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All Journal Jurnal Kesehatan Andalas Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Kedokteran Andalas Health and Medical Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Pengabdian Masyarakat Kesehatan (JURABDIKES)
Kam, Alexander
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Journal : Universa Medicina

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In-hospital mortality and its determinant factors among patients with sepsis Fadrian, Fadrian; Decroli, Eva; Ahmad, Armen; Kam, Alexander; Muharramah, Disa Hijratul; Pradana, Genta; Putri, Vidola Yasena
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.3-15

Abstract

BACKGROUNDSepsis is a heterogeneous syndrome characterized by a variety of clinical features. Multiple studies have identified sepsis as the leading cause of death in hospitalized patients. A comprehensive report on the incidence, clinical characteristics, and predictors of sepsis is important. This study aimed to determine the relative importance of predictors of in-hospital mortality in sepsis. METHODSA retrospective cohort study at Dr. M. Djamil Central General Hospital focused on sepsis patients. A total of 200 participants, aged 18 and older, were included based on specific criteria and recruited through consecutive sampling. Data was gathered from medical records and laboratory results to identify factors influencing mortality in sepsis patients. These factors were classified into sociodemographic, intrinsic, and extrinsic categories. Statistical analysis utilized simple and multiple logistic regression. A p-value of less than 0.05 indicated statistical significance for predicting in-hospital mortality in sepsis. RESULTSThe sepsis patient mortality rate was 69.50%. Hospital-acquired pneumonia (HAP) emerged as the most common infectious diagnosis, impacting 47.50% of the patients. Type 2 diabetes mellitus (Type 2 DM) was identified as the most frequent comorbidity, present in 36.50% of cases. Multivariate analysis indicated that HAP (adjusted odds ratio [aOR] 2.32; 95% confidence interval [CI] 1.19–4.49; p=0.013) and hyperlactatemia (aOR 2.11; 95% CI 1.06–4.18; p=0.032) significantly increased the risk of mortality in sepsis patients. CONCLUSIONHospital-acquired pneumonia was the primary predictor of mortality in sepsis patients. Timely prediction and evaluation of sepsis outcomes are essential for developing strategies to reduce mortality rates.
Pituitary macroadenoma with optic chiasm compression and hypopituitarism: a case report Kam, Alexander; Aprilia, Dinda; Decroli, Eva
Universa Medicina Vol. 45 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.81-87

Abstract

INTRODUCTIONPituitary macroadenomas are benign pituitary tumors measuring more than 1 cm in diameter that constitute a substantial proportion of intracranial neoplasms. Despite their benign histology, these tumors may lead to significant morbidity due to local mass effects and endocrine dysfunction. Compression of the optic chiasm can result in progressive visual impairment and irreversible blindness if not promptly treated. Additionally, pituitary hormonal deficiencies may cause life-threatening metabolic and systemic complications. Early recognition and multidisciplinary management are therefore essential to prevent permanent sequelae and optimize functional recovery. Case DescriptionA 40-year-old woman presented with a one-year history of recurrent headaches accompanied by progressive blurring of vision, diplopia, and visual field defects. She also reported irregular menstruation and unintended weight loss. Brain magnetic resonance imaging demonstrated a 2.13 × 2.28 × 3.05 cm pituitary macroadenoma with a characteristic “snowman appearance” compressing the optic chiasm. Hormonal evaluation revealed secondary adrenal insufficiency, hypogonadotropic hypogonadism, suppressed thyroid-stimulating hormone (TSH) with elevated free thyroxine (T4), and hyperprolactinemia attributed to the stalk effect, consistent with hypopituitarism and thyroid dysfunction. Initial stabilization with hydrocortisone and methimazole was performed prior to definitive management. The patient subsequently underwent transsphenoidal tumor resection with appropriate perioperative glucocorticoid coverage. Postoperatively, she remained clinically stable with improvement in headache and visual symptoms, and continued hormonal therapy under close endocrinological supervision. ConclusionsThis case underscores the importance of comprehensive hormonal assessment, timely neurosurgical intervention, and coordinated multidisciplinary care in managing pituitary macroadenomas complicated by optic chiasm compression and hypopituitarism to achieve favorable clinical outcomes.
Co-Authors Abdullah, Farhan Ahmad, Armen Amelia, Rinita Andry Kurniawan Aprilia, Dinda Arnelis Arnelis Deka Viotra Efendi, Yanne Pradwi Eva Decroli Fadrian, Fadrian Fahrurozi, R. Ifan Arief Fauzar, Fauzar Fikri, Avino Mulana Genta Pradana, Genta Harun Harnavi Jalmas, Dela Hangri Muharramah, Disa Hijratul Namanda Putri, Athari Fadhila Nasrul Zubir Putri, Vidola Yasena Rahayuningsih, Sri Puji Rahimi, Abdul Alim Ranazeri, Jersivindo Roza Kurniati Rudy Afriant Saptino Miro, Saptino Sofiani, Dinda Putri Tamayo, Auliangi Ulvyana, Vyora Veronike, Evelin Vesri Yoga