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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia Jurnal Teknologi Industri Pertanian CHEMISTRY PROGRESS BIOTROPIA - The Southeast Asian Journal of Tropical Biology Current Biochemistry ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) EnviroScienteae JURNAL PERTANIAN Journal of Science Innovare FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Ilmiah Teknik Industri JSMARTech : Journal of Smart Bioprospecting and Technology Indonesian Journal of Applied Research (IJAR) Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Pusat Inovasi Masyarakat Odonto dental journal Journal of Pharmascience Jurnal Agroindustri Halal
Akhmad Endang Zainal Hasan
Department Of Biochemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Transportation Veterinary

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CAMPURAN PROPOLIS DAN GARAM KELAPA SEBAGAI BAHAN ANTIBAKTERI PLAK GIGI MIXED PROPOLIS AND COCONUT SALT AS A DENTAL PLAQUE ANTIBACTERIAL AGENT Akhmad Endang Zainal Hasan; I Made Artika, Henry Adiprabowo
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 2, No 2 (2012): FITOFARMAKA
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.064 KB) | DOI: 10.33751/jf.v2i2.168

Abstract

Karies gigi merupakan masalah kesehatan yang umum terjadi di kalanganmasyarakat Indonesia. Faktor yang paling banyak menyebabkan karies gigi adalah plak gigi.Bakteri yang dominan dalam plak gigi adalah Streptococcus mutans. Salah satu bahanantibakteri kariogenik yang biasa dipakai dalam pasta gigi saat ini adalah fluor. Penggunaanpasta gigi berfluor dapat menimbulkan fluorosis yaitu pelemahan email gigi bila dipakaidalam konsentrasi yang berlebihan. Propolis dan garam kelapa merupakan bahan alamiyang berpotensi sebagai antibakteri pengganti fluor. Penelitian bertujuan untuk mengujiaktivitas antibakteri dari campuran propolis dan garam kelapa dan membandingkankeefektifannya dengan antibakteri NaF yang terdapat dalam pasta gigi komersial. Ujiaktivitas antibakteri S. mutans dilakukan dengan metode hitungan cawan yaitupenghitungan jumlah bakteri yang tumbuh di media contoh dalam cawan petri. Propoliskasar diekstrak dengan alkohol dan didapatkan rendemen sebesar 8.52%. Hasil penelitianmenunjukkan bahwa campuran propolis 6.25% dan garam kelapa 1 M mempunyaikemampuan paling besar sebagai antibakteri dan dapat menghambat S. mutans lebih baikdaripada NaF 0.3%. Keefektifan propolis-garam terhadap NaF 0.3% sebesar 203.88%.Kata kunci : propolis, garam kelapa, antibakteri, antikaries gigi, Streptococcus mutans,
Pemanfaatan Kulit Jambu Kristal dan Daun Ubi Jalar sebagai Pupuk Cair dengan Cara Polinasi untuk Meningkatkan Produksi Jambu Kristal Akhmad Endang Zainal Hasan; Ulya Utami
Jurnal Pusat Inovasi Masyarakat (PIM) Vol. 2 No. 1 (2020): Februari 2020
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (446.769 KB)

Abstract

Cikarawang Village is one of the villages located around the IPB Campus, Dramaga District, Bogor Regency, West Java Province. Based on the potential of existing resources in the Village Cikarawang, there are important commodities to meet the need of life for the surrounding community. Agriculture in Cikarawang Village is dominated by cassava, sweet potato and guava plants. Waste management of crystal guava and sweet potato leaves has not been utilized optimally. This community service aims to utilize the abundant local potential in the manufacture of liquid fertilizer by pollination to increase the production of guava. The method used was counseling and demonstration of liquid fertilizer. The activity was carried out in Cikarawang Village, Dramaga District, Bogor Regency. Participants numbered 17 people consisting of village heads, chairmen of farmers and farmers. The activity was carried out with two sessions, namely the delivery of material and the practice of making liquid fertilizer. This community service activity from an economic perspective can increase farmers' income by maximizing production.
Hepatoprotective Activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in Rats Induced by Paracetamol Akhmad Endang Zainal Hasan; Agus Setiyono; Miko Afrian
Current Biochemistry Vol. 9 No. 1 (2022)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.9.1.4

Abstract

Negative effects on health will occur in excessive use of paracetamol. The main objective of this study was to determine the hepatoprotective activity of Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats induced by paracetamol. The study was conducted on 36 Sprague Dawley rats with 6 rats in each group. Group 1 (normal control), group 2 (positive control, temulawak 42.86 mg/kg BW), group 3 (negative control), group 4 (infusion of Myrmeleon 10 mg/kg BW), group 5 (propolis extract 0.02 ml/kg BW), and group 6 (Hibiscus sabdariffa infusion 0.02 ml/kg BW). Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) concentrations were determined spectrophotometrically and microscopically for liver histopathology. The results showed that during three weeks of treatment with Propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. in rats, this treatment could decrease ALT and AST activity as the positive control. The ALT activity values ​​of the three materials were 69.26, 51.00, 51.00, 43.67, U/I with AST values ​​of 110.29, 97.33, 91.00, 91.33 U/I. Based on Duncan's test, there were significant differences between all treatments with negative and positive control groups. Likewise, with the histopathological scoring results, the negative control was found to be significantly different from all treatments. Therefore, treatment with propolis Trigona spp., Hibiscus sabdariffa, and Myrmeleon sp. may have hepatoprotective benefit.
EXTRACTION OF ROBUSTA COFFEE BEANS (Coffea canephora) FROM WONOSOBO BY ULTRASONIC WAVES AND ANTICANCER TESTS Akhmad Endang Zainal Hasan; Novi Fajar Utami; Mona .
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 1 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i1.4933

Abstract

Wonosobo Robusta coffee beans are one of the natural source ingredients that potentially could be used as ananticancer. It contains polyphenolic compounds such as chlorogenic acid, flavonoids, and hydroxy hydroquinone. Thisresearch aims to determine the optimum conditions for the extraction temperature and time of the Ultrasonic-Assisted Extraction (UAE) method on the extract yield and to determine the anticancer activity. Extraction optimizations wereanalyzed using Response Surface Methodology (RSM) with Central Composite Design (CCD) experimental design on atemperature factor of 40, 50, 60 ºC and extraction times of 10, 30 and 50 minutes. Determination of anticancer activitywas conducted using the Methyl Thiazole Tetrazolium (MTT) Assay method against MCF-7 cells. The optimization results indicate that the temperature of 52.74 ºC and time of 29,53 min are the optimum conditions for extraction with an extract yield of 9,16%. The anticancer activity test result at a concentration of 400 µg/mL is 83,25% so it has the potential to be used as an anticancer.
Isolasi dan Karakterisasi Bakteri Endofit dari Daun Sirsak Annona Muricata L. dan Aktivitas Antibakterinya terhadap Beberapa Bakteri Patogen Isra Janatiningrum; Akhmad Endang Zainal Hasan; Eny Ida Riyanti
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 3, No 2 (2021)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v3i2.24321

Abstract

Soursop (Annona muricata L.) is a plant with many health benefits. Soursop leaves are widely used as traditional medicine by Indonesian citizen for wound infection healing. The antibacterial activity of soursop leaves cannot be separated from the presence of endophytic microbes that live inside. Endophytic bacteria live in plant tissues and have beneficial for their host plants. Endophytic microbes are able to produce same secondary metabolites as their host such as producing antibacterial compounds. Thirty one bacterial endophytes were isolated from soursop leaves that from 3 different regions: Garut, Cianjur, and Sukabumi. Morphologically, endophytic bacterial isolates from the three regions had different diversity. Bacterial isolates were tested for their activity against 4 test pathogenic bacteria, such as Pseudomonas aeroginosa, Escherichia coli, Staphylococcus mutans, and Streptococcus aureus. Antibacterial test using disc diffusion method with chloramphenicol 500 m/mL as positive control. Based on the antibacterial activity test, isolate G42 was able to inhibit all types of test bacteria. G42 isolates forms a zone of inhibition up to 17 mm in P. aeroginosa. Based on 16S rRNA, G42 isolates had similarity with Pantoea wallisii up to 93.24%. This study shows that endophytic bacteria isolated from soursop leaves have the potential to be developed into antibacterial agents.
Activity of Antioxidant and Inhibitor ?-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) and Tea Benalu (Scurulla atropurpureea BL Dans) Bina Lohita Sari; Akhmad Endang Zainal Hasan; Lusi Agus Setiani
Journal of Science Innovare Vol 1, No 01 (2018): Journal of Science Innovare
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (490.824 KB) | DOI: 10.33751/jsi.v1i01.676

Abstract

Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants and anti diabetic. The ?-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by dissolving in water. This study aims to determine the antioxidant activity and inhibitors of instant granular ?-glucosidase ethanolic extract of Tea and Tea Tea leaves. The extract was obtained from extraction with 60% ethanol solvent-assisted extraction (MAE) method. Research was done by making 3 formula (Formula 1, 2 and 3) with comparison of tea leaf extract, parasite, Polivinil pyrrolidone (PVP) and cyclodextrin ie 26,88%, 1,8%, 2%, 0% (Formula 1) 26.88%, 0%, 3%, 12% and 0% (Formula 2), 1.8%, 4%, 15% (Formula 3). Formula 2 is active as an antioxidant and ?-glucosidase enzyme inhibitor with IC50 values of 68.21 and 56.76 ppm. Keywords: Tea Leaves, Benalu Tea, Antioxidants, ?-glucosidase Inhibitors, Instant Granules
Identifikasi Penyebab Kematian Domba Melalui Bedah Bangkai di Desa Pantai Mekar, Muara Gembong, Kabupaten Bekasi Sharon Aurellia; Armando Balses Ishimora; Dwi Rofifah Putri Jania; Putri Ramadhanty; Aisyah Aisyah; Alfina Zalfa Suryono; Rafida Nisa Maghfiroh; Siti Magfiroh; Antonius Anre Sianturi; Ranady Perwira Nuruzzaman; Akhmad Endang Zainal Hasan; Vetnizah Juniantito
Jurnal Pusat Inovasi Masyarakat (PIM) Vol. 5 No. 1 (2023): April 2023
Publisher : Direktorat Pengembangan Masyarakat Agromaritim, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jpim.5.1.116-127

Abstract

Sheep breeders generally raise their sheep by releasing and allowing their livestock to graze wildly. This causes the sheep to receive feed intake with unbalanced nutrition. One of the student programs in the KKN-T IPB University in Pantai Mekar Village, Muara Gembong District, Bekasi Regency, were checking physical conditions, socializing management of sheep maintenance and distribution of vitamin B complex which to improve the health of the sheep. It was reported that four sheep were found dead after B complex vitamin administration to in four days. The sheep cadavers were brought to the School of Veterinary and Biomedical Sciences, IPB to undergo carcass surgery or necropsy to reveal the cause of death. The results of necropsy found Haemonchus contortus worm infestation in the abomasum of sheep, accompanied by accumulation of fluid under the skin, chest cavity, stomach, and lungs. The cause of death of the four sheep based on necropsy was caused by severe infestation of the Haemonchus contortus type of worm and malnutrition, which lead to hypoalbuminemia and progressed to edema in the lungs, which resulted in shortness of breath (dyspnea). In this case the necropsy results showed that the administration of vitamin B complex was not the cause of the death of the sheep.
Activity of Antioxidant and Inhibitor ?-Glucosidase Instant Granul Ethanol Tea Leaf Extract (Camellia sinensis) and Tea Benalu (Scurulla atropurpureea BL Dans) Bina Lohita Sari; Akhmad Endang Zainal Hasan; Lusi Agus Setiani
Journal of Science Innovare Vol 1, No 1 (2018): Journal of Science Innovare, Volume 01 Number 01 2018
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jsi.v1i01.676

Abstract

Tea leaves are plants that are widely spread especially in the area of West Java, while parasites are parasitic plants in tea trees that empirically have various properties such as antioxidants and anti diabetic. The ?-glucosidase inhibitor is one of the therapeutic drugs for diabetic that works by inhibiting carbohydrate metabolism. Instant granule preparation is one form of dosage used by dissolving in water. This study aims to determine the antioxidant activity and inhibitors of instant granular ?-glucosidase ethanolic extract of Tea and Tea Tea leaves. The extract was obtained from extraction with 60% ethanol solvent-assisted extraction (MAE) method. Research was done by making 3 formula (Formula 1, 2 and 3) with comparison of tea leaf extract, parasite, Polivinil pyrrolidone (PVP) and cyclodextrin ie 26,88%, 1,8%, 2%, 0% (Formula 1) 26.88%, 0%, 3%, 12% and 0% (Formula 2), 1.8%, 4%, 15% (Formula 3). Formula 2 is active as an antioxidant and ?-glucosidase enzyme inhibitor with IC50 values of 68.21 and 56.76 ppm. Keywords: Tea Leaves, Benalu Tea, Antioxidants, ?-glucosidase Inhibitors, Instant Granules
Anticancer Activity of Trigona sp. Honey against Breast Cancer, Colon Cancer, and Lung Cancer Bustomi - Bustomi; Akhmad Endang Zainal - Hasan; Khaswar - Syamsu
EnviroScienteae Vol 19, No 2 (2023): ENVIROSCIENTEAE VOLUME 19 NOMOR 2, MEI 2023
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/es.v19i2.15021

Abstract

Since ancient times, honey has been utilized as a medication, while Trigona sp. honey is a special kind of honey. Breast, colon, and lung cancers are very malignant types of cancer and need to be treated with caution This investigation intended to establish the in vitro toxicity activity of eight Trigona sp. honey opposed to breast cancer (MCF-7), colon cancer (WiDr), and lung cancer (A549). Cytotoxicity using the MTT test technique (3,4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide). The honey used is Trigona sp. honey with Indonesian standards and the concentration of honey tested is 5.5%. The results obtained were that honey Banten 1 dan 2, Bogor, Bangka Belitung, Batu Ampar, Sumedang, Garut, and Klaten inhibited MCF-7 cancer cells by 89.46, 84.56, 77.96, 86.39, 84.58, 85.26, 88.24, 84.40; honey Banten 1 dan 2, Bogor, Bangka Belitung, Batu Ampar, Sumedang, Garut, and Klaten inhibited WiDr cancer cells by 83.22, 76.74, 68.85, 75.51, 78.53, 81.43, 81.96, 78.33; honey Banten 1 dan 2, Bogor, Bangka Belitung, Batu Ampar, Sumedang, Garut, and Klaten inhibited cancer cells A549 by 52.16, 0, 63.21, 85.92, 82.60, 84.68, 69.63, 56.38. It was found that all types of honey could inhibit cells except honey from Banten 2. The highest percentages of inhibition against MCF-7, A549, and WiDr cells were 89.46, 85.92, and 83.22 from honey Banten 1, Bangka Belitung, and Banten 1.
The effect of trigona spp. Propolis extract to saliva substitute ph as xerostomia therapy Ingrid Aurelia Genacia Cokro; Dewi Priandini; Deviyanti Pratiwi; Akhmad Endang Zainal Hasan
Odonto : Dental Journal Vol 10, No 1 (2023): July 2023
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.10.1.117-124

Abstract

Background: Patients with xerostomia generally have an acidic salivary pH. Low oral pH increases the occurrence of tooth caries and development of oral lesions such as recurrent aphthous stomatitis (RAS) which are prone to occur in patients with xerostomia. Trigona spp. propolis extract with antimicrobial compounds was used as an additional natural ingredient in saliva substitute to inhibit the growth of Streptococcus mutans and prevent the decrease of salivary pH in patients with xerostomia. This study aimed to determine the effect of Trigona spp. propolis extract to saliva substitute pH as therapy for xerostomia with antimicrobial activity. Method: This study was experimental laboratory, namely Post-test only Control Group Design. The propolis Trigona spp. extract used in this study was extracted using maceration method with 70% ethanol as solvent which was then diluted into 5 concentrations 1,25%, 2,5%, 5%, 10%, 20%. This study used Streptococcus mutans (ATCC 25175) and saliva substitute with pH of 6.8. The research includes phytochemical test, absorbance measurement and pH test. Result: There is a significant difference in the pH value between saliva substitute induced with Streptococcus mutans with Trigona spp. propolis extract and the control group. Data analysis using One-way ANOVA test showed a significant value of
Co-Authors Agus Setiyono Aisyah Aisyah Alfina Zalfa Suryono Amalia, Lathifah Anita Purnamasari Antonius Anre Sianturi Aris Tri Wahyudi Armando Balses Ishimora Aton Yulianto Aziz Syamsul Huda Aziz Syamsul Huda Bayu Sandi Bina Lohita Sari Bram Kusbiantoro Bustomi - Bustomi Chintia Ayu Puspita Cokro, Ingrid Aurelia Genacia Dadan Rohdiana Deviyanti Pratiwi Dewi Priandini Dewi Priandini, Dewi DIMAS ANDRIANTO Djarot Sasongko Hami Seno Djumali Mangunwidjaja Dwi Rofifah Putri Jania E. Mulyati Effend Effend, E. Mulyati Ekowati Handharyani Eny Ida Riyanti Eny Ida Riyanti Erlank Bagjavicenna Faisal Rahman Handayani, Septa Fitri Hasanah, Rima Nidaul Hasim Hasim Hasim Hasim Heddy Julistiono Heddy Julistiono Henry Adiprabowo, I Made Artika, Heny Herawati Huda, Aziz Syamsul Husnawati, . I MADE ARTIKA Ika Mulawati Purwanti Noviana Ike Agustiani Ike Yulia Wiendarlina Ilham Gilang Cahya Ahmada Indradewa, Rhian Ingrid Aurelia Genacia Cokro Isra Janatiningrum Karichsa Hariana Khaswar Syamsu Kristina Mulia LAKSMI AMBARSARI Luthfi Ramadhani, Dhani Mega Safithri Miko Afrian Moerfiah Mona . Muhamad Alvin Adriyan Muhammad Zulkifli Mutholaah Nashrianto, Husain Ni Putu Ratna Ayu Krishanti Noli Novidahlia Novi Fajar Utami Novia Juhaeni, Rani Nurliani Bermawie Olive Wisepti Pratama Ono Suparno Purnamasari, Anita Purnomo Purnomo Putri Ramadhanty Rafida Nisa Maghfiroh Ranady Perwira Nuruzzaman Rara Annisaur Rosyidah Rini Kurniasih, Rini Rosyidah, Rara Annisaur Safira, Ukhradiya Maharaniq Salim, Richentya Feiby Sandi, Bayu Sekar Winahyu Ariadini Sharon Aurellia Siti Magfiroh Siti Sholekha Siti Wachidatun Zulaikha Siwi Putri Andini Sri Budiarti Sri Wahyuni Sri Wardatun Sri Wardatun SURYANI Suryani Suryani Syaeful Abidin Syifa Khaerani Tansza Setiana Putri Titi Candra Sunarti Tommy Abrar Tri Joko Santoso Ukhradiya Maharaniq Safira Ulya Utami Vetnizah Juniantito Winahyu Ariadini, Sekar Witdiastuti Witdiastuti Zainal Alim Mas'ud