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All Journal Jurnal Kedokteran Brawijaya AGRIKA CEMARA Journal of Natural Sciences and Mathematics Research Jurnal Ekonika : Jurnal Ekonomi Universitas Kadiri Jurnal Agrotek UMMat Jurnal Teknik Pertanian Lampung (Journal of Agricultural Engineering) TEKNOLOGI PANGAN : Media Informasi dan Komunikasi Ilmiah Teknologi Pertanian AGROMIX BUANA SAINS Jurnal Ilmiah Hijau Cendekia Jurnal Aplikasi Dan Inovasi Ipteks SOLIDITAS Cendekia : Jurnal Pengabdian Masyarakat AGROTEK: Jurnal Ilmiah Ilmu Pertanian Jurnal Agriovet Journal of Food Technology and Agroindustry JURNAL ILMIAH AGRINECA Jurnal Abdiraja Fruitset Sains : Jurnal Pertanian Agroteknologi East Asian Journal of Multidisciplinary Research (EAJMR) Jurnal Manajemen Agribisnis dan Agroindustri Formosa Journal of Multidisciplinary Research (FJMR) Formosa Journal of Applied Sciences (FJAS) Asian Journal of Community Services (AJCS) JAPI: Jurnal Akses Pengabdian Indonesia Journal Research of Social Science, Economics, and Management Journal of Soilscape and Agriculture International Journal of Integrative Research (IJIR) International Journal of Advanced Technology and Social Sciences (IJATSS) JTePP
Nunuk Helilusiatiningsih
Departemen Agroteknologi , Fakultas Pertanian, Universitas Islam Kadiri
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Aktivitas Sitotoksik Fraksi Heksana Terung Pokak (Solanum torvum) terhadap Sel Kanker T47D Helilusiatiningsih, Nunuk; Yunianta, Yunianta; Harijono, Harijono; Widjanarko, Simon Bambang; Sujuti, Hidayat
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2019.030.04.4

Abstract

Terung pokak adalah tanaman dari genus Solanum yang diperkirakan memiliki sifat antikanker. Tujuan penelitian ini menganalisis kandungan dan aktivitas sitotoksik fraksi heksana terung pokak terhadap sel kanker T47D secara invitro. Uji identifikasi senyawa pada fraksi heksana terung pokak menggunakan uji kualitatif dengan penapisan fitokimia dan  (Gas Chromatography-Mass Spectometry), uji sitotoksik menggunakan metode MTT, uji siklus sel kanker T47D dan apoptosis menggunakan metode flowcytometry.  Hasil uji fitokimia menunjukkan terung pokak  mengandung alkaloid, saponin, glikosida dan steroid.  Hasil uji identifikasi kimia fraksi heksana  terung pokak menunjukkan 29 komponen yaitu asam asetat, asam propionat, 2- pentenal, 2- metilfuran, 1- penten-3-on, asam butirat, 2 -metilbutan, 2,3 butanedion, dimetil disuksipirazin, lfida, asam valerat, furfural, 3- heksanon, metional, heksanal, benzaldehid, 2-heptenal, 4- heptenal, 1,5 - octadien 3-on, 2- butilfuran, 3,5- oktadien-2- on, 1 okten-3-on, 2-pentilfuran, 2,6-nonadienal, 2- nonenal, 2- Isopropil-3-metoksipirazin, linalool, 2- isobutil metoksipirazin, dekalakton. Fraksi heksana terung pokak bersifat sitotoksik terhadap sel kanker T47D  dengan IC50 sebesar  85,58µg/mL. Fraksi heksana terung pokak dapat menghambat siklus sel T47D pada fase G0-G1 sebesar 35,84%, fase S 27,05%, fase G2-M 37,46% dari pengamatan 20.000 sel T47D . Fraksi heksana terung pokak dapat memacu apoptosis awal sebesar 28,89% dan apoptosis akhir  1,04% dari pengamatan 20.000 sel T47D.  Hasil tersebut menunjukkan bahwa  fraksi heksana terung pokak bersifat sitotoksik, menghambat proliferasi dan memacu apoptosis sel T47D, sehingga layak dikembangkan  sebagai antikanker.
Aktivitas Sitotoksik Fraksi Heksana Terung Pokak (Solanum torvum) terhadap Sel Kanker T47D Helilusiatiningsih, Nunuk; Yunianta, Yunianta; Harijono, Harijono; Widjanarko, Simon Bambang; Sujuti, Hidayat
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2019.030.04.4

Abstract

Terung pokak adalah tanaman dari genus Solanum yang diperkirakan memiliki sifat antikanker. Tujuan penelitian ini menganalisis kandungan dan aktivitas sitotoksik fraksi heksana terung pokak terhadap sel kanker T47D secara invitro. Uji identifikasi senyawa pada fraksi heksana terung pokak menggunakan uji kualitatif dengan penapisan fitokimia dan  (Gas Chromatography-Mass Spectometry), uji sitotoksik menggunakan metode MTT, uji siklus sel kanker T47D dan apoptosis menggunakan metode flowcytometry.  Hasil uji fitokimia menunjukkan terung pokak  mengandung alkaloid, saponin, glikosida dan steroid.  Hasil uji identifikasi kimia fraksi heksana  terung pokak menunjukkan 29 komponen yaitu asam asetat, asam propionat, 2- pentenal, 2- metilfuran, 1- penten-3-on, asam butirat, 2 -metilbutan, 2,3 butanedion, dimetil disuksipirazin, lfida, asam valerat, furfural, 3- heksanon, metional, heksanal, benzaldehid, 2-heptenal, 4- heptenal, 1,5 - octadien 3-on, 2- butilfuran, 3,5- oktadien-2- on, 1 okten-3-on, 2-pentilfuran, 2,6-nonadienal, 2- nonenal, 2- Isopropil-3-metoksipirazin, linalool, 2- isobutil metoksipirazin, dekalakton. Fraksi heksana terung pokak bersifat sitotoksik terhadap sel kanker T47D  dengan IC50 sebesar  85,58µg/mL. Fraksi heksana terung pokak dapat menghambat siklus sel T47D pada fase G0-G1 sebesar 35,84%, fase S 27,05%, fase G2-M 37,46% dari pengamatan 20.000 sel T47D . Fraksi heksana terung pokak dapat memacu apoptosis awal sebesar 28,89% dan apoptosis akhir  1,04% dari pengamatan 20.000 sel T47D.  Hasil tersebut menunjukkan bahwa  fraksi heksana terung pokak bersifat sitotoksik, menghambat proliferasi dan memacu apoptosis sel T47D, sehingga layak dikembangkan  sebagai antikanker.
WILLINGNESS TO PAY TEH HERBAL TAKOKAK MASA PANDEMI COVID-19 DI KOTA KEDIRI Heru Setiyadi; Nunuk Helilusiatiningsih
JURNAL PERTANIAN CEMARA Vol 18 No 1 (2021): JURNAL PERTANIAN CEMARA (CENDEKIAWAN MADURA)
Publisher : Fakultas Pertanian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24929/fp.v18i1.1245

Abstract

Konsumen mulai beralih menggunakan produk herbal yang terbukti mempunyai khasiat untuk tubuh bagi yang mengonsumsinya, termasuk minuman herbal. Salah satu jenis minuman herbal dengan keunggulan manfaat kesehatan adalah Teh Herbal Takokak yang berasal dari pengolahan buah takokak. Pada masa pandemi Covid- 19 seperti saat ini, tentunya teh herbal takokak bisa menjadi alternatif konsumen dalam mengoonsumsi minuman dengan orientasi kesehatan karena bisa meningkatkan imunitas. Tujuan penelitian ini adalah untuk mengetahui nilai willingness to pay (WTP) terhadap Teh Herbal Takokak serta mengetahui hubungan karakteristik responden dengan WTP Teh Herbal Takokak pada Masa Pandemi Covid-19 di Kota Kediri. Penelitian ini dilaksanakan pada September hingga Desember 2020 di Kota Kediri. Penelitian ini menggunakan populasi yaitu seluruh penduduk Kota Kediri dengan usia 30 tahun ke atas dengan sampel yang digunakan sebanyak 100 responden. Untuk mengetahui nilai WTP Teh Herbal Takokak pada Masa Pandemi Covid-19 di Kota Kediri menggunakan pendekatan Contingent Valuation Method (CVM) yang menanyakan langsung kepada responden mengenai nilai kesediaan membayar (harga) Teh Herbal Takokak di Kota Kediri. Sedangkan analisis hubungan karakteristik responden dengan kesediaan membayar WTP Teh Herbal Takokak pada Masa Pandemi Covid-19 di Kota Kediri menggunakan metode uji Chi-Square dengan SPSS. Dari penelitian yang telah dilakukan diperoleh hasil bahwa 1) nilai rataan WTP responden Teh Herbal Takokak sebesar Rp31.150 per 80 gram dan responden yang mempunyai WTP Teh Herbal Takokak sebesar 72 responden (72%) dengan harga lebih dari sama dengan Rp30.000,00 per 80 gram; 2) karakteristik responden yang mempunyai hubungan siginifikan terhadap WTP Teh Herbal Takokak adalah status usia, tingkat pendidikan, tingkat pendapatan, status pekerjaan, dan status pengetahuan.
RESPON PUPUK PETROBIO DAN JARAK TANAM TERHADAP PRODUKTIVITAS KACANG PANJANG (VIGNA SINENSIS L.) VARIETAS KATON Diana Indra Atmanegara; Nunuk Helilusiatiningsih; Eva Pebriana
Jurnal Agrotek Ummat Vol 8, No 1 (2021): April 2021
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Long bean is a vegetable that contains vitamins A, B, and C, fiber, minerals, and also protein. The purpose of this research was to determine the interaction between petrobio fertilizer and planting distance on long bean productivity of katon variety. The method used was a completely randomized design with 2 factors, namely petrobio fertilizer (30, 60, 90 kg/ha) and planting distance (30 x 30, 30x40, 30x50 cm).  The results showed that there is interaction between petrobio fertilizer at  60 kg /ha and plant distance of 30 x 40 cm in the number of fruits at 1st, 2nd, and 4th harvests, which is as much as 5, 6, and 7 fruits.
RESPON PUPUK PETROBIO DAN JARAK TANAM TERHADAP PRODUKTIVITAS KACANG PANJANG (VIGNA SINENSIS L.) VARIETAS KATON Diana Indra Atmanegara; Nunuk Helilusiatiningsih; Eva Pebriana
Jurnal Agrotek Ummat Vol 8, No 1 (2021): April 2021
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Long bean is a vegetable that contains vitamins A, B, and C, fiber, minerals, and also protein. The purpose of this research was to determine the interaction between petrobio fertilizer and planting distance on long bean productivity of katon variety. The method used was a completely randomized design with 2 factors, namely petrobio fertilizer (30, 60, 90 kg/ha) and planting distance (30 x 30, 30x40, 30x50 cm).  The results showed that there is interaction between petrobio fertilizer at  60 kg /ha and plant distance of 30 x 40 cm in the number of fruits at 1st, 2nd, and 4th harvests, which is as much as 5, 6, and 7 fruits.
RESPON PUPUK PETROBIO DAN JARAK TANAM TERHADAP PRODUKTIVITAS KACANG PANJANG (VIGNA SINENSIS L.) VARIETAS KATON Diana Indra Atmanegara; Nunuk Helilusiatiningsih; Eva Pebriana
Jurnal Agrotek Ummat Vol 8, No 1 (2021): April 2021
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Long bean is a vegetable that contains vitamins A, B, and C, fiber, minerals, and also protein. The purpose of this research was to determine the interaction between petrobio fertilizer and planting distance on long bean productivity of katon variety. The method used was a completely randomized design with 2 factors, namely petrobio fertilizer (30, 60, 90 kg/ha) and planting distance (30 x 30, 30x40, 30x50 cm).  The results showed that there is interaction between petrobio fertilizer at  60 kg /ha and plant distance of 30 x 40 cm in the number of fruits at 1st, 2nd, and 4th harvests, which is as much as 5, 6, and 7 fruits.
PENGARUH JUMLAH MATA TUNAS BATANG ATAS DAN TINGGI BATANG BAWAH PADA SAMBUNG PUCUK TERHADAP PERSENTASE TUMBUH JAMBU AIR (Syzygium Samarangense) Supriyono Supriyono; Tarwa Mustopa; Nunuk Helilusiatiningsih; Fristama Maulana
Jurnal Agrotek Ummat Vol 7, No 2 (2020): October 2020
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jau.v7i2.2853

Abstract

Water guava (Syzygium Samarangense) was a popular plant in Indonesia because it was fresh and sweet. The aim of this research was to analyze the effect of the number of shoots of the upper stems and height of the rootstock at the shoot graft on the percentage of growing water guava. The method used in this study was a completely randomized design, factor into one rootstock length, namely 10 cm, 15 cm, and 20 cm. and the second factor was the number of buds on the scion, namely 2, 3, and 4. The results showed that there was a significant interaction in the treatment combination of the number of 4 buds on the upper stem and the length of the rootstock 15 cm at 35 days after grafting affected the growth percentage and growth in the number of leaves and length of the scion.
IDENTIFIKASI SENYAWA KIMIA PADA BUAH SEGAR TERUNG POKAK (Solanum torvum) DENGAN METODE LCMS Nunuk Helilusiatiningsih
Journal of Food Technology and Agroindustry Vol 3 No 1 (2021): Journal of Food Technology and Agroindustry
Publisher : Journal of Food Technology and Agroindustry dipublikasikan oleh Universitas Wiraraja

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24929/jfta.v3i1.1179

Abstract

The content of antioxidant compounds in pokak eggplant (Solanum torvum) had the potential as an herbal medicine and was consumed by the world population. The research objective was to study the chemical compound content of the LCMS method. Experimental design with fresh fruit extraction of pokak eggplant using 95% ethanol solvent. The parameters measured were the chemical components found in fresh fruit. The results of analysis of chemical compounds include Choline, Proline, Bis (2-ethylhexyl) phthalate, BMK ethyl glycidate, 4- Methoxycinnamic acid, chlorogenic acid, 7- Hydroxycoumarine, Trigonelline, 1- Vinylimidazole, Pipecolic acid, L- (+) - Arginine- Stearoylglycerol, Caffeine, Cetrimonium, l- Pyroglutamic acid, Erucamide, Muscone, Cucurmin, Stearamide, Betulin, Acetophenone, Ethyl oleate, SSR146977, D - (+) - Maltose, M-144, Monoolein, L-ide, Histidine, Tomatidine, Oleamide Hexadecanamide, Isoleucine, DIPEA, L- Aspartic acid, Octadecanimine, Maltol, 1-Linoleoyl glycerol, 3- Hydroxy-L- proline, Sakuranin, Leucylprolin, Diaminopimelic acid, Nervonic acid, Nootkatone, Caffeic acid, 5-Hydroxymethyl , Methyl cinnamate, Octyl decyl phthalate, 1-Aminocyclohexanecarboxylic acid, Glycerophospho-N-palmitoyl ethanolamine, 4-Methoxybenzaldehyde, Methyl palmitate, Cyclohexyl, phenyl ketone, Esculin, n-Pentyl isopentyl phthalate, - 6 -Ketoprostaglandin F1α, N, N-Dimethylsphingosin e, α-Eleostearic acid, cis-12-Octadecenoic acid methyl ester, Oleoyl ethanolamide, Citral, L-Tyrosine, XLR-11, Isovanillic acid, 1-Tetradecylamine, Isoquinoline, Calocarpin, Sedanolide, N-Acetyltyramine, Testosterone isocaproate , 2-Methyl-S-benzothiazole, 1-Aminocyclohexanecarboxylic acid, 4-Methylumbelliferyl-α-D-glucopyranoside, Dodecyltrimethylammonium, cis, cis-Muconic acid, 6-Ketoprostaglandin 4-octopamine, Lupeol, N-FeroyETl, [4- (4-Hydroxy-3-methoxyphenyl) tetrahydro-1H, 3H-furo [3,4-c] furan-1-yl] -2-methoxyphenyl hexopyranoside.
PENGARUH PROSES CURING BUAH TAKOKAK (Solanum torvum) SELAMA PENYIMPANAN SUHU RUANG 5 HARI TERHADAP KADAR PROKSIMAT DAN SUSUT BOBOT Nunuk Helilusiatiningsih
Journal of Food Technology and Agroindustry Vol 4 No 1 (2022): Journal of Food Technology and Agroindustry
Publisher : Journal of Food Technology and Agroindustry dipublikasikan oleh Universitas Wiraraja

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24929/jfta.v4i1.1855

Abstract

Takokak plants are often called eggplant pokak or eggplant sparrows can grow in a moist, fertile and shaded area and are popular abroad under the name turkey berry. The problem is that this plant is still relatively few who consume and cultivate it. The research objective was to study the effect of takokak curing treatment on proximate components and weight loss during 5 days room temperature storage. The method used is the proximate compound test and quantitative weight loss with valid analytical procedures. The test parameters include water content, ash content, protein, fat, carbohydrates and weight loss. Chemical analysis results for 5 days of curing are: Water content (%) : 81.72 ; 79, 24; 77.16 ; 75.42 ; 72.31. Ash content (%): 1.63 ; 1.72; 1.98; 2.15; 2.24. Protein (%): 9.28 ; 8.47; 7.91; 6.98; 5.76. Fat (%): 2.65; 2.51; 2.38; 2.24; 2.18. Carbohydrates (%): 5.36 ; 7.21; 9.53; 11.20; 13.36. Weight Loss (grams): 5.68; 5.12; 4.84 ; 4.41; 4.08.
PENGARUH LOKASI TUMBUH TERHADAP SENYAWA FITOKIMIA PADA BUAH, BIJI, DAUN, KULIT BUAH TANAMAN TAKOKAK (Solanum torvum) Nunuk Helilusiatiningsih; Titik Irawati
BUANA SAINS Vol 21, No 1 (2021)
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/bs.v21i1.2662

Abstract

Takokak was a plant that was widespread in Indonesia and quite a lot is made culinary at this time. Research on takokak eggplant was developed due to the high content of phytochemical compounds. The problem that exists was that this plant had not been planted by many people but grows by itself in various locations. The purpose of this study was to know the content of phytochemical compounds in the fruit, seeds, and leaves of takokak that grow and develop in different locations. The experimental design used quantitative tests including antioxidant activity, total phenol, tannin content, flavonoids. The locations studied are at Mojokerto and Malang city. The research resulted show that there were differences in phytochemical content, the best data was eggplant takokak originating in the city of Batu, East Java. The Takokak eggplant plant thrives and had higher levels of bioactive/phytochemical compounds in the sub-tropical climate highlands near the mountains of Batu, Malang.
Co-Authors A. Harijono Adam Indra Nirwana Adji, Galih Dina Oktavia Edy Soenyoto Endro Puji Astoko Endro Puji Astoko Endro Puji Astoko Eva Pebriana Eva Pebriana Fahmi Hidayat FITRIYAH, NUR Fristama Maulana H., Nunuk Haliza, Nadiyah Nur Heru Setiyadi Hidayat Sujuti Idris, Ahmad Imam Habibi Indis, Nadhifah Al Irawati, Titik Lisnanti, Ertika Fitri Mardiana, Yushi Micko Widiyatmoyo Muhamad Abdul Aziz Al Wafa Muhamad Alwi Shahara Muhammad Alwi Syahara, Muhammad Alwi Nadhiva Al Indis Nastiti Winahyu Naufa Anwar, Diva Navita Maharani Pamuji Setyo Utama Pamuji SU Purbowo, Muhammad Lukman Rahmatika, Widyana Ribut Santosa RIBUT SANTOSA Rizky Arief Shobirin Rosanti, Aulia Dewi Sani, Muhammad Yulius Saptaria, Lina Setyo Utomo, Pamuji SIMON BAMBANG WIDJANARKO Sumarji Supriyono Supriyono Tarwa Mustopa Titik Irawati Titik Irawati Titik Irawati Titik Irawati Vifi Nurul Choirina