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Microbioma in Aging Skin Nugraheni Pasaribu, Uly Aanda Maria; Rihatmadja, Rahadi; Yusharyahya, Shannaz Nadia; Widaty, Sandra; Legiawati, Lili; Pandjaitan-Sirait, Sondang MHA
Journal La Medihealtico Vol. 5 No. 3 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i3.1315

Abstract

Microbiota is inseparable to the skin. Just as in the gastrointestinal tract, the skin microbiome reflects the health of the organ where it resides. It contributes to skin barrier function and ensures its homeostasis. However relatively stable over time, microbiome composition and number may be influenced by various aging -related changes − dryness, blemish, wrinkles and alteration of sebaceous gland activity impacting the skin ecological conditions − and vice versa. Several generations have been reported to promote the process while others may play a more protective role in this regard.
The development and use of artificial intelligence (AI) in dermatology: a narrative review Irene Darmawan; Shannaz Nadia Yusharyahya; Sampurna, Adhimukti T.; Saputro, Adhi Harmoko
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 3 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i3.15970

Abstract

Artificial intelligence (AI) is defined as a computer science involving program development aiming to reproduce human cognition to analyze complex data. Artificial intelligence has rapidly developed in the medical field. In dermatology, its development is relatively new and is generally used in the diagnostic, especially for skin imaging analysis and classification, and also for risk assessment. The greatest advances have been primarily in the diagnosis of melanoma, followed by the assessment of psoriasis, ulcers, and various other skin diseases. The use of AI has shown good accuracy and is comparable to dermatologists in various studies, especially related to melanoma and skin tumors. However, several obstacles exist in the application of AI to daily clinical practice, including generalizability, image standardization, the need for large data quantities, and legal and privacy aspects. In current developments, AI should be aimed at helping enhance the decision-making of clinicians.
Herpes Zoster dengan Manifestasi Eritema Multiforme Bulosa pada Pasien Geriatri Imunokompromais: Laporan Kasus Halim, Dionisius Ivan Yonathan; Legiawati, Lili; Yusharyahya, Shannaz Nadia; Astriningrum, Rinadewi
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.531

Abstract

   Pendahuluan: Herpes zoster (HZ) merupakan sekumpulan gejala dan manifestasi klinis yang disebabkan oleh reaktivasi varicella-zoster virus (VZV). Faktor predisposisinya antara lain: usia lanjut, keadaan imunokompromi, obat imunosupresif, keganasan, stres psikologis, trauma, dan tindakan pembedahan. Manifestasinya bervariasi, namun manifestasi eritema multiforme (EM) bulosa jarang dilaporkan. Kasus: Seorang perempuan berusia 65 tahun mengeluhkan bercak gatal pada kedua lengan dan tungkai sejak 3 hari yang lalu. Pasien sedang menjalani kemoterapi atas indikasi kanker payudara metastasis tulang dengan multikomorbid. Pada pemeriksaan ditemukan lesi target tipikal EM yang beberapa berkembang menjadi EM bulosa. Terdapat riwayat demam. Pasien ditatalaksana dengan kortikosteroid serta terapi simptomatik. Satu minggu kemudian ditemukan lenting berkelompok di lengan kiri atas sampai ke leher kiri sesuai dermatom C4 dan C7 yang disertai rasa nyeri dan terbakar. Kortikosteroid dihentikan dan diobati dengan valasiklovir 3 x 1000 mg selama 10 hari dan terapi simptomatik. Setelah 2 minggu terdapat perbaikan klinis dan gejala. Diskusi: Kasus HZ aberans dengan manifestasi EM bulosa dapat terjadi pada individu dengan komorbid dan keadaan imunokompromi. Pada pasien ini terdapat usia lanjut riwayat kanker payudara, obat kemoterapi, serta komplikasi infeksi sekunder pasca tindakan pembedahan. Manifestasi HZ mirip dengan EM minor karena ditemukannya lesi target tipikal pada kedua ekstremitas tanpa lesi mukosa. Perubahan perjalanan penyakit menjadi vesikel berkelompok sesuai dermatom, kemungkinan HZ aberans lebih dipertimbangkan. Kesimpulan: Herpes zoster dapat menimbulkan manifestasi EM. Terapi dengan obat antiviral menunjukkan perbaikan baik klinis maupun gejala. Kemungkinan manifestasi EM pada HZ harus dipertimbangkan untuk diagnosis dini dan tatalaksana efektif.
Characteristics of pressure injuries among geriatric patients at an Indonesian tertiary hospital: a cross-sectional study Yusharyahya, Shannaz Nadia; Legiawati, Lili; Astriningrum, Rinadewi; Jonlean, Reganedgary; Andhira, Vega
Medical Journal of Indonesia Vol. 32 No. 3 (2023): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.237092

Abstract

BACKGROUND Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric patients with pressure injuries admitted at a tertiary hospital in Indonesia. METHODS This cross-sectional study used medical records of geriatric patients admitted with all stages of pressure injuries consulted to the Department of Dermatology and Venereology at a tertiary hospital in Indonesia between January 2017 and April 2021. Pressure injuries were classified based on the 2019 National Pressure Injury Advisory Panel guideline. RESULTS 39 patients presented with varied pressure injury characteristics. The sacral region was the most reported site (36%), with stage 2 pressure injury being the most commonly found stage in the patients (74%). Interestingly, 22% of the patients had pressure injuries found on the atypical sites due to prolonged surgery or the pressure of medical devices. More than half of the patients used conventional dressings (51.3%). Immobility was found in 35.9% of the patients due to being bedridden. CONCLUSIONS No characteristics were found as a significant risk factor for pressure injury formation during or outside the admission period. However, a history of surgery might be related to pressure injury formation during admission.
Herpes Zoster Reactivation Following COVID-19 mRNA Vaccination in an Elderly Patient: A Case Report Sarah, Ratu Siti Khadijah; Hapsari, Yari Castiliani; Yusharyahya, Shannaz Nadia; Miranda, Eliza; Edwar, Sarah Qanita
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Latent varicella-zoster virus (VZV) in nerve ganglia may reactivate into herpes zoster infection. The coronavirus disease (COVID-19) vaccine is suspected of triggering VZV reactivation, although the exact cause is unclear. This case report aims to raise awareness of the potential complications induced by the COVID-19 mRNA vaccine, particularly in elderly patients. Case Illustration: A 62-year-old woman complained of itchy and painful unilateral dermatomal herpetiform blisters six days after mRNA COVID-19 vaccination. The vesicle first appeared on the left breast, spreading to the back. The patient has a history of hypertension. After the administration of 800 mg of acyclovir five times a day for seven days, the vesicles dried up, and no new vesicles emerged. Discussion: The incidence of herpes zoster has been widely reported to occur within 5-7 days after the COVID-19 vaccination, mostly due to the mRNA vaccine. The dysregulated cell-mediated immune system may trigger VZV reactivation. The vaccines have been shown to induce a cellular response with increased CD8+ T-cells and T-helper type 1 CD4+ T cells. The VZV-specific CD8+ cells cannot control VZV after the massive shift of naïve CD8+ T-cells in the setting of COVID-19 vaccination. Hypertension is also allegedly the main comorbid factor for herpes zoster reactivation after COVID-19 vaccination. Conclusion: Increased awareness and early recognition of potential COVID-19 vaccine-related complications, especially in elderly individuals with comorbidities, are important for timely management and prevention of further issues.