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All Journal HAYATI Journal of Biosciences CHEMPUBLISH JOURNAL Jurnal Farmasi Sains dan Komunitas JCES (Journal of Character Education Society) SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Walisongo Journal of Chemistry Jurnal Kreativitas PKM Jambura Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JKPK (Jurnal Kimia dan Pendidikan Kimia) Jurnal Kefarmasian Indonesia JURNAL REKAYASA KIMIA & LINGKUNGAN Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Susanto, Nindita Clourisa Amaris
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : CHEMPUBLISH JOURNAL

 1 
Flavonoid Compounds from Ethanol Extract of Sungkai Leaves (Peronema canescens. Jack) and Antibacterial Activity Test Against Staphylococcus epidermidis and Escherchia coli Susanto, Nindita Clourisa Amaris; Ardhica, Jammes; Nelson; Latief, Madyawati
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41653

Abstract

The rise of antibiotic-resistant bacteria has intensified the global search for alternative antimicrobial agents, particularly from natural sources. Traditional medicinal plants have been widely recognized for their therapeutic potential, and Peronema canescens Jack is well-known to contain bioactive compounds. Among its pharmacological properties, its antibacterial potential has drawn scientific interest. Secondary metabolites such as flavonoids, tannins, and phenolics are believed to contribute to its antimicrobial activity. However, the specific antibacterial compounds in P. canescens remain largely unidentified. This study seeks to isolate and characterize antibacterial compounds from the ethanol extract of Sungkai leaves, aiming to discover new natural antibacterial agents. The research objectives include isolating antibacterial compounds using maceration extraction and fractionation, conducting phytochemical screening to identify metabolite classes, assessing antibacterial activity using the paper disc diffusion method, and characterizing bioactive isolates through UV-Vis spectrophotometry and FTIR analysis. The results indicate that the ethyl acetate fraction of the ethanol extract of P. canescens leaves exhibits significant antibacterial activity, particularly at concentrations of 500 and 1000 ppm. UV-Vis spectrophotometric analysis identified flavonoid compounds, including apigenin, flavones, and flavonols, based on characteristic absorption peaks. FTIR analysis confirmed the presence of functional groups associated with flavonoids, supporting their antibacterial potential. These findings highlight P. canescens as a promising source of natural antibacterial agents. Further studies focusing on compound purification and in vivo antibacterial testing are recommended to explore its pharmaceutical applications.
Cytotoxic Activity of Polymethoxyflavone Compounds Ethyl Acetate Extract of Sungkai Leaves (Peronema canescens Jack) as Anticancer Candidates Adriliana, Zairaini Adriliana; Susanto, Nindita Clourisa Amaris; Fikriansyah, Muhammad; Tarigan, Indra Lasmana; Sutrisno, Sutrisno
Chempublish Journal Vol. 6 No. 4 (2022): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v6i4.41660

Abstract

Green Synthesis of Ag/Chitosan Nanoparticles using Avocado Leaves Bioreductor (Persea americana Mill.) as a Nitrite Colorimetry Detector Lestari, Nani; Puspitasari, Ratih Dyah Puspitasari; Susanto, Nindita Clourisa Amaris; Tarigan, Indra Lasmana; Nelson, Nelson
Chempublish Journal Vol. 9 No. 2 (2025): Chempublish Journal (July - December)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i2.46583

Abstract

Urinary tract infection (UTI) is one of the most common types of infection caused by the growth of microorganisms in the human urinary tract. Nitrite can be detected using spectroscopy, electrochemistry, chemiluminescence, chromatography, capillary electrophoresis, and flow injection analysis methods. However, this method takes quite a long time. So, this method is not suitable for rapid screening because it requires time for bacterial incubation and adequate sample preparation. So, there is a need for a fast-screening method that can diagnose UTIs through a nitrite colorimetric sensor. The colorimetric method is based on nanoparticles, which are relatively cheap and can provide visual and rapid detection. Nitrite is an indicator in diagnosing UTI. This research aims to determine the synthesis of Ag nanoparticles using avocado leaf bio-reductors (Persea americana Mill.) and chitosan as a stabilizer, which can be used as a colorimetric nitrite detector to minimize the use of dangerous and environmentally unfriendly inorganic materials. Characterization and analysis in this research used a UV-Vis spectrophotometer, FT-IR (Fourier Transform Infra-Red), and PSA (Particle Size Analyzer). The Ag nanoparticle synthesis process was carried out by varying the bioreductant volume, synthesis time, and chitosan concentration. It was found that the optimum synthesis time was 4 hours with an SPR value of 428 nm, an absorbance of 2.112 and a nanoparticle size. Apart from that, the optimum concentration of chitosan was obtained at a concentration of 2.5% with an SPR of 435 nm and an absorbance of 1.341 with a nanoparticle size. The results obtained from AgNPs/chitosan as a colorimetric nitrite detector showed a color change to purple with an LOD value of 0.1303 µM and an LOQ of 0.4345 µM. Keywords: Ag Nanoparticles; Avocado Leaveas; Colorimetry; Nitrite.
Co-Authors Aderita, Novi Indah Adriliana, Zairaini Adriliana Aminuyati Ananda, Hertanti Dwi Anif Nur Artanti, Anif Nur Aratanti, Anif Nur Ardhica, Jammes Darojati, Ulfa Afrinurfadhilah Diah Riski Gusti ERMAWATI, DIAN EKA Fajri, Nadiatul Fikriansyah, Muhammad Fitria, Krismona Rizky Nur Hanuriansyah, Yavi Hapsari, Aulia Ratri Heriyanti Heriyanti, Heriyanti Hertanti, Hertanti Heru Sasongko Indra Lasmana Tarigan Madyawati Latief Megananda, Nadya Karlina Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muslimah, Intan Muzaroah Ermawati Ulkhasanah Nani Lestari Nelson Nelson Nelson Nuralang nuralang, nuralang Pradina, Armitha Dea Prasetio, M. Reza Prasetio, Muhamad Reza Puspitasari, Ratih Dyah Puspitasari, Ratih Dyah Puspitasari Rahayu Rahayu Restina Bemis, Restina Rochmani, Sholichah Sawitri, Arinda Handiyah Sholichah Rohmani, Sholichah Susanto, Bela Novita Amaris Sutrisno, Sutrisno untari, meta kartika Utami, Diyah Tri Wulan Safitri, Wulan Zulpadly, M. Fiqri Zulpadly, Muhammad Fiqri