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All Journal Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini Jurnal Penelitian Pendidikan IPA (JPPIPA) Prima JODS Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Journal of English Language and Education Afeksi: Jurnal Penelitian dan Evaluasi Pendidikan Jurnal Social Library Prosiding Seri Seminar Nasional Buletin Kedokteran dan Kesehatan Prima Gotong Royong : Jurnal Pengabdian, Pemberdayaan Dan Penyuluhan Kepada Masyarakat (J-P3KM) E-Amal: Jurnal Pengabdian Kepada Masyarakat Journal of Citizen Research and Development
Susanto, Chandra
Prodi Psikologi, Universitas Jakarta Internasional
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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Pengaruh Hydrogel Acemannan dengan Konsentrasi 25%, 50%, 75% terhadap Jumlah Neutrofil pada Tikus Wistar Periodontitis yang Diinduksi Aloksan Susanto, Chandra; Wijaya, Cindy Denhara; Turnip, Gebriela Lam Ulina Putri
Jurnal Penelitian Pendidikan IPA Vol 10 No 4 (2024): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i4.7054

Abstract

Neutrophils occur in periodontitis, an infection of the periodontal tissue that may increase the risk of diabetes. Because of its excellent physicochemical properties and biological capabilities, hydrogel is a promising biomaterial for treating periodontal disease. This study consisted of four groups of Acemannan hydrogel 25%, 50%, 75%, and the Federer formula was used to determine the sample size and six replicate experiments were performed for each group to form a positive control group. Considering the investigation's conclusions, in the acemannan hydrogel administration group, the average ± SD levels of neutrophils in samples on day 3 were 25%, 50%, and 75%, and the positive control group was 3.08 ± 0.736. 2.46 ± 0.459; 1.54 ± 0.510; 1.17 ± 0.258. This value decreased to 1.83 ± 0.258 by day 5 were 1.29 ± 0.459; 0.50±0.447; 0.21 ± 0.292. As a result of the Kruskal-Wallis statistical test, there was a significant difference in the average number of neutrophils after administering 25%, 50%, and 75% Acemannan hydrogel and the positive control group to rats with alloxan-induced Wistar periodontitis on the third and fifth days. The study's findings suggest that 75% of acemannan hydrogel is the most effective concentration for reducing neutrophils
Effectiveness of Acemannan Hydrogel Administration at Concentrations of 25%, 50%, 75% Against Decrease in the Number of Macrophages in Periodontitis Rats with Diabetes Mellitus Susanto, Chandra; Halim, Susanna; Rusip, Gusbakti; Aurelia, Nada
Jurnal Penelitian Pendidikan IPA Vol 10 No 4 (2024): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i4.7077

Abstract

Acemannan activity as a natural polysaccharide from Aloevera has good biodegradability and biocompatibility and has an effect on cell tissue repair. The study's objective was to ascertain whether giving Hydrogel Acemannan at concentrations of 25%, 50%, and 75% would be beneficial in lowering the quantity of macrophages in diabetic periodontitis mice . 48 white Wistar rats were used as research samples, and they were split into four groups at two different observation intervals (days 3 and 7).One-way ANOVA and posthoc LSD statistical tests were used to assess the data. The number of macrophages in each group decreased on day 7 to 3.50 ± 0.354; 2.79±0.431; 1.54 ± 0.292; 0.54 ± 0.292. The results of the one-way ANOVAX test (p≤0.05) showed that the Hydrogel Acemannan concentrations of 25%, 50%, and 75% were effective in reducing the number of macrophages in periodontitis mice with diabetes mellitus. The results of the LSD posthoc test showed that Hydrogel Acemannan concentrations of 25%, 50%, and 75% were substantially more effective than the positive control in reducing the number of macrophages in periodontal mice with diabetes mellitus (p≤0.05).
Co-Authors Abdullah, Ardiani Adriana, Shirley Agnes Agitza Jaya Amalia Shifa Aldila Andhika Andini, Siwi Putri Antonius Juniarto Aurelia, Nada Azzanjani, Aisyah Bella Chan, Alice Cindy Fransisca, Cindy Davidson, Johan Duha, Jessicca Erawati, Suci Ferdinand, Fitzpatrick Gusbakti Rusip Hafshah, Nur Halim, Susanna Hartono Hartono Jacky, Jacky Jenny, Jenny Juniarto, Antonius Kurniawan, Wilona Keegan Lawrence Adi Supriyono Lestari, Vandersun Miranti Andhita Scantya Molek, Molek nababan, idamawati Novita, Wanda Putri Apriliani Rahmah Hastuti Ricko, Ricko Rita Markus Idulfilastri Santy Deasy Siregar Sarah Khairunnisa Budiyanto Savant, Andika Marcho Sefryansah, Sefryansah Sinamo, Sopan Siregar, Fitri Dona Suriono, Suriono Toar, Yandri Ardolof Toar, Yandri Ardolof B.L. Turnip, Gebriela Lam Ulina Putri Wijaya, Cindy Denhara Yang, Ambrose Yasmine, Kayla Rinita Zamralita Zamralita