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All Journal Jurnal Kesehatan Andalas Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Kedokteran Andalas Health and Medical Journal Scientific Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Kam, Alexander
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Non Classic - Congenital Adrenal Hyperplasia: Suatu Kasus Langka Sofiani, Dinda Putri; Decroli, Eva; Aprilia, Dinda; Kam, Alexander
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1643

Abstract

Congenital Adrenal Hyperplasia (CAH) adalah kelainan autosomal resesif yang disebabkan defek steroidogenesis. Salah satu tipe CAH adalah defisiensi 21-hydroxylase yang terdiri dari sub tipe classic dan non-classic. Penegakan diagnosis dan penatalaksanaan CAH merupakan suatu tantangan dikarenakan langkanya kasus dan manifestasi klinis yang bervariasi, tergantung pada jenis dan tingkat keparahan defisiensi enzim. Telah dilaporkan suatu kasus yang langka berupa klitoromegali dengan hirsutisme dan amenorea primer, yang merupakan suatu non classic - congenital adrenal hyperplasia (NC-CAH). Penegakan diagnosis NC-CAH pada kasus ini didapatkan dari gambaran virilisasi pada wanita dewasa berupa klitoromegali dan hirsutisme yang disertai amenorea primer dengan kadar kortisol serum dan elektrolit yang normal. Penelusuran riwayat keluarga dan pencitraan membantu penegakan diagnosis, namun pemeriksaan 17-Hydroxyprogesterone tetap disarankan untuk konfirmasi diagnosis dan pemantauan terapi.
The Profile of COVID-19 Patients in Semen Padang Hospital Indonesia Fauzar, Fauzar; Kurniati, Roza; Abdullah, Farhan; Kam, Alexander
Jurnal Kesehatan Andalas Vol. 10 No. 1 (2021): Online March 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i1.1684

Abstract

The rapid increase in the number of Coronavirus Disease 2019 (COVID-19) cases, including in Padang, has led the government to designate several hospitals as referrals for COVID-19 patients. The profile of COVID-19 patients is needed to describe the pattern of this disease in Padang. Objectives: To revealed the profile of COVID-19 patients in SPH, Indonesia. Methods: This was a retrospective study. This study was conducted and collected data of COVID-19 patients from March to June 2020. Results: There are 54 patients with mean age of 50.93 (14.6) years old, 43% male and 57% female. The clinical manifestations are cough (74%), fever (37%), sore throat (22%), and fatigue (35%). There are 82% of patients admitted that they have contacted with other COVID-19 patients or have activities in COVID-19 cluster area, and only 7% have traveled to other cities. The mean length of stay is 31.91 (14.87) days. The mean laboratory data: Hemoglobin 13.7 (1.39) gr/dl, WBC 8,037.04 (2,846.27) /mm3, platelet 274,389 (75,053.80) /mm3, and NLR 3.16 (3.37). Chest radiograph results are bronchopneumonia (22.22%), cardiomegaly (7.41%), and normal (70.37%). Conclusion: The profile of COVID-19 patients in SPH is more in female patients, cough is the most clinical manifestation that appeared, the mean laboratory data (hemoglobin, WBC, and platelet) are normal, and normal chest radiography is the most chest radiograph results in these patients.Kata kunci: COVID-19, Padang, profile
Coronavirus Disease 2019 in Chronic Kidney Disease: A Case Report Jalmas, Dela Hangri; Fauzar, Fauzar; Kurniati, Roza; Viotra, Deka; Harun, Harnavi; Yoga, Vesri; Kam, Alexander
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1718

Abstract

The COVID-19 pandemic has caused substantial morbidity and mortality worldwide. Older patients, male gender and those with preexisting comorbidities such as chronic kidney disease are reported to be more likely infected with SARS CoV-2 and are at higher risk of severe illness or death. It has been reported a 24 years old male was admitted to the hospital with shortness of breath, coughing, fever and paleness. The history of contact with confirmed COVID-19 cases was unclear. The patient works as a security officer. A history of hypertension is present. Laboratory results showed hemoglobin 7 g/dl, ureum 261 mg/dl, and creatinine 22,9 mg/dl. On the second day of admission, the patient experience increased shortness of breath, decreased consciousness and epistaxis. From the result of the nasopharyngeal swab, the patient tested positive for COVID-19 and was given Oseltamivir 75mg. The patient is prepared for hemodialysis, which was performed in the isolation room. After hemodialysis, the patient's condition improved with decreased shortness of breath and increased of consciousness. The patient comes out from the isolation room and discharges home in good condition. Antiviral therapy in CKD patients with Covid-19 infection requires dose adjustment. Immediate hemodialysis is required in patients with CKD and coexisting COVID-19 infection to improve the patient's condition. Prompt management for patients with CKD and COVID-19 will reduce the risk of mortality.Keywords:  COVID-19, chronic kidney disease, hemodialysis
Risiko Perdarahan Saluran Cerna pada Pasien COVID-19 berdasarkan Jenis Obat Antivirus di Rumah Sakit Umum Pusat Dr. M. Djamil Padang Arnelis, Arnelis; Miro, Saptino; Zubir, Nasrul; Yoga, Vesri; Kurniawan, Andry; Kam, Alexander; Rahimi, Abdul Alim; Ranazeri, Jersivindo; Fahrurozi, R. Ifan Arief
Jurnal Kesehatan Andalas Vol. 11 No. 2 (2022): Online July 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i2.2042

Abstract

Coronavirus disease 2019 (COVID-19) has become a global pandemic to date. Some studies reported gastrointestinal tract (GIT) bleeding occurs in several patients hospitalized with COVID-19. Medications known to be associated with an increased risk of GIT bleeding were not associated with GIT bleeding in COVID-19 patients. Objectives: To examined the risk of gastrointestinal tract (GIT) bleeding in COVID-19 patients based on antiviral drugs at Dr. M. Djamil General Hospital Padang. Methods: A nested cohort study was conducted in Dr. M. Djamil General Hospital Padang from May until October 2021. All COVID-19 patients who received antiviral drugs with GIT bleeding with onset days 0 - 7 were included. COVID-19 was confirmed by RT-PCR swab. Data entry and analysis were conducted by computerized. Results: 30 patients were involved in this study. 43,3% COVID-19 Moderate stage and 56,7% Severe stage. 63,3% were treated with remdesivir and 36,7% were treated with favipiravir. Onset on GIT tract bleeding at day 4 (23,3%), day 5 (26.7%), day 6 (30%), and day 7 (20%). The Chi-square test to determine the factors associated with GIT bleeding in COVID-19 patients including COVID-19 severity, type of antiviral drugs, anticoagulant, and corticosteroid revealed that none of all potential factors above related to GI bleeding. Conclusion: The type of antiviral drugs was not related to GIT bleeding in COVID-19 patients.Keywords: antiviral drugs,  COVID-19, gastrointestinal tract bleeding
In-hospital mortality and its determinant factors among patients with sepsis Fadrian, Fadrian; Decroli, Eva; Ahmad, Armen; Kam, Alexander; Muharramah, Disa Hijratul; Pradana, Genta; Putri, Vidola Yasena
Universa Medicina Vol. 44 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.3-15

Abstract

BACKGROUNDSepsis is a heterogeneous syndrome characterized by a variety of clinical features. Multiple studies have identified sepsis as the leading cause of death in hospitalized patients. A comprehensive report on the incidence, clinical characteristics, and predictors of sepsis is important. This study aimed to determine the relative importance of predictors of in-hospital mortality in sepsis. METHODSA retrospective cohort study at Dr. M. Djamil Central General Hospital focused on sepsis patients. A total of 200 participants, aged 18 and older, were included based on specific criteria and recruited through consecutive sampling. Data was gathered from medical records and laboratory results to identify factors influencing mortality in sepsis patients. These factors were classified into sociodemographic, intrinsic, and extrinsic categories. Statistical analysis utilized simple and multiple logistic regression. A p-value of less than 0.05 indicated statistical significance for predicting in-hospital mortality in sepsis. RESULTSThe sepsis patient mortality rate was 69.50%. Hospital-acquired pneumonia (HAP) emerged as the most common infectious diagnosis, impacting 47.50% of the patients. Type 2 diabetes mellitus (Type 2 DM) was identified as the most frequent comorbidity, present in 36.50% of cases. Multivariate analysis indicated that HAP (adjusted odds ratio [aOR] 2.32; 95% confidence interval [CI] 1.19–4.49; p=0.013) and hyperlactatemia (aOR 2.11; 95% CI 1.06–4.18; p=0.032) significantly increased the risk of mortality in sepsis patients. CONCLUSIONHospital-acquired pneumonia was the primary predictor of mortality in sepsis patients. Timely prediction and evaluation of sepsis outcomes are essential for developing strategies to reduce mortality rates.
Hiperparatiroid Primer Namanda Putri, Athari Fadhila; Decroli, Eva; Aprilia, Dinda; Kam, Alexander
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 2 (2025): Juni 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i2.1499

Abstract

Latar Belakang: Hiperparatiroid primer merupakan suatu kondisi klinis yang disebabkan peningkatan sintesis hormon paratiroid (HPT) akibat tumor paratiroid. Hiperparatiroid primer dapat mengganggu metabolisme kalsium. Dengan demikian, diagnosis hiperparatiroid primer secara umum dapat ditentukan melalui pemeriksaan kadar kalsium serum dan HPT serta ditemukannya tumor paratiroid melalui pemeriksaan pencitraan. Secara garis besar tatalaksana hiperparatiroid primer terdiri dari tatalaksana medikamentosa dan intervensi pembedahan. Tatalaksana medikamentosa meliputi pemberian suplementasi vitamin D, kalsimimetik dan bifosfonat. Intervensi pembedahan untuk mengangkat tumor paratiroid merupakan terapi definitif hiperparatiroid primer. Klinisi perlu meningkatkan pengetahuan dan keterampilan terhadap hiperparatiroid primer agar pelayanan pasien lebih komprehensif.  
Marine-Lenhart Syndrome: Current Perspectives on Diagnosis and Management Kam, Alexander; Pradwi Efendi, Yanne; Aprilia, Dinda; Decroli, Eva; Syahbuddin, Syafril; Berlian Hemilton, Suci
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.264

Abstract

Marine-Lenhart syndrome (MLS) is an uncommon disorder characterised by the concurrent presence of Graves’ disease and hyperfunctioning thyroid nodules. Its global prevalence ranges between 2.7- 4.1% of Graves’ disease cases, presenting significant challenges in diagnosis and management. MLS is often difficult to detect due to limitations in autoimmune serology tests, thyroid ultrasonography, and access to nuclear medicine facilities. Diagnosis relies on a combination of clinical hyperthyroidism symptoms, the presence of specific thyroid antibodies, and scintigraphy findings that reveal "hot" or "cold" nodules. The primary therapeutic options for MLS include antithyroid drugs, radioactive iodine (RAI) therapy, and surgery. RAI is commonly employed as definitive treatment, often requiring higher doses to address the resistance of hyperfunctioning nodules. Surgery is indicated in cases involving large nodules, compressive symptoms, or suspected malignancies. Treatment strategies should be tailored to the individual clinical characteristics of each patient to minimize complications and ensure optimal outcomes. Advancing the diagnosis and management of MLS requires enhanced access to advanced diagnostic technologies and improved healthcare provider proficiency in identifying and treating the syndrome. A multidisciplinary and integrated approach is essential for achieving favorable clinical outcomes for MLS patients.
Liothyronine Therapy in Hypothyroidism Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Oktaviandra Siahaan, Jonggara
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.277

Abstract

Hypothyroidism is a clinical condition characterized by reduced production of thyroid hormones and is among the most common endocrine disorders, affecting about 3% of the general population, with a higher prevalence in women (5.1%) than in men (0.9%). In Indonesia, the prevalence of hypothyroidism is estimated at 5-10%. Despite achieving normal thyroid stimulating hormone (TSH) levels with levothyroxine (LT4) therapy, many patients continue to experience symptoms like fatigue, depression, and cognitive impairment, which impact their quality of life. A study of 969 hypothyroid patients found that 77.6% were dissatisfied with their treatment and reported low quality of life scores. Although LT4 has been the standard therapy for nearly 50 years due to its stability and the peripheral conversion of thyroxine (T4) to triiodothyronine (T3), recent recommendations from experts in developed countries suggest using liothyronine (LT3) monotherapy or a combination of LT3 and LT4 in selected cases.
The Role of Genomic Sequencing in Diabetes Mellitus Pradwi Efendi, Yanne; Kam, Alexander; Decroli, Eva; Aprilia, Dinda; Syahbuddin, Syafril
Scientific Journal Vol. 4 No. 5 (2025): SCIENA Volume IV No 5, September 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i5.279

Abstract

Diabetes Mellitus is a chronic metabolic disorder caused by impaired insulin secretion and/or insulin resistance. Genetic testing through genomic sequencing is one of the modalities available for diabetes mellitus. Genomic sequencing is the process of analysing DNA obtained from a blood sample (or alternatively from tissue samples). Broadly, genomic sequencing plays two major roles in diabetes mellitus: supporting diagnosis and guiding therapeutic approaches. In its development, genomic sequencing has proven valuable for diagnostic investigation in type 1 diabetes and maturity-onset diabetes of the young (MODY), as well as for assessing the polygenic risk score (PRS) in type 2 diabetes. Establishing a definitive diagnosis allows for the selection of individualised therapy. Several randomised controlled trials have demonstrated that the risk of developing diabetes can be reduced by up to half if detected at an earlier stage. Moreover, genomic sequencing can identify genetic variants that influence responsiveness to antidiabetic treatments. At present, several potential antidiabetic agents targeting novel pathways are under development and in various stages of clinical trials. The application of genomic sequencing thus facilitates the implementation of individualised therapy, ultimately contributing to the realisation of precision medicine.
Tiroiditis Hashimoto dan Sindrom Gitelman Aprilia, Dinda; Decroli, Eva; Kam, Alexander; Tamayo, Auliangi
Majalah Kedokteran Andalas Vol. 46 No. 3 (2023): Online Juli 2023
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i4.p772-775.2023

Abstract

Seorang perempuan usia 34 tahun datang dengan keluhan lemah pada kedua tangan dan kaki, benjolan di leher, riwayat berdebar-debar, penurunan berat badan dan siklus menstruasi yang tidak teratur. Pasien didiagnosis dengan tiroiditis Hashimoto dan sindrom Gitelman. Pasien diterapi dengan levotiroksin dan koreksi elektrolit. Pasien kemudian pulang dalam keadaan perbaikan klinis.
Co-Authors Abdullah, Farhan Ahmad, Armen Amelia, Rinita Andry Kurniawan Aprilia, Dinda Arnelis Arnelis Berlian Hemilton, Suci Deas Hadilofyani, Putri Eva Decroli Fadrian, Fadrian Fahrurozi, R. Ifan Arief Fauzar, Fauzar Fikri, Avino Mulana Genta Pradana, Genta Harun Harnavi Jalmas, Dela Hangri Muharramah, Disa Hijratul Namanda Putri, Athari Fadhila Nasrul Zubir Oktaviandra Siahaan, Jonggara Pradwi Efendi, Yanne Putri, Vidola Yasena Rahayuningsih, Sri Puji Rahimi, Abdul Alim Ranazeri, Jersivindo Roza Kurniati Rudy Afriant Saptino Miro, Saptino Sofiani, Dinda Putri Syafril Syahbuddin Tamayo, Auliangi Ulvyana, Vyora Veronike, Evelin Viotra, Deka Yoga, Vesri