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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kedokteran Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Journal of Comprehensive Science Jurnal Kefarmasian Indonesia
Hajrin, Wahida
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Other

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Pengaruh Dua Metode Pengeringan Pada Aktivitas Antibakteri Ashitaba (Angelica keiskei ) Terhadap Streptococcus mutans: Effect of Two Different Drying Methods on Antibacterial Activity of Ashitaba Againts Streptococcus mutans Wirasisya, Dyke Gita; Juliantoni, Yohanes; Hajrin, Wahida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.289 KB) | DOI: 10.22487/j24428744.2018.v4.i1.9629

Abstract

The aim of this study was to determine a change that occurs in total phenolic content (TPC) and antibacterial activity of ashitaba (Angelica keiskei) after dried using two different methods : sun and oven drying. The effectiveness of the drying methods was evaluated in term of total phenolic content (TPC) by using spectrophotometric assay with Folin-Ciocalteu reagent and antibacterial activity againts Streptococcus mutans by in vitro macrodilution assay. Oven drying at 60oC possessed high TPC (2,98 ± 0,0935 g EAG/100g) compared to sun drying method (1,72 ± 0,0142 g EAG/100g). Simillar pattern was also observed in antibacterial activity. Oven drying have higher antibacterial activity with the MBC (minimal bactericidal concentration) value of 0,5 mg/mL againts Streptococcus mutans. Therefore, sun drying is not suggested for drying method of ashitaba in terms of total phenolic content and antibacterial activity compared with oven drying methods.
Optimization of Lip Balm Formula From Buni Fruit Extract (Antidesma bunius L. Spreng) with A Combination of Beeswax Lanolin Syahputri, Acyuta Pramesthi Asmara Sayidina; Hajrin, Wahida; Subaidah, Windah Anugrah
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9913

Abstract

Lip balm is a preparation with a wax base that is applied to the lips to moisturize them so they aren’t easily dry and cracked. Lip balm, when used, is very dependent on its adhesive power and spreadability, which are influenced by the composition of the base and the additional ingredients. The purpose of this study was to determine the optimum concentration of beeswax and lanolin in Lip balm preparations as wax and softening agents using the Simplex Lattice Design (SLD) method. Extraction of buni fruit was carried out by the maceration method using 80% ethanol solvent and 3% citric acid (85: 15). Data analysis was carried out using ANOVA to see the distribution of data on parameters of physical properties, and a one-sample T-test for confirmation analysis of the optimum formula composition. The results of the study obtained an extract yield of 41.534% and positively contained anthocyanins. The analysis results of physical properties using Design Expert v.13, the optimum concentration of beeswax was 12% and lanolin 4% with a desirability value is 1. The Lip balm with buni fruit extract, with the optimum formula, had a dense, homogeneous texture, brownish red with a peach aroma, and a pH of 4. Verification of the optimum formula showed no significant difference between the experimental response and the predicted response, with a value of melting point 53±1 oC; adhesive power 24.42±3.55 seconds; spread power 3.226±0.031 cm. The optimum formula produced physical properties that meet the specified requirements, and the verification results showed a match between the predicted response and the experimental results.
KARAKTERISTIK PENGETAHUAN, SIKAP DAN PERILAKU MAHASISWA PENDERITA AKNE VULGARIS DI UNIVERSITAS MATARAM TERHADAP PENYAKIT DAN PENGOBATAN Prianggawe, Prianggawe; Andanalusia, Mahacita; Hidajat, Dedianto; Hidayati, Agriana Rosmalina; Hanifa, Nisa Isneni; Hajrin, Wahida
Jurnal Kesehatan Tambusai Vol. 6 No. 3 (2025): SEPTEMBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v6i3.49895

Abstract

Penelitian ini mengkaji pengetahuan, sikap, dan perilaku mahasiswa di Universitas Mataram terhadapAV yaitu suatu kondisi kulit inflamasi kronis yang umum disebabkan oleh Cutibacterium acnes danStaphylococcus epidermidis. Kondisi ini banyak ditemukan pada remaja akhir dan dewasa muda berusia 18-25tahun yang sebagian besar adalah mahasiswa. Tujuan penelitian ini yaitu mengetahui karakteristik pengetahuan,sikap dan perilaku mahasiswa penderita AV terhadap penyakit dan pengobatan. Metode penelitian inimenggunakan desain deskriptif dengan pendekatan cross-sectional yang melibatkan 81 responden yang dipilihdengan metode purposive sampling. Teknik pengambilan data dikumpulkan menggunakan kuesioner dandianalisis secara deskriptif. Data disajikan dalam bentuk tabel untuk memvisualisasikan persebaran jawaban.Hasil penelitian menunjukan sebagian besar responden memiliki pengetahuan baik (81,4%), sikap yang positif(100%) dan perilaku (96%). Instrumen penelitian ini telah menunjukkan validitas dan reliabilitas yang dapatdiuji ulang pada scope penelitian yang lebih besar dengan populasi yang lebih beragam meliputi masyarakatumum, mahasiswa, dan kelompok usia berbeda.Kata kunci: Akne vulgaris, Mahasiswa, Pengetahuan, Perilaku, Sikap
Anifungi Activity Test of Ethanoled Extract of Cashew Gua Leaves (Anacardium occidentale) Against Candida albicans Yunita, Yunita; Hidayati, Agriana Rosmalina; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7402

Abstract

Cashew leaves (Western cashew) contains compounds belonging to the class of flavonoids, tannins, and saponins which are thought to have antifungal activity against Candida albicans. This study aims to determine the antifungal activity of the ethanol extract of cashew leaves on growth Candida albicans based on the inhibition zone formed. The method for determining antifungal activity was carried out through disc diffusion. Cashew leaf extract was made into three different concentrations namely, 5%, 7.5%, and 10%, the negative control used 10% DMSO, and 2% ketoconazole as a positive control. Based on the results of the phytochemical screening, the ethanol extract of cashew leaves contains compounds belonging to the class of flavonoids, tannins and saponins. The results of the antifungal activity test of the ethanol extract of cashew leaves at concentrations of 5%, 7.5%, and 10% could inhibit the growth Candida albicans with the diameter of the inhibition zone respectively, 10.35 mm, 11.93 mm, 14.12 mm. The diameter of the inhibition zone on ketoconazole was 21.75 mm and no inhibition zone was formed in the negative control group. From the results of the study it was concluded that the ethanol extract of cashew leaves has activity against Candida albicans.
The Sun Protection Factor (SPF) of Kepundung Leaf Methanol 96% Extract (Baccaurea racemosa) Using The In-Vitro Test Rosida, Naela; Permatasari, Lina; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 24 No. 2b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i2b.7422

Abstract

Excessive sun exposure can reveal harmful effects on the skin. One way to prevent these effects is by using Kepundung (Baccaurea racemosa) a plant known for its antioxidant properties. Several studies have shown that the antioxidant activity of kepundung leaf extract has a very strong IC50 value, making it potentially a sunscreen. However, research on the Sun Protector Factor (SPF) value of kepundung leaf extract has not been reported. Therefore, this study will conduct to determine the SPF value of the extract. Compound extraction will carry out using the sonication method with methanol solvent. The extract obtained was analyzed for SPF value using UV-Vis spectrophotometry and the SPF value will calculated using the Mansur formula. The various concentration of kepundung leaves extract revealed various SPF from minimal and ultra protection. Kepundung leaves extract with concentation 500 ppm have ultra protection with SPF value 15.19. The Kepundung leaves can to be developed as natural SPF.
Anti-Radical Activity Test of Fractions from Ashitaba Herbs (Angelica keiskei) Permatasari, Ni Made Ayu Dinda; Muliasari, Handa; Hanifa, Nisa Isneni; Hidayati, Agriana Rosmalina; Hidajat, Dedianto; Hajrin, Wahida; Rizkika, Adila
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7638

Abstract

Acne vulgaris is a chronic inflammation of the skin’s pilosebaceous unit, caused by oxidative stress due to reactive oxygen species (ROS) release. Oxidative stress conditions can be treated using natural antioxidants, namely ashitaba (Angelica keiskei). In contrast to previous studies that tested column chromatography fraction of the macerated ethanol extract, this study examined the liquid-liquid partition fraction of 80% methanol sonicated extract of Ashitaba herb. This study aims to determine the antiradical activity of various fractions of Ashitaba herb extract against 1,1-diphenyl-2-picrylhidrazyl (DPPH) free radicals. 80% methanol extract of the Ashitaba herb was fractionated using chloroform, ethyl acetate, and water solvents. Each ashitaba herb fraction was identified for the content of flavonoids and phenolic compounds and the antiradical DPPH activity was tested with ascorbic acid standard using a UV-Vis spectrophotometer. The IC50 value of each fraction was statistically analyzed using One-Way ANOVA and Posthoc Tukey. The results of phytochemical identification showed that ashitaba herb fractions positively contain flavonoids and phenolics. Antiradical activity of the chloroform, ethyl acetate, and water fractions against DPPH was indicated by IC50 values of 164.22±5.68 ppm (moderate); 8.70±0.12 ppm (very strong); and 243.60±8.14 ppm (weak). Statistically, each ashitaba herb fraction differed significantly from ascorbic acid (IC50 2.37±0.05 ppm). The ethyl acetate fraction has the strongest antioxidant activity and is in the same category of antioxidant strength as the ascorbic acid standard.
Uji Antiinflamasi Ekstrak Etanol Ashitaba (Angelica keiskei) Secara In Vitro Fitriana, Mariama; Hajrin, Wahida; Subaidah, Windah Anugrah; Ridwan, Sucilawaty; Pratiwi, Eskarani Tri
Jurnal Biologi Tropis Vol. 24 No. 2b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i2b.8105

Abstract

Angelica keiskei has potential as an anti-inflammatory agent because it contains chalcone which has been proven to be able to suppress inflammation through inhibiting nitric oxide production and inhibiting the expression of the iNOS and COX-2. The anti-inflammatory potential of Angelica keiskei needs to be tested. This study aimed to determine the anti-inflammatory activity of Angelica keiskei ethanol extract using the protein denaturation inhibition method. Angelica keiskei was extracted using the sonication method with 96% ethanol. The extract was tested for anti-inflammatory activity using the protein denaturation inhibition method with diclofenac sodium as a positive control. The percent of inflammatory inhibition is used to assess sample activity. The results showed that the percent of inflammatory inhibition of Angelica keiskei ethanol extract increased as the test concentration increased. The maximum percent inhibition was obtained at a concentration of 1.5% with the percent of inflammatory inhibition value of 23.14% ± 0.05. Angelica keiskei ethanol extract has anti-inflammatory activity based on in vitro testing using the protein denaturation inhibition method.
Optimization of Eye Shadow Powder Formula Preparation of Buni Fruit Extract (Antidesma bunius L. Spreng) as Natural Dye Lestari, Neli Aulia; Hajrin, Wahida; Pratiwi, Eskarani Tri
Jurnal Biologi Tropis Vol. 25 No. 4 (2025): Oktober-Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4.10140

Abstract

The use of synthetic dyes in cosmetics can cause side effects such as allergies. Therefore, the presence of natural dyes such as anthocyanins from berries is a safer alternative for the community. However, the stability of anthocyanins as natural dyes can be affected by pH. The purpose of this study was to determine the optimum concentration of citric acid and tartaric acid in eyeshadow powder preparations as pH stabilizers using the Simplex Lattice Design method. The research method used the sonication method. Then, the formulation results from running SLD were carried out and evaluated for particle size, adhesiveness, and pH. Data analysis used SLD to obtain the optimum formula. Then, the evaluation was carried out as before with additional evaluations of organoleptic tests, homogeneity and polish. Furthermore, the data were verified statistically with a one-sample t-test. The results obtained an extract yield of 22.9% and a positive anthocyanin content. Based on the SLD method, the optimum formula was obtained with a citric acid concentration of 1.49% and a tartaric acid concentration of 0.508%. Verification of the optimum formula showed no significant difference between the experimental response and the predicted response with a pH value of 5.75 ± 0.12; adhesive power of 11.66 ± 1.52%; and particle size of 126.32 ± 2.02 μm. The conclusion is that the optimum formula produces good physical characteristics and the verification results show agreement between the predicted response and the experimental results.
Pengaruh Variasi Konsentrasi Asam Sitrat Dan Asam Tartrat Terhadap Sifat Fisik Granul Effervescent Sari Wortel (Daucus Carota L) Ashufiah, Sahsiatun; Hajrin, Wahida; Ridwan, Sucilawaty
Journal of Comprehensive Science Vol. 2 No. 5 (2023): Journal of Comprehensive Science (JCS)
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jcs.v2i5.344

Abstract

Wortel (Daucus carota L) merupakan salah satu sayuran yang memiliki kandungan ?- karoten yang tinggi. Dalam meningkatkan minat masyarakat untuk mengkonsumsi sayuran dan buah-buahan khususnya wortel maka dibuat sediaan yang praktis dan menarik. Salah satu sediaan yang dapat dikembangkan adalah granul effervescent. Konsentrasi asam pada pembuatan granul effervescent ini akan mempengaruhi sifat fisik granul effervescent. Tujuan dari penelitian ini adalah mengetahui pengaruh variasi konsentrasi asam tartrat dan asam sitrat terhadap sifat fisik granul effervescent wortel.Metode: Metode pembuatan granul effervescent menggunakan metode granulasi basah dengan variasi konsentrasi asam sitrat, asam tartrat, dan natrium bikarbonat pada formula 1 terdapat perbandingan 1,5:0,5:2,62; formula 2 dengan perbandingan 0,5:1,5:2,62; dan untuk formula 3 dengan perbandingan 1:1:2,62. Granul effervescent yang terbentuk kemudian dievaluasi sifat fisiknya. Berdasarkan hasil penelitian diperoleh granul effervescent sari wortel berbentuk granula berwarna orange, beraroma asam serta rasanya asam.Hasil: Data hasil pengujian diperoleh bahwa sifat granul effervescent formula 1, 2, dan 3 yang paling memenuhi syarat yaitu pada formula 2 dengan uji kecepatan alir 4,77 ± 0,25 detik, waktu larut 2 menit 76 detik ± 0,14, dan kadar air 2,55 % ± 0,25 %, namun pada uji pH dan sudut diam untuk ketiga formula belum memenuhi syarat uji pH > 6-7, dan untuk sudut diam < 40º. Kesimpulan: Variasi konsentrasi asam sitrat, asam tartrat, dan natrium bikarbonat berpengaruh terhadap sifat fisik dari granul effervescent sari wortel
Formulation and Evaluation of the Physical Properties of Anti-Acne Cream Containing Methanol Extract of Ashitaba Herb (Angelica keiskei) Hidayati, Agriana Rosmalina; Hidajat, Dedianto; Hajrin, Wahida; Hanifa, Nisa Isneni; Andanalusia, Mahacita; Hidayati, Regina Tria; Rizki, Alpa Alfi; Prianggawe, Prianggawe; Ramadhan, Muhammad Rafi Bintang; Rizkika, Adila
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10501

Abstract

Ashitaba herb contains flavonoids, phenolics, tannins, alkaloids, and terpenoids, which are known to have antioxidant, antibacterial, and anti-inflammatory properties. Therefore, ashitaba has the potential to be developed into anti-acne preparations, one of which is cream. Creams have various advantages, namely the ability to deliver hydrophilic and hydrophobic compounds better, provide better moisture, and have emollient and occlusive properties by forming a protective layer on the skin and maintaining skin hydration longer. The purpose of this study was to determine the physical properties of methanol extract cream preparations of ashitaba herb. The research method used was laboratory experimental. Ashitaba herb was extracted using the sonication method with 80% methanol solvent to produce a solid extract. The ashitaba herb's methanol extract was combined to create a cream preparation, and its physical characteristics such as homogeneity, pH, viscosity, spreadability, adhesion, and cream type were assessed. The physical property testing revealed that the cream preparation had a unique scent, a thick consistency, and a green hue. This resulted in a homogenous oil-in-water (O/W) type cream preparation with a pH of 6.29, viscosity of 37.050 cp, spreadability of 5.23 cm, and adhesion of 4.59 seconds. Thus, it can be said that the production of the methanol extract of ashitaba herb cream satisfies the requirements and has good physical qualities.
Co-Authors Alfilaili, Baiq Saomi Ashufiah, Sahsiatun Azizah, Hidayatul Dedianto Hidajat Fitriana, Mariama Habibie, Irhas Anugrahadi Hidayati, Agriana Rosmalina Hidayati, Regina Tria Jannah, Syifaul Lestari, Febia Arien Lestari, Neli Aulia Mahacita Andanalusia Muliasari, Handa Muliasari, Handa Nisa Isneni Hanifa Nugrahani, Baiq Dwiyan Oktaviana, Siti Muhsonah Permatasari, Lina Permatasari, Ni Made Ayu Dinda Pitaloka, Galuh Suli Pratiwi, Eskarani Tri Prianggawe, Prianggawe Ramadhan, Muhammad Rafi Bintang Ridwan, Sucilawaty Rismawati, Dhity rizki, alpa alfi Rizkika, Adila Rosida, Naela Subaidah, Windah A. Syahputri, Acyuta Pramesthi Asmara Sayidina Windah Anugrah Subaidah Wirasisya, Dyke Gita Wirasisya, Dyke Gita Yohanes Juliantoni, Yohanes Yunita Yunita