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All Journal Dimas: Jurnal Pemikiran Agama untuk Pemberdayaan MPI (Media Pharmaceutica Indonesiana) Jurnal IPA Terpadu JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Aisyah : Jurnal Ilmu Kesehatan Chemistry and Materials Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Jurnal Penelitian dan Pengabdian Masyarakat Multidisciplinary Journal of Education, Economic and Culture Miftah Journal of Islamic Education

Mun'im, Abdul

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Author-ID : 1154462

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Removal of Mimosine from Leucaena leucocephala (Lam.) de Wit Seeds to Increase Their Benefits as Nutraceuticals Wardatun, Sri; Harahap, Yahdiana; Mun'im, Abdul; Saputri, Fadlina Chany, Dr.; Sutandyo, Noorwati
Pharmaceutical Sciences and Research Vol. 7, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

The Leucaena leucocephala (Lam.) de Wit tree contains pharmacologically active compounds and can easily be found in abundant quantities. The utilization of this tree as a source of nutraceuticals would increase its value. The extraction yields show the number of compounds that have been extracted by solvent. However, Leucaena leucocephala (Lam.) de Wit seeds also contain mimosine, which can cause hair loss. The present study investigated the process of removing mimosine from the seeds. Three treatments were applied to these seeds: treatment without soaking, soaking with distilled water for 24 hours, and splitting the seeds in half and then soaking with distilled water for 24 hours. The seeds were dried, ground, and then extracted with different concentrations of ethanol solvent. The mimosine levels of the extracts were measured with a JascoV-730 spectrophotometer using ferry chloride as a reagent. The results showed that the soaking process and the concentration of ethanol had significant effects on the extract yields and mimosine levels. The unsoaked seeds, extracted with 70% ethanol, produced the highest ratio of extract yield to mimosine level. Therefore, 70% ethanol can be used as a solvent to utilize unsoaked seeds as nutraceuticals.

Memory Loss induced by Aspartame in Albino Rats: Study on neurobehavioral changes Suswidiantoro, Vicko; Saputri, Fadlina Chany; Mun'im, Abdul
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 6, No 2: June 2021
Publisher : Universitas Aisyah Pringsewu

Objective: Aspartame (ASP) consumption in various food and beverage products has generated a lot of controversy on safety. Many reports, ASP caused deterioration of health condition likes diabetes, psychiatric disorders, memory loss, etc. This study aimed to investigate the optimization duration of ASP to induce memory loss in Sprague Dawley rats. Methods: The ASP was administered 40 mg/kg BW orally for 28 days in rats. Analysis of memory loss by neurobehavioural changes including latency time, length of track, per cent time and frequency target quadrant using Morris Water Maze (MWM) at day 14, 21, 28, and 24 hours after the last treatment. Results: The administration of ASP showed the time-dependent changes for each indicator of neurobehavioural. The results demonstrated during 28 days of induction showed a significant decrease in latency time, length of track, per cent time and frequency target quadrant. Conclusion: From the results, it can be concluded administration of ASP during 28 days induce neurobehavioural changes related to memory loss in rats. Abstrak: Objektif: Penggunaan aspartame (ASP) sebagai pemanis buatan yang banyak terdapat pada makanan, dan minuman menimbulkan berbagai kontroversi dalam hal keamanan. Berbagai data menunjukkan ASP dapat menyebabkan gangguan kesehatan seperti diabetes, gangguan psikiatrik, penurunan fungsi memori, dll. Penelitian ini bertujuan untuk menentukan waktu durasi penggunaan ASP yang dapat menyebabkan gangguan fungsi memori pada tikus Sprague Dawley. Metode:ASP diberikan secara oral pada tikus dengan dosis 40 mg/kg BB selama 28 hari. Analisis terhadap fungsi memori dilakukan dengan adanya perubahan perilaku pada hewan, meliputi waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran menggunakan Morris Water Maze (MWM) setelah 24 jam setelah pemberian pada hari ke 14,21, 28. Hasil: Pemberian ASP menunjukkan adanya perbedaan waktu pada setiap indicator perilaku. Pemberian selama 28 hari menujukkan adanya perbedaan signifikan pada penurunan waktu latensi, Panjang lintasan, persentase waktu dan frekuensi kuadran. Kesimpulan: Berdasarkan hasil, pemberian ASP selama 28 hari dapat menyebabkan adanya perubahan perilaku yang berkaitan dengan fungsi memori pada tikus.

Exploring Rosella (Hibiscus sabdariffa L.) Calyx Extracts as Natural Dye and Antioxidants in Lip Cream Product: Formulation and Evaluation Ariestanti, Donna Maretta; Mun'im, Abdul; Djajadisastra, Joshita; Hutami, Riska Amalia Putri; Fadhila, Redhalfi; James, Richard Johari
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

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Rosella, also known as Hibiscus sabdariffa L., is a plant that contains anthocyanin compounds in its calyx, which are known for their antioxidant properties. These compounds give the plant a captivating red color and can be used as natural dyes. This study aimed to exploit anthocyanins in rosella calyx as natural dyes and antioxidants in lip cream product. The formulations employed extracts from rosella calyx, a viscous extract from maceration in 96% ethanol (F1) and a commercially available powdered rosella extract (F2). Evaluation on the formulations demonstrated that both F1 and F2 effectively maintained the color integrity of the lip cream. Moreover, an irritation test among 10 respondents showed no adverse reactions. Additionally, a hedonic test of 30 respondents revealed uniformity in homogeneity, odor, and spreadability on both formulations. However, a noticeable contrast emerged in color intensity, with F2 exhibiting greater intensity and preference over F1. The rosella calyx extract also demonstrated its antioxidant potential with an IC50 value of 130.11 ± 2.08 µg/ml. The study highlights the utility of rosella calyx extracts as a dual-functioning component in lip cosmetics. The findings indicate the variations in formulation efficacy and color intensity, emphasizing the potential of rosella-derived extracts in developing cosmetics with enhanced aesthetic appeal and functional antioxidant attributes.

Review: Potency and Problem in Development of Self-reliance of Traditional Drug Raw Material in Indonesia Suliasih, Babay Asih; Mun'im, Abdul
Chemistry and Materials Vol. 1 No. 1 (2022)
Publisher : Pusat Inovasi Sains

The use of herbs for health purposes has been practiced for thousands of years, long before the discovery of synthetic chemical drugs. Indonesia is widely recognized for its vast biodiversity, boasting approximately 30,000 plant species, equivalent to 75% of the total plant species worldwide, earning it the title of a mega-centre of global biodiversity. This highlights Indonesia's enormous potential in the traditional medicine industry, with the capability to compete on a global scale. However, several challenges hinder the development of traditional raw materials and the production of traditional medicines. These include herbal raw materials that fail to meet quality standards, a non-conducive business climate, limited technological advancements in the extraction and production of raw materials, uneven distribution of third-party laboratories across Indonesia which making it difficult for small and medium-sized industries to access product testing facilities, the exclusion of traditional medicines from the National Health Insurance (JKN) program, and a lack of empirical evidence for many plants with potential as traditional medicines. To address these challenges, intensive support and synergy from the government and legislative bodies are essential to enact policies that accelerate the growth of the traditional medicine industry. Additionally, strong collaboration with business actors, academics, and community organizations is crucial to fostering self-sufficiency in traditional medicine raw materials.

Tradisi Pendidikan Keislaman di Pesantren Sunan Drajat Lamongan Ulum, Miftachul; Mun'im, Abdul
Multidisciplinary Journal of Education , Economic and Culture Vol. 2 No. 2 (2024): September 2024
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/mjeec.v2i2.279

This study aims to describe the educational tradition carried out at the Sunan Drajat Lamongan Islamic Boarding School. This qualitative research method was carried out by conducting a direct survey and exploring the documentation used in educational activities at the Sunan Drajat Lamongan Islamic Boarding School. The results of the study stated that academic and non-academic activities that have been scheduled are daily, weekly, monthly and annually at the Sunan Drajat Islamic Boarding School as a form of Islamic education tradition at the Sunan Drajat Lamongan Islamic Boarding School. These traditional activities can foster a sense of social sensitivity, spirituality and exemplary spirit in forming students who have good morals.

Lottery Prizes and Islamic Law Review on Mudharabah Savings Products at BMT Ar Roudloh Lamongan Mun'im, Abdul; Ulum, Miftachul
Miftah : Jurnal Ekonomi dan Bisnis Islam Vol. 2 No. 2 (2024): October 2024
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/miftah.v2i2.289

One of the efforts to increase customer appeal is by providing a prize draw. BMT Ar Raudloh in an effort to improve its services also applies a promotional strategy through the provision of a prize draw. The purpose of the study is to describe the review of Islamic law in the activities of determining, implementing a prize draw carried out at BMT Ar Roudloh in Lamongan. The triangulation method is used in describing the results of the research analysis and determining the validity of the data source. Informants in the study included managers, employees and customers. The results of the study indicate that the implementation of the prize draw activity starting from determining the requirements, participants and implementation has been in accordance with Islamic law. The implementation of the prize draw shows that the implementation of the prize draw does not conflict with Islamic law

Pendampingan Motivasi Belajar Santri dengan Pembelajaran Kitab Minhajul Muta’allimin di Pondok Pesantren Sunan Drajat Lamongan Ulum, Miftachul; Mun'im, Abdul
Jurnal Penelitian dan Pengabdian Masyarakat Vol. 2 No. 3 (2024): August 2024
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/jp2m.v2i3.274

The purpose of community assistance activities is to provide assistance to SMK Sunan Drajat Lamongan class X students in motivating learning by exploring the study of the Minhajul Muta'allimin book by Imam Ghazali. The method of assistance is by reading the book of Minhajul Muta'allin with the original Arabic text translated into Javanese with pegon writing using pesantren techniques and methods of interpretation. The activity was carried out for 20 days starting from March 12-31, 2024 precisely in the month of Ramadan. The results of mentoring activities assisted participants understand their duties and obligations as students during learning activities. Students understand how to behave and behave in the process of studying in front of teachers. Students are motivated to be enthusiastic in learning and worshiping.

Validasi Metode Analisis Kurkuminoid dan Xantorizol pada Rimpang Temulawak (Curcuma xanthorrhiza) dengan KLT- Densitometri Saputri, Febrina Amelia; Mun'im, Abdul; Putri, Chinthia Rahadi; Aryani, Dewi
MPI (Media Pharmaceutica Indonesiana) Vol. 4 No. 2 (2022): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v4i2.5297

Rimpang temulawak (Curcuma xanthorrhiza) merupakan bagian tanaman yang banyak dimanfaatkan untuk pengobatan tradisional. Metabolit sekunder yang memberikan aktivitas farmakologisnya adalah senyawa kurkuminoid dan xantorizol. Penelitian ini bertujuan untuk memperoleh metode analisis kurkuminoid dan xantorizol yang tervalidasi, cepat, dan sederhana. Analisis dilakukan dengan menggunakan fase diam berupa lempeng KLT silika gel 60 GF254 dan fase gerak diklorometana-kloroform (4:6). Pemindaian (scanning) densitometrik dilakukan pada 224 nm untuk xantorizol dan 425 nm untuk kurkuminoid. Metode menunjukan linieritas, akurasi, dan presisi yang baik, dengan batas deteksi kurkuminoid dan xantorizol yaitu 7,88 bpj dan 28,23 bpj dan batas kuantitasi kurkuminoid dan xantorizol yaitu 23,89 bpj dan 85,55 bpj. Kadar kurkuminoid dan xantorizol pada ekstrak rimpang temulawak adalah 4,95 ± 0,01 dan 31,30 ± 0,09 mg/g serbuk simplisia. The rhizome of temulawak (Curcuma xanthorrhiza) is a part of the plant that is widely used for traditional medicine. Secondary metabolites that provide pharmacological activity are curcuminoids and xanthorrhizol. This study aims to obtain a validated, fast, and simple analytical method for curcuminoids and xanthorrhizol. The analysis was carried out with the stationary phase TLC plates silica gel 60 GF254. The mobile phase used was dichloromethane-chloroform (4:6), with densitometric scanning at 224 nm for xanthorrhizol and 425 nm for curcuminoids. The method showed good linearity, accuracy, and precision, with curcuminoids and xanthorrhizol detection limits of 7.88 ppm and 28.23 ppm, curcuminoids and xanthorrhizol quantitation limits of 23.89 ppm and 85.55 ppm, respectively. The content of curcuminoids and xanthorrhizol in temulawak rhizome extract were 4.95 ± 0.01 and 31.30 ± 0.09 mg/g Simplicia powder, respectively.

Pendampingan Pengolahan Data Penelitian dengan Aplikasi SPSS Bagi Mahasiswa Ulum, Miftachul; Mun'im, Abdul; Zawawi, Abdullah; Al Maghfuri, Rahmah Salsabila
Jurnal Penelitian dan Pengabdian Masyarakat Vol. 3 No. 1 (2025): February 2025
Publisher : Yayasan Pondok Pesantren Sunan Bonang Tuban

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61231/jp2m.v3i1.336

This community service activity aims to provide understanding and training in using the SPSS application in statistical data processing. This activity was attended by 12 students of the Faculty of Islamic Economics and Business, Sunan Ampel State Islamic University, Surabaya on November 14, 2024 through the Google Meet application. The mentoring activity was carried out through stages, preliminary stage, implementation stage and evaluation stage. The results of the mentoring were obtained by participants being able to understand and practice the application in statistical data processing activities. Participants were also able to prepare the application starting from installation to use.

Pengaruh Antioksidan dan Kombinasi Pengawet terhadap Stabilitas Ekstrak Cair NADES Biji Kopi Hijau Ramadon, Delly; Septiani, Rosalina Mesusi; Putri, Salsabila Nursyifa; Mun'im, Abdul
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Green coffee beans (Coffea canephora Pierre ex A. Froehner) contain caffeine and chlorogenic acid which are beneficial for health. These two main ingredients can be extracted using Natural Deep Eutectic Solvents (NADES) in combination with the Ultrasound-Assisted Extraction (UAE) method which is environmentally friendly. NADES can be used for extracting green coffee beans, but the solvent cannot be evaporated, thus the result is a liquid extract. During storage, liquid extracts are susceptible to oxidation and bacterial growth so that they can disrupt physical, chemical, and microbiological stabilities. In this study, butylated hydroxytoluene (BHT) was added as a synthetic antioxidant and a combination of methylparaben-propylparaben as preservative to determine its effect on the physical, chemical, and microbiological stability of the NADES liquid extract of green coffee beans, as well as to determine the best storage temperature. The concentrations of BHT added in this study were 10, 20, and 30 ppm. The concentration of the methyl paraben:propyl paraben combination added was 110:55 ppm, 100:50 ppm, and 90:45 ppm. Each extract was stored at storage temperatures of -20°C ± 5°C, 5°C ± 3°C, and 30°C ± 2°C for 54 days. The results showed that the liquid extract added with 30 ppm BHT concentration and a combination of preservatives with a concentration of 110:55 ppm and stored at a storage with the temperature of -20°C ± 5°C which had the best physical, chemical, and microbiological stability. This shows that the addition of BHT and a combination of preservatives can increase the stability of the green coffee bean NADES extract.

Co-Authors . Katrin Adisti, Adisti Aksa, Awaluddin Al Maghfuri, Rahmah Salsabila Amalia, Sariayuningsi Ariestanti, Donna Maretta Aryani, Dewi Erly Juliyani Fadhila, Redhalfi Fadlina Chany Saputri Fahleni Fahleni Febrina Amelia Saputri, Febrina Amelia Hasan, Nahrul Hayun Hayun, Hayun Herman, MJ. Hherman, M Hutami, Riska Amalia Putri James, Richard Johari Joshita Djajadisastra, Joshita Khoirun Nisa Kristanty, Ruth Elenora Magfirah, Anisah Mamin, Ratnawaty Miftachul Ulum, Miftachul Musyabirah, Musyabirah Noorwati Sutandyo Putri, Chinthia Rahadi Putri, Salsabila Nursyifa Raharni Raharni RAMADON, DELLY Ramlawati Ramlawati Sarjaini Jamal Septiani, Rosalina Mesusi Silvia Surini Sri Wardatun Sriana Azis Sudibyo Supardi Suliasih, Babay Asih Suswidiantoro, Vicko Syam, Farha Mutia Yahdiana Harahap Yunus, Sitti Rahma Zawawi, Abdullah

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