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Burns Wound Healing Activity of Extract Gel Formula of Lidah Buaya (Aloe vera) and Senggani Leaf (Melastoma polyanthum): Aktivitas Penyembuhan Luka Bakar Formula Gel Ekstrak Lidah Buaya (Aloe vera) dan Daun Senggani (Melastoma polyanthum) Wahyuningsih, Sri; Syamsu, A. Suparlan Isya; Awaluddin, Nurhikma; Andriawan, Riki
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15251

Aloe vera and senggani leaf can accelerate tissue regeneration, re-epithelialization, fibroblast stimulation, and collagen formation in the skin for burns wound healing. Burns wound can cause damage in the capillaries of the skin, then Aloe vera and senggani leaf were formulated into the gel formula for burns wound healing. The gel has the advantage of high water content; then it will hydrate the epidermis layer, increasing the penetration of the active substances. This study aims to formulate a gel of extract Aloe vera and senggani leaf (Melastoma polyanthum) and to evaluate the burns wound healing activity. The gel was formulated by composition of Aloe vera : senggani leaf with concentrations (0.5%: 1%); (0.5% : 3%); and (0.5% : 5%). Burns wound healing activity was observed by the diameter of the burn wound. The result showed that the gel with a concentration of (0.5%: 5%) gave a significance value of 0.692 (p >0.05) against positive control, then it was the formula that effective for burns wound healing.

Sosialisasi, Edukasi dan Pemberian Obat Cacing untuk Siswa Kelas VI/A di SD Negeri Pannara” Awaluddin, Nurhikma; Thayeb, Andi Meinar Dwirantisari; Hanfirs, Rahmatia; Awaluddin, Akbar
Journal Of Human And Education (JAHE) Vol. 4 No. 2 (2024): Journal Of Human And Education (JAHE)
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jh.v4i2.605

Penularan penyakit usus yang disebabkan oleh cacing kebanyakan terjadi pada wilayah yang mempunyai iklim subtropis dan tropis yang memiliki iklim basah dimana kurangnya kesadaran pada masyarakatnya akan menjaga kesehatan dan menghiraukan akan sanitasi lingkungan sekitarnya. Penyakit ini dapat disebarkan oleh telur yang ada pada kotoran manusia yang terdapat pada tanah dan air, oleh karena itu kesadaran akan hidup bersih dan saniter sangat berpengaruh, proses atau pola pembuangan tinja sangat sangat berpengaruh juga dalam penyebaran kecacingan ini. Tinggi angka pencemaran tanah oleh Ascaris yang mencapai hingga >70% dapat juga disebabkan oleh kotoran yang dibuang di sembarang tempat seperti di semak-semak atau sekitar rumah dekat dengan tempat tinggal. Peningkatan infeksi cacingan di Indonesia terus meningkat seiring waktu, terutama pada anak-anak. Selain pemerintah, peran guru dan orang tua sangatlah penting untuk memberi pemahaman atau pengetahuan mengenai penyakit cacingan agar lebih disiplin. Adapun tujuan pengabdian masyarakat ini adalah untuk memberikan pemahaman kepada siswa kelas VI/A SD N Pannara tentang bahaya cacingan dan cara pencegahannya serta Pemberian Obat Cacing.

A Study of Drug Interaction with Nifedipine and Magnesium Sulfate in the Management of Preeclampsia: An Observational Study Awaluddin, Nurhikma; Aadilah, Aadilah; Mahasakti, M Tri Budi
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22532

Maternal mortality rate (MMR) remains a major priority in global health. The World Health Organization (WHO) estimates that MMR will decrease to 70 per 100,000 live births by 2030. However, in 2015, MMR in Indonesia reached 305 per 100,000 live births. Drug Related Problems (DRPs) are undesirable events that occur due to drug therapy and can hinder the recovery process of patients. Identifying drug-related issues during treatment is crucial for reducing morbidity, mortality, and therapy costs, as well as enhancing the effectiveness of pharmacological therapy.vThis study aims to identify DRPs caused by the use of the combination of Nifedipine and Magnesium Sulfate in preeclamptic patients at RSIA Sitti Khadijah 1 Makassar. The research method employed is non-experimental (observational) with a descriptive (qualitative) approach. The results indicate that among 32 preeclamptic patients who consumed the combination of Nifedipine and Magnesium Sulfate, there were no reported DRPs or adverse effects that jeopardized the patients' lives. These findings suggest that the combination therapy is in accordance with the management guidelines for preeclampsia in pregnant women based on national medical service protocols.

The Effectiveness of Ethanol Extract Gel of Cumin Leaves (Plectranthus Amboinicus) toward White Male Rat (Rattus Novergicus) Alyidrus, Rugayyah; Alydrus, Nur Laela; Wahyuni, Wahyuni; Awaluddin, Nurhikma; Tangden, Nopianti
Jurnal EduHealth Vol. 13 No. 02 (2022): Jurnal eduHealth, Periode Oktober - December, 2022
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.53 KB)

The leavers of white cumin (Plectranthus amboinicus) are a species of the family. Lamiaceae, previously known as Coleus amboinicus, contains quertesin compounds that are effective in healing wounds. The purpose of this study was to determine the extract of the leaves of white cumin (Plecranthus amboinicus) can be formulated for gel readiness and can affect the healing of cuts in white male rats (Rattus novergicus). The research method was laboratory experimental with the One Group Pretest- posttest research design. The leaves of white cumin (Plectranthus amboinicus) were extracted using 96% ethanol by maceration process and made into a gel form with a concentration of 3%, 5 %, and 7%. Evaluation of the physical and chemical stability of the gel before and after the cycling test for 6 cycles. This study used 15 male white rats divided into 5 groups, each group consisting of 3 and wounded with a depth of 2 cm and a length of 3 cm. the first male white rats were given a gel concentration of 3 %, the second 5%, the third 7 %, the fourth was given a gel without extract (negative control) and fifth was given 10 of octenilin gel (positive control). The incision length was measured on day 1,3,6,9,11,13 then data analysis used the ANOVA and SPSS 22 version. The results showed that leavers of white cumin (Plectranthus amboinicus) extract was p˂ 0,05, so there was a significant difference between each treatment. It can be concluded that gel readiness can be formulated and can affect wound healing in white male rats (Rattus novergicus).

Formulation and Activity Test Of Oil Spray Deodorant Preparations In Black Cumin Seeds (Nigella Sativa L.) Against Staphylococcus Epidermidis Causes Of Body Odor Alyidrus, Rugayyah; Ramadhani, Rezki; Santi, Elvira; Awaluddin, Nurhikma; Alydrus, Nur Laela
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Staphylococcus epidermidis bacteria are able to convert amino acids into isovaleric acid which causes unpleasant odors. This research aims to determine whether the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray physically stable and it has activity against Staphylococcus epidermidis which causes body odor. The research method was laboratory experimental using water distillation to extract essential oils and formulate deodorant spray preparations with concentrations of F1 (1%), F2 (3%), and F3 (5%). Evaluation of preparations includes organoleptic tests, homogeneity tests, pH tests, viscosity tests, spray pattern tests, dry time tests, emulsion type tests, irritation and hedonic tests, stability tests and antibacterial activity tests of preparations. The results of the research showed that the evaluation of the deodorant spray preparation of essential oil of black cumin seeds (Nigella sativa L.) had a P value of >0.05 so that this preparation was physically stable, while the statistical results of the antibacterial activity test obtained a P value of <0.05 indicating that there was a significant difference. This preparation has different activity diameters, including F1 (1%) in the medium category at 8.47 mm, F2 (3%) and F3 (5%) in the strong category with activity above 10-20 mm. It was concluded that the essential oil of black cumin seeds (Nigella sativa L.) can be formulated into a deodorant spray that is physically stable and has activity against Staphylococcus epidermidis which causes body odor

A Study of Drug Interaction with Nifedipine and Magnesium Sulfate in the Management of Preeclampsia: An Observational Study Awaluddin, Nurhikma; Aadilah, Aadilah; Mahasakti, M Tri Budi
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.22532

Maternal mortality rate (MMR) remains a major priority in global health. The World Health Organization (WHO) estimates that MMR will decrease to 70 per 100,000 live births by 2030. However, in 2015, MMR in Indonesia reached 305 per 100,000 live births. Drug Related Problems (DRPs) are undesirable events that occur due to drug therapy and can hinder the recovery process of patients. Identifying drug-related issues during treatment is crucial for reducing morbidity, mortality, and therapy costs, as well as enhancing the effectiveness of pharmacological therapy.vThis study aims to identify DRPs caused by the use of the combination of Nifedipine and Magnesium Sulfate in preeclamptic patients at RSIA Sitti Khadijah 1 Makassar. The research method employed is non-experimental (observational) with a descriptive (qualitative) approach. The results indicate that among 32 preeclamptic patients who consumed the combination of Nifedipine and Magnesium Sulfate, there were no reported DRPs or adverse effects that jeopardized the patients' lives. These findings suggest that the combination therapy is in accordance with the management guidelines for preeclampsia in pregnant women based on national medical service protocols.

Identification of Rationality and Potential Drug Interactions in Preeclampsia Patients with Comorbidities Awaluddin, Nurhikma; Zafira Dedy, Nadya Aliyah; Dwi Rantisari, Andi Meinar; Murtiadi, Nadya Nur Aulia
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23764

Preeclampsia is one of the pregnancy complications that constitutes a major cause of maternal and fetal morbidity and mortality. Its management requires the rational and safe use of medications, as there is a potential for drug interactions that may affect therapeutic outcomes. This study aimed to evaluate the rationality of drug use and potential drug interactions in preeclampsia patients in the inpatient ward of Pertiwi Mother and Child Hospital, Makassar. This research employed a descriptive method with a retrospective approach, utilizing medical records of preeclampsia patients from January 2024 to January 2025. The evaluation of rationality was based on the “four rights” principle: right indication, right drug, right dose, and right time of administration. The results of this study showed that the majority of patients received rational pharmacotherapy, with nifedipine being the most commonly used antihypertensive drug. The potential drug interactions identified were predominantly of moderate severity. The findings indicate that, overall, drug use among preeclampsia patients in this hospital has not yet been fully rational, and the presence of potential drug interactions requires careful consideration in clinical practice.

Identification of Rationality and Potential Drug Interactions in Preeclampsia Patients with Comorbidities Awaluddin, Nurhikma; Zafira Dedy, Nadya Aliyah; Dwi Rantisari, Andi Meinar; Murtiadi, Nadya Nur Aulia
Journal of Food and Pharmaceutical Sciences Vol 13, No 4 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.23764

Preeclampsia is one of the pregnancy complications that constitutes a major cause of maternal and fetal morbidity and mortality. Its management requires the rational and safe use of medications, as there is a potential for drug interactions that may affect therapeutic outcomes. This study aimed to evaluate the rationality of drug use and potential drug interactions in preeclampsia patients in the inpatient ward of Pertiwi Mother and Child Hospital, Makassar. This research employed a descriptive method with a retrospective approach, utilizing medical records of preeclampsia patients from January 2024 to January 2025. The evaluation of rationality was based on the “four rights” principle: right indication, right drug, right dose, and right time of administration. The results of this study showed that the majority of patients received rational pharmacotherapy, with nifedipine being the most commonly used antihypertensive drug. The potential drug interactions identified were predominantly of moderate severity. The findings indicate that, overall, drug use among preeclampsia patients in this hospital has not yet been fully rational, and the presence of potential drug interactions requires careful consideration in clinical practice.

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