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All Journal Jurnal Kebijakan Kesehatan Indonesia Ekonomikawan : Jurnal Ilmu Ekonomi dan Studi Pembangunan Public Health of Indonesia Paediatrica Indonesiana PEDAGOGIA Indonesian Journal of Artificial Intelligence and Data Mining Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Pengabdian Masyarakat AbdiMas JOURNAL OF SCIENCE AND SOCIAL RESEARCH Jurnal Manajemen Informatika Jurnal Manajemen Informasi Kesehatan Indonesia (JMIKI) Indonesian of Health Information Management Journal (INOHIM) Poltekita : Jurnal Ilmu Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Jurnal Ilmiah Perekam dan Informasi Kesehatan Imelda (JIPIKI) J-REMI : Jurnal Rekam Medik dan Informasi Kesehatan KESANS : International Journal of Health and Science NUSRA: Jurnal Penelitian dan Ilmu Pendidikan PELS (Procedia of Engineering and Life Science) Jurnal Ilmu Kesehatan Masyarakat Jurnal Rekam Medik & Manajemen Informasi Kesehatan (RAMMIK) Malcom: Indonesian Journal of Machine Learning and Computer Science Prosiding Seminar Nasional Official Statistics Cerdika: Jurnal Ilmiah Indonesia Indonesian Journal of Health Information Management Services (IJHIMS) International Journal of Health and Information System (IJHIS) Jurnal Karya untuk Masyarakat (JKuM) Jurnal Bioteknologi & Biosains Indonesia (JBBI)
Nurmalasari, Mieke
Universitas Esa Unggul Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Bioteknologi

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THE RELATIONSHIP OF TNFα -308 G/A POLYMORPHISM WITH THE INCIDENCE OF CERVICAL CANCER IN ASIAN WOMEN: A META ANALYSIS OBSERVATIONAL STUDY Saraswati, Henny; Nurmalasari, Mieke
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 1 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.2546

Abstract

Cervical cancer is a malignancy with high mortality rates in women, and its incidence continues to rise. The main etiological factor for cervical cancer is infection with Human Papillomavirus (HPV), which disrupts the regulation of apoptosis in cells. Several studies have shown a correlation between TNFα polymorphisms, including the -308 position (TNFα -308 G/A), and the incidence of cervical cancer.This gene have a role in proliferation of cancer cells. This study investigates the impact of TNFα-308 polymorphism on the risk of cervical cancer in Asian female populations. A meta-analysis of five sources was conducted to determine potential associations. Findings reveal that neither allele A (OR 95%CI = 1.20 [0.70-2.03], p = 0.51) nor genotype AA (OR 95%CI = 0.85 [0.37-1.91], p = 0.69) were significantly linked with an elevated risk of cervical cancer in Asian women. The same result was seen for the G allele (OR 95%CI = 0.84 [0.49-1.42], p = 0.51) and GG genotype (OR 95%CI = 0.80 [0.44-1.48], p = 0.48). The study results indicate that the TNFα-308 polymorphism is not associated with cervical cancer in Asian women. Further research is needed to investigate the role of other gene polymorphisms in cervical cancer susceptibility in Asian women.
Co-Authors AA Sudharmawan, AA Azizatul Azza Azza, Azizatul Badie Uddin Deasy Rosmala Dewi Dewi, Sukmala Firdayana Firdayana Harna, Harna Hosizah Hosizah Hosizah Hosizah Hosizah Husni Abdul Muchlis Ichwani, arief Kendrastuti, Nungky Nurkasih Krismawati, Dewi Kurniawati, Anastasia Cyntia Dewi Laela Indawati Larasati , Dhiar Niken Lestari, Betri Widya Linta Ifada Linta Ifada Mahadewi, Erlina Puspitaloka Mauren Michaela, Sarah Michaela, Sarah Mauren Munggaran, Rahayu Putri Muniroh, Muniroh Mustikawati, Intan Silviana Nafs, Tazkyatun Nauri Anggita Temesvari Nauri Anggita Temesvari Nizirwan Anwar Nori wilantika Panutun, Satria Bagus Pramana, Setia Putri, Suci Sri Endah Lestari Mulyanto Putri, Tacyah Kholifah Rafidah, Arlien Rona Rahmawati, Danisa Ocha Rahmayanti R, Andi Rosida, Putri Lailatul Rubina, Tirzhana Jean Ruhmayanti, Nur Ayu Sa'pang, Mertien Sangadji, Namira Wadjir Saputra, Alief Imran Saraswati, Henny Seprianto, Seprianto Septian Bagus Wibisono Silvia Ni'matul Maula Sulistianingsih Sulistianingsih Suprobowati Suprobowati Supryatno, Adi Temesvari, Nauri Anggita Tita Ardianti Tria Saras Pertiwi Widia Sari Widjaja, Lily Witri Zuama Qomarania Zuama, Witri