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All Journal Health and Medical Journal Jurnal Abdi Insani jurnal abdimas saintika Nusantara Hasana Journal Scientific Journal Jurnal Pengabdian Masyarakat Bangsa AMMA : Jurnal Pengabdian Masyarakat Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES)
Helmizar, Roland
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Skrining Status Gizi dan Edukasi Nutrisi untuk Kesehatan Reproduksi Remaja di Pesantren Putri Al-Fallah Kota Padang Jelmila, Sri Nani; Ajisman, Ruhsyahadati; Hasni, Dita; Liana, Nana; Helmizar, Roland; Triyana, Rahma
Jurnal Pengabdian Masyarakat Bangsa Vol. 1 No. 10 (2023): Desember
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v1i10.518

Abstract

Pemenuhan nutrisi di masa remaja sangat penting untuk mendukung pertumbuhan dan perkembangan yang akan berpengaruh terhadap kehidupan di masa yang akan datang. Kegiatan skrining status gizi dan edukasi nutrisi yang dilakukan di Pesantren Putri Al-Fallah, Kota Padang, Sumatera Barat, bertujuan untuk meningkatkan kesadaran remaja tentang pentingnya gizi seimbang, khususnya bagi kesehatan reproduksi. Metode yang digunakan meliputi skrining status gizi berdasarkan BMI dan LILA pada 50 santriwati Pondok Pesantren Al-Fallah, disertai edukasi nutrisi seimbang dan diskusi interaktif. Hasil skrining menunjukkan 56% santriwati memiliki status gizi normal, 22% kurus, 18% kelebihan berat badan, dan 4% obesitas. Rerata LILA 25,74 cm berada pada kisaran normal. Edukasi nutrisi memberikan pemahaman tentang hubungan antara status gizi dan kesehatan reproduksi. Kesimpulan kegiatan ini adalah status gizi berpengaruh terhadap kesehatan reproduksi, penting memenuhi nutrisi seimbang di pesantren.
ADULT GRANULOSA CELL TUMORS: A COMPREHENSIVE REVIEW OF CLINICOPATHOLOGICAL FEATURES AND MOLECULAR INSIGHTS Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Rasyid, Lismawati; Aliefia, Desi
Nusantara Hasana Journal Vol. 4 No. 6 (2024): Nusantara Hasana Journal, November 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i6.1252

Abstract

Adult granulosa cell tumor (AGCT) is a rare subtype of ovarian cancer, accounting for 2-5% of all ovarian malignancies and originating from granulosa cells that are involved in oocyte development and sex steroid production. Although AGCT is often diagnosed at an early stage and has a better prognosis compared to other types of ovarian cancer, challenges in diagnosis persist. Clinical symptoms such as abdominal pain and distension are often nonspecific and may be accompanied by signs of hyperestrogenism. Histopathological examination of AGCT reveals a characteristic cell pattern; however, variations in histological appearance can complicate diagnosis. Despite a favorable prognosis, there remains a risk of recurrence, with many cases experiencing relapse several years post-initial treatment. This underscores the necessity for long-term monitoring of patients following treatment. This article aims to explore the clinicopathological characteristics of AGCT and provide guidance for more effective patient management through a deeper understanding of molecular mechanisms and appropriate therapeutic approaches
Langkah Awal Mengenal Status Anemia Pada Remaja Perempuan di MAN 1 Padang Anggraini, Debie; Munawaroh, Madina; Helmizar, Roland
Abdika Sciena Vol 2 No 2 (2024): JURABDIKES Volume 2 No 2, Desember 2024
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/jurabdikes.v2i2.190

Abstract

Latar belakang: Anemia merupakan salah satu masalah kesehatan yang signifikan pada remaja, di mana kondisi ini berpotensi menghambat perkembangan fisik dan kognitif. Rendahnya asupan zat besi, pola makan yang tidak seimbang, dan perubahan fisiologis selama masa pubertas merupakan faktor penyebab utama. Deteksi dini anemia melalui pendekatan pengabdian masyarakat dianggap sangat penting guna mencegah komplikasi jangka panjang dan meningkatkan kualitas hidup remaja. Tujuan: Program pengabdian masyarakat ini bertujuan untuk melakukan deteksi dini anemia pada remaja melalui serangkaian kegiatan edukasi dan skrining menggunakan alat Easy Touch. Kegiatan ini diharapkan dapat meningkatkan pengetahuan remaja dan masyarakat sekitarnya mengenai pencegahan serta penanganan dini anemia.Kegiatan dilakukan secara terintegrasi di lingkungan sekolah dengan melibatkan tenaga kesehatan, pendidik, dan masyarakat. Proses skrining meliputi pemeriksaan konsentrasi hemoglobin menggunakan alat Easy Touch, yang dilakukan dengan prosedur pengambilan sampel darah melalui tusuk jari dan analisis hasil secara cepat dan akurat. Selain itu, kegiatan penyuluhan mengenai pentingnya gizi seimbang dan pencegahan anemia dilaksanakan untuk meningkatkan kesadaran serta perubahan perilaku hidup sehat. Kesimpulan: Program pengabdian masyarakat tentang deteksi dini anemia pada remaja merupakan langkah strategis dalam upaya pencegahan dan penanganan anemia sejak dini. Keterlibatan berbagai stakeholder dan pendekatan intervensi yang komprehensif terbukti efektif dalam meningkatkan kesadaran dan mengidentifikasi remaja yang berisiko, sehingga dapat dijadikan dasar bagi pengembangan program kesehatan yang lebih luas di masa mendatang.
Subtipe Histopatologis Adenokarsinoma Kolorektal Berdasarkan WHO : Implikasi Terhadap Prognosis Liana, Nana; Setiawati, Yessy; Ruhsyahadati; Triyana, Rahma; Helmizar, Roland
Scientific Journal Vol. 4 No. 3 (2025): SCIENA Volume IV No 3, May 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i3.209

Abstract

Adenokarsinoma kolorektal merupakan tipe histologis paling umum dari kanker kolorektal yang menunjukkan heterogenitas morfologis dan biologis yang tinggi. Variasi ini memengaruhi tidak hanya pola penyebaran dan respons terhadap terapi, tetapi juga prognosis pasien secara keseluruhan. Klasifikasi histopatologi yang ditetapkan oleh World Health Organization (WHO) memberikan pedoman sistematis dalam membedakan berbagai subtipe adenokarsinoma kolorektal, seperti adenokarsinoma konvensional, mucinous, signet-ring cell, dan medullary carcinoma. Subtipe-subtipe ini diketahui memiliki perbedaan signifikan dalam perilaku klinis dan sensitivitas terhadap pengobatan. Oleh karena itu, pemahaman dan penerapan klasifikasi WHO sangat penting untuk meningkatkan akurasi diagnosis, perencanaan terapi yang tepat sasaran, serta prediksi prognosis yang lebih akurat. Tujuan penulisan ini adalah untuk menyoroti pentingnya klasifikasi histopatologi WHO dalam menunjang pengambilan keputusan klinis terkait terapi dan prognosis pasien dengan adenokarsinoma kolorektal.
DIAGNOSTIC HISTOPATHOLOGY OF JUVENILE GRANULOSA CELL TUMOR: HALLMARK MORPHOLOGICAL AND CYTOLOGICAL FINDINGS Liana, Nana; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Helmizar, Roland; Dhuha, Alief; Malik, Rifkind; Saputra, Muhammad Rizki
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1417

Abstract

Juvenile granulosa cell tumour (JGCT) is a subtype of granulosa cell tumour that predominantly affects young females, particularly those who are premenarchal, with a mean age at diagnosis of 13 years. Although rare, this tumour can occur across a wide age range, from 10 months to 67 years. Histologically, JGCT resembles the adult-type granulosa cell tumour but presents with distinct features, including aggressive growth and the absence of FOXL2 mutations. Common clinical manifestations include an abdominal mass, abdominal pain, precocious puberty in prepubertal girls due to estrogen secretion, and menorrhagia or amenorrhea in premenopausal women. Macroscopically, the tumour typically exhibits a dominant solid component, frequently accompanied by hemorrhagic and necrotic areas. High mitotic activity and variable degrees of cytological atypia are characteristic findings. The diagnosis is supported by positive immunoreactivity for inhibin, calretinin, and CD99. In early-stage disease, the primary treatment is unilateral oophorectomy with fertility preservation. In contrast, advanced stages often require total hysterectomy and adjuvant chemotherapy. Prognosis is highly dependent on disease stage; patients with stage I disease have a survival rate of up to 97%, whereas advanced-stage disease is associated with a poorer outcome. This review aims to provide a comprehensive overview of the epidemiology, pathogenesis, clinical manifestations, diagnostic approaches, and management strategies of Juvenile Granulosa Cell Tumour (JGCT). It also underscores the importance of early detection and the development of more effective therapeutic options to enhance clinical outcomes.
MEKANISME PENSINYALAN VASCULAR ENDOTHELIAL GROWTH FACTOR DALAM PERKEMBANGAN DAN PENYEBARAN KANKER Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Triyana, Rahma; Saputra, Muhammad Rizki
Nusantara Hasana Journal Vol. 5 No. 3 (2025): Nusantara Hasana Journal, August 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i3.1598

Abstract

Vascular Endothelial Growth Factor (VEGF) is a key mediator in the process of angiogenesis, playing a crucial role in the development and spread of malignant tumors. VEGF consists of several isoforms, primarily VEGF-A, which exert their effects through receptors VEGFR-1, VEGFR-2, and VEGFR-3, as well as co-receptors neuropilin-1 and -2. Activation of VEGF signaling pathways stimulates endothelial cell proliferation, migration, and survival, increases vascular permeability, and facilitates the formation and invasion of tumor-associated blood vessels. VEGF expression is regulated by various factors, including hypoxia via HIF-1α activation, oncogenes such as KRAS and Src, and the suppression of tumor suppressor genes such as p53 and PTEN. Additionally, several growth factors including EGF, PDGF, and IGF contribute to the regulation of VEGF. VEGF signaling also promotes tumor invasion by activating proteolytic enzymes such as MMP-2, MMP-9, and uPA, which degrade the basement membrane. Due to its central role in angiogenesis and tumor invasion, VEGF is a strategic target in anti-angiogenic therapies for various types of cancer. A comprehensive understanding of the structure, function, and regulation of VEGF is essential for the development of more effective molecular therapies.
PROFIL RESPIRATORY DISTRESS PADA BAYI BARU LAHIR DI NICU RSIA SITI HAWA PADANG TAHUN 2021 Eldrian, Febiane; Liana, Nana; Aditia Permana, Yudhi; Lismawati; Helmizar, Roland
Nusantara Hasana Journal Vol. 3 No. 12 (2024): Nusantara Hasana Journal, May 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v3i12.1121

Abstract

Respiratory distress (RD) poses a significant issue that can lead to fatal consequences such as respiratory failure, brain damage, and an increase in morbidity and mortality among newborns. The diagnosis of RD is based on the identification of one or more signs of increased respiratory activity, including tachypnea, nasal flaring, retractions in the intercostal area, and grunting. Objective: The purpose of this research is to provide an overview of the occurrence of RD among neonatus who were hospitalized in the Neonatal Intensive Care Unit (NICU) at RSIA Siti Hawa Padang in the year 2021. Methods: This study is an analytic descriptive research. The accessible population in this study consists of newborns who were treated at the NICU of RSIA Siti Hawa Padang during the year 2021. Results: From the study findings, it was observed that 94 newborns (approximately 5.2%) experienced RD. Among them, males were more predominant, accounting for 54 infants (57%). The majority of infants had a gestational age categorized as full-term, totaling 56 infants (59.6%). Furthermore, the birth weight for the majority of newborns was within the normal range, with 65 infants (69.1%) falling into this category. Conclusion: In conclusion, the majority of newborns at NICU RSIA Siti Hawa Padang in 2021 did not experience RD. Among those affected by RD, males were predominant, and most had a gestational age categorized as full-term, indicating a low risk of prematurity. The average birth weight also tended to be within the normal range for newborns born and cared for in NICU RSIA Siti Hawa Padang in 2021.
THE PROFILE OF COLORECTAL ADENOCARCINOMA AT DR. M. DJAMIL GENERAL HOSPITAL PADANG, INDONESIA Liana, Nana; Helmizar, Roland; Ruhsyahadati, Ruhsyahadati; Jelmila, Sri Nani; Triyana, Rahma; Lismawati, Lismawati
Nusantara Hasana Journal Vol. 4 No. 1 (2024): Nusantara Hasana Journal, Juny 2024
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i1.1132

Abstract

Colorectal carcinoma is the third most common malignancy in the world. This malignancy originates from the epithelium of the colon and/or rectum, showing glandular or mucinous differentiation, where tumor cells have penetrated the muscularis mucosae layer. The study aims to report on epidemiological, clinical, and pathological characteristics of colorectal adenocarcinoma. Methods: We performed a retrospective descriptive study of 140 cases of colorectal adenocarcinoma in the gastroenterology and general surgery departments of M. Djamil General Hospital Padang, Indonesia conducted from January 2022 to December 2022. Data collection using medical records of patients in M. Djamil General Hospital Padang, Indonesia. We reported different data: Age, sex, site, and differentiation grade of the tumor. Results: Our study included 140 patients 80 males (57,1%) and 60 females (42.9%), with a median age range of 51-60 years. The tumors were found in the rectum 82 (58.6%), distal colon 37(26.4%), and proximal colon 21(15.0%). The differentiation grade was majority low grade 117 (83.6%). Conclusion: In conclusion, our result showed that colorectal adenocarcinoma is highest in the male population with an age range of 61-70 years. The most common site of adenocarcinoma is rectum. A low grade is the most differentiated grade. Keywords: colorectal adenocarcinoma, anatomical location, differentiation grade, profile
Perbandingan Efektivitas Infusa Bunga Lawang (Illicium Verum) dan Infusa Daun Kunyit Terhadap Mortalitas Larva Aedes aegypti Instar III Triyana, Rahma; Adelin, Prima; Ruhsyahadati, Ruhsyahadati; Helmizar, Roland
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1490

Abstract

Pendahuluan: Nyamuk Aedes sp merupakan vektor penyebab penyakit Demam Berdarah (DBD) yang menginfeksi jutaan orang setiap tahunnya. Salah satu penanganan DBD yaitu membasmi vektor dengan cara pemberian insektisida alami pada larva nyamuk. Bunga Lawang (Illicium verum) dan daun kunyit berpotensi sebagai larvasida alami. Tujuan: Membandingkan efektivitas larvasida infusa bunga lawang dan daun kunyit terhadap mortalitas larva Aedes aegypti. Metode: Penelitian eksperimental menggunakan rancangan Post Test Only Control Group Design, populasi terjangkau penelitian ini adalah larva Aedes aegypti instar III dengan kebutuhan total sampel 560 larva, analisa data menggunakan uji one way anova. Hasil penelitian: Infusa bunga lawang efektif membunuh larva Aedes aegypti instar III pada konsentrasi 2% selama 24 jam dengan kematian sebanyak 8,75%,  konsentrasi 32% sebanyak 100% dalam waktu 24 jam sedangkan kematian larva pada konsentrasi infusa daun kunyit sebesar 30% dalam 24 jam sebanyak 2,5%,   pada konsentrasi 100% selama 24 jam kematian larva hanya mencapai 17,5%. Kesimpulan: Infusa bunga lawang lebih efektif sebagai larvasida dibandingkan infusa daun kunyit.
Pelayanan Kesehatan Bagi Masyarakat Dalam Rangka Kegiatan Pengabdian Kepada Masyarakat Malik, Rifkind; Primawati, Irma; Helmizar, Roland; Lidra Maribeth, Annisa; Rasyadi, Yahdian; Yesika, Relin
AMMA : Jurnal Pengabdian Masyarakat Vol. 2 No. 4 (2023): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The economy and education are important aspects of the community but the other most important is health because health can affect economy and social productivity. Health can be imbalanced due to a poor lifestyle, diet, and lack of physical activity which will trigger various non-communicable diseases. The aim of this service community is to provide understanding on disease, good diet and daily physical activity. The method used is leaflets, posters, and short lectures. The result of this service is that many respondents are elderly. With this service we hope that in the future the elderly can begin to increase their physical activity, consume healthy food and routine health checks to increase the quality of life.
Co-Authors Adelin, Prima Aditia Permana, Yudhi Ajisman, Ruhsyahadati Aliefia, Desi Anggraini, Debie Dhuha, Alief Dian Puspita Eldrian, Febiane Hasni, Dita Jelmila, Sri Nani liana, nana Lidra Maribeth, Annisa Lismawati Lismawati, Lismawati Malik, Rifkind Melya Susanti Muhammad Rizki Saputra, Muhammad Rizki Munawaroh, Madina Nani Jelmila, Sri Primawati, Irma Rasyid, Lismawati Ruhsyahadati Ruhsyahadati, Ruhsyahadati Setiawati, Yessy Suharni Suharni Tri Septiana, Vina Tri Yana, Rahma Triyana, Rahma Yahdian Rasyadi Yesika, Relin Yurizali, Bun