Article Per Year (5 Year)
p-Index From 2021 - 2026
1.77
P-Index
This Author published in this journals
All Journal JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Higea Jurnal Mandala Pharmacon Indonesia SULUH: Jurnal Abdimas Abdi Implementasi Pancasila: Jurnal Pengabdian kepada Masyarakat Journal of Natural Product for Degenerative Diseases
FAIZATUN, FAIZATUN
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Control & Systems Engineering Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

Published : 12 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 12 Documents
Search

 1   2 
Tyrosinase inhibitory activity and physicochemical properties of microalgae extract (Spirulina platensis)-loaded nanostructured lipid carriers gel Faizatun, Faizatun; Abdullah, Abdullah
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1622

Abstract

Microalgae (Spirulina platensis) belongs to the family Cyanobacteria contains phycocyanin which is efficacious as a tyrosinase inhibitor. The purpose of the study was to make gel of Nanostructured Lipid Carriers (NLC) from the Microalgae extract (Spirulina platensis). Extracts were made by maceration with 70% ethanol solvent and evaluation of the enzyme tyrosinase inhibitory activity. The extract was made by NLC with solvent evaporation method and characterized which included particle size, polydispersity index, zeta potential and Transmission Electron Microscope (TEM). NLC extract was made into gel preparations by adding gelling agent, and evaluation included organoleptic homogeneity, viscosity and flow properties, pH, and the enzyme tyrosinase inhibitory activity. The enzyme tyrosinase inhibitory activity of Microalgae extract (Spirulina platensis) with the result IC50 in the amount of 150.22 µg/mL. Five of NLC formulas was made based on the characterization obtained the best formula is NLC formula 2, which includes particle size of 119.6 nm, polydispersity index of 0.356, zeta potential of -37.8 mV, and spherical shape. The evaluation results of the gel were semi-solid, brown, typical smell, homogeneous, viscosity of 19500 cPs, plastic thixotropic flow properties, and pH 5.06. The enzyme tyrosinase inhibitory activity of NLC gel Microalgae extract (Spirulina platensis) with the result IC50 in the amount of 173.38 µg/mL. It can be formulated into a physically and chemically stable gel preparation and has activity as a tyrosinase inhibitor.
Pengembangan Formula Tabir Surya Alami Kombinasi Daun Kecombrang (Etlingera elatior (Jack.) R.M. Sm.) dan Minyak Biji Bunga Matahari (Helianthus annuus L.) beserta Uji Aktivitas SPF In-Vitro Sartono, Anisya Amanda Putri; Taurhesia, Shelly; Faizatun, Faizatun
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1072

Abstract

Radiasi ultraviolet (UV) berpotensi menyebabkan kerusakan kulit mulai dari eritema hingga kanker kulit. Penggunaan tabir surya sintetis seperti oksibenzon berisiko menimbulkan iritasi, sehingga pengembangan tabir surya alami menjadi alternatif yang diperlukan. Mengembangkan formulasi tabir surya alami dari kombinasi minyak biji bunga matahari (Helianthus annuus L.) dan ekstrak daun kecombrang (Etlingera elatior (Jack.) R.M. Sm.) serta mengevaluasi stabilitas dan aktivitas fotoprotektifnya. Minyak diekstraksi dengan cold pressing, sedangkan ekstrak diperoleh melalui maserasi etanol 70%. Kedua bahan distandardisasi berdasarkan parameter mutu. Aktivitas SPF diukur secara in-vitro menggunakan spektrofotometri UV-Vis pada panjang gelombang 290-320 nm dengan persamaan Mansur. Stabilitas formulasi diuji melalui cycling test. Formulasi kombinasi (2:1) menunjukkan stabilitas fisik yang baik selama pengujian dan aktivitas SPF yang signifikan. Hasil pengukuran SPF in-vitro mengonfirmasi potensi fotoprotektif dari kombinasi kedua bahan alam tersebut. Kombinasi minyak biji bunga matahari dan ekstrak daun kecombrang berpotensi sebagai tabir surya alami yang efektif dengan stabilitas memadai, menawarkan alternatif fotoproteksi yang aman dari bahan alam.
Co-Authors Abdullah Abdullah Alfianita, Alfianita Annysa Ellycornia Silvyana Ardi, Maria Yedida Chairunnisa, Dian Fitri Djamil, Ratna Fathul Mufid Gumilar Adhi Nugroho Hakim, Zainur Rahman Jasmadeti, Jasmadeti Larasinta, Nadia Lies Putriana Maharani, Syifa Caroline Marwati, Umi Miftahurrohmah, Nur Murti, Irene Intan Permata Novi Yantih Octa, Mega Maulida Okta, Fauzia Noprima Pratita, Rasta Naya Qodriah, Rahmatul Rosmawati Rosmawati Safira Nafisa Saputra, Andreas Agung Sari, Intan Pertama Sartono, Anisya Amanda Putri Tanoto, Vingko Taurhesia, Shelly Yesi Desmiaty, Yesi Zaidan, Sarah