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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Riset Kimia Jurnal Litbang Industri CHEMPUBLISH JOURNAL Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Jurnal Hilirisasi IPTEKS (JHI) Fullerene Journal of Chemistry Hydrogen: Jurnal Kependidikan Kimia Jurnal Litbang Industri Indonesian Journal of Chemical Studies (Indones. J. Chem. Stud.) Journal of The Indonesian Society of Integrated Chemistry Jurnal Kimia Unand Jurnal Sains dan Kesehatan
Syafrizayanti, Syafrizayanti
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Andalas Kampus Limau Manis, Padang, Sumatera Barat, 25163, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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PENERAPAN TEKNOLOGI PENGOLAHAN SAMPAH ORGANIK BERBASIS ZERO WASTE YANG BERNILAI EKONOMIS DI SUMATERA BARAT Deni Novia; Robi Amizar; Fitrimawati Fitrimawati; Syafrizayanti Syafrizayanti
Jurnal Hilirisasi IPTEKS Vol. 5 No. 1 (2022)
Publisher : LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jhi.v5i1.564

Abstract

Plastic waste gets special attention to deal with it, but the largest waste in the final disposal site is organic waste, about 60% dominates the amount of existing waste. Organic waste if processed and used for daily life can actually provide additional income if taken seriously. The purpose of this activity is to provide knowledge and skills for female partner organization partners, especially from students who live in West Sumatra, about zero waste so that it can process organic waste into several products that are useful and have economic value on a household scale. The activity methods were directives, counseling/awareness/socialization, training, mentoring and business consulting. The stages of implementation were 1) planning the right activities according to the needs of partners, 2) mentoring webinars, 3) evaluation. Based on the activity that have been carried out, it could be concluded that 1) Partners need assistants to solve the waste problem in Partner households, 2) The zero waste mentoring webinar activity had been carried out online using the zoom application, which was attended by more than 108 the participants who came from students and the public were enthusiastically by three presenters as well as reliable practitioners in their respective fields with the topics of eco enzymes, indigenous microorganisms (IMO), waste - maggot - compost. 3) Participants were very impressed with the zero waste webinar and asked to be followed up on other webinars. 4) The eco enzyme, MOL and compost training activities would be held offline and a visit to Minagot.
Simulasi Inhibisi Aktivitas Enzim α-Amilase dan α-Glukosidase oleh Senyawa Bioaktif Mikroalga Spirulina platensis Syafrizayanti Syafrizayanti; Adetya Putri; Marniati Salim; Arif Juliari Kusnanda
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.73120.223-233

Abstract

Diabetes Melitus (DM) Tipe 2 merupakan penyakit dengan gejala hiperglikemia dengan jumlah kasus yang meningkat setiap harinya pada populasi dunia. Enzim yang berperan terkait DM Tipe 2 yaitu α-amilase dan α-glukosidase yang bertindak dalam menghidrolisis pati pada pankreas. Target terapi dalam pengobatan DM Tipe 2 yaitu penurunan reabsorpsi glukosa di usus dengan melakukan penghambatan enzim α-amilase dan α-glukosidase. Tujuan penelitian ini adalah untuk mencari senyawa bioaktif yang terkandung dalam ekstrak Spirulina platensis yang berpotensi menjadi inhibitor α-amilase dan α-glukosidase sebagai antidiabetes secara in silico. Metode yang digunakan berupa skrining senyawa aktif dari literatur, farmakokinetika dengan prediksi ADMET, Lipinski’s Rule of Five dan simulasi penambatan molekul dengan program MOE. Berdasarkan hasil skrining dan simulasi penambatan molekul menunjukkan bahwa senyawa 4-amino-benzoat dapat berikatan dengan enzim α-amilase dengan afinitas pengikatan sebesar -4,16 kcal.mol-1 dengan situs pengikatan dengan asam amino His 299 dan Asp 195, dan berikatan dengan enzim α-glukosidase dengan afinitas pengikatan sebesar -4,08 kcal.mol-1 dengan situs pengikatan dengan asam amino Asn 58 dan Arg 17. Hasil ini menunjukkan senyawa 4-amino-benzoat dari mikroalga Spirulina platensis dapat dijadikan sebagai kandidat bahan alami dalam pengobatan antidiabetes.Inhibition Activity Simulation of α-Amylase and α-Glucosidase Enzyme by Bioactive Compounds of Microalgae Spirulina platensis. Diabetes Mellitus (DM) Type 2 is a disease with symptoms of hyperglycemia, in which its case number is increasing daily in the world population. Enzymes playing a role related to Type 2 DM, namely α-amylase and α-glucosidase, act in hydrolyzing starch in the pancreas. The therapeutic target in treating Type 2 DM is to decrease glucose reabsorption in the intestine by inhibiting the enzymes α-amylase and α-glucosidase. This study aimed to find bioactive compounds in Spirulina platensis extracts that can become α-amylase and α-glucosidase inhibitors as in silico antidiabetics. The method used was screening active compounds from the literature, pharmacokinetics with ADMET predictions, Lipinski’s Rule of Five, and molecular docking simulations with the MOE program. Based on the screening results and molecular docking simulations, it was shown that the 4-amino-benzoic compound could bind to the α-amylase enzyme with a binding affinity of -4.16 kcal.mol-1 with a binding site with the amino acids His 299 and Asp 195, and bind with the α-glucosidase enzyme with a binding affinity of -4.08 kcal.mol-1 with a binding site with the amino acids Asn 58 and Arg 17. These results show that the 4-amino-benzoic compound from Spirulina platensis microalgae can be a candidate for natural ingredients in antidiabetic treatment.
Isolasi Dan Karakterisasi Terpenoid Serta Uji Antioksidan Dari Ekstrak Kulit Batang Shorea singkawang Efdi, Mai; Syafrizayanti, Syafrizayanti; Sari, Dian Kumala
Chempublish Journal Vol. 1 No. 2 (2016): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.162 KB)

Abstract

Isolasi dan karakterisasi terpenoid dari fraksi etil asetat ekstrak kulit batang Shorea singkawang telah dilakukan. Senyawa ini diisolasi dengan metode maserasi, kromatografi kolom, dan rekristalisasi serta dikarakterisasi dengan metode spektroskopi. Terpenoid tersebut berupa padatan putih dengan titik leleh 140-142°C dan berdasarkan data GC menunjukkan adanya 1 puncak. Berdasarkan data spektroskopi UV dan IR, senyawa hasil isolasi dalam pelarut metanol menunjukkan serapan maksimum pada panjang gelombang 201 nm dan memiliki gugus –OH, -CH2, -CH3, dan geminal dimetil namun belum diketahui posisi dari gugus-gugus tersebut. Hasil uji antioksidan dengan metode DPPH menunjukkan ekstrak etil asetat memiliki potensi sebagai antioksidan dengan EC50 sebesar 0,075%. Kata kunci : Shorea singkawang, terpenoid, uji antioksidan  
Co-Authors Abdi Dharma Abdi Wira Septama Adetya Putri Agustian, Dede Rahman Aisyah, Siti Zanuba Aken Putri Nandi Nanti Alfath, Yuma Nur Andre Priandoko Anggela Marta Tasman Arif Juliari Kusnanda Arifah, Zil Armaini Armaini - Armaini, Armaini Ayu, Inna Puspa Bashari, Muhammad Hasan Beginer Subhan Cori Yolanda Elise D. Novia Dian Kumala Sari, Dian Kumala Dondy Arafat Efahmi, Efahmi Elfahmi Elfahmi, Elfahmi Elise, Cori Yolanda Fitrimawati Geliz Luh Titisari Hillman, Prima Fitria Iolantri Handra Jurnal Riset Kimia, Editor in Chief Kusnanda, Arif Juliari Mai Efdi Marniati Salim Marniati Salim Masyerli, Scify Bilqis Nawafi Mochamad Untung Kurnia Agung Nebuchadnezzar Akbar NEVIATY PUTRI ZAMANI Ni Kadek Dita Cahyani, Ni Kadek Dita Novriyandi Hanif Nurhayati Nurul Haviza Nurul Haviza Rahma, Diny Hazita Rahmadani Wulandari Riga, Riga Robi Amizar S. Safni Sani, Lalu M. Iqbal Susanti, Febria Elvy Titisari, Geliz Luh Wulandari, Rahmadani Yosie Andriani Zara Aulia Zulkarnain Chaidir