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All Journal Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Journal Of Vocational Health Studies Jurnal Keperawatan Padjadjaran Jurnal Medik Veteriner PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ners SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Jurnal Layanan Masyarakat (Journal of Public Service) COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Asian Journal of Health Research Journal of Innovation Research and Knowledge Jurnal Pengabdian Masyarakat Bhinneka Folia Medica Indonesiana
Fatimah, Nurmawati
Department Of Anatomy, Histology, And Pharmacology, Faculty Of Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Effect of the leaf pettiveria alliacea extract active compound on mycobacterium tuberculosis Munir, Ratna Sofaria; Fatimah, Nurmawati; Hermanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Indonesia has a variety of herbal plants used as herbal/traditional medicines. Singawalang (Petiveria alliacea) is one of the herbal plants usually used in the United States as a cough medicine because of its expectorant effect. Singawalang plants are also widely used to cure tuberculosis. However, the investigations on the effects of toxicity on this plant leaf extract has not been done. This study aims to investigate the effects of active compounds in singawalang against Mycobacterium tuberculosis using a variety of solvents. The active compound of ethanol extract was obtained by maceration using ethanol solvent. The extract was then fractionated using column chromatography method, and using gradual eluent to produce fraction. The doses used were 0.5 mg/ml; 1 mg/ml; 2 mg/ml; 70% ethanol, h-hexane, benzene, chloroform, ethylacetate, silica gel 60GF254, Middlebrook 7H9, and 7H10. The reactions using Singawalang leaf extract with various solvents resulted in a reduction of the Mycobacterium tuberculosis colony growth, compared with the reaction on control treatment, treatment using DMSO 1%, and treatment using 70% ethanol. As a conclusion, the various solvents used did not make a significant difference. However, control treatment, treatment using DMSO 1%, and treatment using 70% ethanol had significant results.
Effects of Tamarillo (Solanum betaceum) Extract on Glutathione Peroxidase Expression and Inflammatory Reactions in Lead Acetate-Induced Lung Tissue of Mice Harjono, Shella; I’tishom, Reny; Rahniayu, Alphania; Fatimah, Nurmawati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4460

Abstract

Background: Lead acetate exposure through oral route has a significant impact on lung tissue as lead can induces the formation of reactive oxygen species (ROS), resulting in decreased glutathione peroxidase (GPx) and triggering inflammatory responses. The induction of exogenous antioxidants may prevent this mechanism. This study aimed to evaluate the protective effect of Tamarillo ethanol extract on GPx expression and inflammatory reactions in the lung tissue of mice induced with lead acetate.Methods: This true experimental laboratory study utilized stored formalin-fixed-paraffin-embedded (FFPE) lung tissue  from 30 male mice (Mus musculus). The samples were divided into five intervention groups, each consisting of six mice. Immunohistochemistry and histopathology assessments were performed at 100x and 400x magnification to evaluate the GPx expression using the H-score and to assess inflammatory reactions based on five scoring parameters, which were summed to obtain the total lung injury score.Results: Lead exposure significantly increased inflammatory reactions, particularly in the hemorrhage parameters (p=0.041). A significant increase in GPx expression was observed following lead acetate administration (p=0.027). Administration of Tamarillo ethanol extract at a dose of 400 mg/kgBW increased GPx expression compared with the positive control group (p=0.027).Conclusion: Tamarillo ethanol extract, especially at a dose of 400 mg/kgBW, significantly increases GPx expression in lead acetate-induced lung tissue of mice. This finding highlights the potential role of Tamarillo extract as an antioxidant source to reduce lead-induced lung injury, supporting broader efforts to promote healthy lifestyle practices that protect against environmental toxin exposure.
Pengaruh Jus Buah Delima (Punica granatum) sebagai Agen Antioksidan pada Tikus Putih (Rattus norvegicus) yang Diinduksi Larutan Complete Freund’s Adjuvant (CFA) melalui Jalur Penurunan Kadar Malondialdehid (MDA) Shayla Kokomi Rishardy; Nurmawati Fatimah; Gadis Meinar Sari; Mohammad Fathul Qorib
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51842

Abstract

Inflamasi kronis berkontribusi pada berbagai penyakit degeneratif, sehingga diperlukan terapi alternatif berbasis antioksidan alami. Buah delima (Punica granatum) kaya akan polifenol, flavonoid, dan tanin yang memiliki potensi antioksidan dan antiinflamasi. Penelitian ini bertujuan untuk mengevaluasi pengaruh jus buah delima terhadap kadar malondialdehid (MDA) sebagai penanda stres oksidatif pada tikus Wistar jantan yang diinduksi Complete Freund’s Adjuvant (CFA). Penelitian eksperimental menggunakan rancangan post-test only control group design dengan empat kelompok: kontrol negatif (K–), kontrol positif (K+), serta dua kelompok perlakuan (P1: 16,7% jus delima; P2: 33,3% jus delima). Jus diberikan secara oral selama 28 hari. Analisis data menggunakan uji Shapiro-Wilk dan Levene untuk uji normalitas dan homogenitas, dilanjutkan dengan ANOVA satu arah dan uji post hoc LSD atau uji non-parametrik Kruskal-Wallis dan Mann-Whitney U jika data tidak normal. Hasil menunjukkan bahwa kadar MDA tertinggi terjadi pada K+, sedangkan P1 dan P2 mengalami penurunan signifikan (p<0,05). Temuan ini mengindikasikan bahwa jus delima efektif menurunkan stres oksidatif melalui penghambatan peroksidasi lipid, mendukung potensinya sebagai agen terapeutik alami dalam manajemen inflamasi.
Pengaruh Jus Buah Delima (Punica granatum) sebagai Agen Anti-inflmasi pada Tikus Putih (Rattus norvegicus) yang Diinduksi Larutan Complete Freund’s Adjuvant (CFA) melalui Jalur Penurunan Kadar Sitokin Pro-inflamasi TNF-α Muhammad Axel Arsyad; Nurmawati Fatimah; Gadis Meinar Sari; Mohammad Fathul Qorib
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52488

Abstract

Reaksi alami tubuh terhadap kerusakan atau penyakit adalah peradangan, yang ditandai dengan peningkatan mediator pro-inflamasi seperti TNF-α. Karena Complete Freund's Adjuvant (CFA) dapat menimbulkan peradangan kronis dan respons imunologis seluler, zat ini sering digunakan sebagai model induksi peradangan. Punicalagin, asam ellagic, dan flavonoid yang terdapat dalam buah delima (Punica granatum) memiliki sifat anti-inflamasi dan antioksidan yang dapat mengurangi respons inflamasi. Dalam eksperimen laboratorium ini, digunakan lima kelompok tikus jantan putih (Rattus norvegicus) dengan desain kelompok kontrol pasca-tes saja. Kelompok-kelompok tersebut meliputi kelompok kontrol negatif, kelompok kontrol positif (CFA), kelompok vitamin C, dan dua kelompok perlakuan yang menerima dosis oral jus delima yang bervariasi selama 28 hari. Jus delima secara signifikan (p<0.05) menurunkan kadar TNF-α pada tikus yang diinduksi CFA dibandingkan dengan kelompok kontrol positif, dengan penurunan terbesar terjadi pada dosis tertinggi, menurut data. Oleh karena itu, telah dibuktikan bahwa jus delima memiliki sifat antiinflamasi dengan menurunkan kadar sitokin pro-inflamasi TNF-α.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Januar Er Putra Afif Nurul Hidayati Akbar Kurniawan, Mohammad Alpha Fardah Athiyyah Alphania Rahniayu Amatullah, Nida' Fahima Amustikarani, Dewa Ayu Praba Annette d’Arqom, Annette Arifa Mustika Bambang Hermanto Christian Susianto, Steven Damayanti Damayanti Dau, Daniel Dhia Farhan Taufik Dimyati, Sinta Diyah Doman, Zahras Azimuth Edith Frederika Puruhito, Edith Frederika Farhan Nurdiansyah Finna Permata Putri Harjono, Shella Herisulistyo, Aldilatama Herley Windo Setiawan Herwanto, Bambang I Dewa Ayu Sudiari Dewi I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Insyira Rayhana Irsan Irsan, Insyira Rayhana Izzatul Fithriyah I’tishom, Reny Khaerunnisa, Siti Kusuma Eko Purwantari Linda Dewanti Maftuchah Maftuchah Mhd Zamal Nasution Mohammad Fathul Qorib Muhammad Axel Arsyad Mukhoirotin Mukhoirotin Myrna Adianti Nilamsari, Karina Ayu Nurina Hasanatuludhhiyah Nurrosyidah, Iif Hanifa Paramitha, Nabilah Prabowo, Gwenny Ichsan Purba, Abdul Khairul Rizki Raden Mohamad Herdian Bhakti Rania Ratri Fauziyah Ratna Sofaria Munir, Ratna Sofaria Rini Hamsidi Sakina Sakina, Sakina Sari, Gadis Meinar Shayla Kokomi Rishardy Sri Murtiwi Sri Purwaningsih Stefanus, Lusiana Steven Christian Susianto Suhariningsih Suharno, Novianto Edi Sulistiawati Sulistiawati Sumardiko, Dwi Setiani Sutji Kuswarini Sutji Kuswarini Toyib, Muchammad Tri Hartini Yuliawati Trimitasari, Kurnia Turchan, Agus Vita, Angelica Diana Wening Hapsari William Andrew Isaac Yuani Setiawati Yusuf, Muhtarum