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All Journal Althea Medical Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Journal Of Vocational Health Studies Jurnal Keperawatan Padjadjaran Jurnal Medik Veteriner PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Ners SURABAYA PHYSICAL MEDICINE AND REHABILITATION JOURNAL Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Asian Journal of Health Research Journal of Innovation Research and Knowledge Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Fatimah, Nurmawati
Department Of Anatomy, Histology And Pharmacology, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
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Effect of the leaf pettiveria alliacea extract active compound on mycobacterium tuberculosis Munir, Ratna Sofaria; Fatimah, Nurmawati; Hermanto, Bambang
Folia Medica Indonesiana Vol. 53, No. 2
Publisher : Folia Medica Indonesiana

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Abstract

Indonesia has a variety of herbal plants used as herbal/traditional medicines. Singawalang (Petiveria alliacea) is one of the herbal plants usually used in the United States as a cough medicine because of its expectorant effect. Singawalang plants are also widely used to cure tuberculosis. However, the investigations on the effects of toxicity on this plant leaf extract has not been done. This study aims to investigate the effects of active compounds in singawalang against Mycobacterium tuberculosis using a variety of solvents. The active compound of ethanol extract was obtained by maceration using ethanol solvent. The extract was then fractionated using column chromatography method, and using gradual eluent to produce fraction. The doses used were 0.5 mg/ml; 1 mg/ml; 2 mg/ml; 70% ethanol, h-hexane, benzene, chloroform, ethylacetate, silica gel 60GF254, Middlebrook 7H9, and 7H10. The reactions using Singawalang leaf extract with various solvents resulted in a reduction of the Mycobacterium tuberculosis colony growth, compared with the reaction on control treatment, treatment using DMSO 1%, and treatment using 70% ethanol. As a conclusion, the various solvents used did not make a significant difference. However, control treatment, treatment using DMSO 1%, and treatment using 70% ethanol had significant results.
Effects of Tamarillo (Solanum betaceum) Extract on Glutathione Peroxidase Expression and Inflammatory Reactions in Lead Acetate-Induced Lung Tissue of Mice Harjono, Shella; I’tishom, Reny; Rahniayu, Alphania; Fatimah, Nurmawati
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n4.4460

Abstract

Background: Lead acetate exposure through oral route has a significant impact on lung tissue as lead can induces the formation of reactive oxygen species (ROS), resulting in decreased glutathione peroxidase (GPx) and triggering inflammatory responses. The induction of exogenous antioxidants may prevent this mechanism. This study aimed to evaluate the protective effect of Tamarillo ethanol extract on GPx expression and inflammatory reactions in the lung tissue of mice induced with lead acetate.Methods: This true experimental laboratory study utilized stored formalin-fixed-paraffin-embedded (FFPE) lung tissue  from 30 male mice (Mus musculus). The samples were divided into five intervention groups, each consisting of six mice. Immunohistochemistry and histopathology assessments were performed at 100x and 400x magnification to evaluate the GPx expression using the H-score and to assess inflammatory reactions based on five scoring parameters, which were summed to obtain the total lung injury score.Results: Lead exposure significantly increased inflammatory reactions, particularly in the hemorrhage parameters (p=0.041). A significant increase in GPx expression was observed following lead acetate administration (p=0.027). Administration of Tamarillo ethanol extract at a dose of 400 mg/kgBW increased GPx expression compared with the positive control group (p=0.027).Conclusion: Tamarillo ethanol extract, especially at a dose of 400 mg/kgBW, significantly increases GPx expression in lead acetate-induced lung tissue of mice. This finding highlights the potential role of Tamarillo extract as an antioxidant source to reduce lead-induced lung injury, supporting broader efforts to promote healthy lifestyle practices that protect against environmental toxin exposure.
Pengaruh Jus Buah Delima (Punica granatum) sebagai Agen Antioksidan pada Tikus Putih (Rattus norvegicus) yang Diinduksi Larutan Complete Freund’s Adjuvant (CFA) melalui Jalur Penurunan Kadar Malondialdehid (MDA) Shayla Kokomi Rishardy; Nurmawati Fatimah; Gadis Meinar Sari; Mohammad Fathul Qorib
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.51842

Abstract

Inflamasi kronis berkontribusi pada berbagai penyakit degeneratif, sehingga diperlukan terapi alternatif berbasis antioksidan alami. Buah delima (Punica granatum) kaya akan polifenol, flavonoid, dan tanin yang memiliki potensi antioksidan dan antiinflamasi. Penelitian ini bertujuan untuk mengevaluasi pengaruh jus buah delima terhadap kadar malondialdehid (MDA) sebagai penanda stres oksidatif pada tikus Wistar jantan yang diinduksi Complete Freund’s Adjuvant (CFA). Penelitian eksperimental menggunakan rancangan post-test only control group design dengan empat kelompok: kontrol negatif (K–), kontrol positif (K+), serta dua kelompok perlakuan (P1: 16,7% jus delima; P2: 33,3% jus delima). Jus diberikan secara oral selama 28 hari. Analisis data menggunakan uji Shapiro-Wilk dan Levene untuk uji normalitas dan homogenitas, dilanjutkan dengan ANOVA satu arah dan uji post hoc LSD atau uji non-parametrik Kruskal-Wallis dan Mann-Whitney U jika data tidak normal. Hasil menunjukkan bahwa kadar MDA tertinggi terjadi pada K+, sedangkan P1 dan P2 mengalami penurunan signifikan (p<0,05). Temuan ini mengindikasikan bahwa jus delima efektif menurunkan stres oksidatif melalui penghambatan peroksidasi lipid, mendukung potensinya sebagai agen terapeutik alami dalam manajemen inflamasi.
Pengaruh Jus Buah Delima (Punica granatum) sebagai Agen Anti-inflmasi pada Tikus Putih (Rattus norvegicus) yang Diinduksi Larutan Complete Freund’s Adjuvant (CFA) melalui Jalur Penurunan Kadar Sitokin Pro-inflamasi TNF-α Muhammad Axel Arsyad; Nurmawati Fatimah; Gadis Meinar Sari; Mohammad Fathul Qorib
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52488

Abstract

Reaksi alami tubuh terhadap kerusakan atau penyakit adalah peradangan, yang ditandai dengan peningkatan mediator pro-inflamasi seperti TNF-α. Karena Complete Freund's Adjuvant (CFA) dapat menimbulkan peradangan kronis dan respons imunologis seluler, zat ini sering digunakan sebagai model induksi peradangan. Punicalagin, asam ellagic, dan flavonoid yang terdapat dalam buah delima (Punica granatum) memiliki sifat anti-inflamasi dan antioksidan yang dapat mengurangi respons inflamasi. Dalam eksperimen laboratorium ini, digunakan lima kelompok tikus jantan putih (Rattus norvegicus) dengan desain kelompok kontrol pasca-tes saja. Kelompok-kelompok tersebut meliputi kelompok kontrol negatif, kelompok kontrol positif (CFA), kelompok vitamin C, dan dua kelompok perlakuan yang menerima dosis oral jus delima yang bervariasi selama 28 hari. Jus delima secara signifikan (p<0.05) menurunkan kadar TNF-α pada tikus yang diinduksi CFA dibandingkan dengan kelompok kontrol positif, dengan penurunan terbesar terjadi pada dosis tertinggi, menurut data. Oleh karena itu, telah dibuktikan bahwa jus delima memiliki sifat antiinflamasi dengan menurunkan kadar sitokin pro-inflamasi TNF-α.
The Effect of Ethanol Extract of Tamarillo (Solanum betaceum) on Superoxide Dismutase Expression in Mouse (Mus musculus) Lungs after Lead Acetate Exposure Karina Putri Dianita; Herley Windo Setiawan; Nurmawati Fatimah; Reny I'tishom; Mohammad Subkhan
Majalah Biomorfologi Vol. 36 No. 1 (2026): MAJALAH BIOMORFOLOGI
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v36i1.2026.28-39

Abstract

Background: Lead (Pb), a toxic heavy metal that does not break down in the environment, seriously endangers human health. Oral exposure to lead affects the lungs, causing disrupted physiological functions and respiratory disorders, including chronic obstructive pulmonary disease (COPD). Reactive oxygen species (ROS) are produced following lead exposure, reducing endogenous antioxidants, particularly superoxide dismutase (SOD). Administration of exogenous antioxidants to enhance SOD activity is therefore a crucial preventive strategy. Objective: To examine the effect of tamarillo (Solanum betaceum) ethanol extract on SOD expression in the lungs of mice (Mus musculus) after lead acetate exposure. Materials and Methods: The authors used twenty-five mouse lung tissue samples. Each treatment group comprised five samples: C0 (negative control, given only distillated water), C1 (positive control, given lead acetate at a dose of 0.075 g/kg BW), T1 (lead acetate + tamarillo extract at concentration of 100 mg/kg BW), T2 (lead acetate + tamarillo extract 200 mg/kg BW), and T3 (lead acetate + tamarillo extract 400 mg/kg BW). The duration of the treatments was 35 days. Results: After administering 0.075 g/kg BW of lead acetate, the study found a substantial increase in SOD expression (p < 0.05). In addition, compared to the positive control group, the administration of 100 mg/kg BW of tamarillo ethanol extract resulted in a significant increase in SOD expression (p < 0.05). Conclusion: Ethanol extract of tamarillo, particularly at a level of 100 mg/kg BW, efficiently increases SOD expression in mouse lungs.
The Potential of Ethanol Extract Tamarillo (Solanum betaceum) on B-Cell Lymphoma 2 Expression in Mice (Mus musculus) Lungs Exposed to Lead Acetate Cantika Marcellin Princess Iswandi; Herley Windo Setiawan; Nurmawati Fatimah; Reny I’tishom; Mila Qurotul A'yuni
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.44-51

Abstract

Introduction: Lead acetate, a toxic heavy metal compound, induces cellular and tissue injury primarily through oxidative stress. Exposure via inhalation or ingestion enables systemic absorption and distribution to target organs, particularly the lungs. One of the key anti-apoptotic proteins involved in maintaining cell survival is B-cell lymphoma 2 (Bcl-2). The administration of exogenous antioxidants represents a preventive approach to counteract the cytotoxic effects of lead, including the use of ethanol extract of tamarillo fruit. This study investigated the potential influence of tamarillo (Solanum betaceum) ethanol extract, known for its antioxidant content. Specifically, it examined its effect on Bcl-2 expression in the lung tissue of male mice exposed to lead acetate. Methods: This study used a true experimental design in a controlled laboratory setting. The specimens were divided into five groups: K0 served as the negative control, while K1 acted as the positive control and was treated with lead acetate at a dose of 0.075 g/kgBW. Group P1, P2, and P3 received lead acetate combined with ethanol extract of tamarillo at doses of 100 mg/kgBW, 200 mg/kgBW, and 400 mg/kgBW, respectively. Results: The findings showed that tamarillo ethanol extract significantly increased lung Bcl-2 expression in lead-exposed mice (p<0.05). B-cell lymphoma 2 expression increased progressively with higher extract doses compared with the positive control group. Conclusion: Administration of the tamarillo ethanol extract at 100 mg/kgBW was the most effective and provided protective effects on lung tissue.
Upaya Peningkatan Kualitas Hidup Pasien TB Melalui Penyuluhan Dagusibu Obat Pada Masyarakat di Desa Lepolima Provinsi Nusa Tenggara Timur Nurmawati Fatimah; Herley Windo Setiawan; Arifa Mustika; Siti Khaerunnisa; Mohammad Akbar Kurniawan
Jurnal Pengabdian Masyarakat Bangsa Vol. 3 No. 10 (2025): Desember
Publisher : Amirul Bangun Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59837/jpmba.v3i10.3505

Abstract

Tuberkulosis (TB) merupakan masalah serius di Nusa Tenggara Timur (NTT). Data penelitian menunjukkan bahwa NTT merupakan provinsi dengan target deteksi kasus yang belum terpenuhi. Pemerintah Indonesia berkomitmen untuk menurunkan insiden TB melalui berbagai upaya, termasuk Rencana Pembangunan Jangka Menengah Nasional (RPJMN) 2020-2024 dan Strategi Eliminasi TB Nasional. Pengendalian TB di NTT menghadapi tantangan yang kompleks, seperti terbatasnya akses terhadap layanan kesehatan, kurangnya kesadaran masyarakat tentang pengobatan penyakit ini, dan terbatasnya sumber daya manusia di sektor kesehatan. Oleh karena itu, diperlukan upaya yang lebih efektif untuk meningkatkan deteksi kasus TB, pengobatan rasional yang menjangkau semua tingkat, serta penguatan skrining dan investigasi kontak. Solusi yang ditawarkan dalam kegiatan pengabdian masyarakat meliputi kegiatan pencegahan melalui penyuluhan kesehatan dengan memberikan penyuluhan tentang cara mencegah penyakit menular dan edukasi tentang DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang). Tahap awal kegiatan ini adalah mengukur tingkat pemahaman tenaga kesehatan atau kader kesehatan mengenai definisi tuberkulosis, kemungkinan tindakan pencegahan, pengobatan, dan gaya hidup pasien. Setelah pre-test, akan dilakukan kuliah edukasi mengenai topik-topik tersebut. Peningkatan pemahaman relawan kesehatan dapat diukur setelah kegiatan menggunakan post test. Terdapat peningkatan rata-rata skor pre test dan post testl, dengan skor pre test rata-rata 56,8 dan skor post test rata-rata 77,3. Target luaran yang diharapkan dari kegiatan ini adalah meningkatnya pemahaman relawan kesehatan tentang Program DAGUSIBU dan upaya yang dapat dilakukan untuk mencegah peningkatan jumlah penderita TB di Desa Lepolima.Mumere, Nusa Tenggara Timur
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti Achmad Januar Er Putra Afif Nurul Hidayati Akbar Kurniawan, Mohammad Alpha Fardah Athiyyah Alphania Rahniayu Amatullah, Nida' Fahima Amustikarani, Dewa Ayu Praba Annette d’Arqom, Annette Arifa Mustika Arifa Mustika Bambang Hermanto Cantika Marcellin Princess Iswandi Christian Susianto, Steven Damayanti Damayanti Dau, Daniel Dhia Farhan Taufik Dimyati, Sinta Diyah Doman, Zahras Azimuth Edith Frederika Puruhito, Edith Frederika Farhan Nurdiansyah Finna Permata Putri Harjono, Shella Herisulistyo, Aldilatama Herley Windo Setiawan Herley Windo Setiawan Herwanto, Bambang I Dewa Ayu Sudiari Dewi I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Insyira Rayhana Irsan Irsan, Insyira Rayhana Izzatul Fithriyah I’tishom, Reny Karina Putri Dianita Khaerunnisa, Siti Kusuma Eko Purwantari Linda Dewanti Maftuchah Maftuchah Mhd Zamal Nasution Mila Qurotul A'yuni Mohammad Akbar Kurniawan Mohammad Fathul Qorib Mohammad Subkhan Muhammad Axel Arsyad Mukhoirotin Mukhoirotin Myrna Adianti Nilamsari, Karina Ayu Nurina Hasanatuludhhiyah Nurrosyidah, Iif Hanifa Paramitha, Nabilah Prabowo, Gwenny Ichsan Purba, Abdul Khairul Rizki Raden Mohamad Herdian Bhakti Rania Ratri Fauziyah Ratna Sofaria Munir, Ratna Sofaria Reny I'tishom Reny I’tishom Rini Hamsidi Sakina Sakina, Sakina Sari, Gadis Meinar Shayla Kokomi Rishardy Siti Khaerunnisa Sri Murtiwi Sri Purwaningsih Stefanus, Lusiana Steven Christian Susianto Suhariningsih Suharno, Novianto Edi Sulistiawati Sulistiawati Sumardiko, Dwi Setiani Sutji Kuswarini Sutji Kuswarini Toyib, Muchammad Tri Hartini Yuliawati Trimitasari, Kurnia Turchan, Agus Vita, Angelica Diana Wening Hapsari William Andrew Isaac Yuani Setiawati Yusuf, Muhtarum