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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Kedokteran Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Acta Pharmaciae Indonesia : Acta Pharm Indo Jurnal Biologi Tropis Jurnal Kesehatan Tambusai Sasambo Journal of Pharmacy INDRA: Jurnal Pengabdian kepada Masyarakat TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Jurnal Kefarmasian Indonesia
Hajrin, Wahida
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Aktivitas Antibakteri Ashitaba (Angelica keiskei) terhadap Streptococcus mutans Wirasisya, Dyke Gita; Hajrin, Wahida; Muliasari, Handa
Jurnal Kedokteran Vol 7 No 2 (2018)
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Streptococcus mutan merupakan bakteri penyebab awal terbentuknya karies gigi. Salah satu tanaman yang mempunyai aktivitas sebagai antibakteri adalah Ashitaba (Angelica keiskei) yang banyak ditemui di daerah Sembalun (Lombok Timur). Warga setempat memanfaatkan ashitaba untuk pelengkap makan dan getahnya untuk mempercepat penyembuhan luka.Metode: Penentuan aktivitas antibakteri menggunakan metode makrodilusi dengan parameter akhir berupa Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM). Fraksinasi ekstrak menggunakan metode partisi cair-cari dan skrining fitokimia menggunakan metode Kromatografi Lapis Tipis (KLT) dengan folin-ciocalteu sebagai reagen visualisasi.Hasil: Penelitian yang dilakukan menggunakan ekstrak etanolik ashitaba mendapatkan bahwa KBM ekstrak berada pada 0,5 mg/mL. Ekstrak tersebut kemudian difraksinasi dengan menggunakan pelarut, n-Heksan, etil asetat dan etanol. Hasil uji antibakteri dari 3 fraksi didapatkan bahwa KHM tidak dapat teramati dikarenakan gangguan/bias dari warna fraksi namun KBM dapat teramati pada fraksi N-Hexan (0,125 mg/mL) dan etil asetat (0,5 mg/mL) sedangkan pada hasil fraksi menggunakan etanol 96% tidak teramati adanya KBM.Kesimpulan: Dari hasil penelitian ini dapat disimpulkan bahwa ashitaba merupakan bahan alam potensial sebagai antibakteri.
Optimasi Konsentrasi Vaselin Album dan Adeps Lanae pada Formulasi Sediaan Salep Ekstrak Etanol Daun Kersen (Muntingia calabura L.) Alfilaili, Baiq Saomi; Hajrin, Wahida; Juliantoni, Yohanes
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 9 No 2 (2021): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2021.9.2.4084

Abstract

Cherry leaves (Muntingia calabura L.) contain secondary metabolites such as tannins, flavonoids, and saponins. This secondary metabolite compound functions as an antibacterial, especially Staphylococcus epidermidis bacteria that cause acne, so that it can be developed into a formula. One of the dosage forms that can be developed is the ointment dosage form. The choice of base concentration is very important because it can affect the physical properties and effectiveness of the preparation. The purpose of this study was to determine the optimum composition of the ethanol extract formula of cherry leaves with variations concentration of Vaseline album and adeps lanae, physical properties and level of acceptance of the consumer formula which was declared optimal. Cherry leaves were extracted by maceration method using ethanol 96% solvent. Determination of the optimum value was carried out using the Simplex Lattice Design method available in the Design Expert software Version 11. The results showed that the optimum ointment formula had a composition of vaseline albumin and adeps lanae of 73,29% and 9,71%, with a spreadability 3,10 ± 0,12 cm, adhesion 6,10 ± 0,53 seconds, pH 4,78 ± 0,08, and the acceptability value is 4,02. So it can be concluded that the formula declared optimum has physical properties that meet the requirements and are liked by the respondents.
Solvent optimization of flavonoid extraction from Moringa oleifera L. using simplex lattice design Oktaviana, Siti Muhsonah; Hajrin, Wahida; Hanifa, Nisa Isneni
Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2022.10.1.5271

Abstract

Background: Flavonoids found mainly as pharmacologically active natural ingredient of moringa (Moringa oleifera L.). Therefore, optimizing the solvent to maximize the levels of flavonoid components is needed. Objective: This study was conducted to determine the optimum solvent composition for extracting flavonoid compounds from moringa leaves using the simplex lattice design (SLD). Methods: Moringa leaves were extracted using the sonication method with five combinations of 96% ethanol and water as the solvent. The solvent composition was optimized using Design-Expert version 11 software. Moreover, UV-Vis spectrophotometry was used to screen and identify flavonoid content. Results: Flavonoids were detected in moringa extract. Using the F test, a valid SLD equation, y= 440,243(A) + 142,983(B) - 47,324(A)(B), was obtained. This equation shows that the solvent ethanol 96% : water (100:0) was the best solvent and produced the maximum amount of moringa flavonoid content, which was 440,2427 mg QE/g extract. Conclusion: The flavonoid content was directly proportional to the high composition of 96% ethanol.
Pengaruh Sosialisasi Cek KLIKK BPOM terhadap Tingkat Pengetahuan Pemilihan Kosmetik pada Siswa MTs Al-Hannaniyah NW Praya Fitriana, Mariama; Ridwan, Sucilawaty; Azizah, Hidayatul; Hajrin, Wahida; Subaidah, Windah Anugrah; Pratiwi, Eskarani Tri
TRILOGI: Jurnal Ilmu Teknologi, Kesehatan, dan Humaniora Vol 5, No 2 (2024)
Publisher : Universitas Nurul Jadid

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33650/trilogi.v5i2.8380

Abstract

Tingginya pertumbuhan industri kosmetik di Indonesia menimbulkan permasalahan berupa munculnya oknum-oknum yang mengedarkan kosmetik secara ilegal. Di antara kelompok yang paling rentan terpengaruh oleh oknum-oknum tersebut adalah kelompok usia remaja. Oleh karena itu, diperlukan sosialisasi kriteria pemilihan kosmetik yang aman, meliputi cek kemasan, label, izin edar, kegunaan, dan kadaluarsa (KLIKK) BPOM sebagai langkah cerdas dalam memilih kosmetik. Penelitian ini bertujuan untuk mengetahui pengaruh sosialisasi cek KLIKK BPOM terhadap tingkat pengetahuan pemilihan kosmetik pada siswa/siswi MTs Al-Hannaniyah NW Praya. Rancangan penelitian menggunakan one group pretest-posttest design dengan metode sosialisasi dan pemberian kuesioner untuk mengukur tingkat pengetahuan responden sebelum dan setelah sosialisasi. Hasil penelitian menunjukkan terdapat peningkatan rata-rata pengetahuan pada responden (P<0,05) setelah sosialisasi, di mana sebanyak 43,3% siswa/siswi memiliki tingkat pengetahuan yang cukup, 40% memiliki tingkat pengetahuan yang tinggi, dan 16,7% memiliki tingkat pengetahuan yang rendah.
Optimasi formula sampo ekstrak etanol daun delima (Punica granatum L.) dengan metode Simplex Lattice Design Jannah, Syifaul; Hajrin, Wahida; Hanifa, Nisa Isneni
Sasambo Journal of Pharmacy Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v5i2.347

Abstract

Anti-dandruff shampoo on the market still uses zinc pyriton which has the side effect of causing hair loss. Pomegranate leaves have strong antifungal activity against dandruff-causing fungi. This research aims to determine the optimum formula and physical properties of pomegranate leaf shampoo preparations with variations of SLS and cocamide DEA. The ethanol extract of pomegranate leaves was extracted by soxhletation and carried out in a tube test. Eight shampoo formula designs were determined using the SLD method. The shampoo was tested for foam height, pH, and viscosity to obtain the optimum formula. The optimum shampoo preparation was tested for physical properties, including organoleptic tests, homogeneity, foam stability, foam height, pH, and viscosity. The results of the test for the physical properties of the optimum shampoo preparation were verified using the SPSS application with the one-sample t-test method. Pomegranate leaf ethanol extract positively contains alkaloids, flavonoids, tannins, and saponins. The optimization results obtained the optimum shampoo formula, namely a combination of SLS 5.5% and cocamide DEA 15.5%. Optimum formula shampoo has a black color, menthol odor, gel form, ingredients mixed homogeneously, foam stability 81.83%, foam height 9.30 ± 0.26 cm, pH 5.91 ± 0.45, and viscosity 1646.66 ± 220.23 cP.
Pelatihan pembuatan sabun dari minyak jelantah pada Kader PKK Desa Merembu Subaidah, Windah Anugrah; Hajrin, Wahida; Pratiwi, Eskarani Tri; Ridwan, Sucilawaty
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/indra.v5i2.369

Abstract

Indonesian people have a strong preference for food processed using cooking oil. However, the continuous reuse of cooking oil can pose health hazards and have negative environmental impacts if disposed of directly into the soil and waterways. Therefore, innovation is needed to process used cooking oil waste into a product with economic value. Used cooking oil used for cooking can be transformed into soap which is environmentally friendly and has economic value. Hence, this community service aims to reduce the volume of waste cooking oil and improve the local economy. One area in West Nusa Tenggara that has the potential for this product development is the village of Merembu. Out of 2084 families, 727 are still classified as poor. Therefore, there is a need for business opportunities to improve the economy in the village, one of which is by transforming waste cooking oil into soap products. Community service activities in Merembu Village were well received and received positive responses from Empowerment of Family Welfare (PKK) group in Merembu Village. The positive response is reflected in the results of the final evaluation carried out. This activity is a means for PKK group to increase their knowledge of the dangers and methods of processing used cooking oil so that it does not become a pollutant for the environment.
Formulasi dan Karakterisasi Nanoemulsi dari Ekstrak Biji Buah Makasar (Brucea javanica (L) Merr) Hajrin, Wahida; Subaidah, Windah A.; Juliantoni, Yohanes
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38691

Abstract

Potensi antiinflamasi B. javanica perlu dikembangkan menjadi sediaan topikal. Bioavailabilitas dan stabilitas zat aktif menjadi batasan dalam pengunaannya sehingga perlu pengembangan formula yang sesuai. Nanoemulsi merupakan salah satu alternatif sediaan yang dapat meningkatkan stabilitas maupun penetrasi obat ke dalam kulit. Penelitian ini bertujuan untuk menentukan formula sediaan nanoemulsi ekstrak etanol biji B. javanica serta mengetahui stabilitasnya. Metode formulasi sediaan nanoemulsi dilakukan dengan bantuan pseudoternary phase diagram dengan 3 variasi komponen, yaitu minyak zaitun (EVOO), Smix (tween-propilenglikol 5:1), dan air. Karakterisasi nanoemulsi yang dilakukan adalah ukuran globul, % transmitan, pH, viskositas, dan drug load. Nanoemulsi biji B. javanica kemudian diuji stabilitasnya menggunakan metode Freeze-thaw cycle. Karakteristik sediaan nanoemulsi yang dihasilkan adalah ukuran globul 14,4±0,3 nm, zeta potensial sebesar 7,7±0,2 mV, % transmittant sebesar 93,05±4,06%, pH 7,14±0,05, viskositas 35800±2700 cps, dan drug load 83,81±8,49%. Nanoemulsi B. javanica memiliki karakteristik yang baik, namun tidak stabil berdasarkan nilai transmitan dan zeta potensial.
Optimasi Formula Krim Ekstrak Daun Katuk (Sauropus Androgynus) Variasi Konsentrasi Asam Stearat, Trietanolamin, dan Gliserin Lestari, Febia Arien; Hajrin, Wahida; Hanifa, Nisa Isneni
Jurnal Kefarmasian Indonesia VOLUME 10, NOMOR 2, AGUSTUS 2020
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v10i2.2496

Abstract

Sauropus androgynus (L.) Merr.) contain secondary metabolite compounds: flavonoids and polyphenols which has bioactivity as antioxidants. Antioxidants act as photoprotector, so it can be formulated into sun protection product. The selection of cream base is very important due to it’s not only as vehicle of active ingredients but also affecting cream’s physical properties and effectiveness. This study aims to determine the composition of the optimum base formula and evaluation formula cream of extract katuk leaves with variations concentration of stearic acid, TEA, and glycerin. Formula optimization was conducted through the Simplex Lattice Design methode with 13 formulas. The results of evaluation were processed with Design Expert software. The optimum formula was respectively at 13.16% stearic acid, 12% glycerin, and 3.84% TEA. The optimum formula cream evaluation was spreadability in 4.89 cm, 0.56 s stickiness power, and pH 6,1. Acceptability test results showed that the cream could accepted by society very well.
LITERATURE REVIEW : AKTIVITAS ANTIOKSIDAN SEDIAAN GEL DI BERBAGAI TANAMAN MENGGUNAKAN METODE DPPH Prianggawe, Prianggawe; Hajrin, Wahida
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.33161

Abstract

Penyebab utama penuaan kulit yaitu ROS (Reactive Oxygen Species) atau radikal bebas yang tidak stabil karena elektron pada orbit terluar tidak berpasangan sehingga menarik elektron dari sekitarnya dan menghasilkan reaksi berantai radikal bebas yang berbahaya. Berdasarkan permasalahan tersebut, maka diperlukan antioksidan untuk mencegah stress oksidatif pada sel oleh radikal bebas yang dapat menyebabkan penuaan pada kulit. Gel merupakan sistem semipadat yang terdiri dari suspensi yang dibuat dari partikel anorganik kecil atau molekul organik besar yang terpenetrasi oleh suatu cairan. Kelebihan gel dibandingkan sediaan lain yaitu lebih mudah menyebar dan penyebarannya luas di permukaan kulit sehingga efek antioksidannya dapat bekerja lebih maksimal. Literature Review ini bertujuan untuk memberikan informasi dan merangkum mengenai aktivitas antioksidan pada sediaan gel dari berbagai tanaman menggunakan metode DPPH. Metode Literature Review Article (LRA) melibatkan proses pencarian data dan sumber melalui Google Scholar dan ProQuest dan didapatkan 15 jurnal yang sesuai dengan kriteria inklusi. rentang konsentrasi ekstrak dari 15 jurnal tersebut sangat lebar yaitu dari 0,0052% sampai 30% dan gelling agent yang digunakan berbeda-beda seperti carbopol 940, HPMC, PVA, Na-CMC dan HEC. Kemudian, Nilai IC50 yang didapatkan dalam sediaan gel dari beberapa tanaman tersebut memberikan efek antioksidan dari sedang, kuat, dan sangat kuat. Dari berbagai tanaman yang diformulasikan dalam sediaan gel diperoleh nilai IC50 yang bervariasi, sehingga menunjukkan kemampuan antioksidan dari sedang hingga sangat kuat.
Antibacterial Activity of Eichornia crassipes Leaf and Eggshell Extracts Against Staphylococcus aureus and Staphylococcus mutans Nugrahani, Baiq Dwiyan; Habibie, Irhas Anugrahadi; Ramadhan, Muhammad Rafi Bintang; Pitaloka, Galuh Suli; Rismawati, Dhity; Hajrin, Wahida
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9373

Abstract

Dental disease remains a major health concern in Indonesia, with a high prevalence across various age groups. This study aims to formulate and evaluate herbal toothpaste using Eichhornia crassipes (water hyacinth) leaf extract and eggshell powder, and to determine its antibacterial activity against Streptococcus mutans and Staphylococcus aureus. The toothpaste was prepared in three formulations with varying concentrations, followed by evaluation of its physical properties and antibacterial activity using the well diffusion method. Among the formulations, F1 containing 3% water hyacinth extract and 15 g eggshell powder showed optimal results. F1 fulfilled physical quality standards based on SNI 12-3524-1995, including pH, viscosity, and foam formation. Antibacterial testing demonstrated that F1 exhibited very strong inhibition zones of 21.87 mm against S. aureus and 21.50 mm against S. mutans. These findings indicate that a combination of water hyacinth extract and eggshell powder is effective as an active agent in herbal toothpaste. This research supports the utilization of abundant local waste materials as a sustainable alternative in oral health care formulations.
Co-Authors Alfilaili, Baiq Saomi Azizah, Hidayatul Dedianto Hidajat Fitriana, Mariama Habibie, Irhas Anugrahadi Hidayati, Agriana Rosmalina Jannah, Syifaul Lestari, Febia Arien Mahacita Andanalusia Muliasari, Handa Muliasari, Handa Nisa Isneni Hanifa Nugrahani, Baiq Dwiyan Oktaviana, Siti Muhsonah Permatasari, Lina Permatasari, Ni Made Ayu Dinda Pitaloka, Galuh Suli Pratiwi, Eskarani Tri Prianggawe, Prianggawe Ramadhan, Muhammad Rafi Bintang Ridwan, Sucilawaty Rismawati, Dhity Rizkika, Adila Rosida, Naela Subaidah, Windah A. Syahputri, Acyuta Pramesthi Asmara Sayidina Windah Anugrah Subaidah Wirasisya, Dyke Gita Wirasisya, Dyke Gita Yohanes Juliantoni, Yohanes Yunita Yunita