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All Journal Buletin Farmatera Sumatera Medical Journal SCRIPTA SCORE Scientific Medical Journal Indonesian Journal of Global Health research Cermin Dunia Kedokteran The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Cermin Dunia Kedokteran
Jusuf, Nelva Karmila
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Ritme Sirkadian dan Kesehatan Kulit Siahaan, Ade Gustina; Jusuf, Nelva Karmila
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.483

Abstract

   Ritme sirkadian mengacu pada ritme fisiologis, metabolisme dan perilaku 24 jam endogen tubuh. Ritme sirkadian dikendalikan oleh pengatur pusat atau jam utama yang terletak di nukleus suprakiasmatik hipotalamus anterior dan sangat dipengaruhi oleh cahaya dan lingkungan. Sinkronisasi jam biologis ritme sirkadian pada tubuh disebut sebagai osilasi. Ritme ini memperlihatkan hubungan fase tertentu dengan siklus terang-gelap atau aktivitas-istirahat melalui sinyal neurohumoral. Misalnya, melatonin yang membawa pesan waktu pada seluruh tubuh mengenai informasi tentang waktu dan musim (fotoperiode). Kulit terdiri atas tiga lapisan yaitu epidermis, dermis, dan hipodermis. Ketiganya berperan penting dalam mempertahankan keseimbangan atau homeostasis yang diatur oleh ritme sirkadian. Ritme sirkadian pada kulit memiliki fungsi dalam pengaturan proliferasi berbagai jenis sel, yaitu: keratinosit, fibroblas, melanosit, kelenjar sebasea, dan folikel rambut. Sinar Ultraviolet (UV) dapat menyebabkan pembentukan Reactive Oxygen Species (ROS) berlebihan yang secara langsung dapat menyebabkan stres oksidatif dalam sel. Penuaan dikaitkan dengan perubahan dalam ritme sirkadian dan peningkatan akumulasi ROS. Perawatan kulit (skin care) berdasarkan ritme sirkadian merupakan hal yang penting untuk diketahui. Pemahaman mengenai ritme sirkadian pada kesehatan kulit sangat bermanfaat dalam menjaga kondisi kulit agar tetap sehat. 
Prosedur Non Invasif untuk Body Contouring Tasmil, Adina Miltania; Jusuf, Nelva Karmila
Media Dermato-Venereologica Indonesiana Vol 52 No 1 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i1.473

Abstract

Konsep body contouring berkembang dalam mengoptimalkan definisi, estetika, kehalusan, dan bentuk tubuh manusia. Perangkat kontur noninvasif meningkatkan penampilan tubuh melalui pembuangan jaringan adiposa yang berlebihan, terutama di area di mana lemak tetap ada meskipun diet dan olahraga rutin sudah optimal. Teknologi ini juga dapat digunakan untuk mengencangkan kulit. Tindakan noninvasif body contouring ini telah muncul sebagai alternatif yang populer karenaprofil keamanan yang baik, waktu pemulihan yang minimal, dan biaya yang lebih murah. Lima modalitas body contouring noninvasif yang disetujui Food and Drug Administration (FDA) yaitu: cryolipolysis, laser, high intensity focused electromagnetic field (HIFEM), radiofrequency, dan high intensity focused ultrasound (HIFU). 
Combination of Subcision, Microneedling, and Platelet-Rich Plasma Therapy in Patient with Grade Four Atrophic Acne Scars Dhillon, Jesryn; Nasution, Khairina; Jusuf, Nelva Karmila
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6682

Abstract

Atrophic acne scars affect up to 75% of patients with a history of acne and are often associated with significant psychosocial distress. These scars are classified into three main types: ice pick, rolling, and boxcar. A multimodal therapeutic approach is often required for effective management, particularly in severe cases. This report presents a case of a 40-year-old married woman with a 10-year history of inflammatory acne lesions that progressed into grade 4 atrophic scars. The acne was suspected to be triggered by injectable contraceptive use, which contains progestins with androgenic activity. The patient frequently picked at her acne, leading to deep scarring predominantly on both cheeks. Based on clinical evaluation, dermoscopy, and skin analyzer assessment, the patient underwent a series of treatments combining subcision, microneedling, and platelet-rich plasma (PRP) therapy. Following treatment, the Self-Assessment of Clinical Acne-Related Scars (SCARS) score improved from 22 to 14, while the Facial Acne Scar Quality of Life (FASQoL) score improved from 32 to 16. This case highlights the effectiveness of a combination approach in remodeling scar tissue and improving quality of life in patients with severe atrophic acne scars. A tailored, comprehensive treatment plan is essential for optimal outcomes.
Identification of Microbiota Causing Bromhidrosis in the Axillary Utama, Putri Wahdiah; Jusuf, Nelva Karmila; Putra, Imam Budi; Ichwan, Muhammad; Kusumawati, R. Lia
Indonesian Journal of Global Health Research Vol 7 No 1 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i1.4194

Abstract

Bromhidrosis is a clinical condition defined by an uncomfortable or unpleasant body odor. Since the apocrine glands are only active during puberty, most bromhidrosis occurs in the apocrine glands in the armpit and occurs when apocrine gland secretions approach the skin's surface, where they undergo various biochemical reactions caused by the presence of microbiota in the axillary skin, resulting in odor in the axilla. This research aims to identify microbiota species in the axilla that can cause bromhidrosis. A laboratory experimental research design with purposive sampling is used in this study. In this study, 60 samples were collected from students aged 15 to 18 years old at a high school in Medan, and the samples were analyzed at the University of North Sumatra Hospital's Microbiology Laboratory. All samples were taken from the right axillary skin swab, a Gram stain was performed, and the identified microbiota isolates were identified. The results of skin smear culture revealed a Gram-positive cocci group in 59 samples (98.3%) and a Gram-positive bacilli group in only one sample (1.7%). The microbiota responsible for bromhidrosis was identified as Staphylococcus hominis spp. hominins (30.4%), Staphylococcus epidermidis (27.8%), Staphylococcus aureus (16.5%), Kocuria kristinae and Staphylococcus haemolyticus (6.3%), Staphylococcus lugdunensis and Staphylococcus saprophyticus. The most common microbiota that causes bromhidrosis in the axilla is Staphylococcis hominis spp. Hominis, Staphylococcus epidermidis, and Staphylococcus aureus.
Tingkat Pengetahuan dan Sikap Mahasiswa Mahasiswi Angkatan 2017 terhadap Stretch Marks di Fakultas Kedokteran Universitas Sumatera Utara Tengku, Nabila Nurhafizha; Jusuf, Nelva Karmila
SCRIPTA SCORE Scientific Medical Journal Vol. 3 No. 2 (2022): SCRIPTA SCORE Scientific Medical Journal
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/scripta.v3i2.5432

Abstract

Background: Stretch marks are atrophy of the skin due to stretching. The prevalence of people who have stretch marks almost reaches 80% of the population. Women and the 5-50 years age group have twice the risk of developing stretch marks. Objectives: To determine the prevalence of students who have stretch marks and to find out the level of knowledge and attitudes towards stretch marks in FK USU 2017 students. Methods: Descriptive research with cross-sectional design. The research population was 253 people and the sampling technique used was non-probability sampling, namely consecutive sampling and obtained a total sample of 155 people. Data collection used an online questionnaire of google form created by researchers who had been tested for validity. Results: The respondents who have stretch marks were 85 people (54.8%). The knowledge level of women, good (96,4%), moderate (3,6%), and men, good (91,7%), moderate (8,3%). The level of women's attitudes were good (55.4%), moderate (44,6%), while men, good (31,9%), moderate (66,7%), and less (1.4%). The level of knowledge for those who have stretch marks were good (95,3%), moderate (4,7%), and who do not have stretch marks were good (92,9%), moderate (7,1%). The level of attitudes with stretch marks were good (49,4%), moderate (50,6%), while without it was good (38,6%), moderate (60%), and less (1,4%). Conclusion: The majority of knowledge of the FK USU 2017 students were good (94,2%) and the majority of attitudes of the FK USU 2017 students were moderate (54,8%). Keywords: attitude, knowledge, online questionnaire, stretch marks   Latar Belakang: Stretch marks merupakan penyakit atrofi pada kulit akibat peregangan. Prevalensi orang yang memiliki stretch marks hampir mencapai 80% dari populasi. Wanita dan kelompok usia 5-50 tahun mempunyai risiko dua kali lebih sering terkena stretch marks. Tujuan: Untuk mengetahui prevalensi mahasiswa dan mahasiswi yang memiliki stretch marksdan untuk mengetahui tingkat pengetahuan dan sikap mahasiswa dan mahasiswi terhadap stretch marks. Metode: Penelitian deskriptif dengan rancangan cross-sectional. Populasi penelitian berjumlah 253 orang dan teknik pengambilan sampel yang digunakan berupa non-probability sampling yaitu consecutive sampling dan didapatkan jumlah sampel sebanyak 155 orang. Pengumpulan data dilakukan menggunakan kuesioner online berupa google form yang dibuat oleh peneliti yang sudah dilakukan uji validitas. Hasil: Jumlah responden yang memiliki stretch marks sebanyak 85 orang (54,8%). Tingkat pengetahuan mahasiswi, baik (96,4%), cukup (3,6%), sedangkan pada mahasiswa, baik (91,7%), cukup (8,3%). Tingkat sikap mahasiswi, baik (55,4%), cukup (44,6%), sedangkan pada mahasiswa, baik (31,9%), cukup (66,7%), dan kurang (1,4%). Tingkat pengetahuan responden yang memiliki stretch marks, baik (95,3%), cukup (4,7%), sedangkan responden yang tidak memiliki stretch marks, baik (92,9%), cukup (7,1%). Tingkat sikap responden yang memiliki stretch marks, baik (49,4%), cukup (50,6%), sedangkan responden yang tidak memiliki stretch marks, baik (38,6%), cukup (60%), dan kurang (1,4%). Kesimpulan: Tingkat pengetahuan mahasiswa dan mahasiswi FK USU angkatan 2017 mayoritas baik (94,2%) dan tingkat sikap mahasiswa dan mahasiswi FK USU angkatan 2017 mayoritas cukup (54,8%). Kata Kunci: kuesioner online, pengetahuan, sikap, stretch marks
Skin Care in Dermatology: Between Organic Versus Synthetic Products Zulfa, Riefka Ananda; Jusuf, Nelva Karmila
Sumatera Medical Journal Vol. 7 No. 2 (2024): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v7i2.10427

Abstract

Background: Various skin care products have been used and played essential roles in maintaining good skin conditions. Over the last few decades, cosmetic industries and pharmacies have evolved and created skin care products according to the needs of each skin type, either based on organic or synthetic products. Objective: This article compares organic and synthetic products based on their ingredients, functions, and side effects.  Methods: This is a literature review to analyse the skin care in dermatology. Results: Natural or organic products were produced from natural ingredients, such as plants, flowers, and fruits, while synthetic products were made from a combination of organic chemical compounds. Conclusion: Both products work effectively on the skin according to their contents, but adverse effects can also occur, such as mucocutaneous reactions, edema, and allergies.
Patofisiologi Selulit Dhillon, Jesryn; Jusuf, Nelva Karmila
Cermin Dunia Kedokteran Vol 50 No 12 (2023): Penyakit Dalam
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i12.901

Abstract

Cellulite is a topographic change of the skin commonly found in the buttocks and thighs in the majority of post-pubertal women. Cellulite in males is usually accompanied by hormonal disorders. Histological changes were found in the dermis, adipose tissue, and septa. The pathophysiology of cellulite is yet to be determined, several factors are suspected.
Penggunaan Low Level Laser dalam Dermatologi Kosmetik Mutia Fadhila Sy; Jusuf, Nelva Karmila
Cermin Dunia Kedokteran Vol 51 No 6 (2024): Cardiology
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i6.991

Abstract

Low level laser therapy (LLLT) is used in almost all areas of modern medicine, including cosmetic dermatology. LLLT has been beneficial for the treatment of wrinkles, acne vulgaris, hypertrophic scars, hair loss, cellulite, and burns. LLLT can reduce UV damage both as a treatment and as a prophylaxis. In pigmentation disorders such as vitiligo, LLLT can increase pigmentation by stimulating melanocyte proliferation and reducing depigmentation. The non-invasive nature and near absence of side effects of LLLT encourage further research in cosmetic dermatology.
PENGGUNAAN FILLER DAN SKIN BOOSTER PADA PEREMAJAAN KULIT: Penggunaan Filler pada Peremajaan kulit Setio Wati, Sri Karunia; Jusuf, Nelva Karmila
Media Dermato-Venereologica Indonesiana Vol 51 No 2 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i2.447

Abstract

Filler adalah produk yang disuntikkan melalui jarum tajam atau kanula ke dalam kulit pada kedalaman yang berbeda, untuk memberikan volume pada dermis dan lemak subkutan. Filler banyak digunakan untuk indikasi estetika, karena dapat memperbaiki penampilan dengan menghaluskan atau menyamarkan garis-garis, tanda penuaan, dan kerutan di wajah dan tubuh. Selain itu, terdapat partikel kecil asam hialuronat (HA) yang dikenal sebagai skinbooster, yang merupakan metode baru dalam peremajaan kulit. Penyuntikan skinbooster berbeda dari filler, dimana penyuntikan dilakukan secara serial micropuncture intradermal dengan sejumlah kecil produk yang tidak memiliki fungsi untuk menciptakan volume (efek "volumizing") tetapi untuk melembabkan, mengencangkan dan menutrisi kulit secara mendalam dan tahan lama untuk melawan efek penuaan kulit. Tindakan filler dan skinbooster ini dapat dilakukan sesuai indikasi, dengan tetap memperhatikan kontraindikasinya. Selain itu juga harus dilakukan sesuai dengan prosedur yang direkomendasikan, untuk mengurangi kemungkinan terjadinya komplikasi.
Non–invasive vulvovaginal rejuvenation: A review Dhillon, Jesryn; Jusuf, Nelva Karmila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 8, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Non–invasive vulvovaginal rejuvenation is a promising option for women who want to restore the appearance and function of the vagina. Vaginal atrophy and vulvovaginal laxity are caused by several circumstances, including ageing, menopause, delivery, and others. Until now, non–invasive vulvovaginal rejuvenation has not been medically indicated, but it is estimated to be the focus of cosmetic dermatology in the future. Discussion: Non–invasive vulvovaginal rejuvenation can be divided into two methods: using energy-based devices and injectables. Carbon dioxide, Erbium:YAG laser and radiofrequency are the commonly used energy-based devices. Injectables most frequently used are hyaluronic acid and platelet–rich plasma. Some additional therapies, such as vaginal bleaching and vaginal tightening, are available to complement the available modalities. Several proposed combination treatments might be used to improve treatment outcomes. Side effects and complications reported are mild, but no consensus has approved its long–term effects. The legal aspect is not to be forgotten during the whole procedure. Conclusion: Further multicenter, double–randomized studies are needed to determine these procedures' safety and efficacy.
Co-Authors Al Hafiz, OK Muhammad Amalia, Rina Annisa Astari Danil, Rezkyana Deliana, Rizka Dhillon, Jesryn Eka Zhaki Safira Lubis Fitri Puspita Kartayana, Johan Khairina, Fadilah Oliv Kusumawati, R. Lia Lubis, Ade Fitriyani Lubis, Nabila Adani Malinda, Ifen Ayu Meutia, Nanda Muhammad Ichwan Mutia Fadhila Sy Nasution, Khairina Oentari, Widyaningsih Putra, Imam Budi Rina Amelia Risanti, Rinda Chindra Rosyada, Rahma Sari, Lovena Setio Wati, Sri Karunia Siahaan, Ade Gustina Sutrisno, Angie Regina Tamba, Asnita Bella Putri Tasmil, Adina Miltania Tengku, Nabila Nurhafizha Utama, Putri Wahdiah utami, dina rizki Wiryadana, Michelle Wulandari, Puteri Yosi, Ariyati Zulfa, Riefka Ananda