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Bambang Sumantri, R Bagus
Program Studi Sistem Informasi, Universitas Harapan Bangsa
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Journal : Scientific Journal of Engineering Research

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A Thirdweb-Based Smart Contract Framework for Secure Sharing of Human Genetic Data on the Ethereum Blockchain Famuji, Tri Stiyo; Grancho, Bernadine; Fanani, Galih Pramuja Inggam; Talirongan, Hidear; Sumantri, Raden Bagus Bambang
Scientific Journal of Engineering Research Vol. 1 No. 3 (2025): September
Publisher : PT. Teknologi Futuristik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64539/sjer.v1i3.2025.30

Abstract

Human genetic data, crucial for advancing personalized medicine, requires secure and privacy-preserving management solutions. Traditional approaches face challenges in scalability, security, and decentralized access control. This study proposes a blockchain-based framework leveraging Thirdweb and Ethereum smart contracts to address these issues. The framework integrates decentralized storage via IPFS for cost-efficient off-chain genetic data storage, while on-chain smart contracts manage access control, encryption, and audit trails. Utilizing Solidity for smart contract development, the system ensures role-based permissions, wallet-based authentication, and immutable transaction logging. Genetic data in FASTA format, sourced from NCBI, is encrypted and linked to IPFS hashes stored on the blockchain. The architecture supports dual interfaces—command-line for developers and a Thirdweb dashboard for end-users—enabling secure data upload, access, and monitoring. Testing demonstrated functional efficacy in data integrity, access verification, and audit capabilities. Results highlight the system’s ability to enhance privacy, eliminate intermediaries, and provide transparent data governance. The integration of Thirdweb further decentralizes operations, aligning with Web 3.0 principles. Key contributions include a scalable model for genetic data sharing, a customizable smart contract template, and a user-centric design. Future work should explore advanced encryption, real-world healthcare integration, and performance optimization under high-throughput conditions. This research bridges biotechnology and blockchain, offering a robust foundation for secure genomic data ecosystems.
Co-Authors Abdul Hakim Prima Yuniarto Abdurrahman Hakim, Nurfadhli Ali Sya'bana S Amanah Tri Wulandari Anandita, Chairunnisa Al Majra Ratri Anggit Wirasto Ardiyani, Amalia Arfianto, Irfan Ariansyah, Awal Ariefah Khairina I Arif Setia Sandi A. Asharryadi Noegroho Azkiyatun Nadroh Chairunnisa Al Majra Ratri Anandita Cipta Sigitta Haryono, Rito Dede Yusuf Dede Yusuf, Dede Deny Nugroho Triwibowo Deny Nugroho Triwibowo Dewa, Bala Putra Diky Setiawan Dimas Febri Kuncoro Dwita Urip Natasa Eko Agus Priatno Ema Utami Estu Prayoga Evan Irmansyah W Evan Irmansyah W. Fadila Nur Kamala Fadli Anadrea Fahrudin, Imam Fajar Syafani, Henky Fanani, Galih Pramuja Inggam Grancho, Bernadine Guntur Subari Hadi Jayusman Hadi Jayusman Hadi Jayusman Hakim, Walidy Rahman Hani Istiqomah Husna, Aqmal Miftahul Iis Setiawan Mangku Negara Imam Ahmad Ashari Imam Ahmad Ashari Imam Ahmad Ashari, Imam Ahmad Irfani Zuhrufillah Iskandar, Sandi Najib Iwan Purnawan Iwan Safi’i Jayusman, Hadi Jessa Syahputra Khoirun Nisa Khoirun Nisa Kiki Alfaini Nurrizki Korisaputri Korisaputri Korisaputri, Korisaputri Kurnia Sari, Ina Lina Endarwati Lutviana, Lutviana Mahardika, Fajar miftahul Khoeri, Amarulloh Nadroh, Azkiyatun Nugroho Triwibowo, Deny Nuni Wulansari Nur Arifin Nurhalizah, Ria Suci Nurrizki, Kiki Alfaini Nurul Alfiah Pari, Riki Aldi Prayoga, Estu Purnama Sari, Sri Purnomo, Jouska Brillian Putra Purwayanto, Evana Anugrah Putri, Sari Andini Ratih ratih ratih Retno Agus Setiawan Ria Suci Nurhalizah Riska Suryani Riska Suryani Ristianingsih Rizki Ripai Rofi Taufiqurrohman Rohman, Taufik Fadhil Rokhadi, Reza Safitri Dwi Lestari Saksena, Ilham Sidik Salim Nurul Umam Samodra, Galih Sandi Najib Iskandar Sari Andini Putri Setiawan, Retno Agus Somaida, Mochammad Hasymi Suryani, Riska Syifa Marsyanda Chairunnisa Talirongan, Hidear TRI KUSUMA WARDANI Tri Stiyo Famuji Triwibowo, Deny Nughoro Triwibowo, Deny Nugroho Tukiman, Hellena Indriani Ulan Juniarti Walidy Rahman Hakim Widadi, Budi Willy Setiawan Wirakhmi, Ikit Netra Wulandari, Amanah Tri Ziyan Walidanaen Fandol Zulfikar Yusya Mubarak