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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Mandala Pharmacon Indonesia Jurnal Abdi Insani Jurnal Mandala Pengabdian Masyarakat Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Sciences of Pharmacy AMMA : Jurnal Pengabdian Masyarakat Indonesian Journal of Jamu
Alaydrus, Syafika
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Suspension of Sonchus arvensis L Leaves Ethanolic Extract Affects Blood Creatinine and Urea Levels in Streptozotocin-Induced Wistar Male Rats Dewi, Niluh Puspita; Alaydrus, Syafika; Lestari, Widya Ayu; Magfirah, Magfirah; Utami, Indah Kurnia; Polontalo, Nani Astria; Tuldjanah, Muthmainah
Sciences of Pharmacy Volume 3 Issue 1
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0301173

Abstract

The study focused on analyzing the secondary metabolites present in the ethanol extract of Sonchus arvensis L. leaves (SALEE) and their impact on creatinine and urea levels when administered in suspension form at different doses. Phytochemical screening of SALEE identified alkaloids, flavonoids, phenols, saponins, and tannins. In the experiment, twenty-five white male rats were divided into five groups: a healthy control group (Group I), a negative control group (Group II), and three test groups (Groups III, IV, and V) receiving SALEE at doses of 200, 300, and 400 mg/kg BW, respectively. After inducing diabetes with streptozotocin and a 21-day follow-up period, creatinine and urea levels were assessed. The results demonstrated that SALEE administration significantly reduced creatinine levels and increased urea levels. Notably, the 200 mg/kg BW dose of SALEE exhibited a consistent and long-term effect. It was observed that blood urea levels fluctuated even in healthy and negative control groups during the 21-day observation period. In the group receiving the highest dose of SALEE (400 mg/kg BW), blood urea levels increased significantly on days 14 and 21, indicating a potential increase in the rats' appetite rather than renal function failure. Overall, the findings suggest that SALEE has promising potential to regulate creatinine and urea levels in the blood of individuals with diabetes, highlighting its potential for therapeutic and supplemental use.
Cytotoxic Effect of Brazilin on DU145 Prostate Cancer Cells Using the WST-8 Assay Alaydrus, Syafika; Niluh Puspita Dewi; Pratiwi, Dinda
Jurnal Jamu Indonesia Vol. 11 No. 1 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i1.423

Abstract

Prostate cancer is characterized by abnormal growth of prostate gland cells due to uncontrolled cellular proliferation. Brazilin, a homoisoflavonoid compound derived from Caesalpinia sappan L., is known for its anticancer activity. This study aimed to evaluate the cytotoxic effect of brazilin on DU145 prostate cancer cells through an in vitro assay employing the WST-8 method. The results showed that both brazilin and cisplatin significantly reduced the cancer cell survival rate compared to the negative control group (p < 0.05). Although no significant difference was observed between the two compounds at the highest concentration (ns), their IC₅₀ values differed significantly (p < 0.05), recorded at 18.92 ppm for brazilin and 0.03569 ppm for cisplatin; both were classified as highly active. These findings suggest that brazilin possesses cytotoxic potential comparable to cisplatin at elevated concentrations and may be developed further as a naturally derived anticancer agent.
Effect of Purple Leaf (Graptophyllum pictum (L.) Griff) Emulsion on the Histological Parameters of Streptozotocin-Induced Diabetic Rats Dewi, Niluh Puspita; Dewik, Komang; Alaydrus, Syafika; Kasim, Athia Kurnia; Polontalo, Nani Astria; Wirawan, Wayan; Andini, Dian; Irma, Irma; Fatu, Imelda Synthia
Jurnal Penelitian Pendidikan IPA Vol 12 No 1 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i1.14172

Abstract

Damage to vital organs such as the liver, kidneys, and pancreas is a common complication of diabetes mellitus, characterized by chronic hyperglycemia due to pancreatic cell dysfunction. Graptophyllum pictum (purple leaf) is a potential herbal therapy containing bioactive compounds with antioxidant and organ-protective effects. This study aimed to evaluate the effect of purple leaf emulsion on blood glucose levels and the histopathological features of diabetic rats induced by streptozotocin. Rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three doses of purple leaf emulsion (100, 200, and 300 mg/kg BW). After 28 days of treatment, the emulsion significantly reduced blood glucose levels and improved the histological structures of the liver, kidneys, and pancreas. The 200 mg/kg BW dose was most effective for pancreatic protection, while 300 mg/kg BW provided optimal hepatoprotective and renoprotective effects. These findings highlight the potential of purple leaf as a natural antidiabetic and organ-protective agent.
EDUKASI PEMANFAATAN SEDUHAN DAUN TEH HIJAU SEBAGAI ANTIKARIES DI DESA BOSA KEC. TAWAELI, SULAWESI TENGAH R, Sririzqi Muthmainnah A.; Alaydrus, Syafika; Mariyani, Mariyani; Utami, Faikah Dyah; Djumiran, Sandra Sri Dewi; Tamuntuan, Annisa Fitria
Jurnal Abdi Insani Vol 13 No 1 (2026): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v13i1.2775

Abstract

Bosa Village is categorized as a 3T priority area (Frontier, Outermost, and Disadvantaged), resulting in a lack of dental health facilities and limited public knowledge regarding the dangers of dental caries, as well as a lack of understanding of utilizing plants for disease prevention. Shredded green tea leaves (Camellia sinensis) are a widely available commercial product that can be utilized for dental caries prevention due to their antibacterial properties. Therefore, the objective of this community service is to educate the public on dental caries prevention, specifically through the formulation of mouthwash from steeped green tea leaves to enhance knowledge of dental health maintenance using accessible products. The method employed was the lecture method, complemented by the distribution of brochures. This was followed by a recall of the material through a Q&A session. The results showed a significant improvement in the participants' competence between the pre-test and post-test. Although participants initially lacked understanding in several aspects, there was a substantial increase in comprehension following the post-test. This improvement was evident after the community of Bosa, Hamlet II, received education on utilizing green tea leaves as a mouthwash for dental caries prevention. Consequently, the community has begun to understand the prevention and maintenance of oral health, including the use of shredded green tea leaves as an anti-caries mouthwash.
Co-Authors Agustina, Giska Putri Andini, Dian Astria, Nani Darmayanti Darmayanti Dewi, Rai Chika Dewik, Komang Djumiran, Sandra Sri dewi Fatu, Imelda Synthia Ika Yususf, Ratna Irma Irma Joni Tandi, Joni Kasim, Athia Kurnia Kurnia Utami, Indah Lestari, Widya Ayu Magfirah, Magfirah Mariyani, Mariyani Meike Rachmawati Nadila, Nadila Niluh Puspita Dewi Niluh Puspita Dewi, Niluh Puspita Ocvinta, Sisca Polontalo, Nani Astria Pratiwi, Dinda Puspita Dewi, Niluh R, Sririzqi Muthmainnah A. Rianto Rianto Rusliyana, Rusliyana Tampang, Rivani Tamuntuan, Annisa Fitria Tuldjanah, Muthmainah Utami, Faikah Dyah Utami, Indah Kurnia Viani Anggi Wahyuhandayani, Tien Wardani, Yunira Wawang Anwarudin wirawan, Wayan