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Journal : eJournal Kedokteran Indonesia

The Relationship Between Pesticide Use and Cognitive Impairment in an Agricultural Community of Tomohon City, North Sulawesi Masengi, Angelina Stevany Regina; Mambo, Christi Diana; Nangoy, Edward; Posangi, Jimmy; Lasut, Marthen Theogives; Pertiwi, Junita Maja; Warouw, Finny; Sanggelorang, Yulianty; Sengkey, Daniel Febrian; Mamahit, Juliet Merry Eva
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.961.42

Abstract

This study investigates the cognitive effects of pesticide exposure on agricultural workers from a village in Tomohon City, North Sulawesi, Indonesia. Employing a cross-sectional design from July to September 2024. This study assessed the demographic characteristics, pesticide exposure patterns, and cognitive function of 97 participants aged ≥18 using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA-INA). The findings reveal a clear association between direct and indirect pesticide exposure and cognitive impairment. Direct exposure was linked to slightly lower cognitive scores than indirect exposure, with both groups scoring below established thresholds for normal cognitive function, particularly in memory, attention, and executive functions. Inconsistent use of personal protective equipment was noted among participants, with common immediate symptoms including visual disturbances and memory deficits following pesticide application. These results suggest that minimal pesticide exposure may contribute to cognitive decline, potentially accelerating age-related impairments. The underlying neurotoxic mechanisms likely involve oxidative stress, mitochondrial dysfunction, and neuroinflammation, which disrupt neuronal integrity. These findings underscore the urgent need for enhanced occupational health policies, stricter safety measures, and further research to mitigate the cognitive risks of pesticide exposure in agricultural populations.
Co-Authors Akili, Rahayu H, Andika Surya Atmadja Anes, Brenda Militsia Christi Rosalina Angelina Stevany Regina Masengi Anthonius Kurniadi Assa, Winly Yuliana Birang, Meirani F. Budi Ratag, Budi Budi Setiawan Chesya P.R. Salindeho Christoffel M. Memah Daniel Febrian Sengkey Deeng, Gracia V. Y. Desy . Doda, Diana V.D. Edward Nangoy, Edward Frans Wantania Gampu, Agrisia Garusu, Ratna Santika Harvani Boky, Harvani Herlyani Khosama Hugo Dwiputra Jehosua, Seilly Yunita Jimmy Posangi Jootje M.L Umboh Junita Maja P.S Junita Maja Pertiwi Kamae, Sitti Ramlia Kawatu, Paul A.T Kumayas, Putri Elshadai Labagow, Elisa Lantang, Christina Lapian, Albertus Theo Laura Wulandary Kaeng Lengkong, Erlika Lihu, Tutin R. M.L, Jootje Maddusa, Sri Seprianto Maja Pertiwi, Junita Mamahit, Juliet Merry Eva Mambo, Christi Diana Manabung, Apriliani R. Maranatha, Armando Vengo Subito Lewi Marthen Theogives Lasut, Marthen Theogives Melke J. Tumboimbela Mieke A. H. N. Kembuan Mieke A.H.N Kembuan Momole, Ansye Grace Nancy Mutiara Toreh Nike Gledis Monintja Oddi R Pinontoan Odi Pinontoan Odi Roni Pinontoan Paendong, Winner Hiskia George Paul A.T. Kawatu Pertiwi, Junita M. Pertiwi, Junita Maja Purbawijaya, Poek Denny Rahayu H. Akili, Rahayu H. Ratumbanua, Fralen Julio Rianna J Sumampouw Ricky C. Sondakh Rizal Tumewah Sekplin A. S. Sekeon, Sekplin A. S. Sengkey, Aprilia Sengkey, Omega Prisilia Soeratinoyo, Dewi K. Sugiarto, Natanael E. Sumigar, Cindy Keren Suoth, Lery F. Tangkudung, Gilbert Tewuh, Syeri Oktaviani Theresia Runtuwene Togelang, Mega Rossita Umboh, Jootje Marthen Luther Umboh, Jotje M.L Vriska V. Rambing Walewangko, Sarah Alni Wariki, Windy M. V. Wello, Novita L. L. Wiradarma, Elbert Woodford B. S. Joseph Woodford B.S. Joseph, Woodford B.S. Wowor, Ribka Yantu, Sintia Salmawati Yonathan Andrian Yulianty Sanggelorang