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All Journal Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Journal Of Vocational Health Studies Jurnal Keperawatan Padjadjaran Jurnal Medik Veteriner PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Jurnal Layanan Masyarakat (Journal of Public Service) COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Asian Journal of Health Research Journal of Innovation Research and Knowledge Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Fatimah, Nurmawati
Department Of Anatomy, Histology, And Pharmacology, Faculty Of Medicine, Universitas Airlangga
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Treatment of Acute Diarrhea in Children Aged 1–5 Years Provided by Doctors in Surabaya Athiyyah, Alpha Fardah; Irsan, Insyira Rayhana; Fatimah, Nurmawati
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. The focus of this study was on the treatment methods for acute diarrhea, which have not been extensively investigated in the region studied. 2. This study can provide an overview of doctors' adherence to the available guidelines for the treatment of acute diarrhea in children aged 1–5 years in Surabaya, Indonesia. Abstract: Diarrhea is the second leading cause of death among children under five, following pneumonia. Insufficient knowledge of diarrhea and dehydration management may contribute to this high mortality rate. Implementing prompt and effective management and prevention strategies has the potential to decrease morbidity and mortality associated with diarrhea. Therefore, this cross-sectional study aimed to investigate the treatment methods used by doctors for children aged 1–5 suffering from acute diarrhea in Surabaya, Indonesia. Data were collected from doctors in Surabaya using an online form containing case-based questions. Microsoft Excel for Mac version 16.17 (Microsoft Inc., Redmont, WA, USA) was used to process the binary data by calculating frequencies and percentages with a point estimate of 95% confidence interval (CI). A descriptive method was used in the data analysis, and the findings were presented in tables. From a total of 51 respondents who participated in this study, 18 (35.29%) only administered oral rehydration therapy. In addition, 49 respondents (96.08%) prescribed zinc supplementation for ten days, while 10 respondents (19.61%) opted for antibiotics. Interestingly, 49 respondents (96.08%) recommended both breast milk and food for the patients, and nearly all respondents provided guidance to the mother or caregiver of the patient. The findings of this study suggested that the respondents primarily used rehydration therapy to treat children suffering from acute diarrhea with moderate dehydration. However, some respondents still relied on antibiotics despite the available recommendations to use oral rehydration therapy. Nearly all respondents agreed on zinc supplementation, breast milk and food provision, and advice for the mother or caregiver of the patient. While certain aspects of the disease management for diarrhea align with the recommended guidelines, there is room for improvement in promoting the exclusive use of oral rehydration therapy and reducing unnecessary antibiotic prescriptions.
Effect of the leaf pettiveria alliacea extract active compound on mycobacterium tuberculosis Munir, Ratna Sofaria; Fatimah, Nurmawati; Hermanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Indonesia has a variety of herbal plants used as herbal/traditional medicines. Singawalang (Petiveria alliacea) is one of the herbal plants usually used in the United States as a cough medicine because of its expectorant effect. Singawalang plants are also widely used to cure tuberculosis. However, the investigations on the effects of toxicity on this plant leaf extract has not been done. This study aims to investigate the effects of active compounds in singawalang against Mycobacterium tuberculosis using a variety of solvents. The active compound of ethanol extract was obtained by maceration using ethanol solvent. The extract was then fractionated using column chromatography method, and using gradual eluent to produce fraction. The doses used were 0.5 mg/ml; 1 mg/ml; 2 mg/ml; 70% ethanol, h-hexane, benzene, chloroform, ethylacetate, silica gel 60GF254, Middlebrook 7H9, and 7H10. The reactions using Singawalang leaf extract with various solvents resulted in a reduction of the Mycobacterium tuberculosis colony growth, compared with the reaction on control treatment, treatment using DMSO 1%, and treatment using 70% ethanol. As a conclusion, the various solvents used did not make a significant difference. However, control treatment, treatment using DMSO 1%, and treatment using 70% ethanol had significant results.
Effects of Tamarillo (Solanum betaceum) Extract on Glutathione Peroxidase Expression and Inflammatory Reactions in Lead Acetate-Induced Lung Tissue of Mice Harjono, Shella; I’tishom, Reny; Rahniayu, Alphania; Fatimah, Nurmawati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4460

Abstract

Background: Lead acetate exposure through oral route has a significant impact on lung tissue as lead can induces the formation of reactive oxygen species (ROS), resulting in decreased glutathione peroxidase (GPx) and triggering inflammatory responses. The induction of exogenous antioxidants may prevent this mechanism. This study aimed to evaluate the protective effect of Tamarillo ethanol extract on GPx expression and inflammatory reactions in the lung tissue of mice induced with lead acetate.Methods: This true experimental laboratory study utilized stored formalin-fixed-paraffin-embedded (FFPE) lung tissue  from 30 male mice (Mus musculus). The samples were divided into five intervention groups, each consisting of six mice. Immunohistochemistry and histopathology assessments were performed at 100x and 400x magnification to evaluate the GPx expression using the H-score and to assess inflammatory reactions based on five scoring parameters, which were summed to obtain the total lung injury score.Results: Lead exposure significantly increased inflammatory reactions, particularly in the hemorrhage parameters (p=0.041). A significant increase in GPx expression was observed following lead acetate administration (p=0.027). Administration of Tamarillo ethanol extract at a dose of 400 mg/kgBW increased GPx expression compared with the positive control group (p=0.027).Conclusion: Tamarillo ethanol extract, especially at a dose of 400 mg/kgBW, significantly increases GPx expression in lead acetate-induced lung tissue of mice. This finding highlights the potential role of Tamarillo extract as an antioxidant source to reduce lead-induced lung injury, supporting broader efforts to promote healthy lifestyle practices that protect against environmental toxin exposure.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Januar Er Putra Afif Nurul Hidayati Akbar Kurniawan, Mohammad Alpha Fardah Athiyyah Alphania Rahniayu Amatullah, Nida' Fahima Amustikarani, Dewa Ayu Praba Annette d’Arqom, Annette Arifa Mustika Bambang Hermanto Christian Susianto, Steven Damayanti Damayanti Dau, Daniel Dhia Farhan Taufik Dimyati, Sinta Diyah Doman, Zahras Azimuth Edith Frederika Puruhito, Edith Frederika Farhan Nurdiansyah Finna Permata Putri Harjono, Shella Herisulistyo, Aldilatama Herley Windo Setiawan Herwanto, Bambang I Dewa Ayu Sudiari Dewi Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Insyira Rayhana Irsan Irsan, Insyira Rayhana Izzatul Fithriyah I’tishom, Reny Khaerunnisa, Siti Kurniawan, Mohammad Akbar Kusuma Eko Purwantari Linda Dewanti Maftuchah Maftuchah Mhd Zamal Nasution Mukhoirotin Mukhoirotin Myrna Adianti Nilamsari, Karina Ayu Nurina Hasanatuludhhiyah Nurrosyidah, Iif Hanifa Paramitha, Nabilah Prabowo, Gwenny Ichsan Purba, Abdul Khairul Rizki Raden Mohamad Herdian Bhakti Rania Ratri Fauziyah Ratna Sofaria Munir, Ratna Sofaria Rini Hamsidi Sakina Sakina, Sakina Sri Murtiwi Sri Purwaningsih Stefanus, Lusiana Steven Christian Susianto Suhariningsih Suharno, Novianto Edi Sulistiawati Sulistiawati Sumardiko, Dwi Setiani Sutji Kuswarini Sutji Kuswarini Toyib, Muchammad Turchan, Agus Vita, Angelica Diana Wening Hapsari William Andrew Isaac Yuani Setiawati Yusuf, Muhtarum