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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Industri Pertanian Jurnal Veteriner CHEMISTRY PROGRESS BIOTROPIA - The Southeast Asian Journal of Tropical Biology Current Biochemistry Pharmascience Dental Journal (Majalah Kedokteran Gigi) EnviroScienteae JURNAL PERTANIAN Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Teknik Industri JSMARTech : Journal of Smart Bioprospecting and Technology Indonesian Journal of Applied Research (IJAR) Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Pusat Inovasi Masyarakat JURNAL AGROINDUSTRI HALAL Odonto dental journal

Akhmad Endang Zainal Hasan

Department Of Biochemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Bogor 16680, Indonesia

Author-ID : 1333325

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Transportation Veterinary

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SUPLEMENTASI KELAPA KOPYOR TERHADAP AKTIVITAS SUPEROKSIDA DISMUTASE DAN PATOLOGI ANATOMI HATI TIKUS AKIBAT PERLAKUAN PARASETAMOL Akhmad Endang Zainal Hasan; Hasim Hasim; Agus Setiyono; Sekar Winahyu Ariadini
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 3, No 1 (2013): FITOFARMAKA
Publisher : Universitas Pakuan

This research aimed at determining of the effects of the induction of paracetamoland kopyor coconut on the activity of superoxide dismutase (SOD) and pathologicanatomy of rats liver. Previous research shows that paracetamol caused negative effectto the body while kopyor coconut has the ability to improve human health, related to itscapacity to prevent oxidative damage of human body. In this research, the positiveeffect of kopyor is approached through measurement of body weight and the activity ofthe total SOD enzyme of animals tested, which are induced by paracetamol and fed withkopyor. Rats administered with temulawak were positive control. The result showedthat paracetamol treatment using toxic dose was found to reduce body weight of testedanimals. Meanwhile, both kopyor and temulawak supplements were able to counter thenegative effect of paracetamol, indicated by the increase in the body weight of testedanimals. Other results showed that treatments with temulawak and 5 times-dose ofkopyor supplement demonstrated a significantly high total SOD activity in the liver ascompared to negative control. Furthermore, pathologic observation of the testedanimals liver showed that 5 time-dose of kopyor treatment was confirmed to improve the recovery of the liver caused by negative effect of paracetamol, better than the negative control.Key words: kopyor coconut, superoxide dismutase, free radical, pathologic

CAMPURAN PROPOLIS DAN GARAM KELAPA SEBAGAI BAHAN ANTIBAKTERI PLAK GIGI MIXED PROPOLIS AND COCONUT SALT AS A DENTAL PLAQUE ANTIBACTERIAL AGENT Akhmad Endang Zainal Hasan; I Made Artika, Henry Adiprabowo
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 2, No 2 (2012): FITOFARMAKA
Publisher : Universitas Pakuan

Karies gigi merupakan masalah kesehatan yang umum terjadi di kalanganmasyarakat Indonesia. Faktor yang paling banyak menyebabkan karies gigi adalah plak gigi.Bakteri yang dominan dalam plak gigi adalah Streptococcus mutans. Salah satu bahanantibakteri kariogenik yang biasa dipakai dalam pasta gigi saat ini adalah fluor. Penggunaanpasta gigi berfluor dapat menimbulkan fluorosis yaitu pelemahan email gigi bila dipakaidalam konsentrasi yang berlebihan. Propolis dan garam kelapa merupakan bahan alamiyang berpotensi sebagai antibakteri pengganti fluor. Penelitian bertujuan untuk mengujiaktivitas antibakteri dari campuran propolis dan garam kelapa dan membandingkankeefektifannya dengan antibakteri NaF yang terdapat dalam pasta gigi komersial. Ujiaktivitas antibakteri S. mutans dilakukan dengan metode hitungan cawan yaitupenghitungan jumlah bakteri yang tumbuh di media contoh dalam cawan petri. Propoliskasar diekstrak dengan alkohol dan didapatkan rendemen sebesar 8.52%. Hasil penelitianmenunjukkan bahwa campuran propolis 6.25% dan garam kelapa 1 M mempunyaikemampuan paling besar sebagai antibakteri dan dapat menghambat S. mutans lebih baikdaripada NaF 0.3%. Keefektifan propolis-garam terhadap NaF 0.3% sebesar 203.88%.Kata kunci : propolis, garam kelapa, antibakteri, antikaries gigi, Streptococcus mutans,

Pemanfaatan Kulit Jambu Kristal dan Daun Ubi Jalar sebagai Pupuk Cair dengan Cara Polinasi untuk Meningkatkan Produksi Jambu Kristal Akhmad Endang Zainal Hasan; Ulya Utami
Jurnal Pusat Inovasi Masyarakat (PIM) Vol. 2 No. 1 (2020): Februari 2020
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.769 KB)

Cikarawang Village is one of the villages located around the IPB Campus, Dramaga District, Bogor Regency, West Java Province. Based on the potential of existing resources in the Village Cikarawang, there are important commodities to meet the need of life for the surrounding community. Agriculture in Cikarawang Village is dominated by cassava, sweet potato and guava plants. Waste management of crystal guava and sweet potato leaves has not been utilized optimally. This community service aims to utilize the abundant local potential in the manufacture of liquid fertilizer by pollination to increase the production of guava. The method used was counseling and demonstration of liquid fertilizer. The activity was carried out in Cikarawang Village, Dramaga District, Bogor Regency. Participants numbered 17 people consisting of village heads, chairmen of farmers and farmers. The activity was carried out with two sessions, namely the delivery of material and the practice of making liquid fertilizer. This community service activity from an economic perspective can increase farmers' income by maximizing production.

Hepatoprotective Activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in Rats Induced by Paracetamol Akhmad Endang Zainal Hasan; Agus Setiyono; Miko Afrian
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.4

Negative effects on health will occur in excessive use of paracetamol. The main objective of this study was to determine the hepatoprotective activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats induced by paracetamol. The study was conducted on 36 Sprague Dawley rats with 6 rats in each group. Group 1 (normal control), group 2 (positive control, temulawak 42.86 mg/kg BW), group 3 (negative control), group 4 (infusion of Myrmeleon 10 mg/kg BW), group 5 (propolis extract 0.02 ml/kg BW), and group 6 (Hibiscus sabdariffa infusion 0.02 ml/kg BW). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations were determined spectrophotometrically and microscopically for liver histopathology. The results showed that during three weeks of treatment with Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats, this treatment could decrease ALT and AST activity as the positive control. The ALT activity values of the three materials were 69.26, 51.00, 51.00, 43.67, U/I with AST values of 110.29, 97.33, 91.00, 91.33 U/I. Based on Duncan's test, there were significant differences between all treatments with negative and positive control groups. Likewise, with the histopathological scoring results, the negative control was found to be significantly different from all treatments. Therefore, treatment with propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. may have hepatoprotective benefit.

Essential Oil and Ethanolic Extract of Curcuma Inhibits Mammae Tumors in Rats Induction by DMBA Akhmad Endang Zainal Hasan; Ekowati Handharyani; Sri Wahyuni
Jurnal Pharmascience Vol 9, No 1 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i1.13215

Curcuminoids and xanthorizol are active components that may act as anticancer in the rhizome of Curcuma xanthorrhiza. The purpose of this study was to determine the content of the class of compounds in curcuma extract and essential oil using the phytochemical screening test method, the Folin-Ciocalteu method to determine the total phenolic content and the AlCl3 method for the total fentuconoid content. In addition, the activity of curcuma in inhibiting the influence of DMBA on the growth of breast cancer in rats was determined. Curcuma extract used is the result of extraction using 70% ethanol on an industrial scale. Total phenolic content and flavonoid extract of curcuma were determined by spectrophotometer. Inhibition testing of tumors formed due to DMBA induction was carried out by administering temulawak extract at doses of 35, 70, 140, 210 and 280 mg/kg body weight. Based on the phytochemical analysis, the ethanol extract of curcuma contained terpenoids, alkaloids, phenolic compounds and flavonoids. The results of the analysis of the ethanol extract of curcuma contained total phenols and flavonoids with concentrations of 42.96 mg GAE/g and 3.96 mg QE/g, respectively. The group that was given curcuma extract as the control group (p<0.05) had a significant difference. Based on the Mann-Whitney analysis, the third group with a dose of 140 mg/kg BW had the highest effect on tumor inhibition. The hope is that the development of curcuma extract into a standardized herbal medicine so that it can be used for the treatment of breast cancer can use the results of this research.

EXTRACTION OF ROBUSTA COFFEE BEANS (Coffea canephora) FROM WONOSOBO BY ULTRASONIC WAVES AND ANTICANCER TESTS Akhmad Endang Zainal Hasan; Novi Fajar Utami; Mona .
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4933

Wonosobo Robusta coffee beans are one of the natural source ingredients that potentially could be used as ananticancer. It contains polyphenolic compounds such as chlorogenic acid, flavonoids, and hydroxy hydroquinone. Thisresearch aims to determine the optimum conditions for the extraction temperature and time of the Ultrasonic-Assisted Extraction (UAE) method on the extract yield and to determine the anticancer activity. Extraction optimizations wereanalyzed using Response Surface Methodology (RSM) with Central Composite Design (CCD) experimental design on atemperature factor of 40, 50, 60 ºC and extraction times of 10, 30 and 50 minutes. Determination of anticancer activitywas conducted using the Methyl Thiazole Tetrazolium (MTT) Assay method against MCF-7 cells. The optimization results indicate that the temperature of 52.74 ºC and time of 29,53 min are the optimum conditions for extraction with an extract yield of 9,16%. The anticancer activity test result at a concentration of 400 µg/mL is 83,25% so it has the potential to be used as an anticancer.

Isolasi dan Karakterisasi Bakteri Endofit dari Daun Sirsak Annona Muricata L. dan Aktivitas Antibakterinya terhadap Beberapa Bakteri Patogen Isra Janatiningrum; Akhmad Endang Zainal Hasan; Eny Ida Riyanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24321

Soursop (Annona muricata L.) is a plant with many health benefits. Soursop leaves are widely used as traditional medicine by Indonesian citizen for wound infection healing. The antibacterial activity of soursop leaves cannot be separated from the presence of endophytic microbes that live inside. Endophytic bacteria live in plant tissues and have beneficial for their host plants. Endophytic microbes are able to produce same secondary metabolites as their host such as producing antibacterial compounds. Thirty one bacterial endophytes were isolated from soursop leaves that from 3 different regions: Garut, Cianjur, and Sukabumi. Morphologically, endophytic bacterial isolates from the three regions had different diversity. Bacterial isolates were tested for their activity against 4 test pathogenic bacteria, such as Pseudomonas aeroginosa, Escherichia coli, Staphylococcus mutans, and Streptococcus aureus. Antibacterial test using disc diffusion method with chloramphenicol 500 m/mL as positive control. Based on the antibacterial activity test, isolate G42 was able to inhibit all types of test bacteria. G42 isolates forms a zone of inhibition up to 17 mm in P. aeroginosa. Based on 16S rRNA, G42 isolates had similarity with Pantoea wallisii up to 93.24%. This study shows that endophytic bacteria isolated from soursop leaves have the potential to be developed into antibacterial agents.

Penerapan Ekstraksi Cair Tekanan Uap Tinggi Menggunakan Bahan Halal untuk Optimasi Antioksidan Akhmad Endang Zainal Hasan; Ike Yulia Wiendarlina; Witdiastuti Witdiastuti
JURNAL AGROINDUSTRI HALAL Vol. 8 No. 1 (2022): Jurnal Agroindustri Halal 8(1)
Publisher : Lembaga Riset dan Pengabdian Kepada Masyarakat Universitas Djuanda Bogor

Soursop is a plant that is used as traditional medicine. Antioxidants are compounds that are able to delay, slow down, or inhibit oxidation reactions. This study aims to determine the effect of variations in extraction time and the comparison of variations in the amount of simplicia with aquadest solvent on the high pressure extraction method on antioxidant activity. The study made 13 treatments using the Response Surface Methodology (RSM) design with the fit of the Central Composite Design (CCD) model. The results showed that from the 13 treatments, the extraction time had an effect on the percent yield with the equation Y = -51.9692 + 24.2030 X1 + 1.2984 X2. The extraction time (X1) has a value greater than the ratio of simplicia powder to the volume of distilled water (X2) as well as the IC50 value as shown in the equation Y = 171,983 + 13,828 X1 – 4,110 X2. Extraction time (X1) has a greater value when compared to simplicia with aquadest solvent volume (X2). The results of the analysis of the percentage of extract yield and the optimal IC50 value using RSM analysis were thought to have an extraction time of 6.3 minutes and the ratio of simplicia powder to the volume of aquadest solvent was 1:61,2. The results of the antioxidant activity obtained that the optimal IC50 value was estimated at 4.3 minutes of extraction time and the ratio of simplicia powder to the volume of aquadest solvent was 1:78.2.

Uji Penghambatan α-Glukosidase dari Kombinasi Ekstrak Kunyit, Teh Hitam dan Jahe: The α-Glucosidase Inhibition Test from a Combination of Turmeric Extract, Black Tea, and Ginger Akhmad Endang Zainal Hasan; Dimas Andrianto; Rara Annisaur Rosyidah
JURNAL AGROINDUSTRI HALAL Vol. 8 No. 1 (2022): Jurnal Agroindustri Halal 8(1)
Publisher : Lembaga Riset dan Pengabdian Kepada Masyarakat Universitas Djuanda Bogor

Traditional medicines that can be used as α-glucosidase inhibitors are turmeric (Curcuma longa L.), black tea (Camellia sinensi L), and ginger (Zingiber officinale). It is necessary to research the use of a combination of tea, turmeric, and ginger in inhibiting the α -glucosidase enzyme. This study aims to determine the optimal combination of extracts of turmeric, black tea, and ginger in inhibiting the α-glucosidase enzyme. The research carried out was the measurement of IC50 values for the inhibition of α-glucosidase of each extract, and the inhibition of the enzyme α-glucosidase in combination. The results of the test of ethanol extract of turmeric, ginger and black tea water extract obtained the inhibition value of α-glucosidase with IC50 values of 9.48±0.05 g/mL, 66.64±0.44 g/mL and 9.52±0.25, respectively. F7 is a combination of turmeric, ginger and black tea which produces the highest α-glucosidase inhibition, which is 67.86±0.93%.

Activity of Antioxidant and Inhibitor ?-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) and Tea Benalu (Scurulla atropurpureea BL Dans) Bina Lohita Sari; Akhmad Endang Zainal Hasan; Lusi Agus Setiani
Journal of Science Innovare Vol 1, No 01 (2018): Journal of Science Innovare
Publisher : Universitas Pakuan

Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants and anti diabetic. The ?-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by dissolving in water. This study aims to determine the antioxidant activity and inhibitors of instant granular ?-glucosidase ethanolic extract of Tea and Tea Tea leaves. The extract was obtained from extraction with 60% ethanol solvent-assisted extraction (MAE) method. Research was done by making 3 formula (Formula 1, 2 and 3) with comparison of tea leaf extract, parasite, Polivinil pyrrolidone (PVP) and cyclodextrin ie 26,88%, 1,8%, 2%, 0% (Formula 1) 26.88%, 0%, 3%, 12% and 0% (Formula 2), 1.8%, 4%, 15% (Formula 3). Formula 2 is active as an antioxidant and ?-glucosidase enzyme inhibitor with IC50 values of 68.21 and 56.76 ppm. Keywords: Tea Leaves, Benalu Tea, Antioxidants, ?-glucosidase Inhibitors, Instant Granules

Co-Authors Agus Setiyono Aisyah Aisyah Alfina Zalfa Suryono Amalia, Lathifah Antonius Anre Sianturi Aris Tri Wahyudi Armando Balses Ishimora Aton Yulianto Aziz Syamsul Huda Aziz Syamsul Huda Bayu Sandi Bina Lohita Sari Bram Kusbiantoro Bustomi - Bustomi Chintia Ayu Puspita Dadan Rohdiana Deviyanti Pratiwi Dewi Priandini Dhani Luthfi Ramadhani DIMAS ANDRIANTO Djarot Sasongko Hami Seno Djumali Mangunwidjaja Dwi Rofifah Putri Jania E. Mulyati Effend Effend, E. Mulyati Ekowati Handharyani Eny Ida Riyanti Eny Ida Riyanti Erlank Bagjavicenna Faisal Rahman Handayani, Septa Fitri Hasanah, Rima Nidaul Hasim Hasim Hasim Hasim Heddy Julistiono Heddy Julistiono Henry Adiprabowo, I Made Artika, Heny Herawati Huda, Aziz Syamsul Husnawati, . I MADE ARTIKA Ika Mulawati Purwanti Noviana Ike Agustiani Ike Yulia Wiendarlina Ilham Gilang Cahya Ahmada Indradewa, Rhian Ingrid Aurelia Genacia Cokro Isra Janatiningrum Karichsa Hariana Khaswar Syamsu Kristina Mulia LAKSMI AMBARSARI Mega Safithri Miko Afrian Moerfiah Mona . Muhamad Alvin Adriyan Muhammad Zulkifli Mutholaah Nashrianto, Husain Ni Putu Ratna Ayu Krishanti Noli Novidahlia Novi Fajar Utami Novia Juhaeni, Rani Nurliani Bermawie Olive Wisepti Pratama Ono Suparno Purnamasari, Anita Purnomo Purnomo Putri Ramadhanty Rafida Nisa Maghfiroh Ranady Perwira Nuruzzaman Rara Annisaur Rosyidah Rini Kurniasih, Rini Rosyidah, Rara Annisaur Safira, Ukhradiya Maharaniq Salim, Richentya Feiby Sandi, Bayu Sekar Winahyu Ariadini Sharon Aurellia Siti Magfiroh Siti Sholekha Siti Wachidatun Zulaikha Siwi Putri Andini Sri Budiarti Sri Wahyuni Sri Wardatun Suryani Suryani Suryani Syaeful Abidin Syifa Khaerani Tansza Setiana Putri Titi Candra Sunarti Tommy Abrar Tri Joko Santoso Ulya Utami Vetnizah Juniantito Winahyu Ariadini, Sekar Witdiastuti Witdiastuti Zainal Alim Mas'ud

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