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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Kesehatan Suara Forikes Jurnal Penelitian Pendidikan IPA (JPPIPA) Media Kesehatan Politeknik Kesehatan Makassar JURNAL FARMASIMED (JFM) Amalee: Indonesian Journal of Community Research & Engagement Jurnal farmasi UIN Alauddin Makassar Yumary: Jurnal Pengabdian kepada Masyarakat Journal of Experimental and Clinical Pharmacy (JECP) Jurnal EduHealth Medical Sains : Jurnal Ilmiah Kefarmasian Journal Of Human And Education (JAHE) Pharmacology And Pharmacy Scientific Journals (PAPS Journals) Jurnal Katalisator Nusantara Scientific Medical Research Journal Majority Science Journal Jurnal Medika: Medika Medical Sains : Jurnal Ilmiah Kefarmasian
Nurhikma Awaluddin
Fakultas Farmasi, Universitas Megarezky Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Formulation and Antibacterial Activity Test of Ethanol Extract Gel of Laruna Root (Chromolaena odorata L.) Against Staphylococcus aureus and Propionibacterium acnes St. Rahmadani; Awaluddin, Nurhikma; Awaluddin, Akbar
Jurnal FARMASIMED (JFM) Vol 7 No 1 (2024): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i1.2231

Abstract

Background: The formulation of gel preparations from laruna root extract (Chromolaena odorata L.) has been carried out using Na-CMC base accompanied by physical stability tests of the gel preparations. Objectives: to determine the physical stability of the laruna root extract gel preparation and its good concentration against Staphylococcus aureus and Propionibacterium acnes bacteria. Research method: The physical stability of the gel preparation was determined based on observations of changes in color, odor, shape, pH, uniformity, spreadability, and viscosity before and after storage for 6 cycles at temperatures of 4o C and 40oC. The pH test was carried out using a pH meter and viscosity measurements were carried out using a Brokfield viscometer. Results: The results of the study showed that the laruna root extract gel preparation was declared stable in the homogeneity indicator Results: The results showed that the gel preparation of laruna root extract could be said to be stable on homogeneity parameters where there were no solid particles in the preparation. Stable in good spreading power diameter, i.e. formulas 0, I, II, and III have a diameter of no more than 5-7 cm. For the results of measuring the viscosity of the gel preparation of laruna root extract, it is said to be stable because it is not more than 2000-4000 mPaS. For pH measurement, it is said to be stable because it has a pH in accordance with the quality requirements of skin preparations, which is 4.5-8.0. Conclusion: In the antibacterial activity test, a good clear zone result was obtained at a concentration of 0.3%.
POTENSI EKSTRAK ETANOL BUAH KELOR (Moringa oleifera L.) SEBAGAI BAHAN AKTIF SEDIAAN GEL TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS PUTIH JANTAN Sadsyam, Sriyanty; Awaluddin, Nurhikma; Suharniayanti, Suharniayanti
Pharmacology And Pharmacy Scientific Journals Vol. 4 No. 1: Juni, 2025, PAPS
Publisher : Unit Publikasi Ilmiah Perkumpulan Intelektual Madani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51577/papsjournals.v4i1.692

Abstract

Ekstrak Buah Kelor (Moringa oleifera L.) memiliki senyawa alkaloid, flavonoid, tannin, fenol, yang dapat menyembuhkan luka diabetes pada tikus putih Jantan. Penelitian ini bertujuan untuk mengetahui bahwa ekstrak etanol buah kelor (Moringa oleifera L.) dapat dijadikan sediaan gel yang stabil secara fisika dan kimia dan untuk mengetahui pada konsentrasi efektif ektrak etanol buah kelor (Moringa oleifera L.) dapat menyembuhkan luka diabetes pada tikus putih Jantan. Metode penelitian ini dilakukan secara eksperimental laboratorium. Ekstrak buah kelor dimaserasi dengan pelarut etanol 96%, lalu hasil diekstraksi diambil 5%,10% dan 15% untuk dibuat menjadi sediaan gel penyembuh luka diabetes dengan variasi konsentrasi F1 (5%), F2 (10%), dan F3 (15%). Selanjutnya dilakukan pengujian pada luka diabetes pada tikus putih jantan. Hasil formulasi sediaan gel ekstrak buah kelor (Moringa oleifera L.) menunjukkan stabil pada pengujian organoleptik, homogenitas, pH, viskositas, daya lekat dan daya sebar. Hasil uji terhadap luka diabetes menunjukkan bahwa F1 memiliki persentase penurunan diameter luka 100% pada hari ke-19, sedangkan untuk F2 dan F3 memiliki persentase penurunan diameter luka 100% pada hari ke-18 dan hari ke-17. Hasil analisis statistik One Way ANOVA, menunjukkan perbedaan yang signifikan (p<0,05) persentase penurunan diameter luka diabetes pada tikus putih jantan dan konsentrasi efektif F3 (15%). Moringa fruit extract (Moringa oleifera L.) has alkaloid, flavonoid, tannin, and phenol compounds that can heal diabetic wounds in male white rats. This study aims to determine that moringa fruit ethanol extract (Moringa oleifera L.) can be used as a physically and chemically stable gel preparation and to determine the concentration of moringa fruit ethanol extract (Moringa oleifera L.) that is effective in healing diabetic wounds in male white rats. This research method was conducted experimentally in the laboratory. Moringa fruit extract was macerated using 96% ethanol solvent, then the extraction results were taken 5%, 10%, 15% to be used as a gel preparation as a diabetic wound healing gel with variations in concentration, namely F1 (5%). F2 (10%), and F3 (15%). Furthermore, testing was carried out on diabetic wounds in male white rats. The results of the formulation of moringa fruit extract gel preparation (Moringa oleifera L.) showed stable in organoleptical testing, homogeneity, pH, viscosity, adhesion and spreadability. The test results on diabetic wounds showed that F1 had a percentage decrease in wound diameter of 100% on day 19, while for F2 and F3 had a percentage decrease in wound diameter of 100% on day 18 and day 17. The results of One Way ANOVA statistical analysis, showed a significant difference (p<0.05) in the percentage of diabetic wound diameter reduction in male white rats and the effective concentration of F3 (15%).
Peran Apoteker Dalam Edukasi Obat Untuk Lansia di Desa Belabori Kab. Gowa Awaluddin, Nurhikma; Basir, Nasrawati; Sadsyam, Sriyanty; Awaluddin, Akbar
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/c3qm7k08

Abstract

Di Indonesia, populasi usia lanjut terus meningkat seiring dengan tingginya angka harapan hidup. Menurut Badan Pusat Statistik, jumlah penduduk lansia di Indonesia pada tahun 2024 diperkirakan mencapai lebih dari 26 juta orang. Lansia sering kali menghadapi berbagai tantangan kesehatan yang kompleks, termasuk penyakit kronis seperti diabetes, hipertensi, dan gangguan jantung. Selain itu, mereka juga cenderung menggunakan beberapa jenis obat secara bersamaan, yang dikenal sebagai polifarmasi. Polifarmasi dapat meningkatkan risiko terjadinya efek samping, interaksi antar obat, serta kesalahan penggunaan obat, yang semuanya dapat berdampak negatif pada kesehatan lansia. Dalam konteks ini, peran apoteker menjadi sangat vital. Apoteker memiliki pengetahuan mendalam tentang farmakologi, termasuk mekanisme kerja obat, interaksi obat, dan efek samping yang mungkin terjadi. Dengan pengetahuan ini, apoteker dapat memberikan edukasi yang tepat kepada lansia mengenai cara penggunaan obat yang aman dan efektif. Edukasi ini meliputi informasi mengenai dosis yang benar, waktu yang tepat untuk mengonsumsi obat, serta tanda-tanda efek samping yang perlu diwaspadai. Selain itu, apoteker juga dapat membantu lansia dalam memahami pentingnya mematuhi regimen pengobatan yang telah ditentukan oleh dokter, sehingga dapat mencegah komplikasi yang lebih serius. Pemeriksaan kesehatan secara berkala juga merupakan aspek penting dalam pengelolaan kesehatan lansia. Melalui pemeriksaan rutin, masalah kesehatan dapat terdeteksi lebih awal, sehingga penanganan yang tepat dapat dilakukan. Apoteker dapat berkontribusi dalam hal ini dengan mengedukasi masyarakat tentang pentingnya pemeriksaan kesehatan dan bagaimana cara mengakses layanan kesehatan yang ada. Dengan memberikan informasi yang akurat dan mudah dipahami, apoteker dapat memberdayakan lansia untuk mengambil keputusan yang lebih baik terkait kesehatan mereka.
Burns Wound Healing Activity of Extract Gel Formula of Lidah Buaya (Aloe vera) and Senggani Leaf (Melastoma polyanthum): Aktivitas Penyembuhan Luka Bakar Formula Gel Ekstrak Lidah Buaya (Aloe vera) dan Daun Senggani (Melastoma polyanthum) Wahyuningsih, Sri; Syamsu, A. Suparlan Isya; Awaluddin, Nurhikma; Andriawan, Riki
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15251

Abstract

Aloe vera and senggani leaf can accelerate tissue regeneration, re-epithelialization, fibroblast stimulation, and collagen formation in the skin for burns wound healing. Burns wound can cause damage in the capillaries of the skin, then Aloe vera and senggani leaf were formulated into the gel formula for burns wound healing. The gel has the advantage of high water content; then it will hydrate the epidermis layer, increasing the penetration of the active substances. This study aims to formulate a gel of extract Aloe vera and senggani leaf (Melastoma polyanthum) and to evaluate the burns wound healing activity. The gel was formulated by composition of Aloe vera : senggani leaf with concentrations (0.5%: 1%); (0.5% : 3%); and (0.5% : 5%). Burns wound healing activity was observed by the diameter of the burn wound. The result showed that the gel with a concentration of (0.5%: 5%) gave a significance value of 0.692 (p >0.05) against positive control, then it was the formula that effective for burns wound healing.
Co-Authors - Sri Prilmayanti Awaluddin, - Adhelia, Dhea Handa Akbar Awaluddin Akbar Awaluddin Akbar Awaluddin Akbar Awaluddin Alyidrus, Rugayyah Andi Meinar Dwi Rantisari Thayeb Andi Meinar Dwirantisari Thayeb Andi Ulfiana Utari Andriawan, Riki Arafah Nurfadillah Awaluddin, Akbar Awaluddin, Akbar Awaluddin, Sri Wahyuni Elvira Santi Farid, Nurfiddin Fawzy, Nabiyl Ahmad Hamka Inda Andriani Ismah Mahmud Junita, Nurfitria Laksono Trisnantoro Maulita Indrisari, Maulita Muhammad Yusuf Muntasir, Muntasir Nadjamuddin, Mirfaidah Nasrawati Basir Ni Luh Gebi Parwati Nopianti Tangden Nur Laela Alydrus Nur Pebrianti Caronge Nurani Nurani Nurjannah Bachri Nurjannah Bachri Rahmania Rahmania Rahmatia Hanfirs Rezki Ramadhani Rugayyah Alyidrus Rugayyah Alyidrus Rustam, Julaiha Sadsyam, Sriyanty Sella Septiyani Mointi Selviana Sirajul Firdaus, Sirajul Sri Wahyuni Awaluddin Sri Wahyuni Awaluddin Sri Wahyuningsih Sri Wahyuningsih Sriyanty Sadsyam St. Rahmadani Suharniayanti, Suharniayanti Suhartina Hamzah Susanti Ngole Dhadu Syamsu, A. Suparlan Isya Ummu Kalsum Utari, Andi Ulfiana Wahid, Hilmiati Wahyuni, Wahyuni