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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Jurnal Sains dan Teknologi Pangan Jurnal Mandala Pharmacon Indonesia Jurnal Pengabdian Masyarakat Ilmu Terapan (JPMIT) Lansau: Jurnal Ilmu Kefarmasian Molekul: Jurnal Ilmiah Kimia Borneo Journal of Pharmacy
Malaka, Muhammad Hajrul
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Mechanism Of Alpha Mangosteen As An Inhibitor Of Matrixmetalloproteinase-1 In Skin Cancer By In-Silico Study Fristiohady, Adryan; Arfan, Arfan; Asasutjarit, Rathapon; Haruna, Lidya Agriningsih; Purnama, La Ode Muhammad Julian; Sahidin, Idin; Malik, Fadhliyah; Kirana, Rezky Marwah; Kardin, Laode; Idrus, Loly Subhiaty; Malaka, Muhammad Hajrul
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.505

Abstract

?-mangostin (?-MG) is a metabolite of xanthones isolated from fruit of Garcinia mangostana Linn pericarps. Skin cancer is one of the most common malignancies affecting many people. The development of skin cancer is mainly due to intermittent or long-term exposure to ultraviolet (UV) radiation resulting in reduced cell-mediated immune response, production of reactive oxygen species (ROS), and DNA changes. Increased levels of ROS can induce the production of matrix metalloproteinases (MMPs). ?-MG showing potential as an anti-metastatic agent with reduced the expression of MMP-1. This study aims to determine the affinity and stability profiles of ?-MG as anti-skin cancer by applying the In-Silico method. Molecular simulation of ?-MG was successfully docked to the MMP-1. ?-MG showed stable results after 100 ns molecular dynamics simulation based on the root mean square deviation (RMSD) and the root mean squared fluctuation (RMSF). The binding energies of the xanthone derivatives were calculated using the MM/PBSA method.
Aktivitas Peningkatan Fagositosis Sel Makrofag oleh Ekstrak Etanol Buah Etlingera rubroloba A.D. Poulsen Pada Mencit Yang Distimulasi Antigen Mtb Badia, Esti; Yulianti, Sri Samrina; Rusli, Nirwati; Jabbar, Asriullah; Malaka, Muhammad Hajrul; Sahidin, Idin; Ilyas Y., Muhammad
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.649

Abstract

Peningkatan aktivitas fagositosis sel makrofag sangat dibutuhkan oleh penderita penyakit tubekulosis (TB) untuk melawan invasi patogenitas dari bakteri Mycobacterium tuberculosis (Mtb) dan mengatasi keparahan infeksi sehingga pengobatan akan lebih optimal. Pengoptimalan fagositosis sel makrofag dengan pemberian imunostimulator dari tumbuhan seperti buah Etingera rubroloba A.D Poulsen penting diungkap. Buah diyakini sebagai imunostimulator berdasarkan penggunaan empiris oleh masyarakat Sulawesi Tenggara untuk memelihara daya tahan tubuhnya serta menyembuhkan penyakit infeksi demam typhoid, dan secara ilmiah terbukti sebagai imunomodulator, antiinflamasi dan antioksidan. Tujuan penelitian ini adalah membuktikan aktivitas buah E. rubroloba meningkatkan aktivitas fagositosis sel makrofag pada penyakit TB. Jenis penelitian ini eksperimental menggunakan 30 ekor mencit jantan yang terdiri dari kelompok normal (tanpa infeksi Mtb), kelompok negatif (Na.CMC 0.5% + infeksi Mtb), kelompok positif (ekstrak meniran komersial + infeksi Mtb), kelompok ekstrak dosis 200 mg/kg BB + infeksi Mtb, kelompok ekstrak dosis 300 mg/kg BB + infeksi Mtb, kelompok ekstrak dosis 400 mg/kg BB + infeksi Mtb. Hewan uji diberikan perlakuan selama 7 hari dan pada hari ke-8 diinfeksi antigen Mtb (Esat-6)  secara intra perintonium. Peningkatan fagositosis sel makrofag dihitung dengan mikroskop, selanjutnya data yang diperoleh dianalisis statistik one way ANOVA dan uji post hoc tukey. Hasil penelitian menunjukan ekstrak etanol buah E.rubroloba terbukti meningkatkan aktivitas fagositosis sel makrofag pada mencit distimulasi Mtb yang berbeda signifikan dengan kontrol negatif (P<0.05). Penelitian ini berhasil mengungkap informasi ilmiah baru dari tumbuhan E.rubroloba sebagai imunostimulator pada infeksi TB, sehingga berpotensi dikembangkan sebagai agen imunostimulator baru pada penyakit TB.
Isolation and Identification of Secondary Metabolites from Etlingera rubroloba Rhizome and Their Biological Activity as Antimicrobial and Antioxidant Malaka, Muhammad Hajrul; Solo, Dian Munasari; Trinovitasari, Nita; Sahidin, Sahidin
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.9752

Abstract

ABSTRACT. Etlingera is a genus known for its potential medicinal properties. Etlingera rubroloba A.D. Poulsen is a recently identified species within the Etlingera genus found in Southeast Sulawesi. This study aims to isolate and identify secondary metabolite compounds from the methanol extract of the E.rubroloba A.D. Poulsen rhizome and its activity as an antimicrobial and antioxidant. The compound was isolated by using Thin Layer Chromatography (TLC), Vacuum Liquid Chromatography (VLC), and Radial Chromatography (RC) techniques. Isolated compounds were identified by 1H and 13C NMR spectroscopy techniques and compared the data with reference. Antimicrobial tests were carried out on Escherichia coli, Streptococcus mutans, and Candida albicans by broth microdilution method. The antioxidant test was carried out using the 1,1-dipheny1-2-picrylhydrazyl (DPPH) method. Four isolated compounds were successfully isolated : stigmasterol (1); 1,7-diphenyl-6-hepten-3-on; (2); and 1,7-diphenyl-heptan-3-on (3); and sinapyl alcohol diacetate (4). Antimicrobial activity test results extract were active against all bacteria and C. albicans. The results of antioxidant activity test showed that extract, compound 2, 3, and 4 had strong and medium antioxidant activity with IC50 values at 75.05 μg/mL; 201.4 μg/mL; 207.88 μg/mL, and 190.59 μg/mL, respectively. Keywords: antioxidant, antimicrobial, DPPH, Etlingera, isolation
Co-Authors Andriani, Rina Arfan Arfan Asasutjarit, Rathapon Aspadiah, Vica Asrul Sani, Asrul Badia, Esti Daud, Nur Saadah Fadhliyah Malik Fristiohady, Adryan Hamid, Mustakim Haruna, Lidya Agriningsih Hasanuddin, Didi Dharmadi Idrus, Loly Subhiaty Ilyas Y, Muhammad Ilyas Y., Muhammad Indalifiany, Astrid Jabbar, Asriullah Justawan, H. Kardin, Laode Karmilah, Karmilah Kirana, Rezky Marwah Mawarni, Indah Mugiarno, Dita Oktavianti Musadar Mappasomba Musdalipah Musdalipah, Musdalipah Nurpajriani, Nurpajriani Parrung, Arsyani Pascayantri, Asniar Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian RAHMAT MULIADI, RAHMAT Rini Hamsidi Rusli, Nirwati Sahidin . Sahidin, Idin Sahidin, S Solo, Dian Munasari Sutardi Sutardi Trinovitasari, Nita W Wahyuni, W Wirasmanto, Bayu Yamin, Muh Yodha, Agung Wibawa Mahatva Yulianti, Sri Samrina Zubaydah, Wa Ode Sitti Zulbayu, La Ode Muhammad Andi