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All Journal Journal of Tropical AgriFood Buletin LOUPE (Laporan Umum Penelitian) Jurnal Pengabdian kepada Masyarakat Nusantara Buletin Poltanesa Journal of World Future Medicine, Health and Nursing Journal of Biomedical and Techno Nanomaterials
Naibaho, Netty Maria
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Protein-Protein Interaction Analysis to Identify New Drug Targets for Diabetes Savitri, Dita Nurul; Syauqi, Anis; Naibaho, Netty Maria; Muntasir, Muntasir
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 1 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i1.2023

Abstract

The background of this study focuses on diabetes, a chronic metabolic disease characterized by impaired glucose and insulin regulation. Although existing therapies are available, insulin resistance and other complications remain a major challenge. The purpose of this study is to identify new drug targets through the analysis of protein interactions that play a role in the pathogenesis of diabetes. The method used is protein interaction network analysis (PPI) using public databases such as STRING and BioGRID to map the interaction between proteins related to glucose metabolism and insulin. The results of this study identified more than 150 proteins that interact with each other in the regulatory pathways of glucose and insulin metabolism, with several new proteins found to have the potential to be drug targets to overcome insulin resistance. The study concludes that a protein interaction-based approach can open up opportunities to develop new therapies that are more specific and effective in managing diabetes. Further development should be undertaken for the validation of these findings in animal models and clinical trials to confirm their effectiveness as a diabetes therapy.
Co-Authors Alves, Livia Bary, M. Atta Edy Wibowo Kurniawan Farida Aryani Hamka Hamka Hamka, Hamka Joto, Nur Abri Lisnawati, Andi Mika Debora Br Barus Muntasir, Muntasir Numarini, Eva Popang, Elisa Ginsel Pratama, Adnan Putra Rahman, Mujibu Rinten Anjang Sari RR. Ella Evrita Hestiandari Rudito Rudito Rudito Salusu, Heriad Daud Sari, Swasti Purnama Savitri, Dita Nurul Sitohang, Agnes Chrisvera Souza, Felipe Syauqi, Anis Utami, Riana Pangestu Yamin, Muh Yanti, Rahma Zamroni, Ahmad