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All Journal Edufisika: Jurnal Pendidikan Fisika Chimica et Natura Acta SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Pharmacology and Clinical Pharmacy Research Jurnal Pengabdian Masyarakat (JPM) Pinang Masak Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry
Yusnaidar, Yusnaidar
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Nanoemulsion Formulation as a Drug Delivery System for Coleus atropurpureus Bioactive Compounds Oktavioni, Marsella; Natasya, Dian; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra L.
Pharmacology and Clinical Pharmacy Research Vol 9, No 1 (2024)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v9i1.50371

Abstract

Miana plant (Coleus) is a plant with compound flowers. Miana leaves have various bioactive compounds widely used to treat diseases such as fever, cold, cough, headaches, asthma, constipation, and skin diseases. Based on phytochemical screening of Coleus atropurpureus Benth. Several bioactive compounds are produced, such as sterols, terpenoids, alkaloids, phenols, flavonoids, glycosides, lactones, catechols, and tannins. Miana leaf extract has been tested for antioxidants using the DPPH method, and the IC50 value obtained from the antioxidant test results is 3.80 ppm and is categorized as a powerful antioxidant. There were four formulations of miana leaf extract nanoemulsion. Based on the characterization on the Miana leaf extract nanoemulsion preparation, formulations with good results were obtained in F1 and F3 with precise results and high transmittance values. In testing the miana leaf extract nanoemulsion, an organoleptic test was carried out on each formulation. It was found that all formulations had a distinctive smell of miana leaves, and no phase separation occurred, with the clarity of F1 and F3 classified as straightforward but F2 and F4 not clear, and the resulting color increased from F1 -F4. Meanwhile, for the physicochemical test, an O/W type nanoemulsion was produced, physically stable, with a particle size of F1 153.9 nm and F3 795.6 nm, with a zeta potential of F1 of 16.4 and F3 of -28.266.
LC-MS Based Metabolite Profiling of Ethanol Extract From the Sungkai (Peronema canescens Jack) and In Silico Prediction of Antidiabetic Activity With α-Glucosidase Latief, Madyawati; Arum, Dewi; Nurjannah, Sofia; Tarigan, Indra Lasmana; Khatib, Alfi; Yusnaidar, Yusnaidar
Molekul Vol 19 No 3 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.3.8806

Abstract

Sungkai (Peronema canescens Jack) is a medicinal plant in the Verbenaceae family that is known to have antidiabetic activity. The secondary metabolite content found in sungkai leaves is in the form of alkaloids, flavonoids, triterpenoids, steroids, phenolics, and saponins. This research aimed to identify the biological activity of compounds in sungkai plants as antidiabetic agents using α-glucosidase inhibitors in silico. Sungkai leaf extract with ethanol solvent was identified using a Liquid Chromatography Mass Spectrometer (LC-MS/MS). There are 15 compounds resulting from LC-MS/MS analysis which will then predict antidiabetic activity using molecular docking. Molecular docking was carried out using AutoDock Tools software and visualized with Discovery Studio. The highest scoring result obtained from the molecular docking test was the compound C13H23N6S with a free bond energy result of -7.31 and an inhibition constant value of 4.41 μM, which binds three hydrogen bonds in GLU 78, ALA 75, and GLU 198. Keywords: In sillico, metabolite profilling, Peronema canescens
Diseminasi Pembelajaran Kreatif Menggunakan Media Mobile Gamification Learning System (MGLS) Sulaksono, Aulia Sanova; Yusnaidar, Yusnaidar; Hasibuan , M Haris Effendi; Afrida, Afrida; Asmiyunda, Asmiyunda
Jurnal Pengabdian Masyarakat Pinang Masak Vol. 5 No. 2 (2024): Desember 2024
Publisher : Fakultas Sains dan Teknologi, Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jpm.v5i2.36797

Abstract

The learning phenomenon in the era of the industrial revolution 5.0 based on mobile digital is being loved and is in great demand by the current generation of digital natives, namely incorporating mobile cycle game elements on smartphone devices, this mode is called the Mobile Gamification Learning System, considering that the current generation of students have learning styles that tend to be active visually, kinesthetic, sequential and sensing. However, the term gamification itself still sounds foreign to some teachers at SMA Negeri 6 Kerinci and has never applied it in class, considering the limited knowledge of teachers in using ICT. Seeing these conditions and situations, it is necessary to carry out dissemination activities on the use of gamification application tools in order to advance the quality of education through developing teacher competence in applying technology-based science. The results of this dissemination activity have had a very good effect on teachers' basic knowledge and skills in utilizing gamification media and creating an active, creative, fun and motivating classroom atmosphere for student learning.
Development of a Multi-Representation Electrochemistry E-Book Utilizing 3D PageFlip Technology Syahri, Wilda; Yusnaidar, Yusnaidar
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 2 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i2.37641

Abstract

Physical Chemistry II course in the Chemistry Education Study Program is one of the subjects with an abstract nature, such as Electrochemistry materials. The abstract nature of Electrochemistry makes it difficult for students to observe the processes occurring in Electrochemical systems directly. When explained theoretically, these concepts are often challenging for students to understand. Therefore, teaching Electrochemistry requires an e-book that incorporates chemical representations, particularly multiple representations. To address this, it is deemed necessary to develop an Electrochemistry e-book based on multiple representations using 3D PageFlip. This e-book integrates multiple representations, enabling students to independently study and comprehend Electrochemistry materials while providing flexibility and convenience. An Electrochemistry e-book with multiple representations, particularly in a computer-assisted learning format, is a viable alternative to support student learning. This study aims to develop an Electrochemistry e-book using 3D PageFlip based on multiple representations. This software allows the creation of interactive and engaging educational resources. The resulting e-book aims to enhance students' individual abilities and increase their interest and motivation, which in turn is expected to improve their academic performance and learning outcomes. Moreover, this multimedia learning tool is intended to address challenges related to students' limited comprehension during classroom learning processes, accommodate individual characteristics, and offer alternative solutions to the low self-actualization of students. Through this e-book, students can revisit and explore difficult concepts, facilitating deeper understanding. The ultimate goal of this research is to produce an Electrochemistry e-book based on multiple representations across macroscopic, microscopic, and symbolic levels using 3D PageFlip. This e-book will align with the applicable curriculum and adhere to educational principles while incorporating essential educational elements. By improving concept mastery in Electrochemistry, this resource is expected to enhance students' cognitive abilities and overall learning outcomes
In Silico Study of Bioactive Compounds of Putat Leaf Extract (Planchonia valida) as Anti-Cancer Against the VEGFR2 Receptor Bela, Anisa; Farid, Faizar; Nelson; Dewi, Tribuana Tungga; Prabawa, Satria; Khatib, Alfi; Yusnaidar, Yusnaidar; Latief, Madyawati; Tarigan, Indra Lasmana
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.32049

Abstract

Cancer is the process of forming new tissue that is abnormal and malignant. Efforts to discover anti-cancer drug compounds continue to be made to minimize the toxic effects of chemotherapy, so it is necessary to look for other alternatives to treat cancer. This research aims to determine the anti-cancer activity of putat plant bioactive compounds through identification of receptor targets and interaction studies using the molecular docking method against the VEGFR2 (Vascular endothelial growth factor receptor-2) receptor. The results showed that in the test of eight putat plant bioactive compounds the best results were obtained for the compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with a binding free energy value of -9.86 kcal-mol-1 with an inhibition constant value of 1.47 Micromolar. The best docking result has an inhibition constant value that is higher than the native ligand and has a binding free energy that is almost close to the binding free energy of the native ligand with an inhibition constant value of 42.38 Micromolar and a binding free energy value of 10.06 kcal-mol-1. Therefore, the results of the docking of the bioactive compound 3-oxo-N-(1,3-thiazol-2-yl) butanamide with the VEGFR-2 receptor are considered capable of being an alternative as a candidate for anti-cancer drugs.
INCREASING CRITICAL THINKING SKILLS THROUGH STEM-PJBL LEARNING MODELS: RESEARCH TREND AND SYSTEMATIC LITERATURE REVIEW Azzahra, Miftahul Zannah; Anggereini, Evita; Yusnaidar, Yusnaidar
EduFisika: Jurnal Pendidikan Fisika Vol 10 No 1 (2025): EduFisika: Jurnal Pendidikan Fisika Volume 10 Nomor 1 April 2025
Publisher : Program Studi Pendidikan Fisika FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59052/edufisika.v10i1.43461

Abstract

This study aims to analyze research trends on the effectiveness of STEM-PjBL learning models in improving students' critical thinking skills through a systematic literature review from 2013 to 2024. The research employs a bibliometric approach and follows the PRISMA framework to select and analyze 32 articles from the Scopus database. The results indicate that the implementation of STEM-PjBL significantly enhances students' critical thinking skills, particularly when integrated with technology and interactive learning tools. The analysis highlights trends in research focus, dominant contributing countries, and the most cited studies. Indonesia emerges as the leading contributor to STEM-PjBL research. Additionally, bibliometric visualizations using VOSviewer reveal key themes, including project-based learning models and their impact on 21st-century skills. The findings contribute to the advancement of science and technology education, offering valuable insights for educators and policymakers to develop more adaptive and effective curricula. Despite its contributions, this study is limited by potential publication bias and the absence of meta-analytical findings.
In-silico of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors of Seven Bioactive Compounds from Sonneratia alba Latief, Madyawati; Melani, Fitria; Yusnaidar, Yusnaidar; Tarigan, Indra Lasmana
Chimica et Natura Acta Vol 13, No 2 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n2.59525

Abstract

Cancer is a disorder resulting from genetic changes, abnormal growth, and spread to other parts of the body. Cancer treatment is commonly administered through chemotherapy, which often results in adverse side effects. Therefore, research is essential to identify safer alternative cancer therapies. This study aims to identify potential bioactive compound ligand receptor targets from Sonneratia alba as anticancer candidates in silico by identifying VEGFR target proteins based on their pharmacophores and studying their interactions through the reverse docking method. Docking simulations between the native ligand (Tivozanib) and the receptor yielded promising results, with a free energy value of -12.76 kcal/mol and an inhibition constant of 440.70 μM. Among the seven bioactive compounds, Meperidine (C15H21NO2) exhibited favorable outcomes, showing a free energy value of -7.39 kcal/mol and an inhibition constant of 3.83 μM. Additionally, the meperidine and gibberellin A7 compounds formed three and four hydrogen bonds, respectively, including one with Ala866, and interacted with 15 and 18 amino acid residues, such as Glu917, Cys919, Glu885, and Asp1046. The presence of active sites on the ligand or test compounds that bind to the target receptor indicates a potential for comparable affinity in inhibiting VEGFR-2 receptor activity.
Metabolomic Profiling LC-MS Based Bioactive Compound of Sonneratia alba, Antioxidant Activities and Its In-silico molecular docking Studies Tarigan, Indra Lasmana; Latief, Madyawati; Anshori, Jamaludin Al; Melani, Fitria; Putri, Silvi Ayudiah; Husna, Naimul; Warni, Tri; Ramadhan, Ilham Ifandi; Yusnaidar, Yusnaidar; Sutrisno, Sustrisno
Molekul Vol 20 No 2 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.2.13578

Abstract

ABSTRACT. Mangrove Perepat (Sonneratia alba) plants have various potentials that need to be utilized optimally because they have varying bioactive compound content. A comprehensive exploration of secondary metabolite compound content and plant bioactivity based on metabolomics and in-silico molecular docking is needed to see the effects of single or multiple compounds. This study aimed to obtain a profile of medicinal compounds from Perepat leaves as antioxidants. Extraction was carried out using five gradients of Ethanol: Water concentration. EP1 (water), EP2 (25% Ethanol), EP3 (50% Ethanol), EP4 (75% Ethanol), EP5 (100% Ethanol). The research was carried out through extraction, antioxidant determination, metabolomics, and molecular docking. Exploration data showed that increasing ethanol concentration increased phenolics, flavonoids, and antioxidant activity. EP5 has the highest total phenolics and flavonoids of 24.978 mgGAE/g and 42.97 mgQE/g, respectively, with an IC50 value of 8.263 ppm. Docking analysis of 37 test compounds identified 12 compounds with low binding energy, ranging from -7 to -9 kcal/mol, with the NADPH oxidase protein receptor (PDB ID: 2CDU). These compounds include kaempferol-3-rhamnoside, meperidine, apigenin-7-O-glucoside, 2-keto benzothiazole 54, methyl propanoic acid, salicyloylaminotriazole, salicylihalamide A, and gibberellin A7. Our findings suggest that S. alba extract holds potential for further exploration as a natural antioxidant source. Keywords: Antioxidant; In-silico; Metabolomics; S. alba
Pendalaman materi penelitian tindakan kelas bagi guru-guru SMP Purwaningsih, Sri; Yusnaidar, Yusnaidar; Lestari, Neneng
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 4 (2025): Juli
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i4.31438

Abstract

Abstrak                                                                                 Berdasarkan observasi yang telah dilakukan di SMP Negeri 1 Muaro Jambi, masih dibutuhkan penyegaran terutama pendalaman materi Penelitian Tindakan Kelas, hal ini mengingat bahwa materi Penelitian Tindakan kelas sangat dibutuhkan bagi guru dalam rangka berinovasi membenahi proses pembelajaran agar proses pembelajaran terlaksana dengan baik. Mengingat pentingnya materi tersebut bagi guru-guru di SMP Negeri 1 Muaro Jambi, maka harus dilakukan pelatihan agar guru-guru memiliki keterampilan dan handal dalam memahami pelaksanaan Penelitian Tindakan Kelas dengan baik. Tujuan pengabdian ini adalah untuk memberikan wawasan dan pengetahuan kepada para guru agar guru-guru mampu melaksakan Penelitian Tindakan Kelas, guru-guru dapat melakukan penelitian dalam rangka memperbaiki proses pembelajaran di sekolah. Metode yang digunakan dalam pengabdian ini adalah workshop, tanya jawab dan pelatihan. Adapun tahap pengabdian adalah observasi menidentifikasi masalah dan kebutuhan, pelaksaan kegiatan berupa workshop, tanya jawab dan pelatihan tentang penelitian tindakan kelas, dari hasil pengabdian ini dapat disimpulkan bahwa guru-guru di SMP Negeri 1 Muaro Jambi sangat membutuhkan pendalaman materi penelitian Tindakan kelas, hal ini terlihat dari hasil workshop, diskusi dan pelatihan, mereka sangat perperan aktif selama kegiatan tersebut.  Kata kunci: penelitian tindakan kelas; SMPN 1 Muaro Jambi. AbstractCommunity service has been carried out at SMP Negeri 1 Muaro Jambi with the title "Deepening of Classroom Action Research Material for Teachers at State Junior High School 1 Muaro Jambi". Based on observations that have been carried out at State Junior High School 1 Muaro Jambi, there is still a need for refreshment, especially deepening of Classroom Action Research material, this is considering that Classroom Action Research material is very much needed for teachers in order to innovate to improve the learning process so that the learning process is carried out properly. Given the importance of this material for teachers at State Junior High School 1 Muaro Jambi, training must be carried out so that teachers have the skills and are reliable in understanding the implementation of Classroom Action Research properly. This activity is generally intended to provide insight and knowledge to teachers so that teachers are able to implement Classroom Action Research, teachers can conduct research in order to improve the learning process at school Keywords: classroom action research; State Junior High School 1 Muaro Jambi
Co-Authors Afrida Afrida Alfi Khatib, Alfi Arum, Dewi Asmiyunda, Asmiyunda Azzahra, Miftahul Zannah Bela, Anisa Dewi, Tribuana Tungga Evita Anggereini Faizar Farid Hasibuan , M Haris Effendi Husna, Naimul Indra Lasmana Tarigan Jamaludin Al-Anshori Lestari, Neneng Madyawati Latief Melani, Fitria Natasya, Dian Nelson Nurjannah, Sofia Oktavioni, Marsella Prabawa, Satria Putri, Silvi Ayudiah Ramadhan, Ilham Ifandi Sri Purwaningsih Sulaksono, Aulia Sanova Sutrisno, Sustrisno Tarigan, Indra L. Warni, Tri Wilda Syahri