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Journal of Islamic Pharmacy
Published by Universitas Islam Negeri Maulana Malik Ibrahim Malang
ISSN : 24605182     EISSN : 25276123     DOI : http://dx.doi.org/10.18860/jip
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health
Welcome to Journal of Islamic Pharmacy (e-ISSN : 2527-6123) formerly Jurnal Farmasains (p-ISSN : 2460-5182) Department of Pharmacy, Universitas Islam Negeri Maulana Malik Ibrahim Malang, Indonesia. The journal was established in 2015 and online publication was begun in 2016. Since 2016, the journal has been published in English and only receives manuscripts in English.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 156 Documents
 1   2   3   4   5 
FORMULATION AND ANTIBACTERIAL ACTIVITY TEST OF Staphylococcus aureus MICROEMULSION OF ANTING-ANTING (Acalypha indica) LEAF EXTRACT USING ISOPROPYL MIRISTAT AS OIL PHASE Husniyah, Jauharatul; Annisa, Rahmi; Ma'arif, Burhan
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4991

Abstract

Leaf of Anting-Anting (Acalypha indica) is one of the plants that contain potent flavonoid compounds as antibacterial Staphylococcus aureus. The purpose of this research is to know physical characteristic of microemulsion of A. Indica leaf extract and to know antibacterial activity against Staphylococcus aureus bacteria. The microemulsions in this study used isopropyl myristate as the oil phase, tween 80 and span 80 as surfactant, isopropanol as kosurfactant and free water from CO2. Microemulsion was made by varying the concentration of the extract into 3 formulas, there are 5%, 10% and 15%. A. indica extract obtained using ultrasonic maseration extraction method with 70% ethanol solvent. All the formulas were evaluated for the characteristics of the preparations and the antibacterial activity test against Staphylococcus aureus bacteria with the sumuran diffusion method. The research results showed that the microemulsion of A. indica leaf extract has good physical characteristic with pH value between 4.9-5.8, deep oil type, that particle size F1 9.34 μm, F2 14.22 μm and F3 9.68 μm and stable physically at 25°± 2°C and 40°± 2°C. The result of antibacterial activity test showed that F1 did not differ significantly with positive control. However, the inhibitory power of F1 is still under positive clindamycin control of 12.98 mm and 15.05 mm. So it can be collected that F1 is an ideal formula which has good physical characteristics and has optimum drag power.
PHARMACIST COUNSELING EFFECT TO THE LEVEL OF PATIENT KNOWLEDGE WITH TYPE 2 DIABETES MELLITUS IN “KIMIA FARMA KAWI” PHARMACY, MALANG CITY Hakim, Abdul; Atmaja, Ria Ramadhani Dwi; Sugihantoro, Hajar; Mufidah, Fahda Dina
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4507

Abstract

Diabetes mellitus is a carbohydrates, fats, protein metabolism disorder that caused by impaired insulin secretion, insulin disruption or both. Diabetes mellitus sufferer need a special care to make the blood glucose level always in normal condition and no complications in various organs. Type 2 diabetes mellitus is inception of disease begins with development of key metabolic abnormality, insulin resistance. Causes of type 2 diabetes mellitus is obesity, age over 40, lifesyle, genetic suscetibility. Pharmacist counseling to the patients of type 2 diabetes mellitus is very important because it can improve patient knowledge, patient compliance to the treatment and the quality of patients life. The purpose of this study is to determine the effect of counseling by pharmacists to the level of patient’s knowledge of type 2 diabetes mellitus in “Kimia Farma Kawi” Pharmacy, Malang City.This research is a quantitative study with Pre-Experimental design in the form of pretest – post-test design. Number of samples was taken during one month by using consecutive sampling method. The result of this study was using through Wilcoxon test that there was difference of value before and after the pharmacist counseling the patients of type 2 diabetes mellitus with significance value equal to 0.000 (p value 0,05). The conclusion of this research is the pharmacist counseling can improve patient knowledge of type 2 diabetes mellitus. Keywords : pharmacist counseling, knowledge, type 2 diabetes mellitus 
INFLUENCE OF MEDIA COMMUNICATION ON ATTITUDES AND KNOWLEDGE PREGNANT WOMEN CONSUMING FE TABLET IN THE MATERNITY CLINIC DELTA MUTIARA SIDOARJO Faristasari, Evvin
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4246

Abstract

The effectiveness of learning and teaching processes are influenced by the precision of the use of methods and media used. The role of Fe tablet in pregnancy is very important for the health of the mother or her fetus. This research aims to know the influence of the communications media towards the knowledge and attitude to pregnant mothers in consuming Fe tablets in Maternity Clinic Delta Mutiara Sidoarjo.This type of research is a true experimental design with pretest-posttest Design. The treatment using the the extension with lectures and outreach with leaflets. The population of as many as 40 people, the sample as many as 36 people, the sampling technique used simple random sampling of each group is made up of 18 people aged 20-25 years old and high school education. Tested with Chi-Square.In the control group, pregnant women who have good knowledge score of 33,33% and obtained results of 44,44% are being received while on a group of experiments, pregnant women are knowledgeable well as much 77,78% and obtained results 93,03% of pregnant women who received. The research result obtained from X2 to calculate X2 table (7.85 5) on knowledge so Ho denied and H1 are accepted. On the attitude of expectant mothers count X2 X2 tables (4.98 3.84), so Ho denied and H1 are accepted. From the results of this research it can be concluded that there is an influence of media communication to knowledge and attitude of pregnant women to consume Fe tablets.Keywords: leaflets, Fe tablet, knowledge, attitude
LIPASE ACTIVITIY OF MIXTURE OF FERMENTED AVOCADO (Persea americana), BANANA (Moses paradisiaca) AND SNAKEFRUIT (Salacca zalacca) Yazid, Edy Agustian
Journal of Islamic Pharmacy Vol 2, No 1 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i1.4252

Abstract

Fermentation is one of the bioconversion processes to produce anaerobic microbes which are beneficial and can produce enzymes. One of the enzymes that can be produced is lipase. Mixed fruit fermentation is an effort to produce lipase that can be done simply. The purpose of this research is to know the activity of lipase enzyme from mixture of fermented avocado fruit (Persea americana), bananas (Musa paradisiaca) and snakefruit (Salacca zalacca). Lipase enzyme activity is tested by measuring of free fatty acid (FFA) content obtained from olive oil hydrolysis process by lipase enzyme. The results showed the highest activity obtained 17.425 U/ml and the percentage of FFA produced was 12.94%. The highest activity of lipase enzyme was obtained at 450C and pH 6.5. From this research can be concluded that the fermentation of the mixture of avocado, bananas and snakefruit can produce lipase enzyme that has relatively high activity. Keywords: Enzyme Activity, Fruits, Fermentation, Lipase. 
ACTIVITY OF ETHYL ACETATE EXTRACT FROM Chrysophyllum cainito L. LEAVES IN DECREASING BLOOD SUGAR LEVEL IN MALE WISTAR RATS Arrijal, Imam Malikul Hadi; Ma'arif, Burhan; Suryadinata, Arief
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4996

Abstract

The high morbidity or mortality due to diabetes mellitus becomes the world health problem. That fact encourages the study about antidiabetes drugs from natural material especially plants. This study aims to analyze the effect of ethyl acetate extract from Chrysophyllum cainito L. leaves in decreasing of blood sugar level of alloxan-induced male male wistar rats. This research is considered as experimental research with pre and post test randomized controlled group design. The experimental animals in this study were 25 male male wistar rats divided into 5 treatment groups, treatment with CMC-Na (negative control), metformin with the dose of 9 mg/200gBW (positive control), and leaves extract C. cainito dose 25; 50; 75 mg/kgBW. All treatment groups had significant decrease of blood sugar levels at 7, 10 and 14 day observations with p 0.05. While in the day 3 had insignificant decrease of blood sugar level with p 0.05. Every C. cainito leaves extract doses group have the ability to decrease sugar blood level better than negative control, but still below positif control. The optimum dose in decreasing sugar blood level in this study is 75 mg/kg BW.
POTENSI TERAPI TUNGGAL ANTIMALARIA EKSTRAK ETANOL AKAR WIDURI (Calotropis gigantea) SECARA IN VIVO Fiisyatirodiyah, Fiisyatirodiyah; Hakim, Abdul; Muti’ah, Roihatul; Hayati, Elok Kamilah
Journal of Islamic Pharmacy Vol 1, No 1 (2015): Jurnal Farmasains
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v1i1.4173

Abstract

Tanaman Widuri mengandung beberapa golongan senyawa aktif, diantaranya flavonoid, alkaloid, terpenoid dan steroid.Senyawa-senyawa tersebut telah terbukti bermanfaat sebagai antimalaria.Selain itu, daun Calotropis proceraberpotensi antimalaria, sehingga diduga akar Calotropis gigantea juga berpotensi sebagai antimalaria karena mempunyai kekerabatan dalam satu genus.Penelitian ini bertujuan untuk mengetahui  efektivitas antimalaria ekstrak etanol 80 % akar Widuri (Calotropis gigantea) pada mencit terinfeksi Plasmodium berghei dan identifikasi golongan senyawa aktifnya.Tahapan penelitian ini meliputi analisis kadar air sampel basah, preparasi sampel, analisis kadar air sampel kering, kemudian ekstraksi senyawa aktif dengan maserasi. Setelah itu, dilakukan uji antimalaria dan dilanjutkan dengan uji fitokimia.Senyawa aktif yang positif terhadap uji fitokimia diidentifikasi dengan metode Kromatografi Lapis Tipis.Hasil kadar air sampel basah sebesar 51,17 %, sedangkan kadar air sampel keringnya sebesar 4,96 %. Isolasi senyawa aktif dilakukan dengan metode maserasi menggunakan pelarut etanol 80 %. Efektivitas antimalaria ekstrak etanol 80 % akar tanaman Widuri (Calotropis gigantea) dalam menghambat pertumbuhan Plasmodium berghei pada mencit adalah sangat baik dengan nilai ED50 sebesar 4,26 mg/Kg BB. Golongan senyawa aktif  yang terkandung dalam ekstrak etanol 80 % akar Widuri (Calotropis gigantea) berdasarkan uji reagen adalah golongan senyawa terpenoid dan saponin. Hasil identifikasi menggunakan Kromatografi Lapis Tipis menunjukkan bahwa eluen terbaik untuk golongan senyawa terpenoid adalah n-heksana : etil asetat (2 : 8) yang menghasilkan penampakan warna ungu pada panjang gelombang 366 nm dengan pereaksi Lieberman-Burchard, sedangkan eluen terbaik untuk saponin adalah kloroform : aseton (4 : 1) dengan penampakan warna ungu pada panjang gelombang 366 nm dengan pereaksi H2SO4 0,1 M. Kata kunci :Calotropis gigantea, antimalarial, Fitokimia, Kromatografi Lapis Tipis
OPTIMIZATION AND QUERCETIN RELEASE TEST OF MORINGA LEAF EXTRACT (MORINGA OLEIFERA) IN GEL-MICROEMULSION PREPARATION Bhagawan, Weka Sidha; Atmaja, Ria Ramadhani Dwi; Atiqah, Sri Nur
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4508

Abstract

Quercetin is a flavonoid compound of the flavonol group that has various biological activities for health. Moringa leaf is one of the plants rich in quercetin which is about 384.61 mg / 100 g. Quercetin is practically insoluble (4.5 μg / mL). To increase the solubility and release of quercetin microemulsion may be used as Drug Delivery Systems formulated with gels for transdermal use.The aim of this research is to obtain optimum combination formulation of surfactant (tween 80): cosurfactant (propylene glycol) to form optimal microemulsion system, to find out the characteristics of the preparation and to find out the rate of quercetin release of Moringa leaf extract (M. oliefera) in a gel-microemulsion preparation compared with a control gel (without microemulsion) using an HPMC (Hydroxypropyl methylcellulose) gel basis.The result shows that optimal concentration tween 80 comparison : propylene glycol to form optimal microemulsion system up to 30%: 20 % with VCO (virgin coconut oil) oil phase 5%. The characteristics observed including organoleptic, pH, viscosity, and stability are showing optimal condition. The average of quercetin content in gel-microemulsion preparation was 2,22 ± 0,077 ppm and on control gel was 2.37 ± 0.042 ppm. Quercetin release test using Franz diffusion cell using cellophane membrane, saline phosphate buffer pH 7,4 ± 0,05 and temperature 37 ± 0,5 °C for 6 hours. The average quercetin release flux in the gel-microemulsion preparation was 9.436 ± 1.178 (μg/cm 2/min1/2) and the control gel was 5,816 ± 0.485 (μg/cm2/min1/2).Based on these results it can concluded that the microemulsion gel preparation gives significant difference of quercetin flux rate compared with gel preparation. Keywords: Quercetin, Gel-Microemulsion, quercetin release, moringa leaf extract (Moringa oliefera)
ESTIMATION OF CEPHALOSPORINS (CEFTRIAXONE, CEFTAZIDIME) ANTIBIOTICS AS PURE AND PHARMACEUTIC FORMS BY COLOR PRODUCED REACTION IN UV-VIS SPECTROPHOTOMETIC TECHNIQUE Al-Rufaie, Mohauman Mohammad Majeed; Motaweq, Zahraa Yosif
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6098

Abstract

A new simple, accurate and low cost-effective UV-VIS spectrophotometric methods has been developed for the analysis of chosen cephalosporins (ceftriaxone, ceftazidime) in bulk samples and pharmaceutical dosage forms by using a specific  color-generated reaction. This method involves the Schiff 's base formation reaction between selected cephalosporins with alcoholic 5-sulfo salicylaldehyde reagent 5SSA with heating to establish a yellow colored product displaying λmax at 426 nm as well as 412 nm sequentially. These methods applied to the Beer’s law through the range of concentration was  (4 - 60 µg.ml-1), (5 -50µg ml-1) respectively for two drugs. The analysis results for these studies  have been tested statistically by the studies of recovery. These methods were successfully applied to the determination of the cephalosporins in bulk form and in Pharmaceuticals additionally it was shown that these methods have equivalent accuracy with the common method(BP)estimation procedures for the studied  drugs. The interferences from frequently taken excipients were  no influence on the estimation process .The study could discover a good  as an employment cost-influence and speed method which that possibility used for making quality control for  these cephalosporin antibiotics.
EVOLUTION AND EFFECTIVENESS OF COLORMETRIC APPROACH FOR INVESTIGATION OF CEFTRIAXONE MEDICINE AS IN PURE FORM AND IN FORMULATION VIALS Al-Rufaie, Mohauman Mohammad Majeed
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6099

Abstract

A third-generation cephalosporin antibiotic was aceftriaxone medicine. Similar another (3rd generation cephalosporins), it has wide broad spectrum effectiveness versus gram positive as well as gram negative bacteria. Diverse approachs for analyses of the studied medicine are obtainable but are costly additionally time consumption. Therefor we have sophisticated developed novel, easy, simple as well as accurate colormetric approach for investigation of ceftriaxone medicine as pure form as well as in formulation vials by depending on  a specific color-generated reaction. This reaction involves the Schiff 's base formation reaction between ceftriaxone drug  with alcoholic 4- di ethyl amino benzaldehyde  (DEAB) reagent to produce a new ligand that reacts with cobalt (II) ion with heating to (50°C) in acidic media to form green colored complex exhibiting λmax at 496 nm. The medicine conformed with the Beer’s law with the linearity was observed between (2 –52) μg/ml additionally that  correlation coefficient was 0.9992 .The analyses outcomes were supported with LOD, LOQ, accuracy, recovery studies, ruggedness as well as precision. The approach was establish to be robust as well as economical.
PHYTOCHEMICAL SCREENING, TOTAL FLAVONOID, ANTIOXIDANT ACTIVITY, AND TOXICITY OF ETHANOL EXTRACT Cleome gynandra L. HERB Widodo, Agustinus; Pratiwi, Ritha
Journal of Islamic Pharmacy Vol 3, No 2 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i2.6101

Abstract

Cleome gynandra L. is one of the plants that the people of Palu, Central Sulawesi use as food ingredients. This plant is empirically used in traditional medicine. This study aims to determine phytochemical constituents, total flavonoid, antioxidant activity, and toxicity of 96% ethanol extract of C. gynandra herb. C. gynandra herb extract was obtained by maceration. Phytochemical screening of the ethanol extract was carried out qualitatively according to the standard methods. Determination of total flavonoid using AlCl3 then determined by Spectrophotometric UV-Vis. Antioxidant activity using the DPPH method and determined IC50 value. Toxicity test was assessed using shrimp lethality as an indicator of toxicity. Phytochemical screening showed 96% ethanol extract containing alkaloid compounds, flavonoids, saponins, steroids, and tannins. Total flavonoid of the 96% ethanol extract was 4,778 ± 0,522 mg QE/g extract. Antioxidant activity (IC50) of the ethanol 96% extract was 189,455 µg/ml. Lethal concentration 50% of the 96% ethanol extract was 472,648 mg/L (toxic). The results of this study indicate that 96% ethanol extract of C. gynandra herb has antioxidant activity and has the potential to be further tested as an anticancer activity.

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