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All Journal Jurnal Pengabdian UntukMu NegeRI Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Journal of Pharmaceutical and Sciences. Molekul: Jurnal Ilmiah Kimia Jurnal ABDIMAS MUTIARA Nusantara Bioscience
Eka Nugraha, Sony
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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EDUKASI PENYAKIT DEGENERATIF HIPERTENSI SERTA PENCEGAHANNYA KEPADA MASYARAKAT DI DESA KUALA LAMA, KABUPATEN SERDANG BEDAGAI Melasari, Wulan Panduwi; Satria, Denny; Lisda Rimayanti Nasution; Aminah Dalimunthe; Yanti Yemima; Sony Eka Nugraha; Hafid Syahputra
Jurnal Abdimas Mutiara Vol. 7 No. 1 (2026): JURNAL ABDIMAS MUTIARA
Publisher : Universitas Sari Mutiara Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51544/jam.v7i1.6771

Abstract

Latar belakang : Penyakit degeneratif hipertensi menjadi masalah kesehatan yang prevalensinya terus meningkat. Kurangnya kesadaran akan pentingnya kesehatan serta rendahnya pengetahuan mengenai penyakit degeneratif hipertensi dan pemeriksaan kesehatan menyebabkan rendahnya kepedulian terhadap deteksi dini dan upaya pencegahan penyakit tersebut. Tujuan : Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pemahaman mengenai pentingnya kesehatan dan melakukan penyampaian edukasi langsung kepada masyarakat secara individu terkait penyakit degeneratif hipertensi serta melakukan pemeriksaan/screening kesehatan. Kegiatan ini dilaksanakan dengan desain deskriptif menggunakan pendekatan edukatif-partisipatif. Metode yang dilakukan dalam bentuk edukasi oleh apoteker terkait pengenalan penyakit degeneratif, gejala yang mungkin timbul serta upaya untuk pencegahan penyakit degeneratif terutama hipertensi dengan menerapkan pola hidup sehat. Proses edukasi yang dilakukan menggunakan media brosur dan penyampaian langsung kepada masyarakat secara individual. Untuk mengetahui tingkat kesehatan masyarakat, maka dilakukan pula pemeriksaan tekanan darah kepada masyarakat yang mengikuti proses edukasi kesehatan secara langsung. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan dan kesadaran masyarakat mengenai penyakit degeneratif hipertensi serta pentingnya penerapan pola hidup sehat. Edukasi kesehatan disertai pemeriksaan tekanan darah efektif dalam meningkatkan pengetahuan dan kesadaran masyarakat terhadap penyakit degeneratif hipertensi. Kesimpulan: Kegiatan ini berimplikasi positif dalam mendorong perubahan perilaku menuju pola hidup sehat serta mendukung upaya pencegahan hipertensi secara berkelanjutan.
Antibiofilm Formation Activities of Ethanol Extract of Curcuma domestica Val. Rhizome Against Multidrug-resistant Acinetobacter baumannii Nasution, Halimah Raina; Yuandani; Abdi Wira Septama; Sony Eka Nugraha; Sufitni
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.883

Abstract

Abstract. Multidrug resistance is still a major health problem worldwide. Biofilm formation was related to the resistance of bacteria mechanism. Acinetobacter baumannii, one of the bacteria that cause nosocomial infections, is given particular attention due to its high prevalence of resistance. The current study address observing the antibacterial activity and antibiofilm formation activity of Curcuma domestica rhizome extract against multidrug-resistant Acinetobacter baumannii (MDR A.baumannii). Curcuma domestica rhizome was macerated by ethanol 96%. Determination of Minimum Inhibitory Concentration (MIC) was carried out by the microdilution method. Antibiofilm formation analysis was determined by standard quantitative using crystal violet-stained assay. Ethanol extract of C. domestica possesses antibacterial activity against MDR A. baumannii with MIC value 250 µg/mL. Additionally, the ethanol extract of C. domestica could inhibit the biofilm formation of MDR A.baumannii, thus percentage of biofilm formed only 23.7% and significance different with control after analyzed using ANOVA post hoc test Tukey. According to these results, ethanol extract of C. domestica revealed antibacterial activity and had the potency in suppressing the biofilm formation of MDR A.baumannii, thus could be utilized in clinical application, especially in MDR A.baumannii infection. Keywords: Antibiofilm, antibacterial, Curcuma domestica, multidrug-resistant, Acinetobacter baumannii
Short Communication: Stimulatory effect of Curcuma mangga on immune response against Staphylococcus aureus Yuandani YUANDANI; SONY EKA NUGRAHA; LIA LAILA; SETIA DAME SILABAN; FADHILAH RAMADHANI
Nusantara Bioscience Vol. 12 No. 2 (2020)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n120204

Abstract

Abstract. Yuandani, Nugraha SE, Laila L, Silaban SD, Ramadhani F. 2020. Short Communication: Stimulatory effect of Curcuma mangga on immune response against Staphylococcus aureus. Nusantara Bioscience 12: 109-113. Recently, the ethanol extract of Curcuma mangga Val. rhizomes were found to have immunomodulatory activity by enhancing phagocytic ability. This study was carried out to evaluate the effect of C. mangga rhizomes on antibody titer and delayed-type hypersensitivity response in normal and doxorubicin-induced rats against Staphylococcus aureus. The extract was administered orally at doses of 100, 200, and 400 mg/kg body weight (bw) to rats for 72 hours prior to sensitization of Staphylococcus aureus, then continued for 14 days. Doxorubicin (4.67 mg/kg bw) was administered on days 8 and 11 to suppress the immune system. The antibody titer of normal and immune-suppressed rats after the treatment with C. mangga ethanolic extract was significantly higher than the rats with negative control (P<0.05). Ethanol extract of C. mangga also demonstrated stimulation on delayed-type hypersensitivity response which was indicated by the increase of paw volume. The extract at dose of 400 mg/kg bw showed higher immunostimulatory activity than Levamisole as a positive control. The results indicated that the ethanol extract of C. mangga shows immunostimulatory activity, confirming its potential to be developed as a therapeutic agent.
Formulasi dan Evaluasi Gel Aloe vera–Andaliman (Zanthoxylum acanthopodium) untuk Penyembuhan Luka Epidermolisis Bulosa: Pendekatan Fitokimia, In Silico, dan In Vivo Farah Dhiba; Mawandha Sari Harahap; Sony Eka Nugraha
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 2 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i2.1646

Abstract

Epidermolysis Bullosa (EB) is a rare genetic skin disorder characterized by chronic wounds and delayed healing, requiring alternative therapies that support tissue regeneration. This study aimed to develop and evaluate a gel formulation containing Aloe vera extract and Andaliman (Zanthoxylum acanthopodium) essential oil for EB wound healing. The novelty of this study lies in the combination of Aloe vera and Andaliman as a topical phytopharmaceutical approach for EB-like wounds. This combination was selected based on the complementary mechanisms of Aloe vera, which supports wound healing, fibroblast activity, and re-epithelialization, and Andaliman, which exhibits antioxidant, antimicrobial, and anti-inflammatory properties. Phytochemical screening, GC–MS analysis, antioxidant assay, gel evaluation, in silico docking against VEGF-A, and in vivo testing in EB-like wound rats were performed. Phytochemical screening revealed alkaloids, flavonoids, saponins, tannins, steroids, and glycosides. GC–MS identified 38 compounds in Aloe vera and 20 compounds in Andaliman. Antioxidant testing showed IC50 values of 165.2 µg/mL for Aloe vera and 98.7 µg/mL for Andaliman. The gel formulations showed acceptable physicochemical properties, with pH 5.8–6.1, viscosity 3,800–4,700 cPs, and good adhesion. Docking results showed strong interactions of lupeol, anthranol, and paulownin with VEGF-A. In vivo, F3 (4% Aloe vera and 3% Andaliman) accelerated wound closure, improved epithelialization, reduced inflammatory infiltration, and significantly increased VEGF expression (p < 0.0001). These findings suggest that Aloe vera–Andaliman gel is a promising topical candidate for EB wound management.
Co-Authors . Marianne Abdi Wira Septama Abdi Wira Septama Achmad, Suryadi Aminah Dalimunthe Anayanti Arianto Denny Satria, Denny Dewi Pertiwi Embun Suci Nasution Erly Sitompul FADHILAH RAMADHANI Farah Dhiba Fashilah, Noor Febiola P, Dian Hafid Syahputra Jane Melita Keliat Keliat, Jane Melita Khairunnisa, Nur Aini Kumar, Manan LIA LAILA Lisda Rimayanti Nasution Maha, Hetty Lendora Marline Nainggolan Mawandha Sari Harahap Melasari, Wulan Panduwi Nabila, Nabila Nasution, Azizah Nasution, Halimah Raina SETIA DAME SILABAN Sitompul, Erly Sufitni Sumaiyah Sumaiyah Suryadi Achmad Syahputra , Rony Abdi Togatorop, Grace Mutiara Yanti Yemima Yuandani Yuandani YUANDANI