statistic analytic used alternative mann whitney test with p=0,161 (p>0,05) showed no differencesof total serum LDH levels after the combination chemotherapy CHOP in NHL’s patients between staging group I-II and III-IV.Keywords: total serum LDH levels, NHL, combination chemotherapy CHOP Abstrak: Laktat dehidrogenase (LDH) adalah tumor prognostic pada kanker Limfoma Non Hodgkin (LNH) dan kadarnya selalu menunjukan peningkatan. Penelitian sebelumnya melaporkan bahwa terdapat hubungan antara kadar LDH serum total dengan kelompok stadium kanker LNH. Penelitian ini bertujuan untuk mengetahui perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP (Siklofosfamid, Doksorubisin, Vinkristin, dan Prednison) pada penderita kanker LNH di RSUD Ulin Banjarmasin selama 3 tahun.Penelitian ini menggunakan rancangan studi observasional analitik dan metode pendekatan cross sectional, pengambilan sampel dengan teknik rancangan totally sampling. Dari 51 data rekam medik yang termasuk kriteria inklusi, 54,9% kelompok stadium I-II dan 45,1% kelompok stadium III-IV. Analisis statistik pertama menggunakan uji T berpasangandengan p=0,303 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium I-II. Analisis statistik kedua menggunakan uji alternatif yaitu uji wilcoxondengan p=0,013 (p<0,05) sehingga terdapat perbedaan kadar LDH serum total sebelum dan sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH kelompok stadium III-IV. Analisis statistik ketiga menggunakan uji alternatif yaitu uji mann whitney dengan p=0,161 (p>0,05) sehingga tidak terdapat perbedaan kadar LDH serum total sesudah kemoterapi kombinasi CHOP pada penderita kanker LNH antara kelompok stadium I-II dan III-IV. Kata-kata kunci: kadar LDH serum total, LNH, kemoterapi kombinasi CHOP
Studi Interaksi Farmakodinamik Efek Analgesik Kombinasi Perasan Buah Mengkudu (Morinda citrifolia) dengan Parasetamol: Kajian terhadap waktu reaksi nyeri menggunakan metode hot plate pada mencit (Mus musculus) Wirasari, Firda; Bakhriansyah, Mohammad; Istiana, Istiana
Jurnal Berkala Kedokteran Vol 10, No 1 (2014): Februari 2014
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i1.927

Abstract

ABSTRACT: Mengkudu (Morinda citrifolia) has been proven in  possessing the analgesic effect. The similarity of analgesic activity of mengkudu and paracetamol enable the existence of analgesic effect interaction synergistically when they are both combined. The objective of this research is to find out the pharmacodynamic interaction between the juice of mengkudu and paracetamol. The research was an experimental research with posttest-only with control group design. The control group consists of 6 groups, and each group had 5 mice. The 1st group was given aquadest 0.5 ml; the 2nd group was given the juice of mengkudu 0.042 mg/g BB; the 3rd group was given paracetamol 0.065 mg/g BB; while the 4th , 5th, 6th groups were given the combination of mengkudu juice 0.042 mg/g BB and paracetamol with the dosages 0.01625 mg/g BB; 0.0325 mg/g BB; 0.065 mg/g BB, respectively. Treatments were given 10 minutes before mice were painly induced by using hot plate. The average of onset of pain for group I, II, III, IV, V, VI were 5.36; 8.28; 8.02; 9.67; 10.5 and 11.74 seconds, respectively. Statistical anaysis using Kruskal Wallis showed that there was significance difference among groups (p = 0.000) while the very potential effect was in group with paracetamol dosage on 0,065 mg/g BB. Based on this research, it can be concluded that there is sinergycal interaction between the combination of mengkudu juice with paracetamol on mice. Keywords : analgesic effect, mengkudu, paracetamol, onset of pain, synergycal interaction ABSTRAK: Mengkudu (Morinda citrifolia) telah terbukti memiliki efek analgesik. Kesamaan aktivitas analgesik buah mengkudu dan parasetamol memungkinkan adanya interaksi efek analgesik yang sinergis ketika keduanya dikombinasikan. Tujuan penelitian ini adalah untuk mengetahui interaksi farmakodinamik efek analgesik kombinasi perasan buah mengkudu dengan parasetamol. Penelitian ini bersifat eksperimental dengan pendekatan posttest-only with control group design, terdiri dari 6 kelompok. Setiap kelompok memiliki 5 ekor mencit. Kelompok I diberikan aquadest 0,5ml, kelompok II diberikan perasan buah mengkudu dengan dosis 0,042 mg/g BB, kelompok III diberikan parasetamol 0,065 mg/g BB sedangkan, kelompok IV, V, VI diberikan kombinasi perasan buah mengkudu 0,042 mg/g BB dan parasetamol dengan dosis masing-masing: 0,01625 mg/g BB; 0,0325 mg/g BB; 0,065 mg/g BB, diberikan 10 menit sebelum dilakukan induksi nyeri di atas hot plate. Rerata waktu reaksi nyeri mencit pada kelompok  I, II, III, IV, V, dan VI berturut-turut adalah 5,36; 8,28; 8,02; 9,67; 10,5 dan 11,74 detik. Hasil analisis statistik Kruskal-Wallis menunjukkan bahwa terdapat perbedaan yang bermakna antara berbagai kelompok dengan nilai p = 0,000, dengan dosis kelompok kombinasi yang paling potensial memberikan efek analgesik adalah kelompok dengan dosis parasetamol 0,065 mg/g BB. Berdasarkan penelitian ini dapat disimpulkan bahwa terdapat interaksi yang sinergis pada kombinasi perasan buah mengkudu dengan parasetamol pada mencit. Kata-kata kunci: efek analgesik, buah mengkudu, parasetamol, waktu reaksi, interaksi.
DESCRIPTION OF EFFECTIVENESS OF CILOSTAZOL AND ASPIRIN AS ADJUVANT OF DIABETIC FOOT WAGNER GRADE II AND III Nurikhwan, Pandji Winata; Noor, Zairin; Al Audhah, Nelly
Berkala Kedokteran Vol 10, No 2 (2014): September 2014
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v10i12.961

Abstract

Abstract: Inflammation in patients with diabetic foot will activate platelets and cause aggregation and lead to stasis of blood flow. This inflammation is caused by infection of the diabetic foot. Management of diabetic foot infections in patients is the use of antibiotics. However, the presence of vascularization disorders causing antibiotic delivery to the site of infection to be disrupted so that the process of eradication of infection would be inhibited. One of inflamation markers on patient with diabetic foot is increasing of ESRs.The general objective of this study was to determine the efficacy difference between cilostazol and aspirin as an adjuvant to accelerate tissue healing of diabetic foot care Wagner Grade II – III based on erythrocyte sedimentation rate. This study is a descriptive study using the double-blind and randomized pretest-posttest design. A total of 14 samples is obtained by consecutive sampling. The results showed that four patients given cilostazol showed a 35% reduction in ESR and ten patients were given aspirin showed a 35% reduction in ESR. It can be concluded giving cilostazol and aspirin as adjuvant diabetic foot Wagner II and III showed a decrease in ESR. Key words: erythrocyte sedimentation rate, diabetic foot, cilostazol, aspirin. Listen 
GAMBARAN ANGKA KEJADIAN Post Operative Nausea and Vomiting (PONV) DI RSUD ULIN BANJARMASIN MEI-JULI 2014 Sholihah, Amalia; Sikumbang, Kenanga Marwan; Husairi, Ahmad
Jurnal Berkala Kedokteran Vol 11, No 1 (2015): Februari 2015
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i1.192

Abstract

Post operative nausea and vomiting (PONV) are defined as episode of nausea and emesis after a surgical act and before hospital discharge. Over 100 million patients undergo surgery in the worldwide with about 30% experiencing PONV. PONV have been associated with multifactorial such as age, gender, anaesthesia techniques, and type of surgery. The aim of this study was to determine the incidence of PONV in RSUD Ulin Banjarmasin May-July 2014. It was a descriftive study. Data was collected from a questioner on the first postoperative day. Consecutive sampling was used with a total of 96 patients as the subjects of this study. Of the 96 patients studied, 26 patients (27.08%) experienced PONV. The highest incidence of PONV occurred the age group 40-54 years with 11 patients (11.46%). Most of patients with PONV were female with 18 patients (18.75%). Based on the type of anaesthesia techniques used, those who were given general anaesthesia were the ones who mostly experienced PONV with 18 patients (18,75%). There were 12 patients (12.50%) who experienced PONV undergone digestive surgery. In conclusion, the highest incidence of ponv was found in the age group 40-54 years, female gender, patients who received general anaesthesia, and patients undergone digestive surgery. Keywords: post operative nausea and vomiting (PONV), age, gender, general anaesthesia techniques, type of surgery.
Gambaran Derajat Infiltrasi Sel Radang Dan Infeksi Helicobacter Pylori Pada Biopsi Lambung Pasien Gastritis: Di RSUD Ulin Banjarmasin Tahun 2009-2011 Yulida, Erna; Oktaviyanti, Ika Kustiyah; Rosida, Lena
Jurnal Berkala Kedokteran Vol 9, No 1 (2013): April 2013
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i1.918

Abstract

ABSTRACT: Gastritis is a common gastrointestinal problem all over the world. In Indonesia, the prevalence of gastritis is high enough, it’s about 274.396 cases among 238.452.952 people. The aim of this research is to find out the type and level of inflammation and the infection Helicobacter pylori on gastritis patient in RSUD Ulin Banjarmasin during 2009-2011. The method uses descriptive research by emphasize on preparation of gastric biopsy to find the level of acute inflammation, chronic inflammation dan Helicobacter pylori’s infection based on Updated Sydney System from Endoscopy and Pathology Department. Data were classified by gender, age, and the level of severity. From 52 cases, acute inflammation is occurred in 35 patients with 29 patients (83%) mild, 5 patients (14%) moderate, 1 patient (3%) severe. Chronic inflammation is occurred in 51 patients with 2 patients (4%) mild, 14 patients (27%) moderate, and 35 patients (69%) severe. Helicobacter pylori’s infection is  occurred in 30 patients with 3 patients (10%) mild, 6 patients (20%) moderate, and 21 patients (70%) severe. Keywords : gastritis, acute inflammation, chronic inflammation, Helicobacter pylori ABSTRAK: Gastritis merupakan salah satu masalah kesehatan saluran pencernaan yang paling sering terjadi di dunia. Angka kejadian gastritis di Indonesia cukup tinggi, yaitu 274.396 kasus dari 238.452.952 jiwa penduduk. Tujuan penelitian ini adalah untuk mengetahui jenis dan derajat keparahan infiltrasi sel radang serta infeksi Helicobacter pylori pada pasien gastritis di RSUD Ulin Banjarmasin. Metode penelitian yang digunakan adalah penelitian deskriptif dengan mengumpulkan data tingkat inflamasi akut, kronis dan infeksi Helicobacter pylori berdasarkan Updated Sydney System dari Instalasi Endoskopi dan Instalasi Patologi Anatomi. Data dikelompokkan menurut jenis kelamin, usia, dan tingkat keparahan. Dari 52 preparat, ditemukan inflamasi akut terjadi pada 35 pasien dengan 29 pasien (83%) derajat ringan, 5 pasien (14%) derajat sedang, dan 1 pasien (3%) derajat berat. Inflamasi kronik terjadi pada 51 pasien dengan  2 pasien (4%) derajat ringan, 14 pasien (27%) derajat sedang, dan 35 pasien (69%) derajat berat. Sedangkan infeksi Helicobacter pylori terjadi pada 30 pasien dengan 3 pasien (10%) derajat ringan, 6 pasien (20%) sedang, dan 21 pasien (70%) derajat berat. Kata-kata Kunci: gastritis, inflamasi akut, inflamasi kronis, Helicobacter pylori
Efek Jus Buah Karamunting (Melastoma malabathricum L.) Terhadap Kadar Trigliserida Serum Darah Tikus Putih Yang Diinduksi Propiltiourasil Noorrafiqi, Muhammad Ichwan; Yasmin, Alfi; Hendriyono, FX
Jurnal Berkala Kedokteran Vol 9, No 2 (2013): September 2013
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v9i2.952

Abstract

ABSTRACT: This study was aimed to understand the effect of karamunting fruit juice on triglyceride serum level in white rats induced with propylthiouracil (PTU). This study design was experimental, conducted on 7 groups, that is, group I who was not given any treatments (normal group), group II who was given PTU and labelled as negative control, group III who was given PTU and fenofibrate and labelled as positive control, group IV-VII who were given PTU and karamunting fruit juice. Result showed that the average values of triglyceride level in  group VI-VII were 105 mg/dL, 222.75 mg/dL, 85.25 mg/dL, 123 mg/dL, 135.25 mg/dL, 132 mg/dL, and 122.5 mg/dL, respectively. There were significant differences between group II and groups VI-VII who were given karamunting fruit juice. It was concluded that karamunting fruit juice from the dose of 1 mg/gBW could inhibit the increase in triglyceride serum level in white rats induced with PTU and given cholesterol diet. Keywords: karamunting juice, triglyceride, propylthiouracil ABSTRAK: Penelitian ini bertujuan mengetahui efek jus buah karamunting terhadap kadar trigliserida pada tikus putih yang diinduksi propiltiourasil (PTU). Penelitian ini bersifat eksperimental yang dilakukan pada 7 kelompok, yaitu kelompok I yang tidak diberikan perlakuan (kelompok normal), kelompok II yang diberi PTU sebagai kontrol negatif, kelompok III yang diberi PTU dan fenofibrat sebagai kontrol positif, dan kelompok IV-VII yang diberi PTU dan jus buah karamunting. Hasil penelitian menunjukkan rerata kadar trigliserida pada kelompok I-VII berturut-turut adalah sebesar 105 mg/dL, 222,75 mg/dL, 85,25 mg/dL, 123 mg/dL, 135,25 mg/dL, 132 mg/dL, dan 122,5 mg/dL. Terdapat perbedaan bermakna antara kelompok II dan kelompok VI-VII yang diberikan jus buah karamunting. Dapat disimpulkan bahwa jus buah karamunting mulai dosis 1 mg/gBB dapat menghambat peningkatan kadar trigliserida dalam serum darah tikus putih yang diberi pakan kolesterol dan diinduksi PTU. Kata-kata kunci: jus buah karamunting, trigliserida, propiltiourasil

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