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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Pengabdian Magister Pendidikan IPA INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Analis Kesehatan Kendari
Fusvita, Angriani
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Religion Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Public Health Social Sciences Other

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Steroidal and Potential Anti-inflammatory Properties of Carteriospongia sp from the Southeast Sulawesi Sea Coast Daud, Nur Saadah; Yodha, Agung Wibawa Mahatva; Musdalipah, Musdalipah; Fusvita, Angriani; Firdayanti, Firdayanti; Sahidin, Sahidin; Arfan, Arfan; Fristiohady, Adryan; Sadarun, Baru
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 30, No 3 (2025): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.30.3.453-464

Abstract

Marine sponges are an abundant yet underutilized resource in Southeast Sulawesi, Indonesia, despite their ecological roles and pharmacological potential. Steroidal metabolites are dominant in many sponge species and have been widely recognized for their strong anti-inflammatory activity. However, the chemical composition and biological potential of Carteriospongia sp from Indonesian waters remain unexplored. Carteriospongia sp was extracted using the Soxhlet method, and the chemical profile was analyzed by Gas Chromatography–Mass Spectrophotometry (GC-MS). Anti-inflammatory activity was evaluated in vitro using the Bovine Serum Albumin (BSA) protein denaturation assay, with methylprednisolone as the positive control. Molecular docking studies were performed to assess the interactions between steroidal compounds and BSA protein. GC-MS analysis identified eight steroidal compounds such as 2-methylenecholestan-3-ol (S1), stigmasterol (S2), 4,4-dimethyl-cholesta-8,24-dien-3-ol (S3), 8,14-seco-3,19-epoxyandrostane-8,14-dione, 17-acetoxy-3ß-methoxy-4,4-dimethyl (S4), cholic acid ethyl ester (S5),  (3ß,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-3,24,25-triol (S6), stigmastan-3-en-6-ol (S7), ß-sitosterol (S8). The extract demonstrated concentration-dependent inhibition of protein denaturation, achieving 84.81% inhibition at 128 mg.L-1. The IC50 value was 3.71 mg.L-1, comparable to methylprednisolone (IC50 4.45 mg.L-1). Molecular docking revealed that compound S1 and S4 exhibited lower binding energies than other steroids, suggesting stronger stabilization of BSA protein. The findings demonstrate that Carteriospongia sp extract possesses significant anti-inflammatory potential, comparable to methylprednisolone. This study provides novel insights into the bioactive potential of Indonesian marine sponges and emphasizes the importance of further pharmacological and molecular studies to develop sponge-derived steroidal compounds as alternative or complementary anti-inflammatory therapeutics.
Assessement of Candida albicans of the oral mucosa among type-2 diabetes mellitus patients attending Bahteramas Hospital, Southeast Sulawesi Province Firdayanti, Firdayanti; Fusvita, Angriani; Umar, Ani
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

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Abstract

Diabetes Mellitus (DM) is a disease characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance. Candida albicans is a fungus generally found on the surface of the mucous membrane, which usually dominates and overgrows among DM patients. This study aims to identify the presence of the C. albicans fungus on the oral mucosa of individuals with Type-2 Diabetes Mellitus at Bahteramas Hospital, Southeast Sulawesi Province, Indonesia. A descriptive study was employed, and a purposive sampling technique was used to select a sample of 62 patients. Swab samples were cultured on Potato Dextrose Agar medium for Gram staining and carbohydrate assimilation tests. The resulting culture was tested using CHROMagarTM Candida (CAC) media. Among the 62 samples, 56 samples were identified to have a convex colony, a cream-color surface, a smooth texture, and a Gram-positive nature. The carbohydrate assimilation test showed that the indicated samples could ferment glucose and maltose, but not lactose and sucrose. Green colonies are formed through CHROMagarTM Candida differential media testing. There are 56 identification results for C. albicans from oral mucosal swab samples from 62 patients with Type-2 Diabetes Mellitus at the Bahteramas Hospital, Southeast Sulawesi Province, yielding six other patients with negative results.
Pencegahan Kecacingan Melalui Pendampingan Pembiasaan Pola Hidup Bersih Sehat dan Pemeriksaan Kecacingan pada Anak-Anak Di SD Negeri 3 Konawe Selatan: Pencegahan Kecacingan Melalui Pendampingan Pembiasaan Pola Hidup Bersih Sehat dan Pemeriksaan Kecacingan pada Anak-Anak Di SD Negeri 3 Konawe Selatan Aulya, Muhammad Sultanul; Idris, Sri Aprilianti; Fusvita, Angriani; firdayanti, Firdayanti; Fusvita; Umar, Ani; Idris, Kemal; Wenty, Darmayanita
Jurnal Pengabdian Magister Pendidikan IPA Vol 6 No 4 (2023): Oktober-Desember 2023
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpmpi.v6i4.6202

Abstract

Worm infections caused by Soil Transmitted Helminth (STH) are intestinal nematode worms which are transmitted through the soil in their life cycle. The various kinds of nematode class worms that are known are roundworms (Ascaris Lumbricoides), whipworms (Trichuris trichiura) and hookworms (Ancylostoma duodenale and Necator americanus). Worms have a very bad effect on health, in children worms will have an impact on learning disorders, decreased quality of intelligence and reduced nutritional intake. The aim of this community service activity is to provide socialization on the prevention of worms through assistance in getting used to a clean, healthy lifestyle and checking for worms among children at SD Negeri 3 Konawe selatan. The respondents in this activity were children at SD Negeri 3 Konawe selatan and 31 stool samples were obtained. The results of stool examination using the direct method on 31 children's stool samples did not find positive samples and 31 children's stool samples did not contain intestinal nematode worm eggs.
UJI DAYA HAMBAT EKSTRAK DAUN PATIWALA (Lantana camara L)TERHADAP PERTUMBUHAN BAKTERI Streptococcus mutans ATCC 25175 Afdillah, Nia; Fusvita, Angriani; Febriyani, Rani
Jurnal Analis Kesehatan Kendari Vol. 6 No. 1 (2023): Jurnal Analis Kesehatan Kendari (JAKK) : Vol. 6 (1) Desember 2023)
Publisher : Program Study of Medical Laboratory Technology , Politeknik Bina Husada Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46356/jakk.v6i1.289

Abstract

ABSTRACT Indonesia has high natural resources and biodiversity, consisting of a number of islands with 34 provinces that have a variety of ethnicities and cultures. Medicinal culture has been proliferating since ancient times which has been preserved from generation to generation. This traditional medicine can be used as a medicine and around 300 types have been utilized for traditional medicinal ingredients.This study was to determine the patiwala leaf extract and its concertation in inhibiting the growth of Streptococcus Mutans bacteria. This research is a labolatory experimental research witch is a quqntitative study. This research method is to explain the cause and effect between one variable and another variable. This research was conducted using 2 methods of the kruskallwallis test and the normality test with the help of the SPSS application. The result of the Kruskallwallis test and normality text with normal result with values (p>0,41) and (p<0,01). Patiwala leaf extract (Lantana camara L) has different abilities against the growth of Streptococcus Mutans bacteria. Keywords : Patiwala Leaves, Lantana camara L, Inhibition ABSTRAK Indonesia memiliki sumber daya alam dan keanekaragaman hayati yang tinggi, terdiri dari jumlah pulau dengan 34 provinsi yang memiliki beranekaragaman suku dan budaya. Budaya pengobatan sangat berkembang sejak dulu yang sangat dilestarikan secara turun-temurun. Pengobatan tradisional ini dapat digunakan sebagai obat dan sekitar 300 jenis yang sudah di manfaatkan untuk bahan obat tradisional. Penelitian ini adalah untuk mengetahui ekstrak daun patiwala dan konsentrasi dalam menghambat pertumbuhan bakteri Streptococcus Mutans. Penelitian ini adalah penelitian eksperimen laboratorium merupakan suatu penelitian kuantitatif. Metode penelitian ini yaitu menjelaskan sebab akibat bahwa antara satu variable dengan varibel lainya. Penelitian ini di lakukan dengan menggunakan 2 metode uji kruskall wallis test dan uji normalitas dengan bantuan aplikasi SPSS. Hasil uji kruskall wallis test dan uji normalitas dengan hasil normal dengan nilai (p<0,41) dan (p<0,01). Ekstrak daun patiwala (Lantana camara L) yang memiliki kemampuan yang brbeda-beda terhadap pertumbuhan bakteri Streptococcus mutans Kata Kunci: Daun patiwala, Lantana camara L, Daya hambat
Pembuatan Teh Kombucha dengan Tambahan Tanaman Herbal sebagai Minuman Probiotik Kesehatan di Desa Soropia Idris, Sri Aprilianti; Pryangan, Wulandari; Karmilah, Karmilah; Firdayanti, Firdayanti; Fusvita, Angriani; Yodha, Agung Wibawa Mahatva; Wenty, Darmayanita; Susanti, Susanti; Zeptiano, Zeptiano; Dhea, Alisha
Jurnal Pengabdian Masyarakat: Pemberdayaan, Inovasi dan Perubahan Vol 5, No 6 (2025): JPM: Pemberdayaan, Inovasi dan Perubahan
Publisher : Penerbit Widina, Widina Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59818/jpm.v5i6.2226

Abstract

Kombucha tea is the result of the fermentation of tea and sugar solution using Symbiotic Culture of Bacteria and Yeast (SCOBY) which produces a drink with a fresh taste, distinctive aroma, and contains various bioactive compounds, such as organic acids, vitamins, and probiotics. The addition of herbal ingredients to kombucha tea, such as ginger, lemongrass, or mint leaves, can enhance the taste and improve health. Soropia Village as a coastal area has great potential in the development of products based on natural ingredients. However, limited knowledge and skills of the community in processing ingredients into value-added products remain a barrier. The purpose of community service is to increase knowledge and training to the community in Soropia Village on making kombucha tea with the addition of herbs as a health drink rich in probiotics. The methods used are socialization, education, training and evaluation. This activity was carried out in Soropia Village with the target group of the Soropia Village Family Welfare Movement (PKK). This training enables the community to know and understand how to make kombucha tea with the addition of herbal plants as a health drink that can be made into a product. The training and interviews following teh kombucha tea-making workshop demonstrated that all participants understood the material, with nearly 30 participants answering the questionnaire correctly. After the training, participants were able to independently make kombucha tea with ginger at home.ABSTRAKTeh kombucha merupakan hasil fermentasi larutan teh dan gula menggunakan Symbiotic Culture of Bacteria and Yeast (SCOBY) yang menghasilkan minuman dengan cita rasa segar, beraroma khas, serta mengandung berbagai senyawa bioaktif, seperti asam organik, vitamin, dan probiotik. Penambahan bahan herbal pada teh kombucha, seperti jahe, serai, atau daun mint, dapat meningkatkan cita rasa sekaligus dapat meningkatkan kesehatan. Desa Soropia sebagai salah satu wilayah pesisir memiliki potensi besar dalam pengembangan produk berbasis bahan alami. Namun, keterbatasan pengetahuan dan keterampilan masyarakat dalam mengolah bahan menjadi produk bernilai tambah masih menjadi kendala. Tujuan pengabdian untuk meningkatkan pengetahuan dan pelatihan kepada masyarakat di desa soropia tentang pembuatan teh kombucha dengan tambahan herbal  sebagai minuman kesehatan yang kaya probiotik. Metode yang digunakan adalah sosialisasi, edukasi, pelatihan dan evaluasi. Kegiatan ini dilaksanakan di desa soropia dengan target kelompok PKK desa Soropia. Pelatihan ini membuat masyarakat dapat mengetahui dan memahami bagaimana cara pembuatan teh kombucha dengan tambahan tanaman herbal sebagai minuman kesehatan yang dapat dijadikan produk. Hasil pelatihan dan wawancara setelah dilakukan pengabdian pembuatan teh kombucha, seluruh peserta memahami materi yang diberikan dengan hasil jawaban hampir 30 peserta menjawab kuesioner dengan benar. Setelah pelatihan, peserta dapat membuat teh kombucha dengan tambahan jahe secara mandiri dirumah.
Co-Authors Afdillah, Nia Arfan Arfan Aulya, Muhammad Sultanul Baru Sadarun Daud, Nur Saadah Dhea, Alisha Febriyani, Rani Firdayanti, Firdayanti Fristiohady, Adryan Fusvita Idris, Kemal Idris, Sri Aprilianti Karmilah, Karmilah Musdalipah Musdalipah, Musdalipah Pryangan, Wulandari Sahidin . Susanti Susanti Umar, Ani Wenty, Darmayanita Yodha, Agung Wibawa Mahatva Zeptiano, Zeptiano