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All Journal Jurnal MIPA PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ CCIT (Creative Communication and Innovative Technology) Journal Jurnal Kesehatan Tambusai Universal Raharja Community (URNITY Journal) Seminar Nasional Produk Terapan Unggulan Vokasi Jurnal Lentera: Penelitian dan Pengabdian Masyarakat
Karlah L. R. Mansauda
Universitas Sam Ratulangi
Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Journal : Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ

 1 
FORMULASI DAN UJI STABILITAS FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN MIANA (Coleus Scutelleroides (L.) Benth.) DENGAN BERBAGAI BASIS Karlah L.R Mansauda, Indriyani Arman,Hosea Jaya Edy,
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 4, No 1 (2021)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (242.774 KB) | DOI: 10.35799/pmj.4.1.2021.34523

Abstract

AbstractMiana leaves (Coleus Scutelleroides (L.) Benth.) contained flavonoid compounds that has antioxidants properties. This study aimed to formulate peel-off gel mask ethanol extract from Miana leaves became peel-off gel mask that is physically stable and to knows the type of base that form a formulation with good physical quality based on the test parameters of physical properties and the stability of preparation. Formulation  of peel-off gel mask ethanol extract of miana leaves used three different types of base, they are HPMC, Carbopol, and Na.CMC. Each formula is differentiated based on base of concentration which were HPMC 4%, carbopol 1%, and Na.CMC 3%. Evaluation to predict the physical stability of the preparation included organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and dry time test. In stability test, each formula is placed at temperature 27 oC for 28 days and made observation on the 1st, 7th, 14th, 21th, and 28th day. Based on the result, the ethanol extract of Miana leaves can be formulated into a peel-off mask and formulation with HPMC and Carbopol base has a good physical quality and physically stable compared to Na.CMC base.Keywords: Miana Leaves, Peel-Off Gel Mask, Stability Teh  AbstrakDaun Miana (Coleus Scutelleroides (L.) Benth.) memiliki kandungan senyawa flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol daun Miana menjadi masker gel peel-off yang stabil secara fisik serta mengetahui jenis basis yang membentuk formulasi sediaan masker dengan mutu fisik yang baik berdasarkan parameter uji sifat fisik dan stabilitas sediaan. Formulasi sediaan masker gel peel-off  ekstrak etanol daun Miana dibuat dengan menggunakan tiga jenis basis yang berbeda yaitu HPMC, karbopol, dan Na.CMC. Masing-masing formula dibedakan berdasarkan basis konsentrasi yaitu HPMC 4%, karbopol 1%, dan Na.CMC 3%. Evaluasi yang dilakukan terhadap stabilitas fisik sediaan masker gel peel-off meliputi uji organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan uji waktu mengering. Uji stabilitas dilakukan pada suhu kamar (27 oC) selama 28 hari dan dilakukan pengamatan pada hari ke 1, 7, 14, 21, dan 28. Hasil uji stabilitas fisik sediaan masker gel peel-off ekstrak etanol daun Miana dapat diformulasikan dalam bentuk sediaan masker gel peel-off , dan formula masker dengan basis HPMC dan karbopol memiliki mutu fisik yang baik dan stabil secara fisik dibandingkan dengan basis Na.CMC.Kata kunci: Daun Miana, Masker gel peel-off, Uji Stabilitas.
PENGGUNAAN PATI SAGU (Metroxylon sp.) SEBAGAI GELLING AGENT TERHADAP KESTABILAN FISIK GEL ASAM SALISILAT Mansauda, Karlah Lifie Riani; Suoth, Elly Juliana; Rumondor, Erladys M.
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 2 (2023): Vol. 6, No.2, 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i2.51703

Abstract

ABSTRACT The gelling agent component is a critical factor that can affect gel’s physical characteristics, such as organoleptic properties, homogeneity, pH, adhesion, and viscosity. Starch is widely use as a filler and binder. The aim of the research was to analyze the effect of the formulation of salicylic acid gel using sago starch as a gelling agent on the physical characteristics of the gel. The research began with the extraction of sago starch, and gel formulations were prepared using starch as the gelling agent with variations in sago starch with F1 (6%), F2 (8%), and F3 (10%). The gels were evaluated for their physical properties, including organoleptic, homogeneity, pH, adhesion, and spreadability testing over a period of 12 weeks at a temperature of 28ºC±2ºC. The research showed that all gel formulations did not undergo changes in organoleptic and homogeneity. In the pH test, all preparations met the requirements. The spreadability test results indicated that all gels did not meet the requirements, while only gel F1 did not meet the adhesion test requirements. Keywords Gelling agent, Sago Starch (Metroxylon sp.), Physical Stability, Gel
Pengembangan dan Karakterisasi Gel Asam Salisilat Menggunakan Pati Sagu Pregelatinasi yang Dimodifikasi sebagai Agen Pembentuk Gel Mansauda, Karlah Lifie Riani; Suoth, Elly Juliana; Rumondor, Erladys M.
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 7 No. 2 (2024): Jurnal Farmasi Medica/Pharmacy Medical Journal
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

ABSTRACT Natural sago starch has limitations, including low solubility, weak structure, and poor storage stability. Modification through pregelatinization can improve the functional properties of starch, including its role as a gelling agent. This study aims to formulate and evaluate a salicylic acid gel using pregelatinized modified sago starch as a gelling agent. The pregelatinized starch was characterized and then formulated into a gel preparation and evaluated for its physical properties. The characterization results showed a starch content of 85.27% with amylose 27.42%, and amylopectin 57.84%. The swelling power was 20.22 g/g, solubility 61.19%, and the degree of gelatinization reached 61.83%. The physical tests of the gel showed good results, including pH (4.8-5.3), adhesion (1.47-4.70 seconds), and spreadability (4.67-7.29 cm). In conclusion, pregelatinized sago starch can function as an effective gelling agent in the formulation of salicylic acid gel. Keywords: Pregelatinization, Gelling agent, Sago Starch (Metroxylon sp.), Gel ABSTRAK Pati sagu alami memiliki keterbatasan, termasuk kelarutan yang rendah, struktur yang lemah dan stabilitas penyimpanan yang buruk. Modifikasi melalui pregelatinisasi dapat meningkatkan sifat fungsional pati, termasuk sebagai bahan pembentuk gel. Penelitian ini bertujuan untuk memformulasikan dan mengevaluasi gel asam salisilat menggunakan pati sagu termodifikasi pregelatinasi sebagai agen pembentuk gel. Pati alami yang mengalami proses pregelatinisasi dikarakterisasi dan kemudian diformulasikan dalam bentuk sediaan gel dan dievaluasi fisik gel. Hasil karakterisasi menunjukkan kadar pati sebesar 85,27% dengan kadar amilosa 27,42%, dan amilopektin 57,84%. Swelling power adalah 20,22 g/g, kelarutan 61,19%, dan derajat gelatinisasi mencapai 61,83%. Uji fisik gel menunjukkan hasil yang baik, termasuk pH (4,8-5,3), daya lekat (1,47-4,7 detik), dan daya sebar (4,67-7,29 cm). Kesimpulannya, pati sagu pregelatinisasi dapat berperan sebagai gelling agent yang efektif dalam formulasi gel asam salisilat. Kata kunci: Pregelatinasi, Agen Pembentuk Gel, Pati Sagu (Metroxylon sp.), Gel
Co-Authors Abbas, Syahruni Ramdhani Adithya Yudistira Apitalau, Etserlisa A. Apriliani Margaret Marista Lourina Rarung Defny S. Wewengkang, Defny S. Desinta, Ni Wayan Dodie, Stanley B. Elly Suoth ERLADYS MELINDAH RUMONDOR, ERLADYS MELINDAH Gayatri Citraningtyas Gloria Sefania Maukar Gratia, Berta Herny E.I. Simbala Hosea Edy Hosea Jaya Edy I Gede Para Atmaja Jaya Edy, Hosea Jayanto, Imam Kumakauw, Vanesa Vebiola Langi, Priski Leony Ariesta Wenno Lolowang, Sheren N. Makalew, Mario Y. Mallaka, Indriyani Marhaba, Fera Anelia Maureen Langie Meldha, Meldha meliska debora saibaka Mende, Rivaldo Mokoginta, Rizkah V. Paulina yamlean Precylia Ribka Rambing Rante, Trian Rizki Kala’ Rondonuwu, Arnold R. Rumokoy, Steven N. Rumondor, Erladys M. Ryan Irwanto Tunggal Siampa, Jainer Pasca Simanjuntak, Christopel Hamonangan Siwi, Herotje Sumerah, Marsella Sumerah, Marsella E. Surya Sumantri Abdullah Tasiam , Ezrani Tunggal, Ryan Irwanto Veren Naftalia Mamangkey Vinny Valentina Kaitu Warokka, Adriyan Warokka, Adriyan H. Widya Lolo