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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Journal of Experimental and Clinical Pharmacy (JECP) Indonesian Community Journal Jurnal Katalisator Jurnal Sains dan Kesehatan
Abdul Rasyid, Faradiba
Universitas MUslim Indonesia, Makassar INdonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Toxicity Activity and Total Phenolic Content of Soursop Leaves from Three Regions in South Sulawesi, Indonesia Rasyid, Faradiba Abdul; Amin, Asni; Sukmawati, Sukmawati; Djakariani, Kurnia Putri; Riska, Riska; Aliansyah, Moch. Rayhan; Sari, Cindy Artika
Journal of Experimental and Clinical Pharmacy (JECP) Vol 3, No 2 (2023): August 2023
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v3i2.674

Abstract

The fruit plant known as the soursop (Annona muricata L.) is indigenous to the Caribbean, Central America, and South America. The leaves of soursop contain substances with the potential to be cytotoxic, such as phenols and anonaceous acetogenins. Numerous variables, including geographic location, climatic conditions, and pest or disease disturbance factors, might impact a compound's phenol levels and toxicity. This study aims to investigate whether there are variations in the phenolic content and toxicity of the ethanol extract of soursop leaves that are grown in Gowa, Takalar, and Pinrang, three distinct regions in South Sulawesi, Indonesia. The Folin-Ciocalteu reagent was used to evaluate the total phenolic content, whereas Artemia salina Leach larvae were used for the BSLT method of the toxicity test. The results showed that the extracts of soursop leaves from Gowa, Pinrang, and Takalar had total phenolic contents of 3.7588% mg GAE/g, 0.9686% mg GAE/g, and 1.3832% mg GAE/g, respectively. Gowa, Pinrang, and Takalar have LC50 values of 38.19 µg/mL, 34.35 µg/mL, and 70.95 µg/mL, respectively, indicating their toxicity. The conclusion is that there were differences in the phenolic content and toxicity level of the ethanol extract of soursop leaves. All of these areas could source raw materials of soursop for the development of herbal medicines with cytotoxicity, i.e., anticancer, because they have LC50< 1,000 µg/mL.
Uji Aktivitas Antioksidan Ekstrak Daun Karet Kebo (Ficus Elastica) dengan Metode Peredaman Radikal Bebas Dpph (1,1-Diphenyl-2-Picrylhydrazil): Antioxidant Assay of Ficus Elastica Extract Leaf with Dpph Free Radical Scavenging (1,1-diphenyl-2-phycrilhydrazyl) Handayani, Selpida; Kurniawati, Ida; Abdul Rasyid, Faradiba
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (515.439 KB) | DOI: 10.22487/j24428744.2020.v6.i1.15022

Abstract

Ficus elastica leaf is one of the Ficus species assumed to be rich in polyphenols so that it can act as an antioxidant. The research aimed to determine the antioxidant activity and IC50 value of methanol and water extracts of rubber leaf. In this research, the extraction was conducted by maceration using methanol and obtained the yield value of 7,03%, while the infundation using water obtained the yield value of 2,82%. The antioxidant activity test was conducted by DPPH free radical scavenging (1,1-diphenyl-2-phycrilhydrazyl) using a quercetin comparator. The qualitative tests were conducted by TLC method using dicloromethane:methanol eluent with a ratio of 99:1 for methanol extracts, and a ratio of 95:5 for water extracts, where all extracts of both methanol and water positively container antioxidants characterized by the formation of yellow spots with a purple background on TLC plates. The results of the quantitative test shower that the methanol extract had medium antioxidant activity with an IC50 value of 78,39 µg/mL, and water extract had an inactive antioxidant activity with an IC50 value of 319,11 µg/mL. While quercetin was classified as a very strong antioxidant with an IC50 value of 7,62 µg/mL.
Application of Natural Deep Eutectic Solvents (NADES) in the Natural Product of Antioxidant Activity Hidayah, Andi Nurul Annisa; Ahmad, Aktsar Roskiana; Rasyid, Faradiba Abdul
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 2 (2025): August 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i2.1345

Abstract

The extraction of bioactive compounds from plant-based materials poses significant challenges due to the limitations of traditional organic solvents, including toxicity and environmental impact. Natural Deep Eutectic Solvents (NADES), formed from natural components at defined molar ratios, have emerged as green, sustainable alternatives for efficient extraction. This literature review aims to investigate the applications, compositions, and effectiveness of NADES in extracting antioxidant-rich compounds from natural sources. Relevant peer-reviewed articles published within the last ten years were retrieved from Google Scholar and PubMed using keywords such as “NADES,” “natural product,” and “antioxidant activity.” Studies included using NADES to extract phytochemicals, pharmaceuticals, or food compounds and address their toxicity, safety, and physicochemical properties. Non-peer-reviewed articles, unrelated solvent systems, and duplicate studies were excluded. The review identified compelling NADES compositions, including choline chloride: lactic acid (1:2), choline chloride: oxalic acid (1:1), and citric acid: glycerol (1:1), which demonstrated high extraction efficiency and antioxidant activity. The tunability of hydrogen bond donor and acceptor ratios allows NADES to be optimized for specific bioactive compounds. In conclusion, NADES offers a promising and eco-friendly approach for future applications in natural product extraction.
Analisis Kepatuhan Minum Obat Oral pada Diabetes Mellitus Tipe 2 Berdasarkan Teori Planned Behaviour di Kota Makassar Provinsi Sulawesi Selatan, Indonesia: Analysis of Oral Medication Adherence in Type 2 Diabetes Mellitus Based on Planned Behaviour Theory in Makassar City, South Sulawesi Province, Indonesia Wahyuni, Andi; Rasyid, Faradiba Abdul; Hasnaeni, Hasnaeni
Jurnal Sains dan Kesehatan Vol. 6 No. 5 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i5.2315

Abstract

The number of people with Diabetes Mellitus in Indonesia ranked seventh globally. Non-compliance with taking medication results in therapy failure. This research aims to study theory of planned behavior on compliance intention factors using hypoglycemic drugs in Type 2 Diabetes Mellitus patients. Type of research is analytical observational, with a cross-sectional study design. Instrument used was questionnaire based theory of planned behavior including attitudes, support, and perceived behavioral control regarding treatment compliance Type 2 Diabetes Mellitus patients. 321 respondents Type 2 Diabetes Mellitus sufferers in this study. Independent variables (attitude, support, perceived behavioral control) influence dependent variable (compliance). Variables contributed most compliance were support (172,099), attitude (59,413) and perceived behavioral control (45,000). The results, there is a relationship between attitude, support and perceived behavioral control on oral medication adherence in Type 2 Diabetes Mellitus patients. The support variable has greatest contribution in influencing adherence to medication use. Keywords:          Diabetes mellitus type 2; medication adherence; theory of planned behavior   Abstrak Jumlah penderita Diabetes Melitus di Indonesia menduduki peringkat ketujuh secara global. Ketidakpatuhan minum obat berdampak kegagalan terapi. Penelitian ini bertujuan menganalisis kepatuhan penggunaan obat oral pada pasien Diabetes Melitus Tipe 2 menggunakan theory of planned behavior. Jenis penelitian adalah observasional analitik, dengan desain studi cross-sectional. Instrumen yang digunakan berupa kuesioner berdasarkan theory of planned behavior meliputi sikap, dukungan, dan persepsi komtrol perilaku terhadap kepatuhan berobat pada pasien Diabetes Melitus Tipe 2. Sebanyak 321 responden penderita Diabetes Melitus Tipe 2 dalam penelitian ini. Variabel independen (sikap,dukungan, dan persepsi kontrol perilaku) berpengaruh terhadap variabel dependen (kepatuhan). Variabel yang paling berkontribusi terhadap kepatuhan adalah dukungan (172,099), sikap (59,413) dan persepsi kontrol perilaku (45,000). Dari hasil penelitian terdapat hubungan antara sikap, dukungan, dan persepsi kontrol perilaku yang dirasakan terhadap kepatuhan pengobatan oral pada pasien Diabetes Melitus Tipe 2. Variabel dukungan mempunyai kontribusi paling besar dalam mempengaruhi kepatuhan menggunakan obat. Kata Kunci:         Diabetes mellitus tipe 2; kepatuhan minum obat; theory of planned behavior
ANTIOXIDANT ACTIVITY OF SOURSOP (ANNONA MURICATA L.) LEAF JELLY CONFECTIONS FORMULATED WITH MULTIPLE GEL MATRICES Jumalia Aswar; Dewi Yuliana; Nasrul Haq; Zufiayu Sapiun; Abdul Rasyid, Faradiba
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3463

Abstract

Jelly confections represent promising nutraceutical products by incorporating bioactive compounds with health-promoting properties. Soursop leaves (Annona muricata L.) are recognized as a potential source of antioxidant and antibacterial agents, yet their application in functional foods remains limited. This study evaluated the antioxidant activity of soursop leaf jelly confections prepared with different gel matrix combinations. Formulation optimization was carried out using three gel matrices, namely carrageenan: agar (9:6), carrageenan: konjac (5:1), and konjac: agar (7:3). Antioxidant activity was assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay using a microplate reader spectrophotometer. The results demonstrated IC₅₀ values of 28.95 µg/mL for carrageenan: agar, 8.82 µg/mL for carrageenan: konjac, and 30.33 µg/mL for konjac: agar formulations. Among these, the carrageenan: konjac (5:1) formulation exhibited the most potent antioxidant activity, indicating its potential for developing functional jelly-based nutraceuticals.
Comparative Antioxidant Capacity of Seed and Fruit Ethanol Extracts of Bitter Melon (Momordica charantia L.) Using FRAP Assay Ariani, Luysi; Rasyid, Faradiba Abdul; Yuliana, Dewi; Rahmawati, Rahmawati; Muflihunna, Andi; Syarif, Rezki Amriati
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 1 (2026): February 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i1.1628

Abstract

Momordica charantia L. (bitter melon) is traditionally consumed as both food and medicine in Indonesia. Its fruit and seeds contain bioactive compounds such as saponins, flavonoids, polyphenols, and unsaturated fatty acids with recognized antioxidant potential. This study compared the antioxidant activity of ethanol extracts from bitter melon seeds and fruit using the Ferric Reducing Antioxidant Power (FRAP) assay. Extraction was conducted by ultrasound-assisted extraction (UAE) with ethanol as solvent, and antioxidant activity was expressed as quercetin equivalents (mg QE/g extract). The seed extract showed an antioxidant value of 8.680 mg QE/g, while the fruit extract exhibited 8.626 mg QE/g. The statistical analysis showed that the p-value was greater than 0.05, indicating no significant difference between the two extracts. This suggests that both extracts exhibit comparable antioxidant activity. These results highlight that both seeds and fruit of M. charantia may serve as promising natural antioxidant sources for functional food and pharmaceutical applications.
Co-Authors A.M, Sinta Faradilla Ahmad, Aktsar Roskiana Aliansyah, Moch. Rayhan Amelia Jabbar Amran Ilyas Tandjung Amran Ilyas Tandjung Andi Fitriyati Andi Muflihunna Andi Wahyuni Ariani, Luysi Asni Amin Aulia Wati Dewi Yuliana Dewi Yuliana Djakariani, Kurnia Putri Dwi Indah Pratiwi Ermina Pakki Fanny Fardiyani Farizah Dhaifina Amran Fauzia Ningrum Syaputri Hasnaeni hasnaeni, Hasnaeni Hidayah, Andi Nurul Annisa Ida Kurniawati, Ida Jumalia Aswar Nasrul haq Nur Fadillah Nurlina Nurlinda Nurlinda Nurmaya Effendi Nursiah Hasyim Rahmawati, Rahmawati Rezki Amriati Syarif Rezki Amriati Syarif, Rezki Amriati Risda Waris Riska Riska Saputri, Dicka Sari, Cindy Artika Selpida Handayani Selpida Handayani, Selpida Sukmawati Sukmawati Virsa Handayani Zufiayu Sapiun