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All Journal E-Jurnal Medika Udayana Jurnal Keperawatan Jiwa (JKJ): Persatuan Perawat Nasional Indonesia Medula Jurnal Pengabdian Kepada Masyarakat Sakai Sambayan Journal of Language and Health Jurnal Pengabdian Masyarakat Medika JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Rudiyanto, Waluyo
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Journal : Medula

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Obstructive Sleep Apnea (OSA) pada Usia Produktif Annisarahma, Lyvia; Karima, Nisa; Sangging, Putu Ristyaning Ayu; Rudiyanto, Waluyo
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.951

Abstract

Obstructive sleep apnea (OSA) is a sleep disorder which characterized by cessation of breathing for more than 10 seconds. A blockage in the upper respiratory tract may be the cause of OSA. One known risk factor for OSA is smoking. Moreover, the degree of physical activity might also influence OSA risk. This article is a literature review with a variety of the latest sources that are relevant to the topic. The sources used were obtained from the search engine for health journals. The prevalence of OSA in the productive age community in Asia is 4.1 - 7.5%. Some factors that affect the symptoms of OSA, especially in productive age, namely obesity, male sex, old age, genetic, smoking habits, and small upper airway diameter. OSA is characterized by snoring, periodic apnea, hypoxemia during sleep and hypersomnolence during the day. Some symptoms of OSA are snoring hard and annoying, stopping repeated breathing during sleep at night, insomnia, fatigue, and drowsiness during the day. Death from OSA in productive age is usually caused by complications after having OSA in the long period ahead.
Anatomi dan Fisiologi Ginjal: Tinjauan Pustaka Alwiyah, Fadilah; Rudiyanto, Waluyo; Anggraini, Dwi Indria; Windarti, Indri
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.977

Abstract

The kidneys are retroperitoneal organs located at the top on both sides of the III lumbar vertebra and attached directly to the abdominal or ventral wall of the M. psoas major and M. quadratus lumborum. The kidneys function to regulate the amount and concentration of ECF electrolytes and maintain nerve and muscle excitability, activating vitamin D which is important for calcium absorption in the digestive tract and producing erythropoietin which is a hormone to stimulate the bone marrow to form red blood cells. The main function of the kidneys is to filter and excrete metabolic waste products in the urine so that administration of toxic compounds or irritating compounds can cause degenerative changes such as fatty degeneration to necrosis of the kidneys. Disorders of the kidneys can disrupt kidney function. Chronic Kidney Disease (CKD) sufferers have several complications such as overhydration, hyperkalemia, metabolic acidosis, mineral and bone disorders, hypertension, anemia and dyslipidemia. The most common etiologies of CKD in adult patients are diabetes mellitus and hypertension. In children, the most common primary cause of PGTA is congenital abnormalities of the kidneys and urinary tract (such as obstructive uropathy, vesicoureteral reflux, renal dysplasia). Indonesian Nephrology Association (PERNEFRI) in 2006, which found that the prevalence of Chronic Kidney Disease (CKD) was 12.5%. Meanwhile, data according to the 2019 Health Insurance Administration (BPJS) shows that there were 1.93 million cases of kidney failure and 1.79 million cases in 2020. With this data, the author is interested in discussing the kidneys in more depth.
Kerusakan, alkohol, kesehatan Kerusakan Lambung Akibat Konsumsi Alkohol: Dampak dan Penanganannya Madina Ghassan Nebraska; Jausal, Annisa Nuraisa; Wulan, Anggraeni Janar; Rudiyanto, Waluyo
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.984

Abstract

Alcohol consumption has spread across various social strata of society, especially among teenagers. Health issues caused by alcohol are often overlooked. This article delves into the damage to the stomach caused by alcohol consumption. Alcohol can damage the gastric mucosa layer and disrupt the balance of stomach acid, leading to various conditions such as gastritis, gastric ulcers, and even gastric cancer. Additionally, alcohol can affect the movement of food and fluids in the digestive tract, increasing the risk of acid reflux, which can worsen stomach conditions. The mechanisms of stomach damage by alcohol involve the direct toxic effects of alcohol itself and the chronic inflammation it induces. Although this damage is often not immediately felt, its long-term effects can lead to serious complications. Management of alcohol-induced stomach damage involves lifestyle modifications, such as reducing or ceasing alcohol consumption, and medical treatment to alleviate symptoms and accelerate healing. To prevent further damage, it is important to raise awareness of the risks of alcohol to stomach health and promote a healthy lifestyle. Understanding the impact and management of stomach damage caused by alcohol consumption is crucial in preventing more serious complications.
Tinjuan Pustaka: Hubungan Jenis Kelamin dan Hormon Androgen dengan Kejadian Dry-Eye Disease Fairuz Hanan, Sifa’Syaharani; Rengganis Wardani, Dyah Wulan Sumekar; Rudiyanto, Waluyo; Himayani, Rani
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.992

Abstract

Dry eye disease (DED) is a multifactorial condition on the surface of the eye that occurs due to disruption of tear film homeostasis with manifestations of symptoms such as tear film instability, hyperosmolarity, inflammation, eye surface damage, and neurosensory abnormalities. DED can occur due to decreased eye fluid production or increased tear evaporation which is generally caused by meibomian gland dysfunction. The global prevalence of DED ranges from 5-50%, with women having a higher risk than men. The prevalence of dry eye in women (3.2 million) is higher than in men (1.6 million) aged over 50 years. Asian ethnicity is the most consistent risk factor for DED. The female gender factor is a risk in the development of DED with increasing age. The pathophysiological mechanisms of DED can be influenced by differences in endocrine function related to sex, especially androgen, estrogen and other hormones. The meibomian and lacrimal glands are target organs for androgen hormones, and low androgen activity can cause meibomian gland dysfunction and inflammation of the lacrimal glands, contributing to the occurrence of DED. In addition, differences in gene expression affect mucin production by the cornea and conjunctiva, as well as other hormonal involvement can also affect eye health and cause dry eye symptoms. Further understanding of the relationship between gender, hormones, and pathophysiological mechanisms of DED may aid the development of more effective treatment strategies.
Insomnia pada Mahasiswa Kedokteran: Sebuah Tinjauan Pustaka Fuad Fadillah; Lisiswanti, Rika; Rudiyanto, Waluyo; Oktafany, Oktafany
Medula Vol 14 No 9 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i9.1416

Abstract

A person who struggles to fall asleep and/or stay asleep is said to have insomnia. In Southeast Asia, 67% of 1,508 persons suffer from insomnia worldwide, and 7.3% of those who suffer from it are students. About 67% of Indonesians suffer from insomnia, with mild insomnia accounting for 55.8% and moderate insomnia for 23.3% of cases. Students who suffer from insomnia suffer, particularly those studying medicine. Medical students' usage of devices and the stress that comes with learning are linked to insomnia. By interfering with the body's sleep and wake cycle and blocking the melatonin hormone's function, using electronics at night, particularly shortly before bed, can make it difficult for the body to regulate and manage the ideal time to go to sleep and the time to be awake. Through the HPA-axis mechanism, which is triggered by corticosteroid releasing factor (CRF) and arginine vasopressin (AVP), anxiety can result in sleeplessness. This may lead the body to produce more cortisol, which would raise the wakefulness system and result in insomnia. Those who suffer from insomnia, particularly the medical students in this piece, incur unpleasant consequences. Fatigue, memory loss, and concentration issues are some of the issues that cause insomnia and impact a person's performance during the day. Disrupting concentration makes learning ineffective, which can ultimately impact medical students' performance and the quality of graduates.
Review Article: Potensi Farmakologi Bunga Telang (Clitoria ternatea) Athallah, Dimas Rifqi; Rudiyanto, Waluyo; Wijaya, Sofyan Musyabiq; Angraini, Dian Isti
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1267

Abstract

Clitoria ternatea, commonly known as butterfly pea flower, is a tropical plant with high historical and cultural value, particularly in traditional medicine in Indonesia and Asia. This plant is rich in bioactive compounds such as phenols, terpenoids, and alkaloids, which contribute to its various pharmacological activities, including antioxidant, antidiabetic, antihyperlipidemic, anticancer, anti-inflammatory, antimicrobial, hepatoprotective, and neuroprotective effects. The phenolic compounds in the flower function as natural antioxidants, while terpenoids and alkaloids support antidiabetic and anticancer effects. This review aims to evaluate the pharmacological potential of C. ternatea based on literature published in the last decade (2014–2024), sourced from PubMed, Google Scholar, Science Direct, and ResearchGate. Inclusion criteria were articles in English and Indonesian, while exclusion criteria included incomplete access articles, secondary reviews, and studies with weak methodologies. Based on this review, C. ternatea shows great potential as an alternative modern therapy, with consistent research demonstrating significant therapeutic activity and low side effects. Its bioactive compounds work through mechanisms such as enzyme inhibition, glucose regulation, inflammation modulation, and protection from oxidative stress, making it a promising candidate for innovative therapeutic development.
The Effectiveness of Phacoemulsification in Cataract Management: Procedures, Benefits, and Challenges Nurhaliza, Rahma; Himayani, Rani; Febriani, Wiwi; Rudiyanto, Waluyo
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1278

Abstract

Cataract is a condition in which the eye's lens, initially clear becomes cloudy, obstructing the passage of light to the retina and causing vision impairments such as blurred vision, reduced visual acuity, and faded color perception. According to WHO data (2022), approximately 2.2 billion people worldwide experience visual impairment, with cataracts being the leading cause of reversible blindness. In Indonesia, the prevalence of cataracts is 1.8%, with an annual incidence rate of 0.1%, and 50% of blindness cases are caused by cataracts. Surgery is the only method to treat cataracts, with phacoemulsification being the most commonly used technique. Phacoemulsification is a cataract surgery technique that employs an ultrasonic tip to break down the cloudy lens, followed by aspiration of the lens fragments. This technique has numerous advantages, including smaller incisions, faster wound healing, good visual acuity outcomes post-surgery, and a lower risk of complications than other surgical methods.
Pengaruh Pemberian Ekstrak Etanol Lada Hitam (Piper nigrum L) Terhadap Kadar Gula Darah dan Jumlah Spermatogonia Model Diabetes Tikus Putih Jantan (Rattus norvegicus) Galur Sprague dawley Talin, Jinan Naura; Hadibrata, Exsa; Rudiyanto, Waluyo; Windarti, Indri
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1431

Abstract

Diabetes mellitus that is not treated properly can result in infertility. The piperine content in black pepper can help in the quality of spermatogenesis process and blood sugar levels. This study aims to determine the effect of black pepper (P. nigrum L) ethanol extract on blood sugar levels and the number of spermatogonia in a diabetes model of male white rats (R. norvegicus) Sprague dawley strain. The study used a Posttest-only Randomized Control Group on 24 rats divided into 4 groups. All groups were induced with alloxan 150 mg/kgBW except for KN. P1 and P2 were given 122.5 mg/kgBW and 245 mg/kgBW black pepper ethanol extract. Blood sugar levels were checked using Easy Touch GCU with a normal limit of 50-135 mg/dL. The number of spermatogonia was calculated using a tool, namely ImageJ. The data were analyzed using the Shapiro- Wilk normality test and homogeneity test, followed by the Kruskal Wallis non-parametric test and the Post Hoc test. The statistical results of blood sugar levels obtained normally distributed data p>0.05, non-homogeneous data p<0.05, significant Kruskal-Wallis test results and continued Post Hoc test obtained significant results at P2 and K-. The number of spermatogonia obtained normally distributed data p>0.05, non-homogeneous data p<0.05. The results of the Kruskal-Wallis test were significant p<0.05 and continued Post Hoc test obtained significant results at P2 and P1. There was a decrease in blood sugar levels in the administration of black pepper ethanol extract (P. nigrum L) in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain. However, there was no effect of administering black pepper ethanol extract (P. nigrum L) on the number of spermatogonia in the diabetes model of male white rats (R. norvegicus) Sprague dawley strain.
Krisis Hiperglikemik: Diabetic Ketoacidosis (DKA) dan Hyperglycemic Hyperosmolar State (HHS) Wibowo, Muhammad Rafi; Rudiyanto, Waluyo; Yunianto, Andi Eka; Soleha, Tri Umiana
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1435

Abstract

Hyperglycemic crisis is an acute metabolic complication of diabetes mellitus that can be life threatening if not treated appropriately. This research aims to examine in more depth the hyperglycemia crisis. This research is a literature study using relevant literature such as articles and journals from various national and international databases such as Google Scholar, NCBI, and PubMed. Diabetic Ketoacidosis (DKA) and Hyperglycemic Hyperosmolar State (HHS) are serious and emergency forms of hyperglycemic crisis. DKA is often found in people with type 1 diabetes due to severe insulin deficiency, which is characterized by the triad of hyperglycemia, acidosis, and ketosis. In contrast, HHS occurs more frequently in type 2 diabetes, with features of hyperglycemia, hyperosmolarity, and dehydration, but without significant ketosis and acidosis. Both of these conditions have a high risk of death if left untreated, with the death rate for DKA around <1% and HHS around 15%. The goal of treatment for both is to improve circulation and tissue perfusion, correct hyperglycemia, ketogenesis, and electrolyte imbalances, and identify precipitating factors. Treatment begins with correcting dehydration and electrolyte imbalances through rehydration with crystalloid fluids, as well as treating hyperglycemia by administering insulin boluses or infusions. Prevention of DKA and HHS is to ensure that patients do not stop insulin or oral hyperglycemic drugs, monitor blood sugar levels regularly and immediately seek professional medical help if something undesirable happens.
Co-Authors Ali, Muhammad Chaidar Alifia, Syafira Alwiyah, Fadilah ananti, anggini tasyakurillah Anggraeni Janar Wulan, Anggraeni Janar Annisarahma, Lyvia Athallah, Dimas Rifqi Aziza, Nurita Danan Jaya, Bayu Putra Dian Isti Angraini Dian Puspita Dwi Indria Anggraini Fairuz Hanan, Sifa’Syaharani Fuad Fadillah Hadibrata, Exsa Hamidi, Syahrul Heriyanto, Mochammad Junaidy Indri Windarti Jausal, Annisa Nuraisa Kanzulli, Mohammad Haidar Karima, Nisa Khairun Nisa M. Mansyur Romi M. Ridho Ulya Madina Ghassan Nebraska Meddy Setiawan Mitayani Purwoko, Mitayani Muhammad Perdana Airlangga, Muhammad Perdana Novitasari, Erlina Krisdianita Nurhaliza, Rahma Nurul Islamy Nurul Utami Oktadoni Saputra, Oktadoni Oktafany, Oktafany Pandhita, Gea Prakoso, Denny Anggoro Putra, Chendra Perdana rahmawati, selvi Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Rengganis Wardani, Dyah Wulan Sumekar Reni Zuraida Rika Lisiswanti Rima January Risal Wintoko Rizki Hanriko Rodiani, Rodiani Sangging, Putu Ristyaning Ayu Setiorini, Anggi Sofyan Musyabiq Wijaya Sriningsih, Solikah Suharmanto Sukarno, Rizky Triutami SULISTIYANI SULISTIYANI Suryadi Islami Susianti Susianti, Susianti Sutarto Sutarto Talin, Jinan Naura Tri Umiana Soleha Tubarad, Gladys Dwiani Tinovella Wibowo, Muhammad Rafi Widia, Chyci Wiwi Febriani Yanuarita Tursinawati, Yanuarita Yunianto, Andi Eka Zain, Muhammad Fathurrahman