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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Riset Kimia Jurnal Litbang Industri CHEMPUBLISH JOURNAL Chimica et Natura Acta Fullerene Journal of Chemistry Hydrogen: Jurnal Kependidikan Kimia Jurnal Litbang Industri Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Journal of The Indonesian Society of Integrated Chemistry Jurnal Kimia Unand Jurnal Sains dan Kesehatan
Syafrizayanti, Syafrizayanti
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Andalas Kampus Limau Manis, Padang, Sumatera Barat, 25163, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology

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Antioxidant of Ethanol Extract and Toxicity of Fractions from Aspergillus unguis a Marine Sponge Symbiont of Aaptos suberitoides Masyerli, Scify Bilqis Nawafi; Efdi, Mai; Bashari, Muhammad Hasan; Untung Kurnia Agung, Mochamad; Subhan, Beginer; Efahmi, Efahmi; Andriani, Yosie; Syafrizayanti, Syafrizayanti
Hydrogen: Jurnal Kependidikan Kimia Vol 13, No 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14645

Abstract

The marine sponge Aaptos suberitoides has been shown to have anticancer properties, with clear evidence of its capacity to suppress the growth of cancer cells. However, the pharmaceutical exploration of chemicals from marine organisms causes significant environmental concerns. Aspergillus unguis, a fungal symbiont of the marine sponge A. suberitoides, has been isolated for its potential in sustainable natural products resources. This study assesses the antioxidant activity of ethanol extract and the toxicity of four levels fractions from ethanol extracts of A. unguis mycelium and these results were reported for the first time in this study. The antioxidant of ethanol extract was determined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The fractions were examined for toxicity using the Brine Shrimp Lethality Test (BSLT). The ethanol extract of A. unguis shows very strong antioxidant bioactivity (IC50 = 42.84 mg/L). The LC50 values for hexane, chloroform, ethyl acetate, and butanol fractions were determined to be 74.11 µg/mL, 93.84 µg/mL, 59.37 µg/mL, and 142.79 µg/mL, respectively. It indicates significant toxicity. These preliminary results are important knowledge for further research into the bioactivity potential of the metabolites as candidate anticancer compounds, aligning with marine pharmaceutical drug development.
Ability Antioxidant and Anti-inflammatory Phycocyanin from Extract Spirulina platensis Rahma, Diny Hazita; Armaini, Armaini; Syafrizayanti, Syafrizayanti
Jurnal Kimia Fullerene Vol 10 No 1 (2025): Fullerene Journal Of Chemistry
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37033/fjc.v10i1.715

Abstract

Increased exposure to free radicals and chronic inflammatory processes are major factors in the development of various degenerative diseases, including cancer, diabetes, and cardiovascular disease. Therefore, the search for natural bioactive compounds with antioxidant and anti-inflammatory properties has become a major focus in pharmaceutical and biomedical research. Phycocyanin is a complex protein pigment from the microalgae Spirulina platensis which is known to have biological activities, especially as an antioxidant and anti-inflammatory. This study aims to evaluate the antioxidant and anti-inflammatory properties of phycocyanin extract obtained through maceration and freeze-thawing methods using PBS solution pH 7.4 and distilled water. Antioxidant activity was evaluated using the ABTS (2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonate)) method, while the anti-inflammatory potential was tested using the protein denaturation inhibition method. The test results showed that the phycocyanin extract had quite strong antioxidant activity with an IC₅₀ value of 82.86 mg/L. In addition, anti-inflammatory activity was also shown with an IC₅₀ value of 73.92 mg/L in the protein denaturation inhibition test. These results indicate that phycocyanin extract from Spirulina platensis has the potential as a natural bioactive agent in the development of nutraceutical, cosmetic, and pharmaceutical products. Further studies are needed to understand the molecular mechanisms and in vivo testing to support its clinical application.
Review: Melastoma malabathricum Natural Compounds as Inhibitors of Resistant Bacterial Development Susanti, Febria Elvy; Efdi, Mai; Syafrizayanti; Septama, Abdi Wira
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.41114

Abstract

The abundance of natural medicines in nature is very capable of being used and developed in various lives both individually and in combination in the modern medical field. Various developments and treatments as well as the discovery of new concepts will be able to interact with human physiology. One plant that has the potential to be developed is Melastoma malabathricum, also known as senduduk. This plant from the Melastomataceae family is easily found in tropical Asia and has long been used as an herb in traditional Chinese medicine. Based on the data collected, various studies have shown the pharmacological bioactivity of Melastoma malabathricum which has antibacterial potential and is able to fight resistant bacteria. Chemicals in this plant, including flavonoids, terpenoids, alkaloids, and steroids have been detected and shown to be inhibitors of bacterial growth, including resistant bacteria.
Harnessing Indigenous Fermentation: Probiotic Lactic Acid Bacteria from West Sumatera’s Dadih Hillman, Prima Fitria; Titisari, Geliz Luh; Syafrizayanti, Syafrizayanti
Jurnal Riset Kimia Vol. 16 No. 2 (2025): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v16i2.853

Abstract

The potential of lactic acid bacteria (LAB) isolated from dadih, a traditional fermented buffalo milk from West Sumatra, was explored as functional starter cultures for yogurt production. The use of local LAB is considered essential due to Indonesia’s dependence on imported cultures, which often exhibit inconsistent performance and suboptimal quality. This study selected bacterial isolates based on their ability to grow in highly acidic media and their tolerance to bile salt treatment. Molecular identification was conducted by amplifying the 16S rRNA gene using the PCR method. Specific LAB isolates with high probiotic potential were further characterized based on their tolerance to acid and bile salts. The results showed that several LAB strains from dadih, such as Lactococcus lactis, Weissella paramesenteroides, and Weissella sp., exhibited good probiotic properties. These isolates could effectively ferment milk and produce yogurt with organoleptic qualities comparable to commercial cultures. In addition, Serratia marcescens, known as an opportunistic pathogen, was also detected during the isolation process; some of its strains are known to participate in fermentation processes. These findings support the utilization of local LAB as an alternative to imported cultures, promoting local food production, improving the nutritional value of fermented dairy products, and preserving traditional culinary heritage.
Studi Molecular Docking dan Farmakoinformatika Senyawa Kurkumin dan Arturmeron pada Tumbuhan Kunyit (Curcuma Longa Linn.) Sebagai Antihipertensi: Molecular Docking and Pharmacoinformatics Study of Curcumin and Arturmeron Compounds in Turmeric Plants (Curcuma Longa Linn.) as Antihypertensive Agustian, Dede Rahman; Syafrizayanti, Syafrizayanti; Alfath, Yuma Nur; Riga, Riga; Kusnanda, Arif Juliari
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2287

Abstract

Content Angiotensin Converting Enzyme (ACE) is an enzyme that is able to convert the peptide angiotensin 1 into angiotensin 2 which plays a role in the process that causes hypertension. Curcumin and artumeron are a group of chemical compounds that are widely contained in the turmeric plant (Curcuma Longa Linn.) which are reported to have the potential to inhibit ACE in vitro. The aim of this research is to predict the binding interactions of the curcumin and artumeron compound groups with the amino acids in ACE and using the native ligand captopril as the standard ligand. The method used was pharmacokinetic screening of active compounds in the curcumin and artumeron groups using ADMET predictions, Lipinski Rule of five and molecular docking simulations with the MOE program. Based on the results of screening and molecular docking simulations, it shows that the curcumin compound can bind to the ACE enzyme with a binding affinity of -6.032 kcal.mol-1 with a binding site with the amino acid Leu 342 better than captopril which has a binding affinity value of 4.427 kcal.mol-1 with binding sites with the amino acids Glu 342, Pro 344 and Thr 345. These results showed the curcumin compound potential used as a candidate for natural ingredients in antihypertensive treatment because according to in silico predictions it has abilities that are not much different from captopril. Keywords:          ACE, antihypertensive, in silico, Curcuma Longa Linn.   Abstrak Angiotensin Converting Enzyme (ACE) merupakan enzim yang mampu merubah peptida angiotensin 1 menjadi angiotensin 2 yang berperan dalam proses penyebab hipertensi. Senyawa kurkumin dan artumeron merupakan golnngan senyawa kimia yang banyak terkandung dalam tumbuhan Kunyit (Curcuma Longa Linn.) dilaporkan mempunyai potensi dalam menghambat ACE secara in vitro. Tujuan penelitian ini adalah untuk prediksi interaksi penambatan golongan senyawa kurkumin dan artumeron  dengan asam-asam amino pada ACE dan menggunakan ligan native kaptopril sebagai ligan standarnya. Metode yang digunakan berupa skrining senyawa aktif golongan kurkumin dan artumeron secara farmakokinetika dengan prediksi ADMET, Lipinski Rule of Five dan simulasi penambatan molekul dengan program MOE. Berdasarkan hasil skrining dan simulasi penambatan molekul menunjukkan bahwa senyawa curcumin dapat berikatan dengan enzim ACE dengan afinitas pengikatan sebesar -6,032 kcal.mol-1 dengan situs pengikatan dengan asam amino Leu 342 lebih baik dibandingkan dengan captopril yang mempunyai nilai afinitas pengikatan sebesar 4,427 kcal.mol-1 dengan situs pengikatan dengan asam amino Glu 342, Pro 344 dan Thr 345. Hasil ini menunjukkan senyawa curcumin  dapat dijadikan sebagai kandidat bahan alami dalam pengobatan antihipertensi karena secara prediksi in silico memiliki kemampuan yang tidak berbeda jauh dengan kaptopril. Kata Kunci:         ACE, antihipertensi, in silico, Curcuma Longa Linn.
Potential Toxicity of Legundi Leaf Extract (Vitex Trifolia L) Using the Brine Shrimp Lethality Test (BSLT) Method Arifah, Zil; Efdi, Mai; Syafrizayanti, Syafrizayanti
Journal of The Indonesian Society of Integrated Chemistry Vol. 16 No. 1 (2024): Journal of The Indonesian Society of Integrated Chemistry
Publisher : Pendidikan Kimia FKIP Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jisic.v16i1.33115

Abstract

Many natural products can be used as starting points in developing modern medicines because of their capabilities in pharmacological activities. Vitex trifolia L is an herbal plant that has been used to treat diseases such as fever, inflammation, colds, irregular menstruation, and diseases related to the female reproductive organs. This study aims to identify the cytotoxic ability of Vitex trifolia L leaf extract using the Brine Shrimp Lethality Test (BSLT) method. Extraction was carried out by maceration and fractionation methods, followed by phytochemical assay and cytotoxic assay using BSLT method. The results showed that the n-hexane extract had a moderate cytotoxic effect (LC50 241 µg/ml), the methanol extract included in the low toxic category (LC50 995 µg/ml) and the other two extracts involved in the non-toxic category (ethyl acetate and butanol).
Antioxidant of Ethanol Extract and Toxicity of Fractions from Aspergillus unguis a Marine Sponge Symbiont of Aaptos suberitoides Masyerli, Scify Bilqis Nawafi; Efdi, Mai; Bashari, Muhammad Hasan; Untung Kurnia Agung, Mochamad; Subhan, Beginer; Efahmi, Efahmi; Andriani, Yosie; Syafrizayanti, Syafrizayanti
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 1 (2025): February 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i1.14645

Abstract

The marine sponge Aaptos suberitoides has been shown to have anticancer properties, with clear evidence of its capacity to suppress the growth of cancer cells. However, the pharmaceutical exploration of chemicals from marine organisms causes significant environmental concerns. Aspergillus unguis, a fungal symbiont of the marine sponge A. suberitoides, has been isolated for its potential in sustainable natural products resources. This study assesses the antioxidant activity of ethanol extract and the toxicity of four levels fractions from ethanol extracts of A. unguis mycelium and these results were reported for the first time in this study. The antioxidant of ethanol extract was determined using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) method. The fractions were examined for toxicity using the Brine Shrimp Lethality Test (BSLT). The ethanol extract of A. unguis shows very strong antioxidant bioactivity (IC50 = 42.84 mg/L). The LC50 values for hexane, chloroform, ethyl acetate, and butanol fractions were determined to be 74.11 µg/mL, 93.84 µg/mL, 59.37 µg/mL, and 142.79 µg/mL, respectively. It indicates significant toxicity. These preliminary results are important knowledge for further research into the bioactivity potential of the metabolites as candidate anticancer compounds, aligning with marine pharmaceutical drug development.
Enzymatic Biodegradation of Polyethylene Terephthalate (PET) by Crude Lipase from Geotrichum candidum Nurul Haviza; Armaini; Syafrizayanti Syafrizayanti
Indonesian Journal of Chemical Studies Vol. 4 No. 2 (2025): Indones. J. Chem. Stud. December 2025
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v4i2.90

Abstract

The issue of plastic waste, particularly polyethylene terephthalate (PET), has become a major global environmental concern due to its resistance to natural degradation. One promising approach to addressing PET waste is the use of lipase enzymes produced by microorganisms. This study aims to explore the potential of the fungus Geotrichum candidum J1 to produce crude lipase enzymes capable of degrading PET plastic. The research involved stages including isolation and rejuvenation of the fungus, enzyme production through solid-state fermentation, and lipase activity assay using the cup-plate method. Subsequently, PET degradation testing was carried out using the crude enzyme extract under controlled conditions for 30 days. The results indicated that the crude lipase from G. candidum J1 exhibited lipolytic activity, as evidenced by clear zones formed on selective media. The average total protein yield reached 2.992 ± 0.05 mg/mL, indicating stable fermentation. Degradation tests showed a weight loss of PET between 5.9% and 6.4%. Characterization by Fourier Transform Infra Red (FTIR) confirmed the cleavage of ester bonds in PET structure, evidenced by spectral changes in carbonyl groups. Observations using a Scanning Electron Microscope (SEM) revealed morphological changes, including cracks and pores, on the PET surface post-treatment. In conclusion, the crude lipase from G. candidum J1 demonstrates significant potential as a biodegradation agent for reducing PET plastic pollution in an environmentally friendly manner.
Evaluation of Antioxidant Activity and In Silico Prediction of Bioactive Compounds from the n-Hexane Extract of Gracilaria compressa (C. Agardh) Greville Syafrizayanti Syafrizayanti; Andre Priandoko; Mai Efdi
Indonesian Journal of Chemical Studies Vol. 5 No. 1 (2026): Indones. J. Chem. Stud. June 2026
Publisher : Indonesian Scholar Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55749/ijcs.v5i1.128

Abstract

This study evaluated the antioxidant potential and in silico pharmacological properties of the n-hexane extract of Gracilaria compressa (C. Agardh) Greville. Antioxidant assays using DPPH and ABTS radicals demonstrated moderate to strong scavenging activities, with IC₅₀ values of 74.51 mg/L and 58.81 mg/L, respectively. LC–MS/MS profiling identified several major lipophilic compounds, including uvaretin, mangostanol, and palmitic acid. Molecular docking simulations against Cyclooxygenase-2 (COX-2) revealed that uvaretin exhibited the strongest binding affinity (–9.0 kcal/mol), supported by hydrogen bonding and hydrophobic interactions with key active-site residues. Pharmacokinetic evaluation based on Lipinski’s Rule of Five indicated favorable drug-likeness and bioavailability properties for the identified compounds. These findings suggest that G. compressa n-hexane extract contains bioactive constituents with promising antioxidant and anti-inflammatory potential for further pharmacological development of marine-derived compounds as candidate therapeutics agents, particularly in the design of natural COX-2 inhibitors, and supports their potential application in pharmaceutical and nutraceutical formulations.
Analisis Potensi Produksi Enzim Amilase oleh Beberapa Species Bacillus serta Penentuan Aktivitasnya secara Kualitatif dan Kuantitatif Geliz Luh Titisari; Nurul Haviza; Aken Putri Nandi Nanti; Syafrizayanti syafrizayanti; Prima Fitria Hillman
Jurnal Kimia Unand Vol. 15 No. 1 (2026): Mei 2026
Publisher : Departemen Kimia Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jku.15.1.1-7.2026

Abstract

This study aimed to analyze the potential of several Bacillus species—Bacillus subtilis, Bacillus thuringiensis, and Bacillus cereus—in producing amylase enzymes and to determine their enzymatic activity both qualitatively and quantitatively. Screening was conducted using starch agar medium, where the formation of clear hydrolysis zones indicated amylase activity. Growth curve analysis was used to determine the optimal harvesting period based on the bacterial growth phase. Enzyme production was carried out in a nutrient medium containing starch, and the crude enzyme extract was tested for activity using the Somogyi–Nelson method. The results showed that all Bacillus species tested exhibited amylolytic activity, with B. subtilis showing the highest amylolytic index (1.97). However, B. cereus demonstrated the greatest enzymatic performance, with an enzyme activity of 0.219 U/mL and a specific activity of 8.193 U/mg protein. These findings indicate that B. cereus possesses strong physiological and genetic potential to produce high levels of extracellular amylase compared to B. subtilis and B. thuringiensis. Therefore, B. cereus can be considered a promising candidate for industrial amylase production, and further optimization of fermentation conditions is suggested to enhance enzyme yield and catalytic efficiency.
Co-Authors Abdi Dharma Abdi Wira Septama Agustian, Dede Rahman Aisyah, Siti Zanuba Aken Putri Nandi Nanti Alfath, Yuma Nur Andre Priandoko Anggela Marta Tasman Arifah, Zil Armaini Armaini Armaini, Armaini Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan Cori Yolanda Elise Dondy Arafat Efahmi, Efahmi Elfahmi Elfahmi, Elfahmi Elise, Cori Yolanda Geliz Luh Titisari Hillman, Prima Fitria Iolantri Handra Jurnal Riset Kimia, Editor in Chief Kusnanda, Arif Juliari Mai Efdi Mai Efdi Marniati Salim Masyerli, Scify Bilqis Nawafi Mochamad Untung Kurnia Agung Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ni Kadek Dita Cahyani, Ni Kadek Dita Novriyandi Hanif Nurhayati Nurul Haviza Nurul Haviza Rahma, Diny Hazita Rahmadani Wulandari Riga, Riga S. Safni Sani, Lalu M. Iqbal Susanti, Febria Elvy Titisari, Geliz Luh Wulandari, Rahmadani Yosie Andriani Zara Aulia Zulkarnain Chaidir