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Diningrat, Diky Setya
Jurusan Biologi Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Negeri Medan
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Journal : Journal of BioSustainability

 1 
In Silico Analytic of Antiacne Potential from Jamblang Flower’s Essential Oil Formulation Hasibuan, Nurfadilah Azizah; Diningrat, Diky Setya; Sari, Ayu Nirmala
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Publisher : Universitas Pendidikan Indonesia and Konsorsium Biologi Indonesia

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Abstract

This study aims to determine the components of compounds contained in Jamblang flower essential oil (Syzygium cumini L.) as antiacne and mechanism of antiacne. Jamblang flower essential oil is obtained through a distillation process. The distilled oil was then analysed using a Gas Chromatography Mass Spectrophotometer (GC-MS). Analysis results GC-MS evaluated using the program MASSLAB. Data obtained from the tool GC-MS then analysed using software PubChem NCBI database (https://pubchem.ncbi.nlm.nih.gov/) and PASS Online. The results of the GC-MS analysis showed that there were 47 bioactive compounds in Jamblang flower essential oil. Analysis results PubChem showed 13 compounds have activity as an antibacterial. Analysis results PASS Online demonstrated an antibacterial mechanism, protein synthesis inhibitor, membrane permeability inhibitor dan cell wall synthesis inhibitor, with the highest Pa value of 0.804 in the compound Benzyl benzoate $$Benzoic acid, phenylmethyl ester (CAS) and lowest Pa value in 1H-Benzimidazole,2-(methylthio)-(CAS)$$2-thiomethylbenzimidazole.
Co-Authors -, Kusdianti Abdul Muin Sibuea Adelia Febriyossa Adi Hartono Adi Hartono Agustina, Rezeki Sri Aidarahmi, Siska Aini Fitri Ana Rahmi Angga Karisto Bangun Aprisa, Naomi Ashar Hasairin Ashar Hasairin Ashar Hasairin Asmin Asmin, Asmin Ayu Nirmala Sari Ayu Nirmala Sari Bangun, Angga Karisto Binari Manurung Binari Manurung, Binari Budiarta, Kustoro Dewi, Gustianti Erly Marwani Erly Marwani, Erly Fadilah Ismail Fahmi, M. Haikal Fahri Setya Maulana Faisal Faisal Faizah, Siti Fajrin, Rahmat Farhana Setya Farhana Farhana, Farhana Setya Fatma Tresno Ingtyas Fitriani, Sonia Fiyantara, Aljun Ginting, Alin Anggreni Gustianti Dewi Harahap, Novita Sari Hartono, Adi Hasairin, Ashar Hasibuan, Nurfadilah Azizah Hasibuan, Safrina Rizkiah Heppy Setya Prima Herbert Sipahutar, Herbert Hodriani Hodriani Ingtyas, Fatma Tresno Jamaludin, Askiah Binti Januardi Januardi Janwardi Reywanda Tarigan Junaidi Junaidi Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti Kusdianti laela Sari, laela Lumbantoruan, Rio Tresia Maulana, Bagoes Maulana, Fahri Setya Muhammad Azhari Muliawati Muliawati Muslich Hidayat Nasution, Risna Lenita Novita Sari Harahap Nurmala Berutu Pasaribu, Anggraini Br. Pasaribu, Anggriani Br. Pitaloka, Cindy Purba, Febi Anjaini Putriana Purba Rahmat Fajrin Rahmi, Anna Rajagukguk, Teresia Junetti Ramadanu Ramadanu Ramadanu, Ramadanu Restuati, Martina Salleh, Rabeta Mohd Samosir, Cresfo Sinaga, Acong Jaya Sinurat, Asri Sipayung, Gratia Anggita Siregar, Batumahadi Siregar, Zulkarnain Sonya Adelina Sipayung Sri Winarsih Syafrina Sari Lubis Tarigan, Janwardi Reywanda Ummi Zaimah Wahyuni Lubis Yetty Machrina Zulaini Zulaini Zulaini, Zulaini