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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan MEDIC MEdical Dedication Journal of Comprehensive Science Makara Journal of Health Research MEDICINUS International Journal of Cell and Biomedical Science Jurnal Penelitian Keperawatan Cermin Dunia Kedokteran
Priskila, Loury
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health

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Journal : MEDICINUS

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The Role of Systemic Immune-Inflammation Index on The Clinical Degree of Dengue Hemorrhagic Fever Patients at Bethesda Hospital Yogyakarta Amumpuni, Antonia Namelia Wahyu; Sooai, Christiane Marlene; Wicaksono, Hendi; Probowati, Wiwiek; Priskila, Loury
MEDICINUS Vol. 38 No. 8 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/y6daha15

Abstract

Background: Dengue hemorrhagic fever (DHF) is a mosquito-borne infectious disease caused by the dengue virus and transmitted primarily by Aedes aegypti. According to the World Health Organization (WHO), DHF remains a major globalhealth concern, particularly in tropical and subtropical regions. The disease can result in severe complications, including hemorrhage and hypovolemic shock, which may lead to death. Despite ongoing vector control initiatives, DHF continues to pose a significant public health challenge, especially in areas with inadequate sanitation and limited healthcare infrastructure.Objectives: To evaluate the role of systemic immune-inflammation index (SII) in determining the clinical severity of denguehemorrhagic fever (DHF) among patients at Bethesda Hospital Yogyakarta.Methods: This was a cross-sectional study utilizing medical records from 333 DHF patients at Bethesda Hospital Yogyakarta. Records were screened based on predefined inclusion and exclusion criteria. A total of 172 eligible cases were selected using odds ratio-based sample size calculations. Consecutive sampling was employed as the samplingtechnique. Data analysis was performed using SPSS and Microsoft Excel to determine statistical significance.Results: The findings demonstrated that neutrophil, lymphocyte, and platelet counts significantly influenced the clinical severity of dengue hemorrhagic fever (DHF). Chi-square analysis revealed a statistically significant association between the systemic immune-inflammation index (SII) and disease classification (DF/DHF) (p<0.001). However, the relationshipbetween SII levels and clinical severity did not follow a linear pattern. Contrary to established theories—where elevated SII values are typically associated with increased disease severity—this study observed variations that may be attributed toconfounding factors such as patient age, comorbidities, and individual immune response.Conclusion: The systemic immune-inflammation index (SII) is significantly associated with the clinical severity of DHF in patients at Bethesda Hospital Yogyakarta, although its correlation may be influenced by additional patient-specificvariables such as patient age, comorbidities, and individual immune responses.Keywords: systemic immune-inflammation index (SII), dengue hemmorhagic fever (DHF), dengue severity, clinicalseverity.
Association Between Neutrophil-to-Lymphocyte Ratio (NLR) and Dengue Severity in Patients Treated at Bethesda Hospital, Yogyakarta Jingan, Forensius; Christiane Marlene Sooai; Loury Priskila; Pradita Sri Mitasari; Wiwiek Probowati; Priskila, Loury
MEDICINUS Vol. 38 No. 10 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/11a64f98

Abstract

Background: Dengue fever, a mosquito borne viral infection, remains a major public health concern in Indonesia, with the challenges in early identification of severe cases. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potentialbiomarker for assessing the disease severity.Objective: This study aimed to investigate the association between NLR and dengue severity in patients treated at Bethesda Hospital, Yogyakarta.Methods: A cross-sectional, quantitative study was conducted using medical record data from dengue patients admitted between 2022 to 2024. The NLR values were calculated from complete blood count results and disease severity was classified according to WHO guidelines. Statistical analysis was performed using the chi-square test and Fisher’s exact test.Results: Among the 68 patient samples, a significant association was found between NLR and dengue severity (p<0.001). Patients with lower NLR values were more likely to develop dengue hemorrhagic fever (DHF) compared to those with higher NLR values.Conclusion: The NLR plays a role in determining the severity of dengue infection and may serve as a predictive biomarker. This examination can be a practical tool in the clinical management of dengue fever patients, particularly for early detectionand optimizing therapeutic decision-making.
The Gut-Brain Axis in Type 2 Diabetes: A Review of Microbial Mechanisms and Clinical Implications Goenadi , Emmanuel Adrian; Pramudito, Ignatius Aditya Haryo; Saputra, Petra Heinson Handoyo; Bararinda, Pradipta Putramachristy; Priskila, Loury
MEDICINUS Vol. 38 No. 12 (2025): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/g87wm568

Abstract

The understanding of Type 2 Diabetes Mellitus (T2DM) is evolving beyond traditional risk factors to recognize the Gut Microbiota (GM) as a pivotal player in its pathogenesis. This narrative review illuminates the critical role of the Gut-Brain Axis (GBA), detailing how microbial dysbiosis—characterized by a loss of butyrate-producing bacteria—drives the systemic inflammation and insulin resistance central to T2DM. This paper provides an overview of microbiota-based interventions (probiotics, prebiotics, FMT) and explore the synergistic impact of physical activity, which not only enhances insulin sensitivity but also beneficially modulates the GM. The evidence indicates that an integrated approach, combining targeted microbial modulation with regular physical activity, represents a powerful therapeutic strategy for improving glucose homeostasis in T2DM.
Co-Authors Amumpuni, Antonia Namelia Wahyu Anggelia Puspasari Anggitama, Andreas Mercyan Atmadi, Lenggana Relung Bagaskara, Arya Taksya Bararinda, Pradipta Putramachristy Cahyani, Ni Kade Dian Ary Christiane Marlene Sooai Christiane Marlene Sooai, Christiane Marlene Danuartha, Made Anom Dinata, Fenita Renny Gasri, Orynta Srikurnia Goenadi , Emmanuel Adrian Helena, Dayceline Hendi Wicaksono Herlambang, Yosafat Reza Jhonatan, Mikha Jingan, Forensius Julianto, Dayceline Helena Kristiyanto, Haryo Dimasto Lestari, MMA Dewi Loury Priskila Nappoe, Angela Aletha Biatrix Neldi, Vina Patabang, Angreini Feshia Pradita Sri Mitasari Pramudito, Ignatius Aditya Haryo Probowati, Wiwiek Rizaldy Pinzon Saputra, Petra Heinson Handoyo Sasabone, Ahava Tasa Simanjuntak, Mario Hendrian Sinulingga, Zenine Charolin Sira, Amaze Grace Tamma, Haryadi Aristo Tarigan, Nadir Putra Indra Tengku Arief Buana Perkasa Widyawati, Dwi Wiwiek Probowati Yeckopradana, Ebenezer Devara Yogik Onky Silvana Wijaya