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All Journal Jurnal Penelitian Saintek Jurnal Ilmiah Farmasi Majalah Farmaseutik Media Ilmu Kesehatan Jurnal Medikes (Media Informasi Kesehatan) Journal of Fundamental and Applied Pharmaceutical Science Journal of Innovation in Community Empowerment (JICE) Jurnal Farmasi Sains dan Praktis Journal of Biotechnology and Natural Science Journal of Pharmaceutical (JOP) Jurnal Pharmacia Mandala Waluya
Sari, Kurnia Rahayu Purnomo
Universitas Jenderal Achmad Yani Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Acute toxicity study of Andrographis paniculata (Burm.f) Ness herbs and Gynura procumbens (Merr) leaves extracts combination Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Nadia Husna
Jurnal Ilmiah Farmasi Vol. 16 No. 1 (2020): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol16.iss1.art5

Abstract

AbstractBackground: Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence to ensure the safety of its use. Recent research on Andrographis paniculata (Burm. f) Ness and Gynura procumbens (Lour.) Merr showed that the combination of these extracts has a potential to be developed into antihyperglycemic agent and there’s no any potential toxicity for each extract.Objective: The aim of this study was to evaluate the acute toxicity level of these two extracts combination. From this research, it is expected that information can be obtained regarding the safety of extracts to support the further development of the extract combination.  Method: The method that used in this research is based on OECD 423. Observation was intensively done to animal behavior 4 h after acute exposure and continued up to 14 days after acute exposure to evaluate whether there were animal died. After the 15 days, all the animals were sacrificed and the vital organ was isolated for histological study.Results: The results showed that the exposure of these combination didn’t caused any to toxicity symptoms and there’s no animals died. Histological study on hepar showed that there’s no mayor damage in the hepar even after exposure of 2000 mg/kgBW dose.Conclusion: The combination of ethanol extract of A. paniculata herbs and G. procumbens leaves was categorized as unclassified (>2000 mg/kgBW) in term of toxicity levels based on Globally Harmonized Classification System.Keywords: Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, acute toxicityIntisariLatar belakang: Pengembangan tanaman obat sebagai alternatif pengobatan perlu dukungan dari segi scientific evidence untuk meningkatkan kepercayaan masyarakat dan menjamin keamanan penggunaannya. Penelitian terbaru tentang sambiloto dan sambung nyawa menunjukkan bahwa kombinasi ekstrak tersebut berpotensi untuk dikembangkan menjadi agen antihiperglikemia dan dibutuhkan pemastian keamanannya.Tujuan: Penelitian bertujuan untuk mengevaluasi potensi ketoksikan secara akut kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa.Metode: Metode yang digunakan pada penelitian ini mengacu pada panduan OECD 423. Pengamatan yang dilakukan termasuk pada tingkah laku hewan uji tikus betina galur Wistar berjumlah 15 ekor, secara intensif terhadap gejala toksisitas selama 4 jam awal setelah paparan sediaan uji kemudian dilanjutkan hingga 14 hari pasca paparan untuk melihat ada/tidaknya hewan uji yang mati. Pada hari ke-15, seluruh hewan uji dikorbankan dan dibedah untuk diisolasi, ditimbang organ vitalnya dan dilakukan pengamatan histologi. Hasil: Hasil penelitian menunjukkan bahwa kombinasi ekstrak tersebut tidak menyebabkan gejala toksik terhadap hewan uji dan tidak ada satupun hewan uji yang mati. Hasil histopatologi organ hepar menunjukkan bahwa kombinasi ekstrak ini tidak menunjukkan efek berbahaya pada organ hepar hewan uji yang telah diberi paparan akut dengan dosis 2000 mg/kgBB. Kesimpulan: Ketoksikan kombinasi ekstrak larut etanol herba sambiloto dan daun sambung nyawa masuk dalam kategori unclassified (>2000mg/kgBB) menurut Globally Harmonized Classification System.Kata kunci : Andrographis paniculata (Burm.f) Ness, Gynura procumbens (Lour.) Merr, toksisitas akut 
Effect of Andrographis paniculata (Burm.f) Ness Herbs and Gynura Procumbens (Merr) Leaves Extracts Combination in Free-Radical Scavenging Activity Kurnia Rahayu Purnomo Sari; Nofran Putra Pratama; Margaretha Kurniasari
Majalah Farmaseutik Vol 15 No 1, (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.772 KB) | DOI: 10.22146/farmaseutik.v15i1.45012

Abstract

Development of medical plants as an alternative treatment needs support in terms of scientific evidence to increase public confidence in its efficacy and to ensure the safety of its use. Recent research on Andrographis paniculata (Burm.f) Ness dan Gynura procumbens (Lour.) Merr show that the combination of these two extracts has a potential to be developed into antihyperglycemic agent, through the mechanism of action as an antioxidant. The aim of this study was to evaluate the antioxidant effect of these two extracts combination. Extraction was done by maceration method. Testing of free radical capture activity was carried out by the DPPH method. The results of the antioxidant activity test showed that the combination of soluble ethanol extract of A. paniculata herbs and G. procumbens leaves 50:50 had the best IC50 value of 91.418 µg/mL, the combination of soluble ethanol extract 75:25 had IC50 value 117,059 µg/mL, and the combination combination of soluble ethanol extract 25:75 had the weakest IC50 of 142,277 µg/mL. The three comparisons of the combination were weaker in antioxidant activity compared to the standard vitamin C which had IC50 3,546 µg/mL. Statistical analysis using one-way ANOVA obtained significant differences in antioxidant activity of the three comparison groups.
Acute Toxicity Study of the Combination of Azadirachta indica A. Juss. and Gynura procumbens (Lour.) Merr. Leave Extracts Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Ririn Irma Marliana
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 2 (2021): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v1i2.9868

Abstract

Azadirachta indica A.Juss. and Gynura procumbens (Merr.) are medicinal herbs widely used in traditional medicine. Recent research on the combination of these two plants showed aggressive antioxidant activity. The combination results can improve insulin and beta-cell morphology and can increase insulin expression. The variety of activities performed is the basis for conducting acute toxicity tests on the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. to increase public confidence in its efficacy and ensure the safety of its use. The acute toxicity test on the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. was carried out on female Wistar rats by following the 423 procedures of OECD (Organization for Economic Cooperation and Development) Guideline with five groups of experimental animals, namely normal treatment, aquadest solvent treatment and 0.5 Na-CMC 0.5%, a separate treatment of the ethanol extract of Azadirachta Indica A. Juss., a separate treatment of the ethanol extract of Gynura procumbens (Lour.) Merr., and combination treatment of the ethanol extract of Azadirachta Indica A. Juss. and leaves of Gynura procumbens (Lour.) Merr. Furthermore, it was proceeded by observing the liver of the experimental animals histopathologically. The acute toxicity test results utilizing the 423 procedures of the OECD did not confirm any death or signs of toxicity in the experimental animals, and histopathological observations did not show any major histopathological damage. Based on these results, according to Globally Harmonized Classification System (GHS), the combination of the ethanol extract of Azadirachta Indica A. Juss. and Gynura procumbens (Lour.) Merr. is included in the unclassified category 2,000 mg/kg BW.
STUDI PREFORMULASI TABLET EFFERVESCENT DAUN TORBANGUN (Coleus Amboinucus L) SEBAGAI ALTERNATIF PENINGKATAN PRODUKSI ASI Nur Rahmawati Sholihah; Kurnia Rahayu Purnomo Sari
Jurnal Medikes (Media Informasi Kesehatan) Vol 9 No 1 (2022): Mei
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36743/medikes.v9i1.344

Abstract

The prevalence of exclusive breastfeeding coverage is still far from the national target. The lack of utilization torbangun leaves an excellent opportunity for the development of science and technology. This study aims to determine the optimum formulation of torbangun leaf effervescent tablets (Coleus Amboinicus L) as an alternative to increasing breast milk production. The research method used was an experimental post-experimental design, with the stages of processing simplicia, extracting torbangun leaves, making effervescent tablet formulas, evaluating granules, and evaluating tablet preparations. The difference in the dose variation of each ingredient used in the manufacture of the torbangun leaf effervescent tablet formula greatly affects the quality which is reviewed based on the moisture test of the formulation and the physical properties of the torbangun leaf granules. The results shown in table 2, obtained the formulation of torbangun leaf effervescent tablets made with a variety of ingredients with 4 formulas with a weight of 100 grams each, from the 4 formulas arranged, the results obtained that the best effervescent tablet formula was found in formula 4. A good formula was then tested for granule moisture, flow properties test for an angle of repose and compressibility index as an effervescent tablet in increasing breast milk production, the Na Bicarbonate content in formula 4 which was 26.56 grams gave an excellent solubility effect in water, with this the galactagogue content in Torbangun extract is more free and effective for breast milk production. Meanwhile, based on the physical properties of the granules, the best granule physical properties is formula 2 with a good flow rate, which is more than 10g/second. The flow rate of a granule is influenced by the shape of the granule and the size of the granule.
FORMULATION OF CHEWABLE TABLET PREPARATIONS FROM THE COMBINATION OF Azadirachta Indica A. Juss. AND Gynura Procumbens (Merr.) Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Endah Kurniawati
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.5918

Abstract

Azadirachta indica A. Juss. and Gynura procumbens (Merr.) are one type of potential medicinal plants because they have various properties. One of the properties of these two plants is as an antioxidant. The combination of the two plants has a strong category of antioxidant activity, does not cause death and physical changes in test animals. This study aimed to make an antioxidant chewable Tablet containing a combination of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) extract with a variation of mannitol-sorbitol as a filler. This variation has the advantage of covering the bitter taste of the active substance so that it is expected to provide a pleasant taste and is easy to swallow. The extract obtained was formulated into chewable Tablets with variations of mannitol-sorbitol (90%:10%), (80%:20%), and (70%:30%). The method used is wet granulation. The granules obtained were tested for their physical properties, namely flow velocity, angle of repose, and compressibility. The physical properties of the Tablets tested included uniformity of weight, size, hardness, friability, disintegration time, quality of taste, shape, and odor. Based on the test results of the physical properties of the granules, the three formulas met the requirements. While the physical properties of Tablets that do not meet the criteria are uniformity of size and disintegration time. This research concludes that the extracts of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) be formulated into chewable Tablets where formula two with variations of mannitol:sorbitol (80:20%) is the best formula by fulfilling 9 of 11 requirements
ANTIBACTERIAL ACTIVITIES OF POLAR FRACTION OF PAPAYA LEAF ETHANOLIC EXTRACT (Carica papaya Linn.) AGAINST Escherichia coli AND Staphylococcus aureus Margaretha Kurniasari; Kurnia Rahayu Purnomo Sari; Nur'aini Purnamaningsih
Jurnal Penelitian Saintek Vol 27, No 2 (2022)
Publisher : Directorate of Research and Community Services, Universitas Negeri Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21831/jps.v2i27.53006

Abstract

Tujuan penelitian untuk mengetahui aktivitas antibakteri fraksi polar ekstrak etanol daun pepaya (Carica papaya L.) terhadap bakteri Staphylococcus aureus dan Escherichia coli. Proses ekstraksi dilakukan menggunakan metode maserasi dengan pelarut etanol 70%. Ekstrak etanol selanjutnya difraksinasi menggunakan pelarut etanol-air. Uji aktivitas antibakteri yang digunakan adalah metode difusi agar cara Kirby Bauer. Variasi konsentrasi fraksi etanol-air ekstrak etanol daun pepaya 10, 15, 20, 25, 30, dan 100%. Zona hambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli diukur menggunakan jangka sorong. Hasil penelitian menunjukkan zona hambat fraksi etanol-air terhadap bakteri Staphylococcus aureus yang paling optimum yaitu pada konsentrasi 100% sebesar 14,75 mm; sedangkan pada bakteri Escherichia coli yang paling optimum yaitu pada konsentrasi 100% sebesar 11,53 mm. Namun tidak efektif jika dibandingkan dengan zona hambat kontrol positif kloramfenikol. Kesimpulan fraksi etanol-air ekstrak etanol daun pepaya (Carica papaya L.) dapat menghambat pertumbuhan bakteri Staphylococcus aureus dan Escherichia coli.Antibacterial activities of polar fraction of papaya leaf ethanolic extract (Carica papaya Linn.) against Escherichia coli and Staphylococcus aureusThis study aimed to determine the antibacterial activities polar fraction of papaya leaf ethanol extract against Escherichia coli and Staphylococcus aureus. Simplicia was extracted by ethanol 70% with the maceration method. Ethanolic extract was fractionated with ethanol water. Kirby Bauer diffusion method agar was used for antibacterial activities. Variation concentration of the ethanol-water fraction of papaya leaf ethanolic extract 10, 15, 20, 25, 30, and 100%. The growth inhibition zones of Escherichia coli and Staphylococcus aureus are measured using a caliper. The zone of inhibition of the ethanol-water fraction against Staphylococcus aureus was the most optimum at a concentration of 100% at 14.75 mm, while the most optimum for Escherichia coli was at a concentration of 100% at 11.53 mm, but did not effective than positive control Chloramphenicol. The conclusion of this study is that the ethanol-water fraction of papaya leaf ethanol extract could inhibit the growth of Staphylococcus aureus and Escherichia coli bacteria.
DETERMINATION OF TOTAL FLAVONOID OF n-HEXANE, ETHYL ACETATE, AND WATER FRACTION FORM CLOVE FLOWER ETHANOL EXTRACT (Syzygium aromaticum) USING UV-VIS SPECTROPHOTOMETRY METHOD Kurnia Rahayu Purnomo Sari
Majalah Farmaseutik Vol 18, No 4 (2022): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i4.69757

Abstract

Research related to clove plants in Indonesia mostly only uses the leaves. There are still few who research phytochemical compounds in clove flowers. This study aims to determine the effect of solvent properties on the flavonoid content properties and to identify the total flavonoid content of each fraction. The three solvent fractions used include water, ethyl acetate, and n-hexane.Clove flower (Syzygium aromaticum) extraction was carried out by the maceration method using 70% ethanol. The separation of compounds based on the level of polarity was done by Liquid-liquid extraction. Determination of the flavonoid compounds was carried out qualitatively by Thin Layer Chromatography (TLC) using chloroform: methanol: glacial acetic acid (9: 1: 0.5) as mobile phase and silica gel F254 as a stationary phase with quercetin as a comparison. Quantitative analysis was performed by the UV-Vis spectrophotometry method.The results show that total flavonoid levels in the ethanolic extract of Clove flower (EEBC) were 7.818% ± 0.270, in the ethyl acetate fraction was 10.458% ± 0.516, in the water fraction was 6.137% ± 0.427, and in the n-hexane fraction was 2.251% ± 0.239. Based on these results, it can be concluded that there is a significant effect between the solvent properties of the ethanol extract and the three clove flower fractions (Syzygium aromaticum) on the total flavonoid content. The highest total flavonoid content respectively was ethyl acetate fraction, clove flower ethanol extract (EEBC), water fraction; and the n-hexane fraction. 
Sosialisasi Upaya Peningkatan Kualitas Hidup Masyarakat Yang Mengalami Hipertensi Dan Diabetes Dengan Pola Gaya Hidup Sehat Di Pedukuhan Dongkelan, Bantul Rizqa Salsabila Firdausia; Kurnia Rahayu Purnomo Sari
The Journal of Innovation in Community Empowerment Vol 4 No 2 (2022): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v4i2.738

Abstract

ABSTRAK. Penyakit tidak menular (PTM) merupakan salah satu masalah kesehatan yang dihadapi baik secara nasional salah satunya di Dusun Dongkelan, Desa Panggungharjo, Sewon, Bantul. Berdasarkan data terdapat sekitar 8,5% masyarakat Dongkelan menderita penyakit hipertensi dan diabetes mellitus (DM). Hal ini perlu dijadikan perhatian karena suatu penyakit degeneratif tidak bisa hanya disembuhkan dengan satu atau dua kali pengobatan saja. Biasanya pengobatan penyakit degeneratif bersifat jangka panjang bahkan sampai seumur hidup, tergantung pada kondisi masing-masing. Adapun salah satu tujuan konsumsi obat secara teratur adalah untuk mencegah terjadinya komplikasi. Pencegahan komplikasi dari penyakit hipertensi dan DM selain dilakukan dengan pengobatan, perlu didukung dengan terapi non farmakologis berupa penerapan gaya hidup sehat. Upaya-upaya ini juga perlu dilakukan untuk meningkatkan kualitas hidup masyarakat penderita hipertensi dan DM. Namun menurut analisa permasalahan di lapangan, informasi terkait upaya ini belum banyak diketahui oleh masyarakat sehingga hal ini menjadi salah satu alasan perlunya kegiatan sosialisasi. Kegiatan ini dilakukan dengan tujuan meningkatkan pengetahuan dan kesadaran dari masyarakat Pedukuhan Dongkelan, khususnya penderita hipertensi dan DM untuk berperilaku hidup sehat demi meningkatkan kualitas hidup untuk mencegah komplikasi penyakit. Sosialisasi dilakukan di Balai Pedukuhan Dongkelan yang diikuti oleh peserta yang menderita hipertensi dan DM, serta beberapa peserta yang memiliki faktor resiko terhadap penyakit tersebut. Kegiatan diawali dengan memberikan pretest terlebih dahulu untuk mengetahui tingkat pengetahuan peserta tentang materi, kemudian dilanjutkan pemaparan materi, diskusi dan diakhiri dengan posttest. Berdasarkan hasil pretest dibandingkan dengan posttest menunjukkan adanya peningkatan pengetahuan dari para peserta terkait materi yang ditandai dengan meningkatnya jumlah jawaban benar dari 73,08% menjadi 98,46%. Berdasarkan hasil tersebut dapat disimpulkan bahwa kegiatan pengabdian masyarakat melalui sosialisasi dengan tema “Upaya Peningkatan Kualitas Hidup Masyarakat Yang Mengalami Hipertensi Dan Diabetes Dengan Pola Gaya Hidup Sehat” ini dapat meningkatkan pengetahuan dan kesadaran masyarakat Pedukuhan Dongkelan, khususnya penderita hipertensi dan DM demi mencegah komplikasi penyakit hipertensi dan DM. KATA KUNCI Diabetes; Hipertensi; Lifestyle ABSTRACT Non-communicable disease is one of the health problems faced nationally, one of which is in Dongkelan, Panggungharjo, Sewon, Bantul. Based on the data, about 8.5% of Dongkelan people suffer from hypertension and diabetes mellitus (DM). This needs to be considered because usually this disease needs long-term until a lifetime medication. One of the goals of taking medication regularly is to prevent complications. Prevention of complications from hypertension and DM, needs to be supported by non-pharmacological therapy in the form of implementing a healthy lifestyle. These efforts also need to improve the patient’s quality of life. However, according to the problem in the field, people in Dongkelan still lack of information related to this effort, so it needed for some education. The aim of the activity is increasing knowledge and awareness of Dongkelan local community, especially people with hypertension and diabetes. The activites was carried out at the Dongkelan, which was attended by participants who suffered from hypertension and DM, as well as several participants who had risk factors for these diseases. The activity begins by giving a pretest first to determine the level of participants knowledge about the material, then continues with the presentation of the material, discussion and ends with a posttest. Based on the results of the pretest compared with the posttest, it showed an increase in the knowledge of the participants regarding the material which was marked by an increase in the number of correct answers from 73.08% to 98.46%. Based on these results, it can be concluded that community service activities through socialization can increase knowledge and awareness of the Dongkelan local community, especially hypertension and DM sufferers in order to prevent complications of hypertension and DM. KEYWORDS Diabetes; Hypertension; Lifestyle
Pengaruh Pemberian Informasi Terhadap Pengetahuan Masyarkat Dusun Turi Tentang TOGA Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari; Budi Rahayu
The Journal of Innovation in Community Empowerment Vol 5 No 2 (2023): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v5i2.968

Abstract

I Peningkatan pembangunan kesehatan menjadi prioritas utama sebagai tolak ukur kemajuan suatu negara. Apoteker adalah salah satu agen tenaga kesehatan yang memiliki peran dalam pembangunan kesehatan, salah satunya dengan melakukan edukasi-edukasi kepada masyarakat seperti pengenalan khasiat bahan alam dalam pengobatan yang dikemas dalam bentuk Tanaman Obat Keluarga atau TOGA yang disertai dengan swamedikasi. TOGA dapat menjadi alternatif pengobatan keluarga yang aman karena bahan yang berasal dari alam. Obat yang berasal dari bahan alam dianggap memiliki efek samping yang lebih kecil, mudah diolah dan dikonsumsi untuk terapi alternatif pada penyakit-penyakit tertentu. Penggunaan TOGA akan lebih baik jika masyarakat juga paham terkait swamedikasi sehingga keberhasilan pengobatan akan semakin tinggi. Banyakanya manfaat dari TOGA berbanding terbalik dengan realita yang ada terutama di Dusun Turi, warga disana banyak yang tidak mengetahui TOGA dan hanya sebagian yang mengetahui tetapi tidak paham bagaimana penggunaanya. Tujuan dari kegiatan ini yaitu memberikan informasi mengenai khasiat dari berbagai jenis TOGA dan cara pengelolaannya TOGA menjadi sehingga menjadi TOGA dengan kualitas yang baik serta mewujudkan masyarakat sehat di Dusun Turi dengan mensinergiskan pengetahuan tentang TOGA dan swamedikasi. Metode yang digunakan dalam pengabdian ini antara lain ceramah, praktik, dan diskusi tanya jawab. Langkah-langkah kegiatan ini melalui beberapa tahapan yaitu tahap persiapan, tahap pelaksanaan, dan tahap evaluasi pelaporan. Dari kegiatan tersebut didapat indikator capaian yaitu pemahaman masyarakat mengenai khasiat dari berbagai jenis TOGA dan cara pengelolaannya TOGA. Kegiatan pengabdian kepada masyarakat ini berjalan dengan baik terbukti dengan banyaknya peserta yang aktif bertanya mengenai materi yang disampaikan. Hasil dari kegiatan ini adalah terjadi peningkatan pengetahuan peserta mengenai TOGA dari 71,43% menjadi 92,86%.
Daya Hambat Fraksi n-heksan, Etil Asetat, dan Air dari Ekstrak Etanol Bunga Cengkeh (Syzygium aromaticum (L.) Merrill & Perry) Terhadap Bakteri Staphylococcus epidermidis Ratih Armay Gustari; Nofran Putra Pratama; Kurnia Rahayu Purnomo Sari
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 1 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i1.865

Abstract

Background: Clove flower plants are known as traditional plants that can be used in food, drink and medicine. Clove flower ethanol extract (Syzygium aromaticum (L.) Merrill & Perry) has antibacterial activity. Antibacterial is a substance that can interfere with the growth or kill bacteria by interfering with the metabolism of harmful microbes.Objective: This study was conducted to determine how effective the n-hexane, ethyl acetate, and water fractions from clove the ethanol extract of clove flower (Syzygium aromaticum (L.) Merrill &Perry) in inhibiting the growth of Staphylococcus epidermidis bacteria.Method: Extract were made by the maceration method with 70% ethanol as a solvent. Then proceed with the fractionation process using a liquid-liquid extraction method using three solvents, namely n-hexane solvent (non-polar), ethyl acetate solvent (semi-polar), and water solvent (polar). Identification of clove flower extract and fraction flower was carried out by organoleptic test, phytochemical screening test, and thin layer chromatography test. A Bacterial inhibition test was carried out using the Kirby-Bauer disc diffusion method using concentrations of 20%, 40%, 60%, 80% and 100% with positive control used chloramphenicol while the negative control used distilled water.Result: The results of the n-hexane and ethyl acetate fraction had bacterial inhibition at concentrations of 60%, 80%, and 100%. The water fraction had a zone of bacterial inhibition at 100% concentration.Conclusion: Based on the results of the study was found that the n-hexane, ethyl acetate, and water fractions had effectiveness in inhibiting the growth of Staphylococcus epidermidis bacteria.
Co-Authors Ardianto, Lisman Septa Azizah, Nuriyatul Azzahra, Cindy Budi Rahayu Budi Rahayu, Budi Endah Kurniawati Endah Kurniawati, Endah Junita, Fina Khusna, Zella Nufusul Lailatul Husna Luluk, Luluk nurjanah Margaretha Kurniasari Margaretha Kurniasari Nadia Husna Nofran Putra Pratama Nofran Putra Pratama Nofran Putra Pratama Novitasari, Trilia Nur Rahmawati Sholihah Nur’Aini Purnamaningsih Pratama, Nofran Pratama, Nofran Putra Putra Pratama, Nofran Putri, Anggraeni Widya Ratih Armay Gustari Ririn Irma Marliana Rizqa Salsabila Firdausia Sabilah, Nakkyah Sal Tenabolo, Vilkanova Asenath Inna Tommy, Muhammad Ulvia, Rengganis Wulandari, Sephia