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All Journal Jurnal Pendidikan Matematika dan IPA Biologi Edukasi : Jurnal Ilmiah Pendidikan Biologi INDRA: Jurnal Pengabdian kepada Masyarakat Biofaal Journal Prosiding Konferensi Nasional PKM-CSR ACROPORA: Jurnal Ilmu Kelautan dan Perikanan Papua TROPICAL GENETICS Rumphius Pattimura Biological Journal Tropical Genetics Kalwedo Sains (KASA)
Moniharapon, Mechiavel
Department Of Biology, Faculty Of Mathematics And Natural Science, Universitas Pattimura
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Expresion of Tumor Necrosis Factor Alfa (TNF-α) in The Pancreas of Diabetic Mice (Mus musculus) Following Adminstration of Catharantus roseus Extract Kaliky, Nunun Ainun Putri Sari Banun; Moniharapon, Mechiavel; Eddy, La
Biofaal Journal Vol 6 No 1 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i1pp10-19

Abstract

Catharanthus roseus is a plant that contains compounds such as alkaloids, flavonoids, saponins, and carotenoids, which act as antioxidants. This study aimed to investigate the effect of Catharanthus roseus extract on the reduction of TNF-α expression in the pancreas of diabetic mice (Mus musculus). In this study, mice with an average body weight of 30 g were induced with streptozotocin (0.1 ml/BB) to induce diabetes mellitus. Subsequently, the diabetic mice were administered Catharanthus roseus extract, using methanol and petroleum benzene solvents at a concentration of 5%, with a dose volume of 1.5 ml/BB, for 14 days. On the final day, the mice were sacrificed, and the pancreas organs were collected, followed by histological preparation using immunohistochemistry methods. The results indicated that administration of Catharanthus roseus extract with methanol and petroleum benzene solvents reduced TNF-α expression. The Catharanthus roseus extract with methanol solvent was more effective in lowering TNF-α expression.
DIURNAL BIRD COMMUNITY STRUCTURE AROUND THE WAILOI RIVER, OF HILA KAITETU (LEIHITU DISTRICT) MALUKU Saman, Risna; Moniharapon, Mechiavel; Eddy, La
RUMPHIUS Vol 1 No 1 (2019): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv1i1p018-024

Abstract

Birds are very dynamic and are found almost everywhere. The purpose of this study was to determine the community structure of diurnal birds around the Wailoi Negeri Hila Kaitetu River, Leihitu District, Central Maluku Regency. The type of this research was quantitative descriptive in nature. The method used is the station line method combined with the count point. The results showed that in the Wailoi River, Negeri Hila Kaitetu, with 2 stations and 11 counting points, several species of diurnal birds were found, namely the type of Trinil beach (Actitis hypoleucos), Tiger Kestrel (Falco severus), Gray Flycatcher (Myagra galeata), Red- cheeked Lorike. (Geoffroyus geoffroyi), Terkukur common (Streptopelia chinensis), Wiwik Jungle (Cacomantis variolosus), Hornbill Irian (Rhyticeros plicatus), Nuri Maluku (Eos borneo), King Prawn Erasia (Alcedo atthis), Pacific Baza (Aviceda subcristata), Small perling (Aplonis minor), Lazuli Checkfish (Halcyon lazuli), Dotted Flycatcher (Muscicapa griseisticta), Sriganti sunbird (Nectarinia jugularis), Asian Tuwur (Eudynamys cyanochepala), Black honey (Necterinia aspesia), Pergam tarut (Ducula concinna). The diversity index for the 2 stations was 1.74 and classified as moderate species diversity criteria. For the average dominance value of station I and station II, which is 0.24, it is included in the low dominance criteria. The evenness value of the two stations is 0.80 and is included in the criteria for a high level of evenness.
ABUNDANCE AND DIVERSITY OF COLLEMBOLA INSECTS IN SWITCHING FIELDS IN WAAI VILLAGE CENTRAL MALUKU Suriani, Sanita; Tuasella, Frisca N; Moniharapon, Mechiavel
RUMPHIUS Vol 3 No 1 (2021): RUMPHIUS Pattimura Biological Journal
Publisher : Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/rumphiusv3i1p001-006

Abstract

Collembola are a good example of the diversity of soil animals and play an important role in nutrient cycling, organic matter decomposition and soil formation which are important parts of forest ecosystems. This research was conducted on cassava land and a vegetable garden in Waai village, Salahutu sub-district, Central Maluku district, on July 18 2020. This study aims to determine the abundance and diversity of the Collembola insect in shifting cultivation in Waai village, Salahutu sub-district, Central Maluku district and its relationship with environmental factors. Results The study obtained 3 families and 6 species with a total abundance of 12.2 individuals/m2. There are differences in the abundance of Collembola found in vegetable gardens and cassava fields. The abundance of Collembola found in the vegetable garden was 3.6 individuals consisting of 2 families and 2 species, while in cassava fields it was 8.6 individuals divided into 2 families and 4 species.
JUMLAH SEL LEYDIG DAN SEL SERTOLI TIKUS GALUR SPARAGUE-DAWLEY TERPAPAR SOPI PASCA DITERAPI EKSTRAK ETANOL SIRIH CINA (Peperomia pellucida L.) Unitly, Adrien Jems Akiles; Killay, Amos; Moniharapon, Mechiavel; Eddy, La; Silahooy, Veince B; Huwae, Laury Marcia Ch; Moniharapon, Debby Dijola; Lakesubun, Bella Frida
Biofaal Journal Vol 5 No 1 (2024): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v5i1pp010-018

Abstract

Tujuan penelitian ini untuk mengetahui jumlah sel Leydig dan sel Sertoli tikus terpapar sopi pasca diterapi ekstrak etanol sirih cina (Peperomia pellucida. L). Rancangan acak lengkap (RAL) digunakan dalam penelitian ini, dengan membagi 15 ekor tikus ke dalam 5 kelompok perlakuan yang diulang sebanyak 3 kali, yaitu kelompok 5.4 adalah 3 ekor tikus yang diberi sopi 5.4 ml/ekor/hari selama 14 hari (kontrol negatif), kelompok Vit. C 6.3 adalah 3 ekor tikus yang diberi sopi 5.4 ml/ekor/hari kemudian diberi Vitamin C 6.3 mg/ekor/hari selama 14 hari (kontrol positif), kelompok 0.71, 1.43 dan 2.86 adalah 3 ekor tikus yang diberi sopi 5.4ml/ekor/hari selama 14 hari kemudian kemudian masing-masing kelompok diberi ekstrak etanol sirih cina 0.71g/ekor/hari selama 14 hari, 1.43g/ekor/hari selama 14 hari dan 2.86g/ekor/hari selama 14 hari. Penelitian ini dilakukan di Laboratorium Zoologi dan Mikroteknik Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Pattimura Ambon mencakup persiapan hewan model, pemberian minuman sopi, ekstraksi sirih cina, pembuatan preparat histologis dan pengamatan. Hasil yang diperoleh dianalisis dengan Analysis of Variance (ANOVA) dan dilanjutkan dengan uji duncan pada taraf nyata a = 0.05 menggunakan perangkat lunak SAS dan dilanjutkan dengan uji beda nyata terkecil untuk mengetahui perbedaan perlakuan yang diberikan. Hasil penelitian menunjukan bahwa pemberian sopi 5.4 ml dapat menyebabkan penurunan jumlah sel Leydig dan sel Sertoli dan setelah diberi ekstrak etanol sirih cina, jumlah sel Leydig dan sel Sertoli mengalami peningkatan, dimana dosis ekstrak etanol sirih cina yang baik untuk sel Leydig adalah 2.86g dan untuk sel Sertoli adalah dosis 1.43g.
Efek Pemberian Ekstrak Etanol Rumput Kebar (Biopythum petersianum Klotzcsh) Terhadap Kadar Hemoglobin dan Nilai Hematokrit (PCV) Tikus Rattus novergicus Terpapar Asap Rokok Kiriweno, Grasia Welma; Unitly, Adrien Jems Akiles; Moniharapon, Mechiavel
Kalwedo Sains (KASA) Vol 2 No 1 (2021): Kalwedo Sains (KASA), Maret 2021
Publisher : Program Studi Di Luar Kampus Utama Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/kasav2i1p24-33

Abstract

Rumput kebar merupakan salah satu tumbuhan obat tradisional yang di duga mampu meningkatkan kualitas hemoglobin dan hematokrit akibat terpapar asap rokok, karena mengandung senyawa flavonoid, vitamin A, vitamin E, dan zat besi, sehingga perlu dilakukan penelitian yang bertujuan melihat pengaruh pemberian ekstrak etanol rumput kebar (Biophytum petersianum Klotzsch) terhadap kadar hemoglobin dan nilai hematokrit (PCV) tikus putih (Rattus norvegicus) terpapar asap rokok. Penelitian mengggunakan metode eksperimental laboratorik dengan rancangan acak lengkap (RAL) yang terdiri dari empat perlakuan yang masing-masing diulang tiga kali, yaitu P0: Kelompok kontrol negatif yaitu tikus yang tidak diberi perlakuan, P1: Kelompok kontrol positif yaitu tikus dipaparkan asap rokok selama 28 hari, P2: Kelompok tikus yang dipapar asap rokok selama 28 hari kemudian diberi ekstrak etanol rumput kebar dosis 0.067 mg/ekor/hari selama 28 hari, dan P3: Kelompok tikus yang dipapar asap rokok selama 28 hari kemudian diberi ekstrak etanol rumput kebar dosis 0.135mg/ekor/hari selama 28 hari. Hasil penelitian memperlihatkan ekstrak etanol rumput kebar dosis 0.135mg dapat meningkatkan kadar hemoglobin (Hb) dan nilai hematokrit (PCV) tikus yang terpapar asap rokok menuju kondisi normal.
Aktivitas Harian Kuskus Genus Phalanger Di Hutan Negeri Saparua, Kecamatan Saparua, Kabupaten Maluku Tengah Muskita, Edwin; Moniharapon, Mechiavel; Unitly, Adrien Jems Akiles; Silahooy, Veince Benjamin; Eddy, La
Kalwedo Sains (KASA) Vol 4 No 2 (2023): Kalwedo Sains (KASA), September 2023
Publisher : Program Studi Di Luar Kampus Utama Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/kasav4i2p70-77

Abstract

Kuskus merupakan salah satu dari jenis mamalia berkantung yang persebarannya sampai di Maluku. Penelitian ini bertujuan untuk melihat aktivitas harian pada kuskus genus phalanger di hutan negeri saparua, kecamatan saparua, kabupaten maluku tengah. Penelitian ini di lakukan di Negeri Saparua, Kecamatan Saparua, Kabupaten Maluku Tengah menggunakan teknik focal animal sampling digunakan sebagai prosedur pengamatan perilaku harian kuskus. Focal animal sampling adalah pengamatan yang difokuskan pada satu individu dalam satu waktu tertentu. Pengamatan di lakukan sebanyak 3 kali pengulangan yang di lakukan sebanyak 2 kali per hari yaitu pada pagi dan malam hari, dengan lama waktu pengambilan data 60 menit (1 jam) dengan interval 1 menit setiap pengambilan data sheet. Variabel yang di amati adalah perilaku makan (feeding), istirahat (resting), berpindah tempat (moving), dan membersihkan diri (grooming). Data yang di peroleh pada hasil pengamatan ditabulasi selanjutnya disajikan secara deskriptif dan etogram. Hasil penelitian menunjukan bahwa rataan presentasi perilaku makan kuskus phalanger pada pagi hari yaitu sebesar 16,3 menit (25,05%), dan pada malam hari sebesar 30 menit (49,96%), waktu istirahat kuskus phalanger pada pagi hari sebesar 30,37 menit (26,05%), dan pada malam hari sebesar 6 menit (8,22%), waktu berjalan (moving) kuskus phalanger pada pagi hari 8,43 menit (14,05%), dan malam hari yaitu 10,33 menit (17,18%), dan untuk presentasi waktu membersihkan diri (Grooming) terjadi pada pagi dan malam hari dengan presentasi yang sama yaitu 3,33 menit (5,33%). Didapati bahwa perilaku harian kuskus phalanger dominan terjadi pada malam hari.
Phytotherapy for Diabetes: A Preclinical Study of Ethanol Extract of Winged Bean (Psophocarpus tetragonolobus L.) Leaves in Diabetic Rat (Rattus norvegicus) Models Moniharapon, Mechiavel; Tahapary, Patrcik Indurian; Kaihena, Martha; Eddy, La
Biofaal Journal Vol 6 No 2 (2025): Biofaal Journal
Publisher : Pattimura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/biofaal.v6i2pp125-140

Abstract

The long-term use of synthetic hypoglycemic agents is known to cause adverse side effects and induce drug resistance. Winged bean (Psophocarpus tetragonolobus L.), a traditional medicinal plant from Maluku, contains secondary metabolites such as flavonoids, saponins, and tannins, which are believed to have potential in lowering blood glucose levels. This study aimed to investigate the effect of ethanolic extract of winged bean leaves on blood glucose reduction and β-cell regeneration in the pancreas of white rats (Rattus norvegicus) as a diabetic model. Thirty rats weighing between 150–200 g were divided into five groups: Group I (negative control), Group II (positive control), and Groups III, IV, and V (diabetic rats treated with ethanolic extract of winged bean leaves at doses of 2.52 mg/g BW, 5.04 mg/g BW, and 7.56 mg/g BW, respectively). Streptozotocin (STZ) was administered to Groups II–V to induce diabetes. Rats with blood glucose levels exceeding 200 mg/dL were subsequently treated with the designated doses of the extract in Groups III–V. On the final day, blood glucose levels were measured, and pancreatic organs were harvested for histological analysis. The results demonstrated that the ethanolic extract of winged bean leaves at a dose of 7.56 mg/g BW effectively reduced blood glucose levels in diabetic rats.
Co-Authors Adrien Jems Akiles Unitly Amos Killay Baszary, Chomsa Dintasari Umi Efraim Samson, Efraim Fredy Pattipeilohy Heryanus Jesajas Kaliky, Nunun Ainun Putri Sari Banun Kiriweno, Grasia Welma La Eddy La Eddy Lakesubun, Bella Frida LAURY CHARA HUWAE Lesbatta, Kezia Josawel Lilian M Soukotta Lokollo, Richard R. Martha Kaihena Meigy N Mailoa Moniharapon, Debby D. Moniharapon, Debby Dijola Muskita, Edwin Nadira Pattimura Pangemanan, Victory O Pieter Kakisina Restu Tuharea Riandini, Rezki Amalia Rony Kunda Rony Marsyal Kunda Sahlan Hamid Saman, Risna Sanita Suriani Sikafir, Beatrix Belina Silahooy, Veince B Silahooy, Veince Benjamin Sillehu, Eka Safitri Sopacua, Gracia N. Tahapary, Patrcik Indurian Theopilus W Watuguly Trijunianto Moniharapon Tuasella, Frisca N Ukratalo, Abdul M Utami, Prasetyarti Veince Benyamin Silahooy, Veince Benyamin