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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Industri Pertanian Jurnal Veteriner CHEMISTRY PROGRESS BIOTROPIA - The Southeast Asian Journal of Tropical Biology Current Biochemistry Pharmascience Dental Journal (Majalah Kedokteran Gigi) EnviroScienteae JURNAL PERTANIAN Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Teknik Industri JSMARTech : Journal of Smart Bioprospecting and Technology Indonesian Journal of Applied Research (IJAR) Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Pusat Inovasi Masyarakat JURNAL AGROINDUSTRI HALAL Odonto dental journal
Akhmad Endang Zainal Hasan
Department Of Biochemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Transportation Veterinary

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Journal : Current Biochemistry

 1 
Produksi Asam Laktat dan Pola Pertumbuhan Bakteri Asam Laktat dengan Pemberian Dosis Rendah Propolis Trigona spp asal Pandeglang Indonesia Akhmad Endang Zainal Hasan; I Made Artika; Syaeful Abidin
Current Biochemistry Vol. 1 No. 3 (2014)
Publisher : IPB University

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Abstract

Propolis is known to have an antimicrobial activity and can prevent various diseases. Propolis consumption is feared to have negative impact on the activity of digestive lactid acid bacteria (LAB). The aim of this research was to examine the effect of propolis on the growth and lactic acid production of three LAB. Ethanol Extraction Propolis (EEP) concentrations examined were control, eep and X propolis 0% (control), 0.2%, 0.6%, 1.0% and X propolis at 0.4% concentration. The parameters analyzed were the growth of bacteria counted with Total Plate Count (TPC) method and lactic acid production using titrable acidity analysis. Propolis at 0,6% concentration stimulated the growth of Lactobacillus casei subsp. rhamnosus (LCR, 24.725x108 cell/mL), but inhibited the average lactic acid production (0.071%) lower than control (0,149%). Propolis did not affect the growth of Streptococcus thermophillus (STP), but propolis at 0,6% concentration stimulated lactic acid production (0.182%) higher than control (0.112%). Propolis inhibited the growth of Lactobacillus delbrueckii subsp. bulgaricus (LDB), but at 0,2% concentration, its population was still highest (3.775x108 cell/mL) and lactic acid production was stimulated (0.195%) higher than control (0.123%).
Total Phenolic, Anticancer and Antioxidant Activity of Ethanol Extract of Piper crocatum Vahl from Pamekasan and Karang Asem Kristina Mulia; Akhmad Endang Zainal Hasan; Suryani Suryani
Current Biochemistry Vol. 3 No. 2 (2016)
Publisher : IPB University

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Abstract

Cancer is a deadly disease that ranks the second after heart disease. One of the causes of cancer is free radicals causing oxidative stress in humans. Antioxidant is compound that can reduce oxidative stress. The antioxidant activity is closely connected with anticancer activity. It is known that in addition to being an analgesic, aphrodisiac of Java chili also has potential as anticancer. This study examined the potential anticancer and antioxidant from the ethanol extract of Java chili from Pamekasan and Karang Asem. The method used in this study began with the extraction of Java chili using ethanol 70 %, phytochemical testing, determination of total phenol anticancer testing using MTT method on MCF-7 breast cancer cell line and antioxidant testing using DPPH. This study uses Java chili extract derived from Pamekasan and Karang Asem. IC50 value of the cytotoxic activity originating from the area Karang Asem amounted to 63.283 ppm and Pamekasan of 83.662 ppm. IC50 value of antioxidants samples derived from Karang Asem area of 285.613 ppm and are derived from Pamekasan amounted to 288.037 ppm.
Effectiveness of Gnetum gnemon Peel Extract as an Antihyperuricemic in White Rats Rattus norvegicus Akhmad Endang Zainal Hasan; Husnawati Husnawati; Chintia Ayu Puspita; Agus Setiyono
Current Biochemistry Vol. 7 No. 1 (2020)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.7.1.3

Abstract

Melinjo (gnetum gnemon) peel extract is believed to have potential as antihyperuricemic agent, however, in vivo assays have yet to be conducted to prove the antihyperuricemic activity. The objectives of this research were to analyze antihyperuricemic activity of melinjo peel extract in Sprague Dawley male white rat. A total of 24 rats were divided into 6 groups, which are a normal, positive, and negative group, 70% ethanolic extract of melinjo peel dose 450 mg/kg BW (ET I) and dose 900 mg/kg BW (ET II), and water extract of melinjo peel dose 93.35 mg/kg BW (EA). The results show that antihyperuricemic potency of 70% ethanolic extract of melinjo peel (ET1 and ET2) was more effective than allopurinol dose 90 mg/kg BW with a percentage decrease of 50% and 54%. Ethanol extract of melinjo peel was able to reduce uric acid levels to be in the range of normal values (<5 mg / dL). Bodyweight gain of rats given ethanol extract of melinjo peel dose 450 mg/kg BW had values that were close to the normal group. Melinjo peel extract contained flavonoid, tannins, saponin, and triterpenoid.
Minimum Concentration of Stingless Bee Propolis (Trigona sp.) in Inhibiting the Growth of Dandruff Bacteria Akhmad Endang Zainal Hasan; I Made Artika; Erlank Bagjavicenna
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.2

Abstract

Lack of confidence in men and women, one of which is when there is dandruff on the hair and scalp. Hair loss is a further symptom of the presence of white scales on the scalp that cause itching. The presence of excessive microorganisms can aggravate this dandruff. Ingredients such as ketocanozole, zinc pyrithione, selenium sulfide and sulfur are compounds commonly used in shampoo formulas. Propolis is an alternative natural ingredient to treat dandruff. The purpose of this study was to determine the minimum growth inhibitory concentration (MIC) of propolis against dandruff-causing bacteria. Dandruff-causing microbes were isolated from dandruff hair and with the well method in a petri dish, the minimum growth inhibitory concentration of propolis was determined. The microbial colonies produced were very diverse with a round shape like grapes, yellowish white in color. The concentration of 6.25% is the MIC value of propolis extract against dandruff microbes. The effectiveness values against ketoconazole and propolis X from the tested propolis extract were 223.52% and 99.59%, respectively. Keywords: hair loss, dandruff, propolis, bacteria , Trigona
Hepatoprotective Activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in Rats Induced by Paracetamol Akhmad Endang Zainal Hasan; Agus Setiyono; Miko Afrian
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.4

Abstract

Negative effects on health will occur in excessive use of paracetamol. The main objective of this study was to determine the hepatoprotective activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats induced by paracetamol. The study was conducted on 36 Sprague Dawley rats with 6 rats in each group. Group 1 (normal control), group 2 (positive control, temulawak 42.86 mg/kg BW), group 3 (negative control), group 4 (infusion of Myrmeleon 10 mg/kg BW), group 5 (propolis extract 0.02 ml/kg BW), and group 6 (Hibiscus sabdariffa infusion 0.02 ml/kg BW). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations were determined spectrophotometrically and microscopically for liver histopathology. The results showed that during three weeks of treatment with Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats, this treatment could decrease ALT and AST activity as the positive control. The ALT activity values ​​of the three materials were 69.26, 51.00, 51.00, 43.67, U/I with AST values ​​of 110.29, 97.33, 91.00, 91.33 U/I. Based on Duncan's test, there were significant differences between all treatments with negative and positive control groups. Likewise, with the histopathological scoring results, the negative control was found to be significantly different from all treatments. Therefore, treatment with propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. may have hepatoprotective benefit.
Sprague Dawley Rat Spermatozoa Quality Due to Bee Pollen Consumption Hasan, Akhmad Endang Zainal; Moerfiah; Handayani, Septa Fitri
Current Biochemistry Vol. 9 No. 2 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.2.4

Abstract

Bee Pollen is a food that has a complete nutritional content including as a source of steroid hormones, helping to improve concentration and brain performance. This study aims to determine the effect of bee pollen on the sperm quality of male rats. Administering 1 ml of water as control (-), 1 ml/kg of Eurycoma longifolia capsule as control (+), 1 ml/kg of nano bee pollen, and bee pollen with concentrations of 0.33 ml/kg, 0.66 ml/kg, 1 ml/kg, and 1.33 ml/kg 34 times in Sprague Dawley male white rats. The mice were then operated on and examined for testicular weight, epididymal weight, sperm pH, sperm motility, sperm concentration, and sperm abnormalities. The results showed that bee pollen and nano bee pollen did not significantly affect the quality of rat spermatozoa. In examining the testicular weight of rats, 0.33 ml/kg of bee pollen had an average testicular weight greater than the control group. For sperm weight and pH of the rat epididymis, the administration of bee pollen showed the average weight and pH were lower than the control. In the examination of sperm motility, 0.33 ml of bee pollen had a higher percentage than the control, while 1 ml of nano bee pollen had the lowest percentage of motility. The results of the concentration and abnormalities of rat spermatozoa from a dose of 1 ml/kg of bee pollen had an average sperm count higher than the control which was 2,129.7 million/ml and the lowest percentage of sperm abnormalities was 8.73%.
Acetylcholinesterase Enzyme Inhibitor and Antioxidant Activities from A Mixture Extracts of Black Tea, Red Betel, Cinnamon and Curcuma Huda, Aziz Syamsul; Hasan, Akhmad Endang Zainal; Safithri, Mega
Current Biochemistry Vol. 9 No. 2 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.2.2

Abstract

Alzheimer's Disease (AD) is one of the consequences of impaired functioning of acetylcholine which can be hydrolyzed by the enzyme acetylcholinesterase. Alzheimer's treatment is carried out using two approaches, namely compounds (acetylcholinesterase inhibitors) and noncholinergics (antioxidants). There are commercial drugs that can slow the progression of Alzheimer's, but their use can cause excessive side effects. The use of herbal plants as a cure for Alzheimer's disease has been proven to be safer and does not cause excessive side effects. Herbal plants that can be used and developed are black tea, red betel, curcuma, and cinnamon. This study determined that extracts of black tea, red betel leaf, curcuma, and cinnamon's formula have the best antioxidant activity and level of inhibition of the acetylcholinesterase enzyme. F1 (cinnamon), F5 (cinnamon, black tea, red betel, and curcuma), F6 (cinnamon and black tea), and F11 (cinnamon, black tea, and curcuma) were the best formulations in each type of sample based on inhibitory AChE enzymes and antioxidants activity. F1 (cinnamon) is the most effective extract out of all formulations analyzed in this study. Keywords: Acetylcholinesterase; Alzheimer; Black Tea; Cinnamon; Red Betel; Curcuma
Co-Authors Agus Setiyono Aisyah Aisyah Alfina Zalfa Suryono Amalia, Lathifah Antonius Anre Sianturi Aris Tri Wahyudi Armando Balses Ishimora Aton Yulianto Aziz Syamsul Huda Aziz Syamsul Huda Bayu Sandi Bina Lohita Sari Bram Kusbiantoro Bustomi - Bustomi Chintia Ayu Puspita Dadan Rohdiana Deviyanti Pratiwi Dewi Priandini Dhani Luthfi Ramadhani DIMAS ANDRIANTO Djarot Sasongko Hami Seno Djumali Mangunwidjaja Dwi Rofifah Putri Jania E. Mulyati Effend Effend, E. Mulyati Ekowati Handharyani Eny Ida Riyanti Eny Ida Riyanti Erlank Bagjavicenna Faisal Rahman Handayani, Septa Fitri Hasanah, Rima Nidaul Hasim Hasim Hasim Hasim Heddy Julistiono Heddy Julistiono Henry Adiprabowo, I Made Artika, Heny Herawati Huda, Aziz Syamsul Husnawati, . I MADE ARTIKA Ika Mulawati Purwanti Noviana Ike Agustiani Ike Yulia Wiendarlina Ilham Gilang Cahya Ahmada Indradewa, Rhian Ingrid Aurelia Genacia Cokro Isra Janatiningrum Karichsa Hariana Khaswar Syamsu Kristina Mulia LAKSMI AMBARSARI Mega Safithri Miko Afrian Moerfiah Mona . Muhamad Alvin Adriyan Muhammad Zulkifli Mutholaah Nashrianto, Husain Ni Putu Ratna Ayu Krishanti Noli Novidahlia Novi Fajar Utami Novia Juhaeni, Rani Nurliani Bermawie Olive Wisepti Pratama Ono Suparno Purnamasari, Anita Purnomo Purnomo Putri Ramadhanty Rafida Nisa Maghfiroh Ranady Perwira Nuruzzaman Rara Annisaur Rosyidah Rini Kurniasih, Rini Rosyidah, Rara Annisaur Safira, Ukhradiya Maharaniq Salim, Richentya Feiby Sandi, Bayu Sekar Winahyu Ariadini Sharon Aurellia Siti Magfiroh Siti Sholekha Siti Wachidatun Zulaikha Siwi Putri Andini Sri Budiarti Sri Wahyuni Sri Wardatun Suryani Suryani Suryani Syaeful Abidin Syifa Khaerani Tansza Setiana Putri Titi Candra Sunarti Tommy Abrar Tri Joko Santoso Ulya Utami Vetnizah Juniantito Winahyu Ariadini, Sekar Witdiastuti Witdiastuti Zainal Alim Mas'ud