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All Journal Science and Technology Indonesia JMM (Jurnal Masyarakat Mandiri) Jurnal Ilmiah Pendidikan Scholastic ASANKA: Journal of Social Science And Education ALACRITY : Journal Of Education Edu Society: Jurnal Pendidikan, Ilmu Sosial dan Pengabdian Kepada Masyarakat Innovative: Journal Of Social Science Research JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah International Journal of Elementary School Jurnal Gladiator
Kurniawan, Gilang
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

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Optimization of Nanoemulsion Formula Containing Erythromycin with VCO and Varying Concentrations of Tween-80 and PEG-400 Mardiyanto; Mohadi, Risfidian; Fithri, Najma Annuria; Kurniawan, Gilang
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.697-709

Abstract

Erythromycin, a macrolide antibiotic is classified into Biopharmaceutical Classification System (BCS) class II which has low solubility in water. The low solubility corresponds to the bioavailability in the blood. One strategy to increase the solubility of Erythromycin is the formulation of erythromycin in nanoemulsion. This research aims to form nanoemulsion using the PIT (Phase Transition Temperature) method for obtaining the optimum formula of erythromycin nanoemulsion using virgin coconut oil (VCO) can be found with varying concentrations of Tween 80 surfactant and PEG 400 cosurfactant. The selection of the optimum formula was assisted by Design Expert software with the Factorial design method 22. The basis for determining the optimum formula is based on the results of organoleptic characterization tests, adsorption efficiency (%EE), percent transmittance, viscosity test, pH test, and stability test. The optimum formula was nanoemulsion which had a concentration of Tween 80 25% and PEG 400 25% as a desirability value of <1. The results of the optimum formula showed that the particle size was 170.6±12.8594 nm, polydispersity index (PDI) 0.403±0.04406, and zeta potential -8.8667±0.25697 mV and had an appropriate stability without phase separation during stability test.
Co-Authors Afriano, Aldi Amin, Muhammad Amirul AS, Fadly Dahliana, Dina Darwati Darwati Desi Armi Eka Putri Eri Barlian Fadhilah, Farhan Furkon Sukanda, Ukon Herwanto Herwanto Jaafar, Azhar Khairunnisa, Elvira Leviana Sari, Hesti Mardiyanto Masri, Zul Mochammad Mirza Murniyati, Murniyati Najma Annuria Fithri, Najma Annuria Nana Fauzana Azima Narawangsa, Naufal Nur Kholifah, Umi Nurhayati Nurhayati Radila, Gustina Ramayani, Novila Risfidian Mohadi Winda, Esis Yumna Yumna, Yumna Zora, Fera Zulaikhah Dwi Jayanti Zulmasri, Zulmasri