Article Per Year (5 Year)
p-Index From 2021 - 2026
2.189
P-Index
This Author published in this journals
All Journal Jurnal Kesehatan Lingkungan indonesia Jurnal Sumberdaya Hayati Jurnal Surya Medika Jurnal Kedokteran Universitas Palangka Raya Journal of Experimental and Clinical Pharmacy (JECP) Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Barigas: Jurnal Riset Mahasiswa
Frethernety, Agnes
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Utilization of Fucoidan Based on Nanodelivery in Health Promotion Perspective, Molecular Mechanism, and Community Empowerment: A Scoping Review Alexandraa, Francisca Diana; Massi, Muh. Nassrum; Leman, Yanti; Manggau, Marianti A.; Frethernety, Agnes; Jayanti, Ira
Media Publikasi Promosi Kesehatan Indonesia (MPPKI) Vol. 8 No. 12: DESEMBER 2025 - Media Publikasi Promosi Kesehatan Indonesia (MPPKI)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i1.9131

Abstract

Introduction: Fucoidan is a sulfated polysaccharide derived from brown algae with proven anticancer, antioxidant, and immunomodulatory properties. However, its clinical utilization remains limited due to high molecular weight and low bioavailability. Recent advances in nanodelivery systems provide promising strategies to overcome these limitations and align with community-based health promotion initiatives. Methods: This scoping review adopted the PEOS framework (Population, Exposure, Outcome, Study Design) and PRISMA flow to map current evidence on fucoidan’s molecular mechanisms, nanocarrier innovations, and community empowerment perspectives. Literature searches were conducted in PubMed, ScienceDirect, EBSCO, and Google Scholar from 2015–2023 using keywords “fucoidan,” “nanoparticle,” “nanocarrier,” “molecular mechanism,” and “health promotion.” Twenty-three eligible articles were critically appraised using Hawker’s Quality Assessment Tool. Results: Fucoidan exhibits anticancer effects through upregulation of Bax, downregulation of Bcl-2, activation of caspases, and inhibition of angiogenesis via NF-?B, MAPK, and Nrf2 signaling pathways. Nanodelivery systems including chitosan fucoidan nanoparticles, PEGylated PLGA, hydrogels, and microneedle patches enhanced stability, absorption, and targeted efficacy. Preclinical studies demonstrated tumor inhibition, wound healing, and immunomodulatory benefits. From a public health perspective, fucoidan-based nanotechnology supports health promotion through increased scientific literacy, integration into Health Promoting Hospitals, and economic empowerment of coastal communities producing brown algae. Conclusion:Fucoidan represents a multifunctional bioactive compound whose efficacy is strengthened by nanodelivery innovation. Integrating molecular insights with health promotion and community empowerment creates a sustainable model linking biotechnology, preventive health, and local economic development. This review emphasizes the importance of interdisciplinary collaboration in translating marine biopolymers into accessible, evidence-based complementary therapies.
Differences in Urea And Creatinine Levels in St-Elevation Myocardial Infarction (STEMI) And Non-St-Elevation Myocardial Infarction (NSTEMI) at Dr. Doris Sylvanus Hospital Mallewa, Nurul Ilmi; Patricia, Tisha; Frethernety, Agnes; Permatasari, Silvani; Shinta, Herlina Eka
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 3 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i3.17663

Abstract

Acute Kidney Injury (AKI) in Acute Myocardial Infarction (AMI) patients occurs due to decreased blood flow to the kidneys. Decreased blood flow caused by blockage in coronary arteries of AMI patients both in ST-Elevation Myocardial Infarction (STEMI) and Non-ST-Elevation Myocardial Infarction (NSTEMI) which causes reduced blood flow so the oxygen supply carried by the blood to the myocardium is reduced. Decreased oxygen supply to myocardium reduces the heart's ability to pump blood throughout the body including to kidneys. Decreased blood flow to kidneys results decreased kidney function. Laboratory examination parameters commonly used to assess kidney function are urea and creatinine. This study aims to determine the differences urea and creatinine levels in STEMI and NSTEMI patients. This research method uses analytical observation with cross-sectional approach. Data urea and creatinine levels taken from medical records using a purposive sampling technique. Samples in this study was 170 people. Data analysis using the manwhitney test and the results of comparison of urea levels in STEMI and NSTEMI patients with a p value = 0.416 and for creatinine levels with a p value = 0.756. This means that there is no significant difference between urea and creatinine levels in STEMI and NSTEMI patients.
Literature Review: The Potential Activity of Secondary Metabolite Compounds in The Rutaceae Family Plants Against Streptococcus Mutans Elvariani, Ni Wayan Dessy Risma; Frethernety, Agnes; Furtuna, Dewi Klarita
Barigas: Jurnal Riset Mahasiswa Vol. 3 No. 3 (2025): Barigas: Jurnal Riset Mahasiswa
Publisher : Fakultas Kedokteran Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/barigas.v3i3.18883

Abstract

Dental caries is caused by Streptococcus mutans, with resistance to fluoride becoming a significant challenge, thus requiring new antibacterial alternatives. The purpose of this literature review is to examine the potential of metabolite compounds from the Rutaceae plant family against S. mutans through a systematic review. The method used includes a literature review from databases such as Google Scholar, PubMed, and Research Gate (2014–2024) following the PRISMA protocol. The analysis covers plants from the Rutaceae family, bacterial inhibition zone tests, and secondary metabolite content. A total of 15 journals (6 national, 9 international) demonstrated that the Rutaceae family plants possess strong antibacterial activity. Active compounds such as flavonoids, alkaloids, tannins, saponins, and terpenoids were found in the bark, leaves, and fruits of the plants. Extracts from the bark of Citrus aurantifolia showed the largest inhibition zone against S. mutans (28.7 mm). Flavonoids and tannins played a significant role in antibacterial activity. The conclusion derived is that the Rutaceae family has great potential as a natural antibacterial agent for the prevention of dental caries. These findings provide a foundation for developing safe and effective oral care products based on natural ingredients. Further research, particularly in the formulation of safe and effective natural-based oral care products
Co-Authors Abigail, Keshia Alexandra, Francisca Diana Alexandra, Francsisca Diana Alexandraa, Francisca Diana Amiani, Winney Aprelea, Reza Nathasya Balyas , Abi Bakring Berliani, Victoria Desimaria Panjaitan Dian Mutiasari, Dian Elsa Trinovita Elvariani, Ni Wayan Dessy Risma Elvina Damayanti Faradila, Faradila Fitri, Nurul Aulia Furtuna, Dewi Klarita Halisa, Nida Hanasia Handayani, Septi Jakung, Benedikta Cemara Raninai Jayanti, Ira Jelita, Helena Larasaty, Anggie Leman, Yanti Lestarisa, Trilianty Malik, Handayani Mallewa, Nurul Ilmi Marianti A Manggau Massi, Muh. Nassrum Nugrahini, Shinta Patricia, Tisha Permatasari, Silvani Prillyanisa , Pasca Purba, As Gaby Clarita Ranti, Dalia Rian Ka Praja Rovik, Anwar Sampurna Putra, Ravenalla Abdurrahman Al Hakim Sri Yuliani, Ni Nyoman Turnip, Oktaviani Naulita Widayati, Ratna Ysrafil, Ysrafil