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Juniarti .
Magister Sains Biomedis, Sekolah Pascasarjana, Universitas YARSI, Jakarta
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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MENCEGAH DAN MENDIDIK MASYARAKAT TERHADAP PENYAKIT HIPERTENSI, DIABETES DAN ASAM URAT Juniarti Juniarti; Nazwirman Nazwirman; Lilian Batubara
ADIMAS Jurnal Pengabdian Kepada Masyarakat Vol 3, No 1 (2019): Maret
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2061.638 KB) | DOI: 10.24269/adi.v3i1.1708

Abstract

Hypertension is a disease characterized by an increase in blood pressure that exceeds normal. Diabetes is a disease caused by metabolic disorders that occur in the organs of the pancreas with an increase in blood sugar and are at risk of other diseases. Uric acid is the result of the final metabolism of purines found in the cell nucleus and results in disturbances in the human body. A healthy lifestyle and healthy diet are the right choices to keep yourself free of hypertension, diabetes and gout. It is important to know and prevent disease early, so that education needs to be made about the symptoms, prevention, causes and treatment of the disease. The implementation of community service activities is the empowerment of the Mosque Prosperity Council and worshipers in Banjar Wijaya Tangerang housing by physical examination and counseling to be able to find early risk factors for hypertension, diabetes and gout. The result is the availability of hypertension, diabetes and gout data. People know the symptoms and signs of disease and know how to prevent disease.
Effects of Methanolic Jatropha multifida L. Extract in Wound Healing Assessed by the Total Number of PMN Leukocytes and Fibroblasts Juniarti, Juniarti; Aryenti, Aryenti; Yuhernita, Yuhernita; Poerwaningsih, Ernie Ernie
Makara Journal of Science Vol. 16, No. 3
Publisher : UI Scholars Hub

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Abstract

The aim of this study was to evaluate the effects of methanol extract of Jatropha multifida leaves on the wound healing process and to investigate the wound healing activity based on reduced numbers of PMN (polymorpho nuclear) leukocytes and increased numbers of fibroblasts. Methanol extract of dried leaves of J. multifida was used in the wound healing activity studies. The study subjects were 36 white male Sprague Dawlay rats aged 2 months with 150-200 gram body weight. The subjects were divided into 4 groups and experimentally injured: Group I (negative control) underwent injury without subsequent treatment; group II (positive control) received topical treatment with Bethasone-N after injury; group III (solvent control) was treated with 70% methanol; group IV (treatment group) was treated with 10 mg methanol extract of J. multifida Each group consisted of 3 rats, which were decapitated on days 3, 6, and 13 after the start of treatment. Histological preparation was stained with hematoxyline-eosin (HE) and was continuously examined by counting the numbers of PMN leukocytes and fibroblasts as indicators of wound healing on days 3, 6, and 13 of treatment. The study showed lower numbers of PMN leukocytes in subjects treated with the extract of J. multifida as compared to the other groups. The numbers of fibroblasts were significantly higher on days 6 and 13 of treatment. The treatment of injuries with methanol extract of leaves from J. multifida provided better results compared to the other groups in our study.
KANDUNGAN SENYAWA KIMIA, UJI TOKSISITAS (Brine Shrimp Lethality Test) DAN ANTIOKSIDAN (1,1-diphenyl-2-pikrilhydrazyl) DARI EKSTRAK DAUN SAGA (Abrus precatorius L.) Juniarti, Juniarti; Osmeli, Delvi; Yuhernita, Yuhernita
Makara Journal of Science Vol. 13, No. 1
Publisher : UI Scholars Hub

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Abstract

Chemical Compound Gynecology, ToxinTest (Brine Shrimp Lethality Test) and Antioxidants (1,1-Diphenyl-2- Pikrilhydrazyl) from Saga Leaf Extract (Abrus Precatorius L.). Cytotoxicity effects and antioxidant activities of saga (Abrus precatorius L.) extract were studied by using Brine Shrimp Lethality Test and 1,1-diphenyl-2-pikrilhydrazyl assays. Saga was extracted with different solvents i.e n-hexane, ethyl acetate and methanol. Result showed that the methanolic extract of saga had been potential to be cytotoxic againts Brine Shrimp with LC50 value of 606.736 ppm. However, all the extract of saga did not have antioxidant activities.
ANALISIS SENYAWA METABOLIT SEKUNDER DARI EKSTRAK METANOL DAUN SURIAN YANG BERPOTENSI SEBAGAI ANTIOKSIDAN Yuhernita, Yuhernita; Juniarti, Juniarti
Makara Journal of Science Vol. 15, No. 1
Publisher : UI Scholars Hub

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Abstract

Secondary Metabolites Analysis of Methanol Extract of Surian (Toona sureni (Bl.) Merr) Leaf as Antioxidant Potential. The study of performed secondary metabolites from the methanol extract of Surian (Toona sureni (Bl.) Merr) leaves have been done by thin-layer chromatography (TLC) method. The result showed that methanol extract of Surian leaves consist of alkaloid, flavonoid, polyphenol and terpenoid. All of them positively have the ability to scavenge 2,2- diphenyl-1-picrylhydrazyl (DPPH). It has IC50 (4.80) are smaller than the ascorbat acid standard (IC50 = 9.23).
DESTILASI MINYAK ATSIRI DAUN SURIAN SEBAGAI KRIM PENCEGAH GIGITAN NYAMUK Aedes aegypty L. Juniarti, Juniarti; Yuhernita, Yuhernita; Endrini, Susi
Makara Journal of Science Vol. 15, No. 1
Publisher : UI Scholars Hub

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Abstract

Distillation of Essential Oil from Surian Leaf (Toona sureni (Bl.) Merr.) as Repellent Cream for Protection Aedes aegypty L. Bites. Isolation of volatile oil of leaf surian (Toona sureni (Bl.) Merr.) have been done by distillation aqueous vapour method. Distillation result had the chocolate colored and stinging aroma, and rendement was 0.23%. GC-MS analysis shown of some compound of terpenoid (naftalen derivated) which correspondence to mass spectrum. One of them is copaene (C15H24), m/z = 204. Cream based of Rajin et al. formula giving stable cream, white coloured and neutral pH. Volatile oil of surian leaf in cream based cause color and aroma cream were changed. Cream stability also was annoyed at oil of atsiri 10%.
Effect of platelet-rich plasma on fibroblasts induced by lipopolysaccharide: in vitro study for wound healing Idris, Muthoharoh; Kusuma, Indra; Juniarti, Juniarti
Current Biomedicine Vol. 2 No. 1 (2024): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.2.1.36-44

Abstract

Platelet-rich plasma (PRP) is expected to be an alternative therapy in wound healing by accelerating the inflammatory process and increasing the healing factors so that the healing process or inflammation is faster. The purpose of this study was to examine the effect of calcium chloride (CaCl2)-activated PRP on the viability, migration, and cytokine levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) of dermal fibroblast cells in lipopolysaccharide (LPS)-induced inflammatory conditions, as a model in wound healing in vitro. Fibroblast cells were grown in DMEM medium induced with LPS, and then CaCl2-activated PRP treatment was added. Measure fibroblast cell viability using CCK-8 kit (cell counting kit-8) was evaluated using a microplate reader, and the cell migration was evaluated using scratch-assay and TScratch software. Expression of IL-6 and VEGF using ELISA kit. All data were analyzed using software SPSS version 26 by performing a one-way analysis of variance (ANOVA), Kruskal Wills, and Mann-Whitney tests. The results showed that PRP significantly increased fibroblast cell viability in the 10% PRP treatment group. This study shows that PRP does not reduce IL-6 cytokine levels but can increase VEGF growth factor in fibroblast cell cultures. PRP increased cell migration so that the healing process was faster. In conclusion, the CaCl2-activated PRP on LPS-induced fibroblast cells can increase viability and accelerate cell migration; it can’t decrease IL-6 but can increase VEGF expression. PRP is expected to be an alternative therapy in wound healing.
Identifikasi Senyawa Kelompok Antosianin dalam Ekstrak Bunga Telang (Clitoria ternatea) dengan menggunakan uHPLC-MS/MS Indranita, Lusy; Ainur Rahmah, Nunung; Juniarti, Juniarti; Abdussalam, Moch
Majalah Sainstekes Vol. 11 No. 1 (2024): JUNI 2024
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v11i1.3940

Abstract

Bunga telang (Clitoria ternatea L) merupakan tanaman yang banyak memiliki efek farmakologis yang cukup baik. Tanaman ini memiliki bunga dengan warna ungu yang menarik yang diduga mengandung senyawa kelompok antosianin. Penelitian ini bertujuan mengidentifikasi senyawa kelompok antosianin dalam ekstrak bunga telang dengan menggunakan ultra high performance liquid chromatography – mass spectroscopy/mass spectroscopy (uHPLC-MS/MS). Pengukuran dengan uHPLC-MS/MS dapat diketahui senyawa kelompok antosianin dalam ekstrak telang adalah Delphinidin-3-(6″-p-coumaroyl)-rutinosida, Sianidin 3-(6″-p-coumaroyl)-rutinosida, Delphinidin-3-(cis-p-coumaroyl-glukosida) dan Cyanidin-3-(p -coumaroyl) glukosa. Oleh karena itu, ekstrak bunga telang telah berhasil dibuktikan mengandung senyawa kelompok antosianin.
In vitro study: thymoquinone inhibits the proliferation and migration of keloid fibroblasts and increases their apoptosis Hadi, Restu Syamsul; Juniarti, Juniarti
MEDISAINS Early Release
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v0i0.23975

Abstract

Background: No treatment can eliminate keloids. Thymoquinone (TQ) is hypothesized to play a pivotal role in treating keloids by modulating cellular processes such as proliferation, migration, and apoptosis. However, the existing studies investigating its effects on these mechanisms in keloid fibroblasts are limited and require further exploration.Objective: This study aims to investigate the effects of TQ on the proliferation, migration, and apoptosis of keloid fibroblasts in vitro.Methods: This experimental study was conducted using keloid fibroblast cultured in vitro. Cells were seeded in a 96-well plate at a density of about 5x103 cells per well with 100 μl of culture medium, and cells were cultured for 24, 48, and 72 hr for each concentration of TQ. Cell proliferation was assessed using a CCK-8 Kit, measuring optical density with a microplate reader. Apoptosis was measured using the TUNEL assay. Cell migration following TQ treatment was evaluated using the Scratch assay. The statistical test used a one-way analysis of variance (ANOVA) followed by the least significant difference (LSD) test. Results: TQ inhibited the proliferation of keloid fibroblasts at a dose of 5 µM after 48 hours of incubation and 10 µM after 24 hours of incubation. The inhibitory effect of TQ on fibroblast proliferation increased in a dose- and time-dependent manner. Treatment at 5 and 10 µM doses increased apoptosis in keloid fibroblast cultures. The TQ5 µM group achieved 60% closure, while the 10 µM group showed 55% closure. Migration was significantly inhibited in the 25 µM and 50 µM groups, with only 30% and 10% closure, respectively, at 72 hours.Conclusion: Thymoquinone inhibits the proliferation and migration of keloid fibroblast cells while promoting apoptosis. These properties suggest that TQ could be developed as a potential treatment for keloid-related skin issues.
Pengaruh Daun Teh Hijau Terhadap Organ Tikus Galur Wistar Setelah Paparan Asap Rokok Juniarti, Juniarti; Rahmah, Nunung Ainur; Janah, Lulu Ah; Dinda, Salsabila Chyllia; Patrisha, Milaviza; Agustin, Rika Alivia; Susmiarsih, Tripanjiasih
Majalah Sainstekes Vol. 12 No. 1 (2025): JUNI 2025
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v12i1.3654

Abstract

Paparan asap rokok dapat menimbulkan berbagai macam penyakit yang berujung pada kematian. Banyak penelitian mengenai dampak merokok aktif terhadap kesehatan dan efek toksik keseluruhan, tetapi efek perokok pasif terhadap kesehatan tidak sepenuhnya dipahami. Asap rokok mengandung radikal bebas yang menyebabkan peningkatan stres oksidatif dan kerusakan organ. Salah satu bahan herbal, yaitu ekstrak daun teh hijau dapat menangani stress oksidatif sebab memiliki aktivitas antioksidan. Tujuan penelitian ini mengetahui pengaruh daun teh hijau terhadap kerusakan organ paru, hepar, dan ginjal akibat paparan pasif asap rokok dengan menggunakan model tikus jantan galur Wistar.Jenis penelitian adalah eksperimen. Sampel berupa tikus putih (Rattus norvegicus) galur Wistar selama 30 hari diberi paparan pasif asap rokok kretek tanpa filter dengan dosis 1 batang sehari dan ekstrak methanol daun teh hijau dengan dosis 100mg/kgBB. Setelah dilakukan pembedahan organ paru, hepar, dan ginjal, kemudian dilakukan pemeriksaan histopatologi dengan pewarnaan Hematoksilin-Eosin. Data diuji secara statistik mengunakan uji Wilcoxon. Hasil penelitian menunjukkan paparan pasif asap rokok pada tikus menyebabkan kerusakan pada organ bermakna secara statistik, pada paru (113,93%, p=0,000), hepar (59%, p=0,003), dan ginjal (89,82%, p=0,001). Pemberian ekstrak daun teh hijau pada tikus yang diberikan paparan pasif asap rokok dapat menurunkan kerusakan organ akibat paparan pasif asap rokok pada paru sebesar (49,04%, p=0,001), hepar sebesar (10,94%, p=0,132), dan ginjal sebesar (40,38%, p=0,003). Disimpulkan bahwa ekstrak daun teh hijau dapat memperbaiki kerusakan organ paru, hepar, dan ginjal akibat paparan pasif asap rokok.
Co-Authors Abdussalam, Moch Agustin, Rika Alivia Ahmad Aulia Jusuf Ainur Rahmah, Nunung Aryenti . Aryenti Aryenti Aryenti, Aryenti Delvi Osmeli Dinda, Salsabila Chyllia Erni Hernawati Purwaningsih, Erni Hernawati Ferlianti, Rika Hans -Joachim Freisleben Idris, Muthoharoh Indah Permata Yuda Indah Permata Yuda Indra Kusuma Indra Kusuma Indranita, Lusy Janah, Lulu Ah Lilian Batubara Moch Abdussalam Moch Abdussalam Mohamad Sadikin Nazwirman Nazwirman Nazwirman Nazwirman Nazwirman Nazwirman Nazwirman Nazwirman Nunung Ainur Rahmah Osmeli, Delvi Patrisha, Milaviza Permata Yuda, Indah Poerwaningsih, Ernie Ernie Restu Syamsul Hadi Susi Endrini Susmiarsih, Tripanjiasih Taufik Nasrullah, Taufik Yuda, Indah Permata Yuhemita . Yuhernita . Yuhernita Yuhernita Yuhernita, Yuhernita Yurika Sandra Zainal Zawir Simon