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All Journal Buletin Farmatera Sumatera Medical Journal Indonesian Journal of Global Health research Cermin Dunia Kedokteran The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia
Jusuf, Nelva Karmila
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Bacterial sensitivity pattern to antibiotics in acne vulgaris at Universitas Sumatera Utara Hospital Medan, Indonesia in 2019 Sari, Lovena; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: The association between psoriasis and metabolic syndrome is appealing as the two may share a similar cross-linking systemic inflammation process. The inflammation processes occurring in obesity and psoriasis may aggravate one another. This raised the question of whether a low-calorie diet would possibly reverse the aforementioned process. This study aims to determine whether calorie restriction reduces psoriasis area and severity index (PASI) in obese patients with moderate-to-severe psoriasis receiving conventional treatment compared to no calorie restriction.Methods: We searched Pubmed/Pubmed Central, ScienceDirect, Cochrane library, EBSCOhost, and Scopus databases using keywords derived from our clinical question. The inclusion criteria were randomized clinical trial (RCT) or systematic review, published in English, and available in full-text.Results: We obtained 2 systematic reviews with meta-analyses by Ko et al. and Upala et al. Ko et al. included 6 RCTs which found that the inclusion of a low-calorie diet shows significant improvement in PASI 75 compared to standard therapy (RR 1.66; 95%CI 1.07, 2.58). Upala et al. also found significant improvement in PASI 75 in a meta-analysis of 7 RCTs (Pooled OR 2.92; 95%CI 1.39, 6.13), but shows moderately high heterogeneity between studies. Other secondary outcomes have also shown significant improvements, such as quality of life and metabolic parameters.Conclusion: The intervention of a low-calorie diet may significantly reduce PASI, improve quality of life and reduce comorbidities in obese patients with moderate-to-severe psoriasis, and thus can be recommended in psoriasis management.
Microneedling and platelet-rich plasma (PRP) treatment for mixed melasma Wulandari, Puteri; Jusuf, Nelva Karmila; Nasution, Khairina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
Publisher : UI Scholars Hub

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Background: Melasma, or chloasma, is an acquired pigmentary disorder caused by increased melanin in the epidermal and dermal layers, characterized by brown or gray patches on the face and neck. There are many treatment options available; however, the difficulties in treating melasma are frequent recalcitrants, high recurrence rate, irregularity in treatment, and the tendency of the patients to self-medicate.Case Ilustration: We report a case of mixed melasma treated by microneedling and topical PRP administration. Thirteen weeks following the therapy, the patient showed a favorable response brighter skin and substantial disappearance of brown patches.Discussion: Studies assessing the efficacy of microneedling and platelet-rich plasma (PRP) treatment for melasma are still lacking. However, melasma improvement has been reported in patients treated with microneedling and PRP. In this study, we provided a study of a patient with mixed melasma treated by microneedling and PRP, which showed a favorable improvement.Conclusion: Microneedling and PRP treatment showed a favorable response in a patient with melasma, with substantial disappearance of brown patches and a decrease in MASI (Melasma Area and Severity Index) score.
Relationship between Thioredoxin Reductase (TrxR) Levels and Melasma Risanti, Rinda Chindra; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.131

Abstract

Introduction: Melasma is a common condition of acquired hypermelanosis in dermatology that often occurs in areas of the body exposed to sunlight, especially the face. Thioredoxin Reductase (TrxR) is a key antioxidant system in defense against oxidative stress through disulfide reductase activity that regulates dithiol/disulfide protein balance. High levels/activity of TrxR correlate with melanin formation and tyrosinase activity which provides additional information about the role of cellular antioxidant proteins in melanogenesis which is suspected to be related to the occurrence of melasma. The aim of this study was to determine the relationship between TrxR levels and melasma Method: This study was an observational analytical study with cross-sectional design on 30 melasma patients and 30 controls. Each patient underwent anamnesis, dermatological examination, and blood sampling to assess TrxR levels by ELISA test. These data were analyzed statistically using the Mann Whitney test. Results: This study shows that the most common distribution pattern of melasma was centrofacial in 24 people (80%). The mean TrxR level in melasma was 12.73±11.66 ng/ml. The results of the study showed that there was a relationship between high TrxR levels and melasma (p<0.001). The TrxR mean level based on the duration of suffering from melasma at <5 years was 11.4±2.89, and ≥ 5 years was 14.0±3,18 Conclusion: There is a relationship between TrxR levels and melasma.
Relationship between Angiotensin Converting Enzyme (ACE) and Cellulite Annisa Astari; Putra, Imam Budi; Jusuf, Nelva Karmila
Journal of Society Medicine Vol. 3 No. 3 (2024): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i3.133

Abstract

Introduction: Cellulite is a local metabolic disorder in subcutaneous tissue characterized by changes in skin topography, occurring in parts of the body with a large accumulation of fat tissue, especially thighs, buttocks, hips, and abdomen. Angiotensin converting enzyme is a zinc metallopeptidase, distributed on the surface of endothelial cells. Increased ACE levels cause microcirculation disorders, adipocyte hypertrophy, increased extracellular matrix, and stimulate the emergence of inflammatory cytokines which will cause an increase in the inflammatory response in the tissue, stimulate fibrogenic response and influences the appearance of cellulite. The aim of this study was too determine the relationship between ACE and cellulite. Method: This study was an observational study with a cross-sectional design of 40 cellulite patients and 40 controls. Each patient underwent history, dermatological examination, and blood sampling to assess ACE levels by ELISA test. These data were analyzed statistically using the Chi square test. Results: The mean ACE level in cellulite was 66.78±15.38 µg/ml. The highest age with cellulite was 26–35 years 17 subjects (42.5%). Most of them had a family history of cellulite from their mother 22 subjects (55%). The majority of cellulite are located on the femoral and gluteus regions by 27 subjects (67.5%). The result of this study showed that there was a relationship between high ACE levels causing a risk of 4.5 times for cellulite (p = 0.002). Conclusion: There is a relationship between ACE levels and cellulite.
The Aryl Hydrocarbon Receptor (AhR) Level Based on Age and Clinical Type of Melasma Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of Society Medicine Vol. 3 No. 7 (2024): July
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i7.153

Abstract

Introduction: Melasma is the most common pigmentation condition on the face due to excessive melanin production and release. The main predisposing factor for melasma is UV exposure. Aryl Hydrocarbon Receptor (AhR) is a ligand-dependent transcription factor that regulates the expression of a very large number of target genes in humans. Facial hyperpigmentation is increased in people living in air-polluted areas with particulate matter2.5  (PM2.5) concentrations. Dioxin compounds contained in PM2.5  can activate AhR signaling. This study aims to determine the aryl hydrocarbon receptor (AhR) level based on age and clinical type of melasma. Methods: This study was an observational study with a cross-sectional design of 30 women with melasma at Prof. CPL Hospital. This study was conducted after obtaining ethical clearance from the Research Ethics Commission of the University of North Sumatra and has obtained permission from the research field of Prof. Chairuddin Panusunan Lubis Hospital. All subjects underwent history taking, physical examination, dermatological examination, and blood sampling to assess AhR levels by ELISA test. Data were analyzed with Chi square test to assess AhR levels based on age, and to assess AhR levels based on clinical type of melasma with Kruskal Wallis test. Results: This study shows that the majority of melasma age is 41-50 years with the highest mean AhR level is 882,61 ng/mL, while the lowest AhR level is in the age range of 20-30 years with a mean of 271,5 ng/mL. Chi square test showed that there was a significant relationship between AhR levels and age (p < 0,001). The highest mean AhR levels in melasma subjects were centrofacial type with a mean of 795,50 ng/mL, while the lowest mean AhR levels were found in melasma subjects with malar type with a mean of 623,36 ng/mL. The Kruskal Wallis test showed that there was no significant difference in AhR levels based on the clinical type of melasma (p = 0,930). Conclusion: That increased the age, the highest AhR levels. The highest average AhR level was centrofacial type of melasma. There was no significant difference in AhR levels based on the clinical type of melasma.
Antifungal Activity of Henna Leaf Extract (Lawsonia inermis linn.) Against Inhibition of Trichophyton rubrum Fungal Growth Cause Tinea Unguium Meutia, Nanda; Putra, Imam Budi; Jusuf, Nelva Karmila
Buletin Farmatera Vol 6, No 2 (2021)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v6i2.4768

Abstract

Tinea unguium is a common fungal nail infection. Most commonly caused by Trichophyton rubrum. It disturbs not only cosmetic figure, but also but also might have an impact on patients emotional, social and occupational functioning, lastly affecting the overall quality of life. The management of tinea unguium is still challenging. The therapy experienced many failures and recurrences. The aim of this research is to determine the presence of antifungal activity of Lawsonia inermis L. extract and to identify the extract concentration that can inhibit the fungal growth. This research is an experimental in vitro study with isolate from Microbiology Laboratory of Faculty of Medicine, Universitas Sumatera Utara. The Lawsonia inermis L. leaves extracted by maceration method. The antifungal assay was done using dilution method with various concentrations of (3,125%; 6,25%; 12.5%; 25%; 50%; 75% w/v). The mixtures of extract, suspension of Trichophyton rubrum and the media is incubated at 37C for 2-3 days. The mixture was streaked on SDA medium to determine the antifungal activity. The results indicates that Lawsonia inermis L. extracts has an antifungal effect, and with concentrations of 25%, 50% and 75% it can be use to inhibit the growth of Trichophyton rubrum qualitatively in vitro.
Tata Laksana Hiperpgmentasi pada Area Lipatan Lubis, Nabila Adani; Jusuf, Nelva Karmila
Media Dermato-Venereologica Indonesiana Vol 51 No 3 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i3.393

Abstract

Hiperpigmentasi pada area lipatan merupakan salah satu gangguan pigmentasi kulit yang menyebabkan seseorang melakukan konsultasi dermatologis, karena hiperpigmentasi ini menjadi masalah kosmetik yang memengaruhi seseorang baik secara emosional maupun psikologis. Beberapa kondisi yang dapat menyebabkan hiperpigmentasi pada area lipatan, seperti hiperpigmentasi pasca inflamasi, acanthosis nigricans, lichen planus pigmentosus, prurigo pigmentosa, gangguan endokrin, dan kondisi lainnya. Tata laksana hiperpigmentasi pada area lipatan memerlukan banyak modalitas dan waktu pengobatan yang berkepanjangan sehingga membutuhkan kesabaran. Tata laksana meliputi tindakan pencegahan, terapi medikal, pengelupasan kimiawi, serta terapi laser. Pencegahan dapat dilakukan dengan menghilangkan kemungkinan penyebab timbulnya hiperpigmentasi. Pengobatan topikal termasuk hidrokuinon (sendiri atau dalam kombinasi dengan agen lain), desonide, retinoid, asam azaleat, asam kojik, arbutin, dan niacinamide. Pengelupasan kimiawi menggunakan asam glikolat, asam salisilat, asam trikloroasetat (TCA), asam laktat, tretinoin, dan resorsinol. Pengobatan berupa terapi laser efektif untuk hiperpigmentasi dengan menunjukkan perbaikan klinis yang bertahan lebih lama. Makalah ini memaparkan tata laksana yang tepat pada hiperpigmentasi area lipatan.
Hubungan Nutrisi dan Penuaan Kulit Rosyada, Rahma; Jusuf, Nelva Karmila
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.432

Abstract

   Penuaan kulit adalah suatu proses biologis kompleks terdiri dari dua mekanisme utama, yaitu penuaan intrinsik dan ekstrinsik. Penuaan kulit intrinsik mengacu pada perubahan fisiologi kulit yang tidak dapat dihindari. Penuaan ekstrinsik dapat terjadi lebih cepat (penuaan dini) akibat paparan faktor eksternal, seperti paparan sinar ultraviolet (UV). Enzim matrix metalloproteinase (MMP) adalah kelompok endopeptidase yang disekresikan oleh keratinosit epidermal dan fibroblast dermal yang dipengaruhi oleh reactive oxygen species (ROS) dan paparan sinar UV. Penuaan ekstrinsik dapat dilakukan intervensi dan pencegahan melalui beberapa cara, salah satunya asupan nutrisi. Fungsi kulit dan penampilan yang sehat bergantung pada nutrisi esensial yang cukup. Peran penting nutrisi pada penuaan kulit adalah membatasi pembentukan reactive oxygen species dengan konsumsi antioksidan yang terdapat pada makanan maupun suplemen. Antioksidan, seperti vitamin E, C, dan A serta antioksidan botani dan mineral efektif memperlambat proses penuaan eksterinsik. Hal ini dibuktikan dari beberapa penelitian yang menunjukkan bahwa pengaruh antioksidan dapat menghambat ekspresi enzim MMP. Namun, data penelitian yang terbatas masih menjadi bahasan yang kontroversial dan saling bertentangan pada terjadinya penuaan kulit atau pencegahannya yang masih menjadi pertanyaan.
PREVALENSI 5 KELAINAN KULIT TERBANYAK POLIKLINIK DERMATOLOGI KOSMETIK RS USU TAHUN 2020 - 2022 Danil, Rezkyana; Jusuf, Nelva Karmila; Putra, Imam Budi
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.460

Abstract

   Pendahuluan: Dermatologi kosmetik merupakan bagian dari ilmu dermatologi yang terfokus pada permasalahan kulit dan kesehatannya. Tujuan: Mengetahui jumlah kunjungan pasien per tahun dan 5 kelainan kulit terbanyak di Poliklinik Dermatologi Kosmetik RS USU periode 2020 – 2022. Metode: Penelitian ini merupakan penelitian retrospektif dengan menggunakan data rekam medis di RS USU periode 2020 – 2022. Hasil: Jumlah pasien di Poliklinik Dermatologi Kosmetik RS USU pada tahun 2020 yaitu 342 pasien (21,8%), tahun 2021 sebanyak 811 pasien (40,8%), dan tahun 2022 sebanyak 640 pasien (26,5%). Kelainan kulit terbanyak pada tahun 2020 adalah akne vulgaris berjumlah 206 pasien (60,2%). Tahun 2021 didapatkan kelainan kulit terbanyak yaitu striae distensae berjumlah 281 pasien (34,6%). Kemudian tahun 2022 didapatkan kelainan kulit terbanyak yaitu akne vulgaris berjumlah 145 pasien (22,7%). Dalam rentang waktu tahun 2020 – 2022 didapatkan 5 kelainan kulit tertinggi dari total kunjungan pasien, yaitu akne vulgaris 527 pasien (29,4%), diikuti striae distensae 453 pasien (25,3%), penuaan kulit 211 pasien (11,7%), melasma 159 pasien (8,9%), dan selulit 120 pasien (6,7%). Kesimpulan: Penelitian ini memberikan gambaran 5 kelainan kulit tertinggi dari total kunjungan pasien di Poliklinik Dermatologi Kosmetik RS USU periode 2020 – 2022, dengan kunjungan pasien tertinggi di tahun 2021 sebanyak 811 pasien (40,8%). 
PROFIL PASIEN SELULIT DI POLIKLINIK DERMATOLOGI DAN VENEREOLOGI RUMAH SAKIT UNIVERSITAS SUMATERA UTARA MEDAN PERIODE 2020–2022: PROFIL PASIEN SELULIT DI POLIKLINIK DERMATOLOGI DAN VENEREOLOGI RUMAH SAKIT UNIVERSITAS SUMATERA UTARA MEDAN PERIODE 2020–2022 Lubis, Ade Fitriyani; Jusuf, Nelva Karmila; Putra, Imam Budi
Media Dermato-Venereologica Indonesiana Vol 51 No 4 (2024): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v51i4.462

Abstract

   Latar belakang: Selulit adalah kondisi kulit yang mengganggu estetika yang merupakan perubahan tekstur kulit menjadi bergelombang atau menyerupai kulit jeruk (orange peel) terutama di bokong, paha, panggul, dan perut. Metode: Penelitian deskriptif yang dilakukan secara retrospektif menggunakan data rekam medis pasien selulit. Hasil: Jumlah kasus pasien selulit periode 2020–2022 sebanyak 120 pasien (2,44%). Prevalensi selulit sebesar 0,63% (10 pasien) tahun 2020, 4,35% (40 pasien) tahun 2021, dan 2,89% (70 pasien) tahun 2022. Awitan kelompok usia terbanyak adalah 26–35 tahun sebanyak 61 orang (50,9%) dan terdapat riwayat keluarga selulit sebanyak 91orang (75%) dengan indeks massa tubuh (IMT) overweight sebanyak 51 orang (42,5%). Lokasi selulit terbanyak di regio femoralis dan glutaeus sebanyak 52 orang (43,3%), diikuti regio gluteus sebanyak 41 orang (33,3%). Derajat keparahan selulit paling dominan berupa derajat II dialami oleh 64 orang (53,3%). Kesimpulan: Prevalensi pasien dengan selulit yang berobat pada tahun 2020–2022 meningkat. 
Co-Authors Al Hafiz, OK Muhammad Amalia, Rina Annisa Astari Danil, Rezkyana Deliana, Rizka Dhillon, Jesryn Eka Zhaki Safira Lubis Fitri Puspita Kartayana, Johan Khairina, Fadilah Oliv Lubis, Ade Fitriyani Lubis, Nabila Adani Meutia, Nanda Nasution, Khairina Oentari, Widyaningsih Putra, Imam Budi Rina Amelia Risanti, Rinda Chindra Rosyada, Rahma Sari, Lovena Siahaan, Ade Gustina Sutrisno, Angie Regina Tamba, Asnita Bella Putri Tasmil, Adina Miltania utami, dina rizki Wiryadana, Michelle Wulandari, Puteri Yosi, Ariyati