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All Journal Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Hearty : Jurnal Kesehatan Masyarakat Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Faletehan Health Journal Biomolecular and Health Science Journal Indonesian Journal of Anesthesiology and Reanimation (IJAR) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Locus Penelitian dan Pengabdian International Journal of Health Science & Medical Research International Journal of Health and Medicine Folia Medica Indonesiana
Romadhon, Pradana Zaky
Medical Hematology Oncology Division, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital Surabaya
Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pregnancy in women with thalassemia dependent transfusion: A case report on the importance of multidisciplinary surveillance to improve maternal and child safety Heryana, Made Oka; Nanda, Kris Gratia Ageng; Romadhon, Pradana Zaky; Prahasanti, Kartika
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 10 No 01 (2026): Qanun Medika Vol 10 No 01 January 2026
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v10i01.25951

Abstract

Thalasemia affects hemoglobin production. Transfusion-dependent thalassemia is a demanding clinical condition requiring lifelong care and follow-up. A 38-year-old woman is pregnant with her fourth child at 35 weeks gestation. This woman was diagnosed with Hb-E thalassemia-dependent transfusion (Hb electrophoresis showing Hb E 51.5%, Hb F 41.5%, and Hb A 3.5%). The Patient appeared pale with anemic conjunctiva, white sclera, and abdominal enlargement due to pregnancy. The Patient weighs 42 kg, and her height is 150 cm (BMI 18.67). Laboratory results were microcytic hypochromic anemia with hemoglobin 7.4 g/dL, erythrocytes 3.12 million/mL, mean cell volume (MCV) 74.0 fl, mean cell hemoglobin (MCH) 23.7 pg, mean cell hemoglobin (MCHC) 32 g/dL, and platelets with a platelet count of 133,000/µL. A cesarean method was chosen to terminate the pregnancy. There was no intrapartum and postpartum complication in this Patient. Her baby was 1.860 grams and 47 cm in length. There are no abnormalities found in the neonatal examination. Management of pregnant women with thalassemia requires special attention from preconception, during pregnancy, and toward delivery time. Multidisciplinary involvement such as hematologists and obstetricians is the primary key to the safety of mothers and children.
Association Between Pediatric Sofa Score and Coagulation Abnormalities in Critically Ill Children at Dr. Soetomo General Hospital: A Retrospective Study Fadillah, Saskia Putri; Setyaningtyas, Arina; Romadhon, Pradana Zaky; Semedi, Bambang Pujo
Indonesian Journal of Anesthesiology and Reanimation Vol. 8 No. 1 (2026): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V8I12026.9-16

Abstract

Introduction: Coagulation disorder is a common complication related to mortality in pediatric patients at the intensive care unit. It is characterized by prolongation of blood clotting time as reflected in activated partial thromboplastin time (APTT) and prothrombin time (PT) values. Organ dysfunction, often found in a patient with critical illness, is one of the causes of coagulation disorder. The degree of organ dysfunction in pediatric patients can be assessed using the pediatric sequential organ failure assessment (pSOFA) score. Objective: To analyze the association of pSOFA score with coagulation disorder and the association of thrombocytopenia with mortality in critically ill children at the PICU. Methods: This study used a retrospective analytical observational design involving 43 critically ill pediatric patients with organ dysfunction treated in the PICU of Dr. Soetomo General Hospital in 2023. The associations between pSOFA score and coagulation parameters, as well as thrombocytopenia and mortality, were statistically analyzed using the chi-square test. The pSOFA cutoff value for predicting coagulation disorder was determined by the ROC curve. Results: The pSOFA score was significantly associated with prolonged APTT (p= <0.001; φ= 0.506) and PT (p= 0.018; φ= 0.362). The cutoff point of a pSOFA score ≥6.5 for APTT prolongation showed 86.7% sensitivity and 71.4% specificity (AUC= 0.804). With a pSOFA score cutoff point of ≥8.5 for PT prolongation, the sensitivity was 56.3% and the specificity was 85.2% (AUC= 0.720). Subanalysis showed a significant association between thrombocytopenia and mortality (p= 0.017; φ= 0.365). Conclusions: The pSOFA score was significantly associated with APTT and PT prolongation, and thrombocytopenia was significantly associated with mortality in critically ill children.
Co-Authors -, Regina Rania Cahya Kusumaningrum Aditea Etnawati Putri Agustin, Esthiningrum Dewi Alkaff, Firas Farisi Almira, Naufalia Ghina Ami Ashariati Ami Ashriati Prayoga Andi Yasmin Wijaya Andriantono, Immanuel Arina Setyaningtyas Bintoro, Siprianus Ugroseno Yudho Cahyono, Maulana Bagus Adi Choirina Windradi Christopher Surya Lodianto Etha Dini Widiasi Fadillah, Saskia Putri Faizal Kurniawan FIRDAUSA, SARAH Friska Kamila Nabilasefanty Galuh Senjani Yulfani Putri Hasan, Helmia Heryana, Made Oka Husnul Khatimah Husnul Khatimah Ilham Rahmanto Kartika Prahasanti Krisnina Nurul Widiyastuti Kurniawan, Faizal Kurniawan Kusumaningrum, Regina Rania Cahya Lilik Djuari Lin, Mei- Feng Made Putra Sedana Mahdi, Bagus Aulia Makhfudli Makhfudli Maulana Bagus Adi Cahyono Maulida, Vetty Silvana Medhi Denisa Alinda, Medhi Denisa Melati, Akilla Nathania Merlyna Savitri Merlyna Savitri Merlyna Savitri Merlyna Savitri Merlyna Savitri Savitri Mia Ratwita Andarsini Muhammad Noor Diansyah Muhammad Noor Muhammad Nabila Rahmaniah Nala Astari Pramesti Nanda, Kris Gratia Ageng Novendrianto, Dwiki Nugraningrum, Rahmi Nuniek Nugraheni Nurul Zulfa Sahiruddin Pionera Seconda Giyanti Putri Pramesti, Nala Astari Putri, Dyfe Alisya Putri, Pionera Seconda Giyanti Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Rahmaniah, Nabila Rahmanto, Ilham Rahmi Nugraningrum Rismia Agustina Rizky Amalia Putri Sahiruddin, Nurul Zulfa Semedi, Bambang Pujo Suryantoro, Satriyo Dwi Ugroseno Yudho Bintoro Ugroseno Yudho Bintoro Vetty Silvana Maulida W, Krisnina Nurul Wardhani, Puspa Widiyastuti, Krisnina Nurul Wiharjo Hadisuwarno Windradi, Choirina Winona May Hendrata Yetti Hernaningsih Yulianti, Erikavitri Yuri Widia, Yuri Zahras Azimuth Doman