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Model Eksperimental Diabetes Melitus Tipe 2 pada Tikus Wistar : Kombinasi Diet Tinggi Lemak, Garam, Fruktosa dan Induksi Streptozotocin Zumrotul Farikhah; Ardyarini Dyah Savitri; Tri Wahyuni Bintarti; Lysa Veterini; Afira Febriani Surya Wijaya
Jurnal Ners Vol. 9 No. 3 (2025): JULI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i3.48318

Abstract

Diabetes melitus tipe 2 (DMT2) merupakan masalah kesehatan global dengan patogenesis kompleks melibatkan resistensi insulin dan disfungsi sel beta. Model hewan yang relevan diperlukan untuk mempelajari mekanisme penyakit dan pengujian terapi. Mengembangkan model DMT2 pada tikus Wistar dengan menggunakan kombinasi diet tinggi lemak-fruktosa-garam dan streptozotocin (STZ) dosis rendah untuk meniru manifestasi klinis dan komplikasi DMT2 pada manusia. Lima ekor tikus Wistar jantan diberi diet tinggi lemak (30%), fruktosa (30%), dan garam (1%) selama 4 minggu, dilanjutkan injeksi STZ (35 mg/kgBB). Parameter yang diukur meliputi kadar glukosa darah puasa, berat badan, serta analisis histopatologi pankreas dan ginjal. Peningkatan signifikan kadar glukosa darah (median: 497 mg/dL) dan penurunan berat badan (21 gram) diamati setelah intervensi. Histopatologi menunjukkan insulitis dengan derajat bervariasi (Score 2: 30% sampel; Score 1: 5% sampel) dan kerusakan tubulus ginjal ringan. Kombinasi diet obesogenik dan STZ berhasil menginduksi hiperglikemia persisten serta perubahan histopatologis yang menyerupai DMT2 manusia. Model ini potensial untuk studi patogenesis dan terapi DMT2, meskipun perlu optimasi untuk mengurangi variabilitas respons.
EDUKASI PEMANFAATAN RUMPUT LAUT SARGASSUM SP. SEBAGAI BAHAN PELEMBAB KULIT Tri Wahyuni Bintarti; Renny Novi Puspitasari; Hotimah Masdan Salim; Zamirah Mabarroh El Haque
Community Development Journal : Jurnal Pengabdian Masyarakat Vol. 5 No. 6 (2024): Vol. 5 No. 6 Tahun 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/cdj.v5i6.37604

Abstract

Pemanfaatan rumput laut Sargassum sp. sebagai bahan pembuatan pelembab kulit secara alami. Potensi Sargassum sp. yang kaya akan kandungan bioaktif untuk produk perawatan kulit masih belum banyak dimanfaatkan, padahal sumber daya ini melimpah di perairan Indonesia. Rumput laut Sargassum sp memiliki potensi antioksidan yang baik, yang menunjukkan kemampuan untuk menghambat reaksi radikal bebas dan mencegah kerusakan sel. Ekstrak Sargassum sp juga memiliki aktivitas anti-inflamasi, yang dapat digunakan dalam pengobatan dan kosmetik. Melalui edukasi rumput raut Sargassum sp sebagai bahan pembuatan pelembab kulit atau lotion, para santri diajak untuk memahami proses pengolahan Sargassum sp. menjadi produk bernilai ekonomi. Edukasi ini tidak hanya bertujuan untuk meningkatkan pengetahuan santri pondok pesantren KH Wahid Hasyim Bangil tentang manfaat Sargassum sp., tetapi juga melatih keterampilan kewirausahaan mereka dalam memanfaatkan sumber daya lokal. Pelaksanaan kegiatan dilakukan dalam beberapa tahap yakni persiapan, pelaksanaan, evaluasi, dan pelaporan. Sasaran responden untuk pengabdian masyarakat ini adalah santri husada poskestren pondok pesantren KH Wahid Hasyim Bangil sebanyak 40 orang dengan jenjang pendidikan antara SMP-SMA. hasil peningkatan pengetahuan santri terukur dengan parameter skor pada pretest dan posttest yang diberikan sebelum dan sesudah diberikan wawasan .Dari hasil rerata skor pre test dan post test terdapat peningkatan dimana skor pada pre test adalah 60 sedangkan skor post test yaitu 90 sehingga dalam hal ini terlihat bahwa terdapat peningkatan wawasan yang diberikan.
Sosialisasi Website PPDB Pada Yayasan Busyri Al Ali Untuk Peningkatan Layanan Siswa [Socialization of the PPDB Website at Busyri Al Ali Foundation for Improving Student Services] Tri Deviasari Wulan; Fajar Annas Susanto; Tri Wahyuni Bintarti; Heni Agustina
Indonesia Berdaya Vol. 7 No. 1 (2026)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.20261375

Abstract

The purpose of this community service activity is to conduct outreach and mentoring on the use of the New Student Admissions website (PPDB website) at the Busyri Al Ali Foundation. This website was built to help smooth the process of admitting new students and make it easier for prospective parents to complete the registration process. In the current student admissions system, the committee must enter the data of registered students along with the identities of their parents one by one in the school ledger. Another problem is that prospective parents have difficulty in obtaining new student registration information, causing the number of new students to tend to decrease every year. Website outreach was conducted to introduce the PPDB website to the entire academic community within the Busyri Al Ali Foundation. This can make it easier for the entire academic community to introduce the school and help prospective parents to register independently. The results of the outreach showed an increase in participant understanding from the results of the outreach activities. This is indicated by an increase in posttest results of 100% from the pretest results conducted before the outreach activities of 78%. In addition, mentoring activities were also carried out to ensure the PPDB Team can operate the system optimally. Mentoring was carried out for one month in a hybrid manner to ensure the admin can operate the system. During the mentoring activities, several evaluations were carried out regarding obstacles in using the system at the school and the difficulties faced by prospective parents in making online payments. Abstrak. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk melakukan sosialisasi dan pendampingan penggunaan website Penerimaan Peserta Didik Baru  (PPDB) di lingkungan  Yayasan Busyri Al Ali. Website ini dibangun untuk membantu kelancaran proses penerimaan siswa baru dan mempermudah calon orang tua siswa dalam melakukan proses pendaftaran. Sistem penerimaan siswa saat ini  masih menggunakan metode konvensional sehingga panitia PPDB harus memasukkan data siswa yang mendaftar beserta identitas orang tua wali satu-persatu pada buku besar sekolah. Selain itu, kesulitan dalam mendapatkan informasi PPDB pada sekolah di lingkungan Yayasan Busyri Al Ali juga menyebabkan jumlah siswa baru cenderung menurun setiap tahun.  Sosialisasi website  dilakukan untuk memperkenalkan website PPDB kepada seluruh civitas akademik di lingkungan Yayasan Busyri Al Ali. Hal ini dapat mempermudah seluruh sivitas akademik dalam memperkenalkan sekolah dan membantu para calon orang tua murid untuk melakukan pendaftaran secara mandiri. Hasil sosialisasi menunjukkan adanya peningkatan pemahaman peserta dari hasil kegiatan sosialisasi. Hal ini ditunjukkan dengan peningkatan hasil posttest sebesar 100% dari hasil prestest yang dilakukan sebelum kegiatan sosialisasi sebesar 78%. Selain itu, Kegiatan pendampingan juga dilakukan untuk memastikan Tim PPDB dapat mengoperasikan sistem secara optimal . Pendampingan dilaksanakan selama satu bulan secara hybrid untuk memastikan admin dapat mengoperasikan sistem. Selama kegiatan pendampingan dilaksanakan terdapat beberapa evaluasi terkait kendala penggunaan sistem di sekolah dan kesulitan yang dihadapi oleh calon orang tua siswa dalam melakukan pembayaran secara online.
High Cholesterol Prevention through Healthy Lifestyle Education and the Use of Bay Leaves (Syzygium polyanthum) as a Cholesterol-Lowering Herbal Remedy in Islamic Boarding Schools Tri Wahyuni Bintarti; Hotimah Masdan Salim; Nanda Fadhilah Witris Salamy; Machmudah Machmudah; Audi Ikhfina Tanra Aji; Rangga Azhaar Faraadies; Khadijah Khairul Bariyah
Indonesia Berdaya Vol. 7 No. 1 (2026)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.20261378

Abstract

Hypercholesterolemia is a growing health problem, including among adolescents in Islamic boarding schools (pesantren) where diets are high in fat and low in fiber, and physical activity is limited. This condition carries a risk of developing cardiovascular disease, necessitating preventive interventions tailored to the characteristics of the Islamic boarding school community. This Community Service (PkM) activity aims to increase students' knowledge and awareness of high cholesterol prevention through healthy lifestyle education and the use of bay leaves (Syzygium polyanthum) as an alternative herbal cholesterol-lowering agent. The program's innovation lies in integrating evidence-based health education with local wisdom, making it easily implemented in Islamic boarding schools. The activity was conducted at the Zainul Hasan Genggong Islamic Boarding School in Probolinggo in May 2025, involving 30 students and 14 religious teachers. The methods used included an initial survey, FGDs, interactive counseling with pre- and post-test evaluations, and free health checks, including anthropometry, blood pressure, and blood sugar measurements, medical consultations, and medication administration. The primary outcome was increased participant knowledge, measured by comparing pre-test and post-test scores and baseline health data from the examination. The results of the activity showed an average increase in participant knowledge of 23.4 points between the pre-test and post-test. Students also gained practical skills in using bay leaves as a daily ingredient beneficial for health.
Clean Water Treatment Training and Its Relation to Organ Damage Prevention at Al-Jihad Islamic Boarding School Lysa Veterini; Hotimah Masdan Salim; Tri Wahyuni Bintarti; Akbar Reza Muhammad; Dian Dakwatul Choiriya
Indonesia Berdaya Vol. 7 No. 1 (2026)
Publisher : UKInstitute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47679/ib.20261401

Abstract

Access to clean water in Indonesia remains a challenge, especially in rural areas and educational environments such as Islamic boarding schools. Consuming contaminated air in the long term from shallow wells can cause damage to organs, such as the kidneys, liver, and digestive tract. Therefore, the availability of sufficient and affordable clean water is very important for the survival and well-being of society. The approach in the Islamic boarding school environment, through community service activities and conducting counseling related to clean water processing and its relationship to preventing organ damage, is very important to create collective awareness in maintaining the availability of clean water. The implementation was carried out on May 17, 2025, at the Al-Jihad Islamic Boarding School in Surabaya. The series of activities began with filling out a pre-test, counseling through interactive lectures, and then continued with filling out a post-test to transmit the students' understanding after participating in this activity. The activity showed an increase in students' knowledge about water quality (management) and its impact on health (p<0.05). Providing counseling to students at the Al Jihad Islamic Boarding School in Surabaya was able to increase students' knowledge about water quality (management) and its impact on health.
Effects of Kratom (Mitragyna speciosa) Hydrogel Application on Pancreatic Histopathology in Type 2 Diabetic Mice Muhammad Aqil Siroj Jazuli; Zainul Hadi Wildan Ismail; Khuzaimah Nur Juhanifah Rihhadatulays; Eka Satria Akbar Ferdinan Hanafi; Puspita Rahmatul Jinan; Rosandhy Alifyah Pramesti; Hotimah Masdan Salim; Tri Wahyuni Bintarti
Jurnal Ilmu Kesehatan dan Kesehatan Vol 9 No 2 (2025): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v9i2.8018

Abstract

Background: Type 2 diabetes mellitus is a metabolic disorder characterized by elevated blood glucose caused by insulin resistance and impaired insulin production by pancreatic β-cells due to oxidative stress. Kratom (Mitragyna speciosa) has been widely investigated for its antidiabetic, anti-inflammatory, and antioxidant effects, attributed to its alkaloid, flavonoid, phenolic, and saponin contents. This study aimed to evaluate the potential of topical kratom hydrogel as an innovative approach to improving pancreatic histology in type 2 diabetic mice, which has not been previously reported. Methods: Fifteen mice were divided into three groups: untreated diabetic group (DM), diabetic group treated with 5% kratom hydrogel (K5), and diabetic group treated with 15% kratom hydrogel (K15). Treatments were administered for two weeks. Parameters assessed included the percentage of healthy β-cells and acinar cells, as well as histological scoring of islet damage. Data were analyzed using parametric or non-parametric tests according to the normality distribution of each parameter. Results: Administration of 5% kratom hydrogel significantly increased the percentage of healthy β-cells (p<0.05) compared with 15% kratom hydrogel, which unexpectedly showed a lower proportion of healthy cells than the untreated group. Interestingly, the higher dose appeared to exert more toxic effects, whereas the lower dose provided better protective effects. No significant differences were observed in acinar cell parameters or islet damage scores, possibly due to the limited sample size. Conclusion: These findings provide preliminary evidence supporting the systemic therapeutic potential of topical kratom hydrogel, particularly in determining the effective dose and the need for larger sample sizes to obtain more consistent outcomes.