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Efektivitas Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Sirih untuk Mempercepat Penyembuhan Luka Fase Proliferasi pada Model Mencit Diabetik Wahyuningtyas, Eka Sakti; Nasruddin, Nasruddin; Rahayu, Heni Setyowati Esti; Lutfiyati, Heni; Sikumbang, Isabella Meliawati; Nurani, Laela Hayu; Rohmani, Afiana; Salsabila, Nia; Putri, Gela Setya Ayu
Jurnal Ilmiah Kesehatan Keperawatan Vol 15, No 2 (2019): JURNAL ILMIAH KESEHATAN KEPERAWATAN
Publisher : LPPM STIKES MUHAMMADIYAH GOMBONG

The continued increase in the number of people with Diabetes Mellitus (DM) in Indonesia is a serious problem. One of the big problems for people with Diabetes Mellitus (DM) is the emergence of complications of diabetic wounds. To date the strategy for treatment of diabetic wounds has been limited to the use of wound dressing, cell therapy and oxygen therapy. The problem is that the strategy is not fully successful. Thus, it is very important to look for new strategies to improve the quality of diabetic wound healing, such as by applying a combination of plasma medicine and local natural product, like the extraction of Daun sirih (Piper betle) leaves. Plasma medicine is a relatively new and multidisciplinary study involving plasma science, biomedical, pharmaceutical and other health sciences aimed at applying plasma to therapeutic health. Plasma is the fourth phase of matter, after the solid, liquid and gas phase. The medical aspects of plasma are related to the ability of plasma to produce biological molecules Reactive Oxygen and Nitrogen Species (RONS). If RONS is controlled in the right dosage it can be efficacious for health therapy. This study intends to examine the effects of combinative treatment of plasma medicine and Piper betel leaf extract for proliferation phase of wound healing in diabetic small animal model. This study used male Balb c mice with acute wounds which were divided into 5 groups, namely groups of untreated normal mice (ND-TP), groups of untreated diabetic mice (D-TP), groups of diabetic mice wounds with Piper betel leaf extract (DS ), the wound group of diabetic mice with plasma medicine (DP) and the wound group of diabetic mice with plasma medicine and Piper betel leaf (DPS). The plasma medicine was treated on wound with condition non-contact style (the plasma jet did not touch the wound) with a distance of plasma jet reactor nozzle to the surface of wound about 20 mm, for 2 minutes, every day. Macroscopic observation of wounds is carried out every day from day 0 to 7. On day 7 it was seen that the size of the wound area for D-P-S was smaller than the other groups. The results of this study indicated that Piper betel leaf extract can potentially be used to optimize the performance of plasma medicine in accelerating diabetic wound healing during the proliferation phase. Further investigation, however, is important to be conducted to study the effect for all phases of wound healing and its mechanism histo-pathologically.

Pemeriksaan Glukosa, Kolesterol dan Asam Urat pada Masyarakat Peserta Car Free Day di Balai Pelatihan Kesehatan (Bapelkes) Kota Semarang Ana Hidayati Mukaromah; Gela Setya Ayu Putri; Nurul Qomariyah; Wijanarko Wijanarko; Pratiwi R. H. Sya’diah
Jurnal Surya Masyarakat Vol 2, No 2 (2020): Mei 2020
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jsm.2.2.2020.133-138

Symptoms of a disease can be prevented if routine health checks are done. Health checks can be carried out in public and private laboratories, or free checks conducted by health education institutions through community service activities. The implementation of community service is carried out by lecturers involving students of the Medical Laboratory Science at the Muhammadiyah University of Semarang. This community service activity was carried out on December 15, 2019 in front of the Semarang Health Training Center Office on December 15, 2019. The inspection method uses Point of Care testing (POCT). The results of the examination that the number of respondents with cholesterol levels above normal for women more than men, while glucose and uric acid levels above normal in men more than women. The average cholesterol, glucose, and uric acid levels for men were 224.2; 123.1; 4.8 mg/dL respectively, while for women is 194.5; 121.2; 6,0 mg/dL. The higher age (12 - 65 years), the average cholesterol level increases from 189 to 217.8 mg/dL (15.25%) and the average glucose level increase from 84.4 to 131.5 mg / dL (55.80%), while the average uric acid level decreases from 5.4 to 5.2 mg / dL (3.85%). The conclusions of the health inspection activity about the result of cholesterol, glucose, and uric acid levels can be used to check public health

Pemeriksaan Glukosa, Kolesterol dan Asam Urat pada Masyarakat Peserta Car Free Day di Balai Pelatihan Kesehatan (Bapelkes) Kota Semarang Ana Hidayati Mukaromah; Gela Setya Ayu Putri; Nurul Qomariyah; Wijanarko Wijanarko; Pratiwi R. H. Sya’diah
Jurnal Surya Masyarakat Vol 2, No 2 (2020): Mei 2020
Publisher : Universitas Muhammadiyah Semarang

Symptoms of a disease can be prevented if routine health checks are done. Health checks can be carried out in public and private laboratories, or free checks conducted by health education institutions through community service activities. The implementation of community service is carried out by lecturers involving students of the Medical Laboratory Science at the Muhammadiyah University of Semarang. This community service activity was carried out on December 15, 2019 in front of the Semarang Health Training Center Office on December 15, 2019. The inspection method uses Point of Care testing (POCT). The results of the examination that the number of respondents with cholesterol levels above normal for women more than men, while glucose and uric acid levels above normal in men more than women. The average cholesterol, glucose, and uric acid levels for men were 224.2; 123.1; 4.8 mg/dL respectively, while for women is 194.5; 121.2; 6,0 mg/dL. The higher age (12 - 65 years), the average cholesterol level increases from 189 to 217.8 mg/dL (15.25%) and the average glucose level increase from 84.4 to 131.5 mg / dL (55.80%), while the average uric acid level decreases from 5.4 to 5.2 mg / dL (3.85%). The conclusions of the health inspection activity about the result of cholesterol, glucose, and uric acid levels can be used to check public health

GAMBARAN HISTOLOGI FASE REMODELLING JARINGAN LUKA KRONIK KULIT MENCIT SETELAH PEMBERIAN PERLAKUAN PLASMA JET Gela Setya Ayu Putri; Ali Ali; Nasruddin Nasruddin
Jurnal Labora Medika Vol 6, No 1 (2022): Jurnal Labora Medika
Publisher : Program Studi Teknologi Laboratorium Medik

The medical aspect of plasma conceptually is concerned with the ability of plasma to produce biological molecules, such as RONS, which can be physically controlled through dose and behavior. RONS in micro concentrations was reported to have wound healing properties. The effect of a plasma jet on chronic skin wounds of mice on day 14 which theoretically included the remodeling phase has not been widely studied. The aim of the study was to calculate the number of inflammatory cells, fibroblasts, blood vessels, the percentage of re-epithelization, and the percentage of necrosis. Experimental research method with an analytic descriptive design. The results of microscopic observations showed that based on the number of inflammatory cells (round cells) data, the control group was significantly higher than the non-contact plasma (P<0.05). Based on the blood vessel count data, it was found that the control group was significantly higher (P<0.05) than the contact group, non-contact group and non-contact group. Based on the data on the number of fibroblasts, the results in contact-non-contact group were significantly (P<0, 05) higher than control group and plasma-contact group. Based on the data on the percentage of reepithelialization, the results were different in all treatment groups but not significant (P>0.05). Based on the data on the percentage of necrosis, the results were were different in all treatment groups but not significant (P>0.05).

Gambaran Mikroskopis Jaringan Kulit Normal Mencit Balb/C Setelah Perlakuan Plasma Jet Dengan Pengecatan Hematoxylin Eosin Nia Salsabila; Nasruddin Nasruddin; Tulus Ariyadi; Gela Setya Ayu Putri
Jurnal Labora Medika Vol 5, No 2 (2021): Jurnal Labora Medika
Publisher : Program Studi Teknologi Laboratorium Medik

Terdapat banyak pilihan pengobatan untuk perbaikan penyembuhan luka. Eksplorasi metode seperti perlakuan terhadap agen teknologi pengobatan plasma untuk terapi medis menghasilkan wawasan baru. Plasma merupakan zat keempat setelah padat, cair dan gas yang mampu menghasilkan Reactive Oxygen and Nitrogen Species (RONS) yang bermanfaat bagi kesehatan jika dosisnya tepat. Penelitian ini bertujuan untuk menguji pengaruh plasma jet pada kulit normal mencit yang rusak akibat pengaruh dosis berlebihan secara histologis dengan pewarnaan hematoxylin eosin (HE). Penelitian menggunakan mencit Balb/c 4 bulan yang dibagi menjadi 3 kelompok jarak paparan. Jarak yang paling berpengaruh pada kulit diperiksa secara mikroskopis untuk mengetahui perbedaan respon inflamasi pada 2 pengamatan yaitu jaringan yang rusak pada kulit dibedah pada hari ke-0 dan hari ke-1. Pada hari ke-0, jaringan kulit mencit dibedah 4 jam setelah terpapar plasma jet (D0) dan hari 2 tikus dibedah 24 jam setelah terkena plasma jet (D1). Hasil penelitian secara visual menyebabkan kerusakan kulit dalam jarak 3 mm. Hasil pengamatan kerusakan mikroskopis menunjukkan bahwa Paired T-test dengan nilai probabilitas 0,238 (P>0,05) berarti kedalaman kerusakan kulit D0 dan D1 tidak berbeda nyata. Kesimpulannya, jarak pancaran plasma 3 mm berpotensi merusak kulit normal, secara mikroskopis kerusakan kulit hanya terjadi pada epidermis, dan kedalaman kerusakan kulit tidak signifikan antara kulit yang dioperasi pada hari ke-0 dan hari-1.

Edukasi Pencegahan Diabetes Melitus dan Hipertensi Sejak Dini di Panti Asuhan Khaira Ummah Demak Sebagai Sebuah Kewaspadaan di Masa Pandemi: Gela Setya Ayu Putri; Sri Darmawati; Mudyawati Khamaruddin
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 1 No 3 (2022): Juli
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Latar belakang: Pandemi Corona Virus Disease (COVID-19) telah menjadi masalah kesehatan di seluruh dunia, termasuk Indonesia. Gejala berat dan komplikasi serius akibat COVID-19 lebih sering dialami oleh orang yang menderita penyakit tidak menular (PTM). Faktor risiko terjadinya PTM berkaitan erat dengan pola hidup sehari-hari, maka perlu dilakukan langkah pencegahan sedini mungkin. Tindakan pencegahan yang dapat dilakukan diantaranya dengan edukasi dan pemeriksaan kesehatan secara rutin. Tujuan: Memberikan edukasi kepada anak-anak dan masyarakat sekitar Panti Asuhan Khaira Ummah tentang pencegahan DM dan hipertensi serta meningkatkan kesadaran untuk melakukan pemeriksaan kesehatan rutin. Metode: Kegiatan dilakukan di Panti Khaira Ummah Perum Pondok Raden Patah, Sriwulan, Kec. Sayung, Kabupaten Demak, Jawa Tengah. Tahapan pengabdian masyarakat terdiri dari persiapan, pelaksanaan, dan evaluasi. Hasil: Hasil evaluasi menunjukkan terdapat kenaikan sebesar 46,3% pada tingkat pemahaman setelah pemberian edukasi pencegahan DM dan hipertensi sejak dini. Pemeriksaan kesehatan rutin didapatkan sebagian besar koresponden mempunyai kadar kolesterol, glukosa sewaktu dan asam urat yang normal. Kesimpulan: Edukasi tentang pencegahan penyakit diabetes melitus dan hipertensi sejak dini dapat meningkatkan pemahaman anak-anak asuh, pengelola dan masyarakat sekitar Panti Asuhan Khaira Ummah. _________________________________________________________________________________________ Abstract Background: The pandemic of Corona Virus Disease (COVID-19) has become a global health issue, affecting countries such as Indonesia. Severe symptoms and serious complications due to COVID-19 are more often experienced by people with non-communicable diseases (NCDs). Because the risk factor for NCDs is directly linked to daily life patterns, it is necessary to take preventive steps as early as possible. Preventative actions that can be performed, such as education and routine health checkups. Objective: Educate children and the community surrounding the Khaira Ummah Orphanage about preventing DM and hypertension as well as increasing awareness of routine health checkups. Method: This community service activity was carried out at the Khaira Ummah Panti Perum Pondok Raden Patah, Sriwulan, Kec. Sayung, Demak Regency, Central Java. The stages of community service consist of preparation, implementation, and evaluation. Result: The results of the evaluation showed a 46,3 percent improvement in knowledge after presenting diabetes and hypertension prevention education to children at a young age. Routine health checkups showed the majority of the correspondents had normal cholesterol, glucose, and uric acid levels. Conclusion of this community service activity is early age education about preventing diabetes mellitus and hypertension can improve the knowledge of children, managers and the community around the Khaira Ummah Orphanage. Keywords: Education, Glucose, Cholesterol, Uric Acid

Efek Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Binahong Terhadap Penyembuhan Luka Fase Proliferasi Pada Mencit Diabetik Eka Sakti Wahyuningtyas; N Nasruddin; Heni Setyowati Esti Rahayu; Heni Lutfiyati; Isabella Meliawati Sikumbang; Laela Hayu Nurani; Arum Kartikadewi; Nia Salsabila; Gela Setya Ayu Putri; Putri Kurniasiwi; Devi Kemala Dewi
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (261.287 KB)

Plasma medicine is a relatively new and multidisciplinary studyinvolving the study of plasma science, biomedicine, pharmacy, andother health sciences to utilizing plasma for medical therapy. Plasmais the fourth substance, after solids, liquids, and gases. Plasma canproduce biological molecules of Reactive Oxygen and NitrogenSpecies (RON) which, if controlled in the right dose, can bebeneficial for health. This animal study examines the effect ofcombinative treatment of medicine plasma and binahong leaf extracton proliferation phase wound healing in a diabetic test model. Thestudy used Balb mice 7-8 years old which were induced by STZ withacute wounds which were divided into 4 groups, namely the woundgroup of diabetic mice without treatment (C), the group of diabeticmice with the treatment of binahong leaf extract (B), the group ofcombined treatment wounds plasma jet (P) and the wound group ofdiabetic mice treated with a combination of plasma and, binahongleaf extract (PB). Binahong leaf extract concentration 1% in DMSOsolvent. The jet type medicine plasma treatment was carried outevery day from day 0 to day 6. Macroscopic observation of thewound was carried out every day from day 0 to day 7. On day 7 itappears that the size of the wound area for P is much smaller thanfor C, B, and PB. The size of area B and PB is relatively the same,but smaller than C. The results of this study indicate that thebinahong leaf extract tends to inhibit the performance of medicineplasma in accelerating the healing of the proliferation phase.

Edukasi Pencegahan Anemia Pada Remaja Di Masa Transisi Menuju Endemi Covid-19 Gela Setya Ayu Putri; Nuria Wijayanti; Bintang Satria Purbaya
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 2 No 2 (2023): April
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v2i2.118

Latar belakang: Anemia masih menjadi masalah global, termasuk pada remaja di Indonesia. Salah satu dampak anemia yaitu penurunan imunitas yang mana dapat berpengaruh pada status kesehatan remaja selama masa transisi menuju endemi COVID-19. Tujuan: Melakukan penyuluhan kesehatan tentang anemia dan pemeriksaan hemoglobindeteksi anemia pada remaja di Panti Asuhan Darul Falah Al-Hasyimiyah. Metode: Kegiatan dilakukan pada bulan Februari 2023 berupa edukasi tentang anemia dan pemeriksaan hemoglobin pada anak-anak dan remaja di Panti Asuhan Darul Falah Al-Hasyimiyah. Tahap pelaksanaan dimulai dengan observasi lapangan, rencana penyusunan program, pelaksanaan dimulai dengan edukasi dan pemeriksaan Hb, dan evaluasi berupa pre-test dan post-test. Hasil: Tahap observasi didapatkan data awal total anak-anak dan remaja berjumlah 36 orang yang sebagian besar masih asing tentang anemia. Tahap edukasi anemia didapatkan peningkatan pengetahuan responden yang signifikan. Selanjutnya pada pemeriksaan hemoglobin ditemukan 9 remaja (25%) yang mengalami gejala anemia dan 27 remaja (75%) yang memiliki kadar Hb normal. Kesimpulan: Edukasi dapat meningkatkan pengetahuan tentang anemia secara signifikan. Ada 9 orang remaja (25%) mengalami anemia dan 27 orang remaja (75%) dengan kadar Hb normal. Kata kunci: anemia, endemi covid-19, hemoglobin, penyuluhan __________________________________________________________________________________________ Abstract Background: Anemia is still a global major issue, particularly among adolescents in Indonesia. Anemia causes a decrease in immunity, which can affect the health of adolescents during the transition to the COVID-19 endemic. Objective: Conduct health education about anemia and hemoglobin examination to detect anemia in adolescents at the Darul Falah Al-Hasyimiyah Orphanage. Method: The activity was carried out in February 2023 including anemia education and hemoglobin checks for children and adolescents at the Darul Falah Al-Hasyimiyah Orphanage. The activity phase begins with field observations, programming plans, implementation begins with education and Hb-testing, and evaluation namely pre-test and post-test. Result: The observation phase collected preliminary data on the total number of children and adolescents 36, the majority of whom were unfamiliar with anemia. The respondent's knowledge increased significantly during the anemia education stage. Furthermore, the hemoglobin test showed 9 adolescents (25%) who had anemia symptoms and 27 adolescents (75%) who had normal Hb levels. Conclusion: Education can significantly increase anemia knowledge. There were 9 (25%) anemic adolescents and 27 (75%) with normal Hb levels. Keywords: anemia, covid-19 endemic, hemoglobin, counseling

Penyuluhan dan Pemeriksaan Kesehatan sebagai Strategi Menghadapi Masa Transisi Menuju Endemi Covid-19: Education and Health examination as a Strategy for Facing the Transition Period Towards the Covid-19 Endemic Sri Darmawati; Gela Setya Ayu Putri
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 3 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i3.4752

The COVID-19 pandemic is caused by the coronavirus (Sars-CoV-2). Government programs and policies are gradually establishing controlled environments. In the current situation, the government is preparing several strategies to transition the COVID-19 pandemic to endemic status. Endemic conditions certainly do not mean harmless. It is necessary to educate the community so that the current status of COVID-19 does not carry away the community. To provide health education and routine blood tests (glucose, cholesterol, uric acid) for residents in the Amposari RT 05 RW 03 Kelurahan Kedungmundu, Tembalang District, Semarang, as one of the strategies for preventing and controlling COVID-19 during the transition to endemic. Community service was conducted in Amposari RT 05 RW 03, Kedungmundu Village, Tembalang District, Semarang, in three stages: preparation, implementation, and evaluation. Results: The knowledge of 35 respondents improved, with a mean pre-test score of 41.0, increasing to 78.3 after the post-test. The health examination showed that most residents had normal blood glucose and uric acid levels, but the results for cholesterol were dominated by above normal. Conclusion: Following education, there was a significant increase in knowledge, and most residents had higher cholesterol levels than normal. There was a significant increase in knowledge after education was carried out, and most residents had cholesterol levels above normal.

Efek Perlakuan Kombinatif Plasma Medis dan Ekstrak Daun Binahong Terhadap Penyembuhan Luka Fase Proliferasi Pada Mencit Diabetik Eka Sakti Wahyuningtyas; N Nasruddin; Heni Setyowati Esti Rahayu; Heni Lutfiyati; Isabella Meliawati Sikumbang; Laela Hayu Nurani; Arum Kartikadewi; Nia Salsabila; Gela Setya Ayu Putri; Putri Kurniasiwi; Devi Kemala Dewi
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Plasma medicine is a relatively new and multidisciplinary studyinvolving the study of plasma science, biomedicine, pharmacy, andother health sciences to utilizing plasma for medical therapy. Plasmais the fourth substance, after solids, liquids, and gases. Plasma canproduce biological molecules of Reactive Oxygen and NitrogenSpecies (RON) which, if controlled in the right dose, can bebeneficial for health. This animal study examines the effect ofcombinative treatment of medicine plasma and binahong leaf extracton proliferation phase wound healing in a diabetic test model. Thestudy used Balb mice 7-8 years old which were induced by STZ withacute wounds which were divided into 4 groups, namely the woundgroup of diabetic mice without treatment (C), the group of diabeticmice with the treatment of binahong leaf extract (B), the group ofcombined treatment wounds plasma jet (P) and the wound group ofdiabetic mice treated with a combination of plasma and, binahongleaf extract (PB). Binahong leaf extract concentration 1% in DMSOsolvent. The jet type medicine plasma treatment was carried outevery day from day 0 to day 6. Macroscopic observation of thewound was carried out every day from day 0 to day 7. On day 7 itappears that the size of the wound area for P is much smaller thanfor C, B, and PB. The size of area B and PB is relatively the same,but smaller than C. The results of this study indicate that thebinahong leaf extract tends to inhibit the performance of medicineplasma in accelerating the healing of the proliferation phase.

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