Article Per Year (5 Year)
p-Index From 2020 - 2025
1.665
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences JURNAL PengaMAS Walisongo Journal of Chemistry Jurnal Pendidikan Kimia Unkhair (JPKU)
Cipta, Indra
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Chemistry Earth & Planetary Sciences Education Mathematics Social Sciences Other

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
Anti-glucosidase Activity and Antioxidant Capacity of Premna serratifolia from Sintang, Kapuas Hulu, and Sambas District, West Kalimantan, Indonesia Hadiarti, Dini; Sunandar, Ari; Cipta, Indra; Kurniawan, Rizmahardian Ashari
HAYATI Journal of Biosciences Vol. 33 No. 1 (2026): January 2026
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.33.1.153-166

Abstract

The secondary metabolites in plants such as Premna serratifolia (P. serratifolia) are influenced by their growing locations, which in turn affects their bioactivity. This study aimed to compare the antioxidant activity and α-glucosidase inhibition of P. serratifolia leaf extracts from the Sintang, Kapuas Hulu, and Sambas districts in West Kalimantan. Antioxidant capacity was evaluated using the DPPH method, while the reduction of α-glucosidase activity was assessed using the PNPG method. Functional groups and active compounds were identified using FTIR and UHPLC-Q-Orbitrap HRMS. The findings indicated that the extract from Kapuas Hulu, obtained through maceration (KHM), exhibited the highest antioxidant activity (IC₅₀ 18.39) and contained the most total phenolic content (TPC). The best α-glucosidase inhibition activity (IC₅₀ 4194.14) was found in the extract from Sambas obtained through Soxhlet extraction (SSI), which had the highest total flavonoid content (TFC). Principal Component Analysis (PCA) revealed that the functional groups and active compounds of P. serratifolia from Kapuas Hulu and Sintang were similar, as both regions are located in eastern West Kalimantan. Additionally, Partial Least Squares (PLS) analysis revealed that the C-H alkane, O-H, and isoferulic acid were the most influential compounds in determining antioxidant activity. At the same time, the C=O group and NP-000308 predominantly influenced α-glucosidase inhibition.
Co-Authors -, merlin Ahmad Muchsin Jayali Annisa, Dira Ayu Baturante, Nur Jannah Dini Hadiarti Embisa, Anjam Putra A. Fadlan Muin Halil, Fitriani Hernawan Hernawan Hud, Rifki Khusna Arif Rakhman, Khusna Arif Liestianty, Deasy Limata, Nur Asbirayani Mauraji, Ilham Muhammad Amin MULIADI -, MULIADI Mustafa, Linda Kurnia Nur Asbirayani Limatahu Nurfatimah Sugrah Rizmahardian Ashari Kurniawan Rombe, Yunita Pare RR. Ella Evrita Hestiandari Selpia, Ruslan Siti Mahmudha Sunandar, Ari Torano, Iklima Hi. Ismail Umahuk, Sabaria Zulkifli Zam Zam