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All Journal PREPOTIF : Jurnal Kesehatan Masyarakat Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Jurnal Kesehatan Tambusai Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Pengabdian Masyarakat Nusantara Jurnal Abdimas Indonesia Journal of Community Service and Society Empowerment ALMURTADO: Journal of Social Innovation and Community Service
Sim, Alfred Sutrisno
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Peran Apolipoprotein B, Apolipoprotein A, dan Rasio ApoA/ApoB sebagai Prediktor Terjadinya Demensia pada Kelompok Lanjut Usia Sim, Alfred Sutrisno; Santoso, Alexander Halim; Gunaidi, Farell Christian; Alifia, Khalisya; Aditya, Vincent; Destra, Edwin
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.4891

Abstract

Neurocognitive disorders, particularly dementia, affect various cognitive functions such as memory, attention, language, learning, and problem-solving, with the elderly population being the most impacted. The prevalence of dementia is projected to rise to 131 million cases by 2050, posing significant social and economic implications. This study employed a cross-sectional method to evaluate the role of Apolipoprotein A (APOA) and Apolipoprotein B (APOB) in the diagnosis and prevention of dementia in older adults. The results showed that Apolipoprotein A was not significantly correlated with MMSE scores, indicating no clear relationship between APOA and cognitive function. In contrast, Apolipoprotein B demonstrated a significant negative correlation with MMSE, suggesting that increased APOB levels are associated with cognitive decline. Elevated ApoB, linked to increased LDL and oxidative stress, correlated with reduced cognitive function, whereas ApoA, the main component of HDL, is associated with neuroprotective effects. These findings underscore the importance of monitoring lipid profiles, including ApoA and ApoB, in the prevention and management of dementia in the elderly.    
Co-Authors Aditya, Vincent Alifia, Khalisya AULIYA, LAHMY LAHMUL Aurellia, Aurellia Christian, Farell Destra, Edwin Febriastuti, Abebi Felicia, Ivana Goh, Daniel Gracieene Gracienne Gunaidi, Farell Christian Herlina Uinarni Kusuma, Kanaya Fide Putra, Feri Yanto Putra, Muhammad Dzakwan Dwi Santoso, Alexander Halim Sitorus, Ribka Anggelline Hariesti